{"id":"https://openalex.org/W4200216629","doi":"https://doi.org/10.1021/acs.analchem.1c04585","title":"Enantioselective UHPLC Screening Combined with In Silico Modeling for Streamlined Development of Ultrafast Enantiopurity Assays","display_name":"Enantioselective UHPLC Screening Combined with In Silico Modeling for Streamlined Development of Ultrafast Enantiopurity Assays","publication_year":2021,"publication_date":"2021-12-21","ids":{"openalex":"https://openalex.org/W4200216629","doi":"https://doi.org/10.1021/acs.analchem.1c04585","pmid":"https://pubmed.ncbi.nlm.nih.gov/34931812"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.1c04585","doi":"https://doi.org/10.1021/acs.analchem.1c04585","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.1c04585","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033189215","display_name":"Gioacchino Luca Losacco","orcid":"https://orcid.org/0000-0001-8981-7778","observed_orcids":["https://orcid.org/0000-0001-8981-7778"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gioacchino Luca Losacco","raw_affiliation_strings":["Analytical Research and Development, MRL, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States"],"raw_orcid":"https://orcid.org/0000-0001-8981-7778","affiliations":[{"raw_affiliation_string":"Analytical Research and Development, MRL, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032971187","display_name":"Heather Wang","orcid":"https://orcid.org/0000-0002-4001-236X","observed_orcids":["https://orcid.org/0000-0002-4001-236X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Wang","raw_affiliation_strings":["Analytical Research and Development, MRL, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Research and Development, MRL, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047087325","display_name":"Imad A. Haidar Ahmad","orcid":"https://orcid.org/0000-0002-3075-049X","observed_orcids":["https://orcid.org/0000-0002-3075-049X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Imad A. Haidar Ahmad","raw_affiliation_strings":["Analytical Research and Development, MRL, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States"],"raw_orcid":"https://orcid.org/0000-0002-3075-049X","affiliations":[{"raw_affiliation_string":"Analytical Research and Development, MRL, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063391606","display_name":"Jimmy DaSilva","orcid":"https://orcid.org/0000-0001-7044-0640","observed_orcids":["https://orcid.org/0000-0001-7044-0640"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jimmy DaSilva","raw_affiliation_strings":["Analytical Research and Development, MRL, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States"],"raw_orcid":"https://orcid.org/0000-0001-7044-0640","affiliations":[{"raw_affiliation_string":"Analytical Research and Development, MRL, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007114172","display_name":"Alexey A. Makarov","orcid":"https://orcid.org/0000-0003-4866-0430","observed_orcids":["https://orcid.org/0000-0003-4866-0430"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexey A. Makarov","raw_affiliation_strings":["Analytical Research and Development, MRL, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States"],"raw_orcid":"https://orcid.org/0000-0003-4866-0430","affiliations":[{"raw_affiliation_string":"Analytical Research and Development, MRL, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023264481","display_name":"Ian K. Mangion","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Mangion","raw_affiliation_strings":["Analytical Research and Development, MRL, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Research and Development, MRL, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080654166","display_name":"Francesco Gasparrini","orcid":"https://orcid.org/0000-0002-4954-7635","observed_orcids":["https://orcid.org/0000-0002-4954-7635"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Gasparrini","raw_affiliation_strings":["Department of Drug Chemistry and Technology, \u201cSapienza\u201d University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy","Department of Drug Chemistry and Technology, \"Sapienza\" University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0003-0970-2917","affiliations":[{"raw_affiliation_string":"Department of Drug Chemistry and Technology, \u201cSapienza\u201d University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Department of Drug Chemistry and Technology, \"Sapienza\" University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111771080","display_name":"Michael L\u00e4mmerhofer","orcid":"https://orcid.org/0000-0002-1318-0974","observed_orcids":["https://orcid.org/0000-0002-1318-0974"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael L\u00e4mmerhofer","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of T\u00fcbingen, Auf der Morgenstelle 8, T\u00fcbingen 72076, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1318-0974","affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of T\u00fcbingen, Auf der Morgenstelle 8, T\u00fcbingen 72076, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077242280","display_name":"Daniel Wayne Armstrong","orcid":"https://orcid.org/0000-0003-0501-6231","observed_orcids":["https://orcid.org/0000-0003-0501-6231"]},"institutions":[{"id":"https://openalex.org/I189196454","display_name":"The University of Texas at Arlington","ror":"https://ror.org/019kgqr73","country_code":"US","type":"education","lineage":["https://openalex.org/I189196454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel W. Armstrong","raw_affiliation_strings":["Department of Chemistry, University of Texas at Arlington, Arlington, Texas 76019, United States"],"raw_orcid":"https://orcid.org/0000-0003-0501-6231","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas at Arlington, Arlington, Texas 76019, United States","institution_ids":["https://openalex.org/I189196454"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008916264","display_name":"Erik L. Regalado","orcid":"https://orcid.org/0000-0002-7352-6391","observed_orcids":["https://orcid.org/0000-0002-7352-6391"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Erik L. Regalado","raw_affiliation_strings":["Analytical Research and Development, MRL, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States"],"raw_orcid":"https://orcid.org/0000-0002-7352-6391","affiliations":[{"raw_affiliation_string":"Analytical Research and Development, MRL, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008916264","https://openalex.org/A5033189215","https://openalex.org/A5047087325"],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":3.5735,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.95543086,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"94","issue":"3","first_page":"1804","last_page":"1812"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12748","display_name":"Molecular spectroscopy and chirality","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chiral-stationary-phase","display_name":"chiral stationary phase","score":0.8140000104904175},{"id":"https://openalex.org/keywords/enantiomeric-excess-determination","display_name":"enantiomeric excess determination","score":0.7369999885559082},{"id":"https://openalex.org/keywords/retention-modeling","display_name":"retention modeling","score":0.7369999885559082},{"id":"https://openalex.org/keywords/hydrophilic-interaction-liquid-chromatography","display_name":"hydrophilic interaction liquid chromatography","score":0.8190000057220459},{"id":"https://openalex.org/keywords/two-dimensional-liquid-chromatography","display_name":"two-dimensional liquid chromatography","score":0.8410000205039978},{"id":"https://openalex.org/keywords/enantiomeric-separation","display_name":"enantiomer separation","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7768108248710632},{"id":"https://openalex.org/C203147553","wikidata":"https://www.wikidata.org/wiki/Q332584","display_name":"Supercritical fluid chromatography","level":3,"score":0.7435449361801147},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.727345883846283},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6088802218437195},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.5280730724334717},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.46188846230506897},{"id":"https://openalex.org/C137535248","wikidata":"https://www.wikidata.org/wiki/Q4914691","display_name":"Bioanalysis","level":2,"score":0.41720911860466003},{"id":"https://openalex.org/C123460561","wikidata":"https://www.wikidata.org/wiki/Q677065","display_name":"Gas chromatography","level":2,"score":0.3480660617351532},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1378871202468872},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.08708280324935913},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056148","descriptor_name":"Chromatography, Reverse-Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056148","descriptor_name":"Chromatography, Reverse-Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056148","descriptor_name":"Chromatography, Reverse-Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.analchem.1c04585","doi":"https://doi.org/10.1021/acs.analchem.1c04585","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.1c04585","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:34931812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34931812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1610045","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/1610045","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9","score":0.5699999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1970198903","https://openalex.org/W2012678037","https://openalex.org/W2131835261","https://openalex.org/W2317343890","https://openalex.org/W2321358083","https://openalex.org/W2398491099","https://openalex.org/W2401353019","https://openalex.org/W2473050365","https://openalex.org/W2516779663","https://openalex.org/W2552886897","https://openalex.org/W2556681983","https://openalex.org/W2573748087","https://openalex.org/W2590071062","https://openalex.org/W2604212071","https://openalex.org/W2605352324","https://openalex.org/W2741966807","https://openalex.org/W2742990815","https://openalex.org/W2782982626","https://openalex.org/W2788726534","https://openalex.org/W2791970258","https://openalex.org/W2792534970","https://openalex.org/W2805399768","https://openalex.org/W2885311230","https://openalex.org/W2888766666","https://openalex.org/W2896309222","https://openalex.org/W2899836869","https://openalex.org/W2903902777","https://openalex.org/W2915373282","https://openalex.org/W2950357364","https://openalex.org/W2965448259","https://openalex.org/W2972166792","https://openalex.org/W2981982393","https://openalex.org/W2984812616","https://openalex.org/W2986359777","https://openalex.org/W2993742015","https://openalex.org/W2999390020","https://openalex.org/W3009475228","https://openalex.org/W3011056653","https://openalex.org/W3013831995","https://openalex.org/W3024074874","https://openalex.org/W3028031544","https://openalex.org/W3034227506","https://openalex.org/W3080162385","https://openalex.org/W3110691960","https://openalex.org/W3114104251","https://openalex.org/W3120918450","https://openalex.org/W3171420485","https://openalex.org/W3183467452","https://openalex.org/W3186381093","https://openalex.org/W3188618288"],"related_works":["https://openalex.org/W4206261876","https://openalex.org/W3155189705","https://openalex.org/W2118332265","https://openalex.org/W2952040026","https://openalex.org/W2949633962","https://openalex.org/W4206608877","https://openalex.org/W2086778627","https://openalex.org/W1980412672","https://openalex.org/W4212912658","https://openalex.org/W3147890108"],"abstract_inverted_index":{"Enantioselective":[0],"chromatography":[1,23,32,217],"has":[2],"been":[3],"the":[4,8,117,129,193,211],"preferred":[5],"technique":[6],"for":[7,136,158,195],"determination":[9],"of":[10,57,87,110,119,131,161,166,172,182,199,214],"enantiomeric":[11,167],"excess":[12],"across":[13,169],"academia":[14],"and":[15,67,97,105,123,163,178,207],"industry.":[16],"Although":[17],"sequential":[18],"multicolumn":[19,52],"enantioselective":[20],"supercritical":[21],"fluid":[22],"screenings":[24],"are":[25,114],"widespread,":[26],"access":[27],"to":[28,154,203],"automated":[29,80],"ultra-high-performance":[30],"liquid":[31,89,93,216],"(UHPLC)":[33],"platforms":[34],"using":[35,144],"state-of-the-art":[36],"small":[37],"particle":[38],"size":[39],"chiral":[40,120,137,159],"stationary":[41],"phases":[42],"(CSPs)":[43],"is":[44],"an":[45],"underdeveloped":[46],"area.":[47],"Herein,":[48],"we":[49,127,187],"introduce":[50],"a":[51,84,196],"UHPLC":[53],"screening":[54,121],"workflow":[55],"capable":[56],"combining":[58],"14":[59],"columns":[60],"(packed":[61],"with":[62,73,101,174],"sub-2":[63],"\u03bcm":[64,69],"fully":[65],"porous":[66,71],"sub-3":[68],"superficially":[70],"particles)":[72],"nine":[74],"mobile":[75],"phase":[76],"eluent":[77],"choices.":[78],"This":[79],"setup":[81],"operates":[82],"under":[83],"vast":[85],"selection":[86],"reversed-phase":[88],"chromatography,":[90,94],"hydrophilic":[91],"interaction":[92],"polar-organic":[95],"mode,":[96],"polar-ionic":[98],"mode":[99],"conditions":[100,122],"minimal":[102],"manual":[103],"intervention":[104],"high":[106],"success":[107],"rate.":[108],"Examples":[109],"highly":[111],"efficient":[112],"enantioseparations":[113,201],"illustrated":[115],"from":[116],"integration":[118],"computer-assisted":[124],"modeling.":[125],"Furthermore,":[126],"describe":[128],"nuances":[130],"in":[132,210],"silico":[133],"method":[134],"development":[135,198],"separations":[138],"via":[139],"second-degree":[140],"polynomial":[141],"regression":[142],"fit":[143],"LC":[145],"simulator":[146],"(ACD/Labs)":[147],"software.":[148],"The":[149],"retention":[150,180],"models":[151],"were":[152],"found":[153],"be":[155],"very":[156],"accurate":[157],"resolution":[160],"single":[162],"multicomponent":[164],"mixtures":[165],"species":[168],"different":[170],"types":[171],"CSPs,":[173],"differences":[175],"between":[176],"experimental":[177],"simulated":[179],"times":[181],"less":[183],"than":[184],"0.5%.":[185],"Finally,":[186],"illustrate":[188],"how":[189],"this":[190],"approach":[191],"lays":[192],"foundation":[194],"streamlined":[197],"ultrafast":[200],"applied":[202],"high-throughput":[204],"enantiopurity":[205],"analysis":[206],"its":[208],"use":[209],"second":[212],"dimension":[213],"two-dimensional":[215],"experiments.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":10}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
