{"id":"https://openalex.org/W4200217473","doi":"https://doi.org/10.7150/ijbs.66602","title":"Enhanced Intracellular Reactive Oxygen Species by Photodynamic Therapy Effectively Promotes Chemoresistant Cell Death","display_name":"Enhanced Intracellular Reactive Oxygen Species by Photodynamic Therapy Effectively Promotes Chemoresistant Cell Death","publication_year":2021,"publication_date":"2021-12-15","ids":{"openalex":"https://openalex.org/W4200217473","doi":"https://doi.org/10.7150/ijbs.66602","pmid":"https://pubmed.ncbi.nlm.nih.gov/34975339","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8692137"},"language":"en","primary_location":{"id":"doi:10.7150/ijbs.66602","doi":"https://doi.org/10.7150/ijbs.66602","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.66602","pdf_url":"https://www.ijbs.com/v18p0374.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ijbs.com/v18p0374.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101945663","display_name":"Xiaolin Xu","orcid":"https://orcid.org/0000-0001-7197-4521","observed_orcids":["https://orcid.org/0000-0001-7197-4521"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210099941","display_name":"Jinshan Hospital of Fudan University","ror":"https://ror.org/013a5fa56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolin Xu","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China","Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210099941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100367817","display_name":"Chenglong Wang","orcid":"https://orcid.org/0000-0002-9291-834X","observed_orcids":["https://orcid.org/0000-0002-9291-834X"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210099941","display_name":"Jinshan Hospital of Fudan University","ror":"https://ror.org/013a5fa56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenglong Wang","raw_affiliation_strings":["Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210099941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319646","display_name":"Peipei Zhang","orcid":"https://orcid.org/0000-0001-9070-9328","observed_orcids":["https://orcid.org/0000-0001-9070-9328"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4391767745","display_name":"State Key Laboratory of Metal Matrix Composites","ror":"https://ror.org/031z5jh56","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4391767745"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peipei Zhang","raw_affiliation_strings":["State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4391767745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056343592","display_name":"Xuzhu Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210099941","display_name":"Jinshan Hospital of Fudan University","ror":"https://ror.org/013a5fa56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuzhu Gao","raw_affiliation_strings":["Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210099941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101955388","display_name":"Wencai Guan","orcid":"https://orcid.org/0000-0001-8168-0711","observed_orcids":["https://orcid.org/0000-0001-8168-0711"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210099941","display_name":"Jinshan Hospital of Fudan University","ror":"https://ror.org/013a5fa56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wencai Guan","raw_affiliation_strings":["Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210099941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103255687","display_name":"Fanchen Wang","orcid":"https://orcid.org/0000-0003-1150-0417","observed_orcids":["https://orcid.org/0000-0003-1150-0417","https://orcid.org/0000-0001-5001-1013"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210099941","display_name":"Jinshan Hospital of Fudan University","ror":"https://ror.org/013a5fa56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fanchen Wang","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China","Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210099941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100353948","display_name":"Xin Li","orcid":"https://orcid.org/0000-0002-7837-7874","observed_orcids":["https://orcid.org/0000-0002-7837-7874"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210099941","display_name":"Jinshan Hospital of Fudan University","ror":"https://ror.org/013a5fa56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Li","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China","Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210099941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078294470","display_name":"Jia Yuan","orcid":"https://orcid.org/0000-0002-4807-8646","observed_orcids":["https://orcid.org/0000-0002-4807-8646"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210099941","display_name":"Jinshan Hospital of Fudan University","ror":"https://ror.org/013a5fa56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Yuan","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China","Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210099941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036744991","display_name":"Hongjing Dou","orcid":"https://orcid.org/0000-0001-5850-9174","observed_orcids":["https://orcid.org/0000-0001-5850-9174"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4391767745","display_name":"State Key Laboratory of Metal Matrix Composites","ror":"https://ror.org/031z5jh56","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4391767745"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongjing Dou","raw_affiliation_strings":["State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4391767745"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017777338","display_name":"Guoxiong Xu","orcid":"https://orcid.org/0000-0002-9074-8754","observed_orcids":["https://orcid.org/0000-0002-9074-8754"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210099941","display_name":"Jinshan Hospital of Fudan University","ror":"https://ror.org/013a5fa56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099941"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guoxiong Xu","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China","Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210099941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5017777338","https://openalex.org/A5036744991"],"corresponding_institution_ids":["https://openalex.org/I133868755","https://openalex.org/I183067930","https://openalex.org/I24943067","https://openalex.org/I4210099941","https://openalex.org/I4391767745"],"apc_list":{"value":2000,"currency":"AUD","value_usd":1337},"apc_paid":{"value":2000,"currency":"AUD","value_usd":1337},"fwci":1.1185,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.75203022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"374","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.4291999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.4291999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.15209999680519104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.11969999969005585,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9020000100135803},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.890999972820282},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9700000286102295},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.6790000200271606},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.6930000185966492},{"id":"https://openalex.org/keywords/chemotherapeutic-drugs","display_name":"chemotherapeutic drugs","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.8611874580383301},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.7055827975273132},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6814591288566589},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.630828857421875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5514765381813049},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5204886794090271},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48485955595970154},{"id":"https://openalex.org/C55885012","wikidata":"https://www.wikidata.org/wiki/Q4750801","display_name":"Anaerobic glycolysis","level":4,"score":0.4722920060157776},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.45087406039237976},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4501490592956543},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4092712998390198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3569994568824768},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34418660402297974},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3374629616737366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24373859167099},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.11194387078285217},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.7150/ijbs.66602","doi":"https://doi.org/10.7150/ijbs.66602","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.66602","pdf_url":"https://www.ijbs.com/v18p0374.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},{"id":"pmid:34975339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34975339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8692137","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8692137/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Biol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7150/ijbs.66602","doi":"https://doi.org/10.7150/ijbs.66602","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.66602","pdf_url":"https://www.ijbs.com/v18p0374.pdf","source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2364064525","display_name":null,"funder_award_id":"81872121","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3554426781","display_name":null,"funder_award_id":"21871180","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4357263930","display_name":null,"funder_award_id":"18520710300","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G8907567796","display_name":null,"funder_award_id":"17ZR1404100","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200217473.pdf","grobid_xml":"https://content.openalex.org/works/W4200217473.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1523565294","https://openalex.org/W1765741204","https://openalex.org/W1977178308","https://openalex.org/W1996447891","https://openalex.org/W2006766211","https://openalex.org/W2014246135","https://openalex.org/W2020224261","https://openalex.org/W2026198465","https://openalex.org/W2042619042","https://openalex.org/W2088270875","https://openalex.org/W2098273451","https://openalex.org/W2118961896","https://openalex.org/W2142046597","https://openalex.org/W2157393167","https://openalex.org/W2436926786","https://openalex.org/W2464503524","https://openalex.org/W2519786994","https://openalex.org/W2522707849","https://openalex.org/W2548475758","https://openalex.org/W2560535385","https://openalex.org/W2621333085","https://openalex.org/W2782557900","https://openalex.org/W2784697242","https://openalex.org/W2789953470","https://openalex.org/W2796552195","https://openalex.org/W2803820506","https://openalex.org/W2814259209","https://openalex.org/W2901265038","https://openalex.org/W2904642543","https://openalex.org/W2906120852","https://openalex.org/W2979135307","https://openalex.org/W2980384497","https://openalex.org/W3022746266","https://openalex.org/W3032582302","https://openalex.org/W3034112560","https://openalex.org/W3123123300","https://openalex.org/W3140383478","https://openalex.org/W3187906220","https://openalex.org/W4236528590","https://openalex.org/W6751605500"],"related_works":["https://openalex.org/W4381681578","https://openalex.org/W1965129675","https://openalex.org/W2184811528","https://openalex.org/W1876338531","https://openalex.org/W2133673081","https://openalex.org/W3128659834","https://openalex.org/W3214254157","https://openalex.org/W2979915343","https://openalex.org/W1980259837","https://openalex.org/W2901265038"],"abstract_inverted_index":{"Anti-cancer":[0],"chemo-drugs":[1],"can":[2],"cause":[3],"a":[4,162],"rapid":[5],"elevation":[6],"of":[7,36,54,58,83,97],"intracellular":[8],"reactive":[9],"oxygen":[10],"species":[11],"(ROS)":[12],"levels.An":[13],"imbalance":[14],"in":[15,41,51,76,88,119,124,135,138],"ROS":[16,37,68,127,146,159],"production":[17,147],"and":[18,34,60,63,107,129,137,152],"elimination":[19],"systems":[20,116,160],"leads":[21],"to":[22,26,30,112,165],"cancer":[23,45,84,121,167],"cell":[24,64,133,155],"resistance":[25,40,151],"chemotherapy.This":[27],"study":[28],"aimed":[29],"evaluate":[31],"the":[32,49,52,56,81],"mechanism":[33],"effect":[35],"on":[38],"multidrug":[39],"various":[42],"human":[43],"chemoresistant":[44,77,91,120,154],"cells":[46,85,92],"by":[47],"detecting":[48],"changes":[50],"amount":[53,128],"ROS,":[55],"expression":[57],"ROS-related":[59],"glycolysis-related":[61],"genes,":[62],"death.We":[65],"found":[66],"that":[67,80,144],"was":[69,74,86],"decreased":[70,126],"while":[71],"oxidative":[72,94],"phosphorylation":[73,95],"increased":[75,104],"cells.We":[78],"verified":[79],"chemoresistance":[82],"achieved":[87],"two":[89],"ways.First,":[90],"preferred":[93],"instead":[96],"anaerobic":[98],"glycolysis":[99],"for":[100],"energy":[101],"generation,":[102],"which":[103,123],"ATPase":[105],"activity":[106],"produced":[108],"much":[109],"more":[110],"ATP":[111],"provide":[113],"energy.Second,":[114],"ROS-scavenging":[115],"were":[117],"enhanced":[118],"cells,":[122],"turn":[125],"thus":[130],"inhibited":[131,149],"chemo-induced":[132],"death.Our":[134],"vitro":[136],"vivo":[139],"photodynamic":[140],"therapy":[141],"further":[142],"demonstrated":[143],"elevated":[145],"efficiently":[148],"chemo-drug":[150],"promoted":[153],"death.Taken":[156],"together,":[157],"targeting":[158],"has":[161],"great":[163],"potential":[164],"treat":[166],"patients":[168],"with":[169],"chemoresistance.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-31T00:00:00"}
