{"id":"https://openalex.org/W4200220360","doi":"https://doi.org/10.15789/1563-0625-rot-2302","title":"Role of the cellular immunity in the formation of the immune response in coronavirus infections","display_name":"Role of the cellular immunity in the formation of the immune response in coronavirus infections","publication_year":2021,"publication_date":"2021-12-20","ids":{"openalex":"https://openalex.org/W4200220360","doi":"https://doi.org/10.15789/1563-0625-rot-2302"},"language":"en","primary_location":{"id":"doi:10.15789/1563-0625-rot-2302","doi":"https://doi.org/10.15789/1563-0625-rot-2302","is_oa":true,"landing_page_url":"https://doi.org/10.15789/1563-0625-rot-2302","pdf_url":"https://www.mimmun.ru/mimmun/article/download/2302/1483","source":{"id":"https://openalex.org/S4210239929","display_name":"Medical Immunology (Russia)","issn_l":"1563-0625","issn":["1563-0625","2313-741X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312639","host_organization_name":"SPb RAACI","host_organization_lineage":["https://openalex.org/P4310312639"],"host_organization_lineage_names":["SPb RAACI"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Immunology (Russia)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.mimmun.ru/mimmun/article/download/2302/1483","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039317481","display_name":"Ivanova Ia","orcid":"https://orcid.org/0000-0001-7068-4071","observed_orcids":["https://orcid.org/0000-0001-7068-4071"]},"institutions":[{"id":"https://openalex.org/I4210104029","display_name":"Rostov-on-Don Anti-plague Institute Rospotrebnadzor","ror":"https://ror.org/01dhvqg75","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210104029"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. A. Ivanova","raw_affiliation_strings":["Rostov-on-Don Plague Control Research Institute"],"raw_orcid":"https://orcid.org/0000-0001-7068-4071","affiliations":[{"raw_affiliation_string":"Rostov-on-Don Plague Control Research Institute","institution_ids":["https://openalex.org/I4210104029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076736417","display_name":"N. D. Omelchenko","orcid":"https://orcid.org/0000-0001-5208-7724","observed_orcids":["https://orcid.org/0000-0001-5208-7724"]},"institutions":[{"id":"https://openalex.org/I4210104029","display_name":"Rostov-on-Don Anti-plague Institute Rospotrebnadzor","ror":"https://ror.org/01dhvqg75","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210104029"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. D. Omelchenko","raw_affiliation_strings":["Rostov-on-Don Plague Control Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rostov-on-Don Plague Control Research Institute","institution_ids":["https://openalex.org/I4210104029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009627470","display_name":"Anna V. Filippenko","orcid":"https://orcid.org/0000-0002-1103-4244","observed_orcids":["https://orcid.org/0000-0002-1103-4244"]},"institutions":[{"id":"https://openalex.org/I4210104029","display_name":"Rostov-on-Don Anti-plague Institute Rospotrebnadzor","ror":"https://ror.org/01dhvqg75","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210104029"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. V. Filippenko","raw_affiliation_strings":["Rostov-on-Don Plague Control Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rostov-on-Don Plague Control Research Institute","institution_ids":["https://openalex.org/I4210104029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018050743","display_name":"Anastasia A. Trufanova","orcid":"https://orcid.org/0000-0002-4770-5994","observed_orcids":["https://orcid.org/0000-0002-4770-5994"]},"institutions":[{"id":"https://openalex.org/I4210104029","display_name":"Rostov-on-Don Anti-plague Institute Rospotrebnadzor","ror":"https://ror.org/01dhvqg75","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210104029"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. A. Trufanova","raw_affiliation_strings":["Rostov-on-Don Plague Control Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rostov-on-Don Plague Control Research Institute","institution_ids":["https://openalex.org/I4210104029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028342345","display_name":"\u0410. \u041a. \u041d\u043e\u0441\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0003-0550-2221","observed_orcids":["https://orcid.org/0000-0003-0550-2221"]},"institutions":[{"id":"https://openalex.org/I4210104029","display_name":"Rostov-on-Don Anti-plague Institute Rospotrebnadzor","ror":"https://ror.org/01dhvqg75","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210104029"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. K. Noskov","raw_affiliation_strings":["Rostov-on-Don Plague Control Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rostov-on-Don Plague Control Research Institute","institution_ids":["https://openalex.org/I4210104029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210104029"],"apc_list":null,"apc_paid":null,"fwci":0.7636,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.73955477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"23","issue":"6","first_page":"1229","last_page":"1238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.890999972820282},{"id":"https://openalex.org/keywords/coronavirus-infection","display_name":"coronavirus infection","score":0.7910000085830688},{"id":"https://openalex.org/keywords/sars-cov","display_name":"SARS-CoV","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mers-cov","display_name":"MERS-CoV","score":1.0},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9869999885559082},{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.9610000252723694},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.8560000061988831},{"id":"https://openalex.org/keywords/lymphodepletion","display_name":"lymphocyte depletion","score":0.6940000057220459},{"id":"https://openalex.org/keywords/lymphopoiesis","display_name":"lymphocyte development","score":0.7239999771118164},{"id":"https://openalex.org/keywords/cross-immunity","display_name":"cross-immunity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/t-cell-epitopes","display_name":"T cell epitopes","score":0.656000018119812},{"id":"https://openalex.org/keywords/long-term-immunity","display_name":"long-term immunity","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8285770416259766},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6963115334510803},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6728823184967041},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.6444119811058044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5953925848007202},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.5143498182296753},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.5116336941719055},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4943225383758545},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.49021202325820923},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3849180340766907},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.287363201379776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23264196515083313},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.22534987330436707},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.15789/1563-0625-rot-2302","doi":"https://doi.org/10.15789/1563-0625-rot-2302","is_oa":true,"landing_page_url":"https://doi.org/10.15789/1563-0625-rot-2302","pdf_url":"https://www.mimmun.ru/mimmun/article/download/2302/1483","source":{"id":"https://openalex.org/S4210239929","display_name":"Medical Immunology (Russia)","issn_l":"1563-0625","issn":["1563-0625","2313-741X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312639","host_organization_name":"SPb RAACI","host_organization_lineage":["https://openalex.org/P4310312639"],"host_organization_lineage_names":["SPb RAACI"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Immunology (Russia)","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:d0d0bf3781a34b698d9d0e68aba6b67a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d0d0bf3781a34b698d9d0e68aba6b67a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430\u044f \u0438\u043c\u043c\u0443\u043d\u043e\u043b\u043e\u0433\u0438\u044f, Vol 23, Iss 6, Pp 1229-1238 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.15789/1563-0625-rot-2302","doi":"https://doi.org/10.15789/1563-0625-rot-2302","is_oa":true,"landing_page_url":"https://doi.org/10.15789/1563-0625-rot-2302","pdf_url":"https://www.mimmun.ru/mimmun/article/download/2302/1483","source":{"id":"https://openalex.org/S4210239929","display_name":"Medical Immunology (Russia)","issn_l":"1563-0625","issn":["1563-0625","2313-741X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312639","host_organization_name":"SPb RAACI","host_organization_lineage":["https://openalex.org/P4310312639"],"host_organization_lineage_names":["SPb RAACI"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Immunology (Russia)","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200220360.pdf","grobid_xml":"https://content.openalex.org/works/W4200220360.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1662940398","https://openalex.org/W1947409115","https://openalex.org/W1971932781","https://openalex.org/W1978623713","https://openalex.org/W1985360059","https://openalex.org/W1985551427","https://openalex.org/W1986187535","https://openalex.org/W1994545268","https://openalex.org/W1999546368","https://openalex.org/W2004583429","https://openalex.org/W2012770524","https://openalex.org/W2025080738","https://openalex.org/W2064961188","https://openalex.org/W2076401107","https://openalex.org/W2078121682","https://openalex.org/W2081417636","https://openalex.org/W2101166094","https://openalex.org/W2102303272","https://openalex.org/W2108756402","https://openalex.org/W2114009119","https://openalex.org/W2116101651","https://openalex.org/W2116922789","https://openalex.org/W2120967846","https://openalex.org/W2129203060","https://openalex.org/W2144410942","https://openalex.org/W2151957195","https://openalex.org/W2166221102","https://openalex.org/W2292472819","https://openalex.org/W2337596057","https://openalex.org/W2343747529","https://openalex.org/W2418601731","https://openalex.org/W2470646526","https://openalex.org/W2473693822","https://openalex.org/W2536224011","https://openalex.org/W2610105739","https://openalex.org/W2742905047","https://openalex.org/W2884893672","https://openalex.org/W2912913974","https://openalex.org/W2965379348","https://openalex.org/W3001638293","https://openalex.org/W3007460166","https://openalex.org/W3007643904","https://openalex.org/W3009859788","https://openalex.org/W3009912996","https://openalex.org/W3010441732","https://openalex.org/W3011508332","https://openalex.org/W3012345473","https://openalex.org/W3013093478","https://openalex.org/W3014361071","https://openalex.org/W3014586511","https://openalex.org/W3015404155","https://openalex.org/W3016288338","https://openalex.org/W3016535750","https://openalex.org/W3017251343","https://openalex.org/W3021544284","https://openalex.org/W3023991776","https://openalex.org/W3025320502","https://openalex.org/W3026558549","https://openalex.org/W3032533580","https://openalex.org/W3037433955","https://openalex.org/W3038761805","https://openalex.org/W3040211421","https://openalex.org/W3040695588","https://openalex.org/W3041173510","https://openalex.org/W3041450977","https://openalex.org/W3042587425","https://openalex.org/W3043257434","https://openalex.org/W3047996214","https://openalex.org/W3048775784","https://openalex.org/W3080677494","https://openalex.org/W3081314995","https://openalex.org/W3092762305","https://openalex.org/W3107235131","https://openalex.org/W3109331896","https://openalex.org/W3125185876"],"related_works":["https://openalex.org/W4229026561","https://openalex.org/W2555838982","https://openalex.org/W4200189389","https://openalex.org/W4254848057","https://openalex.org/W4406489379","https://openalex.org/W3158517217","https://openalex.org/W3084066265","https://openalex.org/W2025080738","https://openalex.org/W3119755440","https://openalex.org/W4200020049"],"abstract_inverted_index":{"The":[0,46,203],"data":[1,329],"obtained":[2,330],"during":[3,331],"previous":[4,332],"epidemics":[5,333],"caused":[6],"by":[7,349],"coronaviruses,":[8],"and":[9,24,43,54,59,82,96,109,139,152,191,219,221,237,255,300,317,346,378],"current":[10],"pandemic":[11],"indicate":[12],"that":[13,132,232],"assessing":[14],"the":[15,25,28,49,74,80,107,115,133,146,156,173,209,265,283],"role":[16,116,223,263],"of":[17,33,51,56,69,76,85,88,93,98,106,117,122,136,158,167,172,176,184,211,264,319,328,338,344],"certain":[18],"immune":[19,71,123,143,169,214,267,358,374],"interactions":[20],"between":[21],"these":[22,99,229,273],"viruses":[23],"microorganism":[26,147],"is":[27,127,178,193,312],"main":[29],"pre-requisite":[30],"for":[31,199,241,295],"development":[32,68,121],"diagnostic":[34],"test":[35],"systems":[36],"as":[37,39,363,365],"well":[38,364],"effective":[40],"medical":[41],"drugs":[42],"preventive":[44,380],"measures.":[45],"review":[47,204],"summarizes":[48],"results":[50],"studying":[52],"patho\u2013":[53],"immunogenesis":[55],"SARSCoV,":[57],"MERS-CoV,":[58],"SARS-CoV-2":[60,192,377],"infections.":[61,230],"These":[62],"coronaviruses":[63,126],"were":[64,244,288],"proven":[65,131],"to":[66,103,125,149,165,201,208,216,235,272,281,297,307,314,336,341,370,376],"suppress":[67],"adaptive":[70,142,339],"response":[72,124,144,268,375],"at":[73],"stage":[75],"its":[77],"induction,":[78],"affecting":[79],"number":[81,318],"functional":[83],"activity":[84],"lymphocytes,":[86],"effectors":[87],"cellular":[89,118,153,174,266],"immunity,":[90],"causing":[91],"impairment":[92],"lymphopoiesis,":[94],"apoptosis":[95],"\u00abdepletion\u00bb":[97],"cells,":[100],"thus":[101,195],"leading":[102],"longer":[104],"duration":[105],"disease":[108],"increased":[110],"viral":[111],"load.":[112],"Information":[113],"about":[114,261],"immunity":[119,177,271,340],"in":[120,145,188,224,251,269,279,290,323,356,360,366],"presented.":[128],"It":[129,275],"was":[130,276],"causative":[134],"agents":[135],"SARS,":[137],"MERS":[138,238],"COVID-19":[140,361],"trigger":[141],"according":[148],"both":[150],"humoral":[151],"types.":[154],"Moreover,":[155],"synthesis":[157],"specific":[159,212,233],"immunoglobulins":[160],"does":[161],"not":[162,246],"yet":[163],"point":[164],"presence":[166,316],"protective":[168],"response.":[170],"Activation":[171],"link":[175],"also":[179],"important.":[180],"A":[181,325],"high":[182],"degree":[183],"antigenic":[185],"epitope":[186],"homology":[187],"SARS-CoV,":[189,217],"MERS-CoV":[190,218],"described,":[194],"suggesting":[196],"an":[197],"opportunity":[198],"cross-immunity":[200],"coronaviruses.":[202,274,342],"addresses":[205],"issues":[206],"related":[207],"terms":[210],"memory":[213,285,320],"cells":[215,287,322],"SARS-CoV-2,":[220],"their":[222],"providing":[225,270],"long-term":[226],"protection":[227],"against":[228],"Given":[231],"antibodies":[234],"SARS":[236,293],"pathogens":[239],"persisted":[240],"a":[242],"year,":[243],"often":[245],"detected":[247],"or":[248],"briefly":[249],"registered":[250,289],"patients":[252,291],"with":[253,292,334],"mild":[254],"asymptomatic":[256],"infections,":[257],"we":[258],"can":[259],"talk":[260],"important":[262],"shown":[277],"that,":[278],"contrast":[280],"antibodies,":[282],"antigen-specific":[284],"T":[286,321,351,372],"virus":[294],"4":[296],"11":[298],"years,":[299],"Middle":[301],"East":[302],"Respiratory":[303],"Syndrome":[304],"\u2013":[305],"up":[306],"two":[308],"years.":[309],"Further":[310],"research":[311],"needed":[313],"determine":[315],"COVID-19.":[324],"comparative":[326],"analysis":[327],"respect":[335],"formation":[337],"Description":[343],"proteins":[345],"epitopes":[347],"recognized":[348],"human":[350],"lymphocytes":[352],"will":[353],"be":[354],"useful":[355],"monitoring":[357],"responses":[359],"patients,":[362],"developing":[367],"informative":[368],"tests":[369],"study":[371],"cell":[373],"new":[379],"drugs.":[381]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-12-31T00:00:00"}