{"id":"https://openalex.org/W4200219648","doi":"https://doi.org/10.1208/s12248-021-00638-1","title":"Systematic Evaluation of the Effect of Formulation Variables on In Vitro Performance of Mometasone Furoate Suspension-Metered Dose Inhalers","display_name":"Systematic Evaluation of the Effect of Formulation Variables on In Vitro Performance of Mometasone Furoate Suspension-Metered Dose Inhalers","publication_year":2021,"publication_date":"2021-12-07","ids":{"openalex":"https://openalex.org/W4200219648","doi":"https://doi.org/10.1208/s12248-021-00638-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/34874508","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10662261"},"language":"en","primary_location":{"id":"doi:10.1208/s12248-021-00638-1","doi":"https://doi.org/10.1208/s12248-021-00638-1","is_oa":false,"landing_page_url":"https://doi.org/10.1208/s12248-021-00638-1","pdf_url":null,"source":{"id":"https://openalex.org/S74983066","display_name":"The AAPS Journal","issn_l":"1550-7416","issn":["1550-7416"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The AAPS Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10662261/pdf/nihms-1942909.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060377538","display_name":"Sagar S. Bachhav","orcid":"https://orcid.org/0000-0003-0736-2656","observed_orcids":["https://orcid.org/0000-0003-0736-2656"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sagar S. Bachhav","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, Florida, 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, Florida, 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052486552","display_name":"Poonam Sheth","orcid":"https://orcid.org/0000-0001-7101-6665","observed_orcids":["https://orcid.org/0000-0001-7101-6665"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Poonam Sheth","raw_affiliation_strings":["AstraZeneca, Durham, North Carolina, USA","Recipharm, Morrisville, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210150756"]},{"raw_affiliation_string":"Recipharm, Morrisville, North Carolina, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088201938","display_name":"Dennis Sandell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis Sandell","raw_affiliation_strings":["S5 Consulting, Blentarp, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S5 Consulting, Blentarp, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109061650","display_name":"M\u00e5rten Svensson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M\u00e5rten Svensson","raw_affiliation_strings":["Emmace Consulting AB, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emmace Consulting AB, Lund, Sweden","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087381413","display_name":"Sharvari Bhagwat","orcid":"https://orcid.org/0009-0006-3606-8308","observed_orcids":["https://orcid.org/0009-0006-3606-8308"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharvari Bhagwat","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, Florida, 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, Florida, 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059163160","display_name":"Denise S. Conti","orcid":"https://orcid.org/0000-0002-6714-1735","observed_orcids":["https://orcid.org/0000-0002-6714-1735"]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1333606569","display_name":"Center for Drug Evaluation and Research","ror":"https://ror.org/00yf3tm42","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1333606569"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise S. Conti","raw_affiliation_strings":["Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I1320320070","https://openalex.org/I1333606569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090977051","display_name":"Oluwamurewa Oguntimein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1333606569","display_name":"Center for Drug Evaluation and Research","ror":"https://ror.org/00yf3tm42","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1333606569"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oluwamurewa Oguntimein","raw_affiliation_strings":["Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I1320320070","https://openalex.org/I1333606569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054421468","display_name":"Sneha Dhapare","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1333606569","display_name":"Center for Drug Evaluation and Research","ror":"https://ror.org/00yf3tm42","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1333606569"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sneha Dhapare","raw_affiliation_strings":["Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I1320320070","https://openalex.org/I1333606569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045809494","display_name":"Bhawana Saluja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1333606569","display_name":"Center for Drug Evaluation and Research","ror":"https://ror.org/00yf3tm42","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070","https://openalex.org/I1333606569"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhawana Saluja","raw_affiliation_strings":["Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA","Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I1320320070","https://openalex.org/I1333606569"]},{"raw_affiliation_string":"Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA","institution_ids":["https://openalex.org/I1320320070","https://openalex.org/I1333606569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034123007","display_name":"Lawrence H. Winner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence Winner","raw_affiliation_strings":["Department of Statistics, University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089733754","display_name":"J\u00fcrgen B. Bulitta","orcid":"https://orcid.org/0000-0001-7352-3097","observed_orcids":["https://orcid.org/0000-0001-7352-3097"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen B. Bulitta","raw_affiliation_strings":["Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Orlando, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033045204","display_name":"G\u00fcnther Hochhaus","orcid":"https://orcid.org/0000-0002-7406-5558","observed_orcids":["https://orcid.org/0000-0002-7406-5558"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Guenther Hochhaus","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, Florida, 32610, USA. hochhaus@ufl.edu","Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, Florida, 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, Florida, 32610, USA. hochhaus@ufl.edu","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, Florida, 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5033045204"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.27660099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"24","issue":"1","first_page":"9","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mometasone-furoate","display_name":"mometasone furoate","score":1.0},{"id":"https://openalex.org/keywords/aerosol-performance","display_name":"aerosol performance","score":0.847000002861023},{"id":"https://openalex.org/keywords/drug-particle-size","display_name":"drug particle size","score":0.8090000152587891},{"id":"https://openalex.org/keywords/ethanol-cosolvent","display_name":"ethanol co-solvent","score":0.7559999823570251},{"id":"https://openalex.org/keywords/oleic-acid-surfactant","display_name":"oleic acid surfactant","score":0.9959999918937683},{"id":"https://openalex.org/keywords/delivered-dose","display_name":"delivered dose","score":0.7519999742507935},{"id":"https://openalex.org/keywords/fine-particle-dose","display_name":"fine particle dose","score":0.9760000109672546},{"id":"https://openalex.org/keywords/factorial-design","display_name":"factorial design","score":0.6019999980926514},{"id":"https://openalex.org/keywords/formulation-variables","display_name":"formulation variables","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2781348165","wikidata":"https://www.wikidata.org/wiki/Q1044248","display_name":"Mometasone furoate","level":3,"score":0.7338279485702515},{"id":"https://openalex.org/C169222746","wikidata":"https://www.wikidata.org/wiki/Q4116558","display_name":"Factorial experiment","level":2,"score":0.536280632019043},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5236037373542786},{"id":"https://openalex.org/C2780667556","wikidata":"https://www.wikidata.org/wiki/Q16897784","display_name":"Metered-dose inhaler","level":4,"score":0.5218031406402588},{"id":"https://openalex.org/C204320433","wikidata":"https://www.wikidata.org/wiki/Q7268772","display_name":"Quality by Design","level":3,"score":0.5082871317863464},{"id":"https://openalex.org/C2781403372","wikidata":"https://www.wikidata.org/wiki/Q207688","display_name":"Oleic acid","level":2,"score":0.4940774738788605},{"id":"https://openalex.org/C2780449318","wikidata":"https://www.wikidata.org/wiki/Q18344773","display_name":"Critical quality attributes","level":3,"score":0.48459112644195557},{"id":"https://openalex.org/C2777239854","wikidata":"https://www.wikidata.org/wiki/Q902638","display_name":"Excipient","level":2,"score":0.47474175691604614},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.4583662152290344},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.42674264311790466},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2868804335594177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17422425746917725},{"id":"https://openalex.org/C2780261241","wikidata":"https://www.wikidata.org/wiki/Q1394363","display_name":"Inhaler","level":3,"score":0.16855710744857788},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.12724930047988892},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08928069472312927},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.08341890573501587},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.07127270102500916},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068656","descriptor_name":"Mometasone Furoate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013535","descriptor_name":"Suspensions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036501","descriptor_name":"Metered Dose Inhalers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1208/s12248-021-00638-1","doi":"https://doi.org/10.1208/s12248-021-00638-1","is_oa":false,"landing_page_url":"https://doi.org/10.1208/s12248-021-00638-1","pdf_url":null,"source":{"id":"https://openalex.org/S74983066","display_name":"The AAPS Journal","issn_l":"1550-7416","issn":["1550-7416"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The AAPS Journal","raw_type":"journal-article"},{"id":"pmid:34874508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34874508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The AAPS journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10662261","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10662261","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10662261/pdf/nihms-1942909.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"AAPS J","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10662261","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10662261","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10662261/pdf/nihms-1942909.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"AAPS J","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3191920116","display_name":null,"funder_award_id":"U01 FD004943","funder_id":"https://openalex.org/F4320332163","funder_display_name":"U.S. Food and Drug Administration"}],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200219648.pdf","grobid_xml":"https://content.openalex.org/works/W4200219648.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1529317955","https://openalex.org/W1966811623","https://openalex.org/W1978259521","https://openalex.org/W1979448840","https://openalex.org/W1988181646","https://openalex.org/W1995144022","https://openalex.org/W1995598839","https://openalex.org/W2015657846","https://openalex.org/W2021023200","https://openalex.org/W2022069744","https://openalex.org/W2025393031","https://openalex.org/W2039282390","https://openalex.org/W2043162795","https://openalex.org/W2045467856","https://openalex.org/W2060160295","https://openalex.org/W2077722212","https://openalex.org/W2079424703","https://openalex.org/W2081223771","https://openalex.org/W2112718944","https://openalex.org/W2114489922","https://openalex.org/W2116847148","https://openalex.org/W2131486402","https://openalex.org/W2136624385","https://openalex.org/W2157951331","https://openalex.org/W2162566700","https://openalex.org/W2168551021","https://openalex.org/W2186625066","https://openalex.org/W2213477389","https://openalex.org/W2621040193","https://openalex.org/W2621806960","https://openalex.org/W2622971040","https://openalex.org/W2805607018","https://openalex.org/W2805873702","https://openalex.org/W2917099635","https://openalex.org/W4238758530"],"related_works":["https://openalex.org/W2622971040","https://openalex.org/W2805607018","https://openalex.org/W2097245651","https://openalex.org/W2804209431","https://openalex.org/W2568623517","https://openalex.org/W2027114189","https://openalex.org/W2045467856","https://openalex.org/W21463662","https://openalex.org/W2030394440","https://openalex.org/W1593092657"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-12-31T00:00:00"}