{"id":"https://openalex.org/W4200224701","doi":"https://doi.org/10.21203/rs.3.rs-1193193/v1","title":"Effect of thyroid dysfunction on hematological profiles at Menelik II Referral Hospital, Addis Ababa, Ethiopia","display_name":"Effect of thyroid dysfunction on hematological profiles at Menelik II Referral Hospital, Addis Ababa, Ethiopia","publication_year":2021,"publication_date":"2021-12-29","ids":{"openalex":"https://openalex.org/W4200224701","doi":"https://doi.org/10.21203/rs.3.rs-1193193/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-1193193/v1","doi":"https://doi.org/10.21203/rs.3.rs-1193193/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1193193/v1","pdf_url":"https://www.researchsquare.com/article/rs-1193193/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W4200224701"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-1193193/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015624348","display_name":"Haymanot Tewabe","orcid":"https://orcid.org/0000-0001-8441-0311","observed_orcids":["https://orcid.org/0000-0001-8441-0311"]},"institutions":[{"id":"https://openalex.org/I4210136909","display_name":"Dilla University","ror":"https://ror.org/04ahz4692","country_code":"ET","type":"education","lineage":["https://openalex.org/I4210136909"]},{"id":"https://openalex.org/I916065895","display_name":"Debre Markos University","ror":"https://ror.org/04sbsx707","country_code":"ET","type":"education","lineage":["https://openalex.org/I916065895"]}],"countries":["ET"],"is_corresponding":true,"raw_author_name":"Haymanot Tewabe","raw_affiliation_strings":["Debre Markos University","Dilla University","University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Debre Markos University","institution_ids":["https://openalex.org/I916065895"]},{"raw_affiliation_string":"Dilla University","institution_ids":["https://openalex.org/I4210136909"]},{"raw_affiliation_string":"University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084922358","display_name":"Assaye Mitiku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136909","display_name":"Dilla University","ror":"https://ror.org/04ahz4692","country_code":"ET","type":"education","lineage":["https://openalex.org/I4210136909"]}],"countries":["ET"],"is_corresponding":false,"raw_author_name":"Assaye Mitiku","raw_affiliation_strings":["Dilla University","University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dilla University","institution_ids":["https://openalex.org/I4210136909"]},{"raw_affiliation_string":"University","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077041772","display_name":"Abtie Abebaw","orcid":"https://orcid.org/0000-0002-8132-4001","observed_orcids":["https://orcid.org/0000-0002-8132-4001"]},"institutions":[{"id":"https://openalex.org/I4210136909","display_name":"Dilla University","ror":"https://ror.org/04ahz4692","country_code":"ET","type":"education","lineage":["https://openalex.org/I4210136909"]},{"id":"https://openalex.org/I916065895","display_name":"Debre Markos University","ror":"https://ror.org/04sbsx707","country_code":"ET","type":"education","lineage":["https://openalex.org/I916065895"]}],"countries":["ET"],"is_corresponding":false,"raw_author_name":"Abtie Abebaw","raw_affiliation_strings":["Debre Markos University","Dilla University","University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Debre Markos University","institution_ids":["https://openalex.org/I916065895"]},{"raw_affiliation_string":"Dilla University","institution_ids":["https://openalex.org/I4210136909"]},{"raw_affiliation_string":"University","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015624348"],"corresponding_institution_ids":["https://openalex.org/I4210136909","https://openalex.org/I916065895"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-disease","display_name":"thyroid dysfunction","score":1.0},{"id":"https://openalex.org/keywords/hematological-profile","display_name":"hematological profile","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":1.0},{"id":"https://openalex.org/keywords/complete-blood-count","display_name":"complete blood count","score":0.953000009059906},{"id":"https://openalex.org/keywords/red-blood-cell-indices","display_name":"red blood cell indices","score":0.8880000114440918},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.7850000262260437},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.7269999980926514},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.781000018119812},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.816241979598999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6312114000320435},{"id":"https://openalex.org/C2994032529","wikidata":"https://www.wikidata.org/wiki/Q6673122","display_name":"Thyroid dysfunction","level":3,"score":0.6042228937149048},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.5890239477157593},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5732923746109009},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4917464554309845},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4779360592365265},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4698046147823334},{"id":"https://openalex.org/C2777886399","wikidata":"https://www.wikidata.org/wiki/Q211544","display_name":"Thyroid-stimulating hormone","level":3,"score":0.41422784328460693}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-1193193/v1","doi":"https://doi.org/10.21203/rs.3.rs-1193193/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1193193/v1","pdf_url":"https://www.researchsquare.com/article/rs-1193193/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-1193193/v1","doi":"https://doi.org/10.21203/rs.3.rs-1193193/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-1193193/v1","pdf_url":"https://www.researchsquare.com/article/rs-1193193/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200224701.pdf","grobid_xml":"https://content.openalex.org/works/W4200224701.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W217633539","https://openalex.org/W1859581417","https://openalex.org/W1978560444","https://openalex.org/W1982063818","https://openalex.org/W1994509864","https://openalex.org/W1995412740","https://openalex.org/W2061977198","https://openalex.org/W2063792917","https://openalex.org/W2080861502","https://openalex.org/W2095389976","https://openalex.org/W2096524107","https://openalex.org/W2106108638","https://openalex.org/W2145648909","https://openalex.org/W2161440542","https://openalex.org/W2343140889","https://openalex.org/W2344264895","https://openalex.org/W2794691062","https://openalex.org/W3040825997","https://openalex.org/W3191192388","https://openalex.org/W4231673686","https://openalex.org/W4294988676"],"related_works":["https://openalex.org/W4205298678","https://openalex.org/W6892577398","https://openalex.org/W4411825642","https://openalex.org/W4407588757","https://openalex.org/W3040825997","https://openalex.org/W3202235962","https://openalex.org/W4406272438","https://openalex.org/W4289173777","https://openalex.org/W2998578277","https://openalex.org/W4387221149"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Thyroid":[2],"hormones":[3],"have":[4],"a":[5,45,126,173,187,232],"crucial":[6],"role":[7],"in":[8,87,163,177,191,196],"the":[9,18,24,74,88,105,164,220],"metabolism,":[10],"production,":[11],"and":[12,53,67,83,85,114,129,151,186,194,212,246,258],"proliferation":[13],"of":[14,27,47,61,80,120,141,167,199,209],"blood":[15,63],"cells.":[16],"So":[17],"current":[19],"study":[20,36,143],"aimed":[21],"to":[22,41,203],"assess":[23],"hematological":[25],"profile":[26],"patients":[28,55],"with":[29,56],"thyroid":[30,57,200,229],"dysfunction.":[31,58],"Methods":[32],"A":[33],"comparative":[34],"prospective":[35],"was":[37,91,98,107,123,135],"conducted":[38],"from":[39],"June":[40],"September":[42],"2021;":[43],"on":[44,235,255],"total":[46],"360":[48,142],"participants":[49,144],"(120":[50,145],"health":[51],"groups":[52,205,221],"240":[54],"10":[59],"ml":[60],"venous":[62],"samples":[64],"were":[65,158,162],"collected":[66],"separated":[68],"into":[69],"two":[70],"test":[71],"tubes":[72,90],"(in":[73],"SST":[75],"tube":[76],"used":[77,92],"for":[78,93],"measurement":[79],"TSH,":[81],"T3,":[82],"T4,":[84],"sample":[86],"EDTA":[89],"CBC":[94],"analysis).":[95],"The":[96,118,170,225],"analysis":[97],"done":[99],"by":[100,109],"using":[101,110],"SPPS":[102],"software.":[103],"Finally,":[104],"result":[106],"interpreted":[108],"chi-square,":[111],"Pearson's":[112],"correlation,":[113],"multivariate":[115],"logistic":[116],"regression.":[117],"level":[119],"statistical":[121],"significance":[122],"set":[124],"at":[125],"95%":[127],"confidence":[128],"P-value":[130],"is":[131],"less":[132],"than":[133],"0.05":[134],"considered":[136],"clinically":[137],"significant.":[138],"Results":[139],"Out":[140],"(33.33%)":[146,149,153],"hypothyroidism,":[147],"120":[148,152],"hyperthyroidism,":[150],"healthy":[154],"controls);":[155],"195":[156],"(54.2%)":[157],"female,":[159],"150":[160],"(41.7%)":[161],"age":[165],"range":[166],"25-44":[168],"years.":[169],"finding":[171,226],"indicated":[172],"statistically":[174],"significant":[175,217,233,253],"decrease":[176],"RBC,":[178],"Hgb,":[179,237],"HCT,":[180,238],"MCV,":[181],"PLT,":[182],"MCH,":[183,241],"MCHC,":[184,240],"MPV,":[185],"significantly":[188],"increased":[189],"valve":[190],"RDW,":[192],"WBC,":[193,242],"NEU%":[195],"both":[197],"types":[198],"dysfunction":[201,230],"compared":[202],"control":[204],"(p-value":[206,222,260],"<0.05).":[207],"Finding":[208],"MON%,":[210],"EOS%":[211],"BAS%":[213],"did":[214],"not":[215],"show":[216,252],"differences":[218],"between":[219],">0.05).":[223],"Conclusion":[224],"showed":[227],"that":[228],"has":[231],"effect":[234,254],"RBCs,":[236],"MCV":[239],"neutrophils,":[243],"PLT":[244],"count,":[245],"MPV":[247],"findings":[248],"(p<0.05).":[249],"But":[250],"no":[251],"monocyte,":[256],"eosinophil":[257],"basophils":[259],">":[261],"0.05).":[262]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2021-12-31T00:00:00"}