{"id":"https://openalex.org/W4200224380","doi":"https://doi.org/10.1080/16078454.2021.2009646","title":"Treatment outcome of 301 aplastic anemia patients in China: a 10-year follow-up and real-world data from single institute experience","display_name":"Treatment outcome of 301 aplastic anemia patients in China: a 10-year follow-up and real-world data from single institute experience","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W4200224380","doi":"https://doi.org/10.1080/16078454.2021.2009646","pmid":"https://pubmed.ncbi.nlm.nih.gov/34895103"},"language":"en","primary_location":{"id":"doi:10.1080/16078454.2021.2009646","doi":"https://doi.org/10.1080/16078454.2021.2009646","is_oa":true,"landing_page_url":"https://doi.org/10.1080/16078454.2021.2009646","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/16078454.2021.2009646?needAccess=true","source":{"id":"https://openalex.org/S195061619","display_name":"Hematology","issn_l":"1024-5332","issn":["1024-5332","1027-7501","1607-8454"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/16078454.2021.2009646?needAccess=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107948733","display_name":"Xiaotian Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-tian Zhang","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102707232","display_name":"Xue Wang","orcid":"https://orcid.org/0000-0003-2461-6304","observed_orcids":["https://orcid.org/0000-0003-2461-6304"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Wang","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045094860","display_name":"Jiang Cao","orcid":"https://orcid.org/0000-0003-3767-9283","observed_orcids":["https://orcid.org/0000-0003-3767-9283"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiang Cao","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344298","display_name":"Wei Chen","orcid":"https://orcid.org/0000-0001-5451-6430","observed_orcids":["https://orcid.org/0000-0001-5451-6430"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073709637","display_name":"Kunming Qi","orcid":"https://orcid.org/0000-0002-0717-9133","observed_orcids":["https://orcid.org/0000-0002-0717-9133"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun-ming Qi","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002009325","display_name":"Na Qi","orcid":"https://orcid.org/0000-0001-5333-1602","observed_orcids":["https://orcid.org/0000-0001-5333-1602","https://orcid.org/0000-0001-5499-8054"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Qi","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fei Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Liang","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034457996","display_name":"Xueyan Dong","orcid":"https://orcid.org/0000-0001-9084-6234","observed_orcids":["https://orcid.org/0000-0001-9084-6234"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue-yan Dong","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076346016","display_name":"Guo-feng Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guo-feng Tang","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101727013","display_name":"Depeng Li","orcid":"https://orcid.org/0000-0001-9650-6249","observed_orcids":["https://orcid.org/0000-0001-9650-6249"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"De-peng Li","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050692462","display_name":"Wei Sang","orcid":"https://orcid.org/0000-0002-1170-7074","observed_orcids":["https://orcid.org/0000-0002-1170-7074","https://orcid.org/0009-0004-2054-1258"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Sang","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-1170-7074","affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100330758","display_name":"Zhenyu Li","orcid":"https://orcid.org/0000-0003-4610-9135","observed_orcids":["https://orcid.org/0000-0003-4610-9135"]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen-yu Li","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113625914","display_name":"Hai Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai Cheng","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210106614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100666262","display_name":"Kailin Xu","orcid":"https://orcid.org/0000-0003-1375-1084","observed_orcids":["https://orcid.org/0000-0003-1375-1084"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210106614","display_name":"Affiliated Hospital of Xuzhou Medical College","ror":"https://ror.org/011xhcs96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106614"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kai-lin Xu","raw_affiliation_strings":["Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","Institute of Hematology, Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","Key Laboratory of Bone Marrow Stem Cell, Xuzhou, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210106614"]},{"raw_affiliation_string":"Institute of Hematology, Xuzhou Medical University, Xuzhou, People\u2019s Republic of China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Key Laboratory of Bone Marrow Stem Cell, Xuzhou, People\u2019s Republic of China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100666262"],"corresponding_institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210106614"],"apc_list":{"value":2085,"currency":"GBP","value_usd":2557},"apc_paid":{"value":2085,"currency":"GBP","value_usd":2557},"fwci":0.6518,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.69170173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"26","issue":"1","first_page":"1025","last_page":"1030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.6807000041007996,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.6807000041007996,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.24079999327659607,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aplastic-anemia","display_name":"aplastic anemia","score":1.0},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.972000002861023},{"id":"https://openalex.org/keywords/antithymocyte-globulin","display_name":"antithymocyte globulin","score":0.9449999928474426},{"id":"https://openalex.org/keywords/antilymphocyte-globulin","display_name":"antilymphocyte globulin","score":0.9739999771118164},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7770000100135803},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9520000219345093},{"id":"https://openalex.org/keywords/severe-aplastic-anemia","display_name":"severe aplastic anemia","score":0.8690000176429749},{"id":"https://openalex.org/keywords/very-severe-aplastic-anemia","display_name":"very severe aplastic anemia","score":0.949999988079071},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7390000224113464},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.49399998784065247},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.4880000054836273},{"id":"https://openalex.org/keywords/economic-status","display_name":"economic status","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8085078001022339},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.689165472984314},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5609557628631592},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5349781513214111},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.4854796230792999},{"id":"https://openalex.org/C81358767","wikidata":"https://www.wikidata.org/wiki/Q321710","display_name":"Globulin","level":2,"score":0.45248135924339294},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.44987666606903076},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.41407328844070435},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33493244647979736}],"mesh":[{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078022","descriptor_name":"Economic Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000741","descriptor_name":"Anemia, Aplastic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000741","descriptor_name":"Anemia, Aplastic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000961","descriptor_name":"Antilymphocyte Serum","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/16078454.2021.2009646","doi":"https://doi.org/10.1080/16078454.2021.2009646","is_oa":true,"landing_page_url":"https://doi.org/10.1080/16078454.2021.2009646","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/16078454.2021.2009646?needAccess=true","source":{"id":"https://openalex.org/S195061619","display_name":"Hematology","issn_l":"1024-5332","issn":["1024-5332","1027-7501","1607-8454"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology","raw_type":"journal-article"},{"id":"pmid:34895103","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34895103","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology (Amsterdam, Netherlands)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1080/16078454.2021.2009646","doi":"https://doi.org/10.1080/16078454.2021.2009646","is_oa":true,"landing_page_url":"https://doi.org/10.1080/16078454.2021.2009646","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/16078454.2021.2009646?needAccess=true","source":{"id":"https://openalex.org/S195061619","display_name":"Hematology","issn_l":"1024-5332","issn":["1024-5332","1027-7501","1607-8454"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6299999952316284,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8294437806","display_name":null,"funder_award_id":"QNRC2016793","funder_id":"https://openalex.org/F4320331087","funder_display_name":"Young Medical Key Talents Foundation of Jiangsu Province"}],"funders":[{"id":"https://openalex.org/F4320331087","display_name":"Young Medical Key Talents Foundation of Jiangsu Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4200224380.pdf"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1502200885","https://openalex.org/W1923634318","https://openalex.org/W1970974307","https://openalex.org/W1987061419","https://openalex.org/W2018493712","https://openalex.org/W2037596769","https://openalex.org/W2052285621","https://openalex.org/W2076225806","https://openalex.org/W2106339572","https://openalex.org/W2107947615","https://openalex.org/W2111099034","https://openalex.org/W2134336793","https://openalex.org/W2142353478","https://openalex.org/W2155971057","https://openalex.org/W2158837255","https://openalex.org/W2171228629","https://openalex.org/W2180801403","https://openalex.org/W2313455490","https://openalex.org/W2341016096","https://openalex.org/W2418980574","https://openalex.org/W2577173078","https://openalex.org/W2738836550","https://openalex.org/W2769836308","https://openalex.org/W2777052989","https://openalex.org/W2923667875","https://openalex.org/W3047134788","https://openalex.org/W3138107828"],"related_works":["https://openalex.org/W4389230090","https://openalex.org/W2080768801","https://openalex.org/W137505998","https://openalex.org/W4317475380","https://openalex.org/W2377065727","https://openalex.org/W7093121256","https://openalex.org/W1523100198","https://openalex.org/W2422516190","https://openalex.org/W3215995703","https://openalex.org/W1984748863"],"abstract_inverted_index":{"Objective":[0],"This":[1],"study":[2],"was":[3,85,113,137,166],"carried":[4],"out":[5],"to":[6,38,71,152,208,218],"explore":[7],"clinical":[8,25],"treatment":[9,196],"and":[10,184],"prognosis":[11],"of":[12,27,157,181,197,211,230,234,238],"patients":[13,29,88,116,199],"with":[14,16,30,51,64,89,94,96,117,120,123,169,200],"AA":[15,31,91,98,105,201,214],"different":[17],"economic":[18],"status.":[19],"Methods:":[20],"We":[21],"retrospectively":[22],"analyzed":[23],"the":[24,155,209,231,236],"outcome":[26],"301":[28],"in":[32,87,115,126,131],"our":[33],"center":[34],"from":[35,224],"April":[36],"2008":[37],"November":[39],"2017.Results":[40],"Treatments":[41],"included":[42],"anti-thymocyte":[43],"globulin":[44,48],"(ATG)":[45],"or":[46,66],"anti-lymphocyte":[47],"(ALG)":[49],"combined":[50,63,122],"cyclosporineA":[52],"(CsA)":[53],"(9%),":[54],"allogeneic":[55],"hematopoietic":[56],"stem":[57],"cell":[58],"transplantation":[59],"(allo-HSCT)":[60],"(7%),":[61],"CsA":[62,67,73,132,153,158,205,220,226],"androgen":[65],"alone":[68],"(hereinafter":[69],"referred":[70],"as":[72],"group)":[74],"(77%),":[75],"no":[76,141,185],"specific":[77,142,186],"therapy":[78,143,187],"(7%).":[79],"The":[80,110,195],"5-year":[81,111],"overall":[82],"survival":[83,171,210],"(OS)":[84],"higher":[86,139],"non-severe":[90],"(94.6%)":[92],"compared":[93],"those":[95,149],"severe":[97,104],"(SAA)":[99],"(66.6%,":[100],"P":[101,108,146,173],"<.001),":[102],"very":[103],"(VSAA)":[106],"(41.3%,":[107],"<.001).":[109,174],"OS":[112],"76.5%":[114],"SAA/VSAA":[118,212],"treated":[119],"ATG/ALG":[121],"CsA,":[124,235],"75%":[125],"allo-HSCT":[127],"group(P":[128],"=.936),":[129],"63.6%":[130],"group":[133,144],"(P":[134],"=.557),":[135],"which":[136],"significantly":[138],"than":[140],"(21.8%,":[145],"=.002).":[147],"For":[148],"who":[150,216],"responded":[151,217],",":[154],"duration":[156],"(median":[159],"follow-up":[160],"time:":[161],"27":[162],"months,":[163],"1\u2013101":[164],"months)":[165],"positively":[167],"correlated":[168],"progression-free":[170],"(r=0.603,":[172],"Multivariate":[175],"analysis":[176],"revealed":[177],"that":[178],"36\u201365":[179],"years":[180],"age,":[182],"SAA/VSAA,":[183],"were":[188],"independent":[189],"risk":[190],"factors":[191],"for":[192],"inferior":[193],"survival.Conclusion":[194],"elderly":[198],"still":[202],"faces":[203],"challenges.":[204],"is":[206,240],"benefit":[207,223],"patients.":[213],"patients,":[215],"initialy":[219],"treatment,":[221],"may":[222],"prolonged":[225],"treatment.":[227],"In":[228],"view":[229],"side":[232],"effects":[233],"timing":[237],"withdrawal":[239],"worth":[241],"further":[242],"exploration.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-12-31T00:00:00"}