{"id":"https://openalex.org/W4200214568","doi":"https://doi.org/10.3390/cancers13246357","title":"Orai1 Boosts SK3 Channel Activation","display_name":"Orai1 Boosts SK3 Channel Activation","publication_year":2021,"publication_date":"2021-12-17","ids":{"openalex":"https://openalex.org/W4200214568","doi":"https://doi.org/10.3390/cancers13246357","pmid":"https://pubmed.ncbi.nlm.nih.gov/34944977","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8699475"},"language":"en","primary_location":{"id":"doi:10.3390/cancers13246357","doi":"https://doi.org/10.3390/cancers13246357","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13246357","pdf_url":"https://www.mdpi.com/2072-6694/13/24/6357/pdf?version=1640162266","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/13/24/6357/pdf?version=1640162266","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075569849","display_name":"Ad\u00e9la Tiffner","orcid":"https://orcid.org/0000-0002-7529-4504","observed_orcids":["https://orcid.org/0000-0002-7529-4504"]},"institutions":[{"id":"https://openalex.org/I121883995","display_name":"Johannes Kepler University of Linz","ror":"https://ror.org/052r2xn60","country_code":"AT","type":"education","lineage":["https://openalex.org/I121883995"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Ad\u00e9la Tiffner","raw_affiliation_strings":["JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria"],"raw_orcid":"https://orcid.org/0000-0002-7529-4504","affiliations":[{"raw_affiliation_string":"JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria","institution_ids":["https://openalex.org/I121883995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039667929","display_name":"Valentina Hopl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121883995","display_name":"Johannes Kepler University of Linz","ror":"https://ror.org/052r2xn60","country_code":"AT","type":"education","lineage":["https://openalex.org/I121883995"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Valentina Hopl","raw_affiliation_strings":["JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria","institution_ids":["https://openalex.org/I121883995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028889288","display_name":"Romana Schober","orcid":"https://orcid.org/0000-0002-9156-6266","observed_orcids":["https://orcid.org/0000-0002-9156-6266"]},"institutions":[{"id":"https://openalex.org/I121883995","display_name":"Johannes Kepler University of Linz","ror":"https://ror.org/052r2xn60","country_code":"AT","type":"education","lineage":["https://openalex.org/I121883995"]},{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Romana Schober","raw_affiliation_strings":["Gottfried Schatz Research Centre, Medical University of Graz, A-8010 Graz, Austria","JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gottfried Schatz Research Centre, Medical University of Graz, A-8010 Graz, Austria","institution_ids":["https://openalex.org/I202276237"]},{"raw_affiliation_string":"JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria","institution_ids":["https://openalex.org/I121883995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074745186","display_name":"Matthias Sallinger","orcid":"https://orcid.org/0000-0001-5225-8925","observed_orcids":["https://orcid.org/0000-0001-5225-8925"]},"institutions":[{"id":"https://openalex.org/I121883995","display_name":"Johannes Kepler University of Linz","ror":"https://ror.org/052r2xn60","country_code":"AT","type":"education","lineage":["https://openalex.org/I121883995"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Matthias Sallinger","raw_affiliation_strings":["JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria","institution_ids":["https://openalex.org/I121883995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067473782","display_name":"Herwig Grabmayr","orcid":"https://orcid.org/0000-0003-0870-5833","observed_orcids":["https://orcid.org/0000-0003-0870-5833"]},"institutions":[{"id":"https://openalex.org/I121883995","display_name":"Johannes Kepler University of Linz","ror":"https://ror.org/052r2xn60","country_code":"AT","type":"education","lineage":["https://openalex.org/I121883995"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Herwig Grabmayr","raw_affiliation_strings":["JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria"],"raw_orcid":"https://orcid.org/0000-0003-0870-5833","affiliations":[{"raw_affiliation_string":"JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria","institution_ids":["https://openalex.org/I121883995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040621600","display_name":"Carmen H\u00f6glinger","orcid":"https://orcid.org/0000-0002-2754-592X","observed_orcids":["https://orcid.org/0000-0002-2754-592X"]},"institutions":[{"id":"https://openalex.org/I121883995","display_name":"Johannes Kepler University of Linz","ror":"https://ror.org/052r2xn60","country_code":"AT","type":"education","lineage":["https://openalex.org/I121883995"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Carmen H\u00f6glinger","raw_affiliation_strings":["JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria","institution_ids":["https://openalex.org/I121883995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052641644","display_name":"Marc Fahrner","orcid":"https://orcid.org/0000-0002-2689-0158","observed_orcids":["https://orcid.org/0000-0002-2689-0158"]},"institutions":[{"id":"https://openalex.org/I121883995","display_name":"Johannes Kepler University of Linz","ror":"https://ror.org/052r2xn60","country_code":"AT","type":"education","lineage":["https://openalex.org/I121883995"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Marc Fahrner","raw_affiliation_strings":["JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria"],"raw_orcid":"https://orcid.org/0000-0002-2689-0158","affiliations":[{"raw_affiliation_string":"JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria","institution_ids":["https://openalex.org/I121883995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030280477","display_name":"Victoria Lunz","orcid":"https://orcid.org/0000-0003-2272-9655","observed_orcids":["https://orcid.org/0000-0003-2272-9655"]},"institutions":[{"id":"https://openalex.org/I121883995","display_name":"Johannes Kepler University of Linz","ror":"https://ror.org/052r2xn60","country_code":"AT","type":"education","lineage":["https://openalex.org/I121883995"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Victoria Lunz","raw_affiliation_strings":["JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria","institution_ids":["https://openalex.org/I121883995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008640470","display_name":"Lena Maltan","orcid":"https://orcid.org/0000-0002-2939-2533","observed_orcids":["https://orcid.org/0000-0002-2939-2533"]},"institutions":[{"id":"https://openalex.org/I121883995","display_name":"Johannes Kepler University of Linz","ror":"https://ror.org/052r2xn60","country_code":"AT","type":"education","lineage":["https://openalex.org/I121883995"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Lena Maltan","raw_affiliation_strings":["JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria"],"raw_orcid":"https://orcid.org/0000-0002-2939-2533","affiliations":[{"raw_affiliation_string":"JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria","institution_ids":["https://openalex.org/I121883995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051661121","display_name":"Irene Frischauf","orcid":"https://orcid.org/0000-0003-0661-2932","observed_orcids":["https://orcid.org/0000-0003-0661-2932"]},"institutions":[{"id":"https://openalex.org/I121883995","display_name":"Johannes Kepler University of Linz","ror":"https://ror.org/052r2xn60","country_code":"AT","type":"education","lineage":["https://openalex.org/I121883995"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Irene Frischauf","raw_affiliation_strings":["JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria"],"raw_orcid":"https://orcid.org/0000-0003-0661-2932","affiliations":[{"raw_affiliation_string":"JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria","institution_ids":["https://openalex.org/I121883995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043043410","display_name":"Denis Krivi\u0107","orcid":"https://orcid.org/0000-0002-2852-4522","observed_orcids":["https://orcid.org/0000-0002-2852-4522"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Denis Krivic","raw_affiliation_strings":["Gottfried Schatz Research Centre, Medical University of Graz, A-8010 Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gottfried Schatz Research Centre, Medical University of Graz, A-8010 Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043082375","display_name":"Rajesh Bhardwaj","orcid":"https://orcid.org/0000-0002-5599-487X","observed_orcids":["https://orcid.org/0000-0002-5599-487X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Rajesh Bhardwaj","raw_affiliation_strings":["Department of Biomedical Research, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland","Department of Nephrology and Hypertension, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-5599-487X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Research, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Department of Nephrology and Hypertension, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062754043","display_name":"Rainer Schindl","orcid":"https://orcid.org/0000-0003-0896-8887","observed_orcids":["https://orcid.org/0000-0003-0896-8887"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Rainer Schindl","raw_affiliation_strings":["Gottfried Schatz Research Centre, Medical University of Graz, A-8010 Graz, Austria"],"raw_orcid":"https://orcid.org/0000-0003-0896-8887","affiliations":[{"raw_affiliation_string":"Gottfried Schatz Research Centre, Medical University of Graz, A-8010 Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078842111","display_name":"Matthias A. Hediger","orcid":"https://orcid.org/0000-0003-1946-027X","observed_orcids":["https://orcid.org/0000-0003-1946-027X"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matthias A. Hediger","raw_affiliation_strings":["Department of Biomedical Research, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland","Department of Nephrology and Hypertension, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-1946-027X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Research, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Department of Nephrology and Hypertension, University of Bern, Inselspital, Freiburgstrasse 15, CH-3010 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036873870","display_name":"Isabella Derler","orcid":"https://orcid.org/0000-0002-4768-146X","observed_orcids":["https://orcid.org/0000-0002-4768-146X"]},"institutions":[{"id":"https://openalex.org/I121883995","display_name":"Johannes Kepler University of Linz","ror":"https://ror.org/052r2xn60","country_code":"AT","type":"education","lineage":["https://openalex.org/I121883995"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Isabella Derler","raw_affiliation_strings":["JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, A-4020 Linz, Austria","institution_ids":["https://openalex.org/I121883995"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5036873870"],"corresponding_institution_ids":["https://openalex.org/I121883995"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":1910,"currency":"EUR","value_usd":2059},"fwci":0.5489,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.59371903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"24","first_page":"6357","last_page":"6357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7548999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7548999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.22859999537467957,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orai1","display_name":"Orai1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sk3-channel","display_name":"SK3 channel","score":0.9169999957084656},{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.8489999771118164},{"id":"https://openalex.org/keywords/stromal-interaction-molecule-1","display_name":"STIM1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.6399999856948853},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.7900000214576721},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.6859999895095825},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/calcium-activated-potassium-channels","display_name":"calcium-activated potassium channels","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C2776610495","wikidata":"https://www.wikidata.org/wiki/Q18047835","display_name":"ORAI1","level":4,"score":0.9048210382461548},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5648072361946106},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5322605967521667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5087316632270813},{"id":"https://openalex.org/C149786707","wikidata":"https://www.wikidata.org/wiki/Q7390712","display_name":"SK channel","level":4,"score":0.48404306173324585},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.44999635219573975},{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.44531941413879395},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.4310658276081085},{"id":"https://openalex.org/C162740809","wikidata":"https://www.wikidata.org/wiki/Q15334560","display_name":"STIM1","level":3,"score":0.3758145272731781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2875925302505493},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.223524808883667},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.16271382570266724},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10826098918914795},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/cancers13246357","doi":"https://doi.org/10.3390/cancers13246357","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13246357","pdf_url":"https://www.mdpi.com/2072-6694/13/24/6357/pdf?version=1640162266","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8699475","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8699475","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:34944977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34944977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:66683336ac42453dbca136ac9d665771","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/66683336ac42453dbca136ac9d665771","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 13, Iss 6357, p 6357 (2021)","raw_type":"article"},{"id":"doi:10.5281/zenodo.20121582","doi":"https://doi.org/10.5281/zenodo.20121582","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.20121582","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.20121583","doi":"https://doi.org/10.5281/zenodo.20121583","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.20121583","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.3390/cancers13246357","doi":"https://doi.org/10.3390/cancers13246357","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13246357","pdf_url":"https://www.mdpi.com/2072-6694/13/24/6357/pdf?version=1640162266","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1447287191","display_name":"Interplay of CRAC channels with Ca2+ activated K+ channels","funder_award_id":"P 32851","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G1918212306","display_name":"Ca2+/Calmodulin-dependent regulation of the MiT-TFE family","funder_award_id":"T1190","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G2737461417","display_name":"Nano-Analytics of Cellular Systems (NanoCell)","funder_award_id":"W1250","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G3289326750","display_name":"Orai Subunit Interactions Control Orai Channel Function","funder_award_id":"P 30567","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G3356625137","display_name":"Ca2+ sensing of STIM1/2 shapes physiological Ca2+ signals","funder_award_id":"P32778","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G3950383732","display_name":null,"funder_award_id":"P32075-B","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G4553701973","display_name":null,"funder_award_id":"doi:10.55776/P32075","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G4797486616","display_name":null,"funder_award_id":"doi:10.55776/P30567","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G4878076690","display_name":"Calcium domain in Orai1 regulates NFAT dependent genes","funder_award_id":"P28701","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G555486831","display_name":"Elucidation of  STIM2 domains for CRAC channel activation","funder_award_id":"P32947","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G5780827725","display_name":null,"funder_award_id":"doi:10.55776/P32851","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G8290198813","display_name":null,"funder_award_id":"FWF T-1190","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G8615997742","display_name":null,"funder_award_id":"FWF W1226","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G8913151998","display_name":null,"funder_award_id":"doi:10.55776/P32947","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"}],"funders":[{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200214568.pdf","grobid_xml":"https://content.openalex.org/works/W4200214568.grobid-xml"},"referenced_works_count":117,"referenced_works":["https://openalex.org/W1423501786","https://openalex.org/W1485297825","https://openalex.org/W1490915066","https://openalex.org/W1537329448","https://openalex.org/W1597579047","https://openalex.org/W1599277155","https://openalex.org/W1599639531","https://openalex.org/W1614963972","https://openalex.org/W1834643162","https://openalex.org/W1843230840","https://openalex.org/W1855929153","https://openalex.org/W1856053518","https://openalex.org/W1963624422","https://openalex.org/W1967008683","https://openalex.org/W1973308215","https://openalex.org/W1977613097","https://openalex.org/W1978593035","https://openalex.org/W1979299821","https://openalex.org/W1990546211","https://openalex.org/W2000708353","https://openalex.org/W2001917660","https://openalex.org/W2015080011","https://openalex.org/W2015426350","https://openalex.org/W2020033048","https://openalex.org/W2020708758","https://openalex.org/W2024336885","https://openalex.org/W2028649950","https://openalex.org/W2034245104","https://openalex.org/W2036145275","https://openalex.org/W2038251790","https://openalex.org/W2039084338","https://openalex.org/W2041474455","https://openalex.org/W2041849569","https://openalex.org/W2043207949","https://openalex.org/W2043822158","https://openalex.org/W2046771994","https://openalex.org/W2047955093","https://openalex.org/W2048489053","https://openalex.org/W2048877525","https://openalex.org/W2056537896","https://openalex.org/W2058455075","https://openalex.org/W2070453934","https://openalex.org/W2073371442","https://openalex.org/W2076006649","https://openalex.org/W2076362618","https://openalex.org/W2082848117","https://openalex.org/W2085269717","https://openalex.org/W2087064822","https://openalex.org/W2090706449","https://openalex.org/W2097439505","https://openalex.org/W2099273812","https://openalex.org/W2118075556","https://openalex.org/W2123115422","https://openalex.org/W2126154043","https://openalex.org/W2128783251","https://openalex.org/W2133603157","https://openalex.org/W2137335872","https://openalex.org/W2137508826","https://openalex.org/W2138497474","https://openalex.org/W2141015134","https://openalex.org/W2142097010","https://openalex.org/W2144543766","https://openalex.org/W2147395929","https://openalex.org/W2157090718","https://openalex.org/W2158652398","https://openalex.org/W2158712017","https://openalex.org/W2163789582","https://openalex.org/W2165077523","https://openalex.org/W2166494286","https://openalex.org/W2168398034","https://openalex.org/W2168401599","https://openalex.org/W2171675911","https://openalex.org/W2185280366","https://openalex.org/W2209604420","https://openalex.org/W2252707930","https://openalex.org/W2258994777","https://openalex.org/W2276578412","https://openalex.org/W2280566736","https://openalex.org/W2313042457","https://openalex.org/W2314856468","https://openalex.org/W2340325620","https://openalex.org/W2342952171","https://openalex.org/W2361036359","https://openalex.org/W2408316633","https://openalex.org/W2496718192","https://openalex.org/W2529766180","https://openalex.org/W2559760636","https://openalex.org/W2582032325","https://openalex.org/W2616240357","https://openalex.org/W2745299804","https://openalex.org/W2754700811","https://openalex.org/W2761531622","https://openalex.org/W2772146535","https://openalex.org/W2774939546","https://openalex.org/W2801595722","https://openalex.org/W2891599232","https://openalex.org/W2916273903","https://openalex.org/W2921519408","https://openalex.org/W2924226601","https://openalex.org/W2937008842","https://openalex.org/W2942151678","https://openalex.org/W2947687199","https://openalex.org/W2979045263","https://openalex.org/W2982111415","https://openalex.org/W2982932710","https://openalex.org/W2990090865","https://openalex.org/W2994040423","https://openalex.org/W3033062974","https://openalex.org/W3036770067","https://openalex.org/W3082760815","https://openalex.org/W3092596863","https://openalex.org/W3112733651","https://openalex.org/W3118109496","https://openalex.org/W3119996063","https://openalex.org/W3127753614","https://openalex.org/W3158722482","https://openalex.org/W3166292510"],"related_works":["https://openalex.org/W2790331772","https://openalex.org/W4313260515","https://openalex.org/W3209890091","https://openalex.org/W3037486443","https://openalex.org/W7128556783","https://openalex.org/W1855929153","https://openalex.org/W7143801163","https://openalex.org/W3005324814","https://openalex.org/W4247151046","https://openalex.org/W2582032325"],"abstract_inverted_index":{"The":[0,182],"interplay":[1,117,165],"of":[2,27,85,100,185],"SK3,":[3],"a":[4,12,34,141,149],"Ca2+":[5,13,22,69,176],"sensitive":[6],"K+":[7,57,74,180],"ion":[8,14],"channel,":[9,15],"with":[10,118,144],"Orai1,":[11,113,128],"has":[16,37,148],"been":[17],"reported":[18],"to":[19,40,61,105,162,187],"increase":[20],"cytosolic":[21,68,133],"levels,":[23],"thereby":[24],"triggering":[25],"proliferation":[26],"breast":[28],"and":[29,87,135,174],"colon":[30],"cancer":[31,199],"cells,":[32],"although":[33],"molecular":[35],"mechanism":[36,84],"remained":[38],"elusive":[39],"date.":[41],"We":[42],"show":[43],"in":[44,59,152,195],"the":[45,119,132,196],"current":[46],"study,":[47],"via":[48,115],"heterologous":[49],"protein":[50],"expression,":[51],"that":[52,71,98,131],"Orai1":[53,77,88,186],"can":[54],"enhance":[55],"SK3":[56,73,79,86,101,179,190],"currents,":[58],"addition":[60],"constitutively":[62],"bound":[63],"calmodulin":[64],"(CaM).":[65],"At":[66],"low":[67],"levels":[70],"decrease":[72],"permeation,":[75],"co-expressed":[76],"potentiates":[78],"currents.":[80,181],"This":[81],"positive":[82],"feedback":[83],"is":[89,160],"enabled":[90],"by":[91,112,166],"their":[92,169],"close":[93],"co-localization.":[94,170],"Remarkably,":[95],"we":[96,129],"discovered":[97],"loss":[99],"channel":[102],"activity":[103,173],"due":[104],"overexpressed":[106],"CaM":[107],"mutants":[108],"could":[109],"be":[110],"restored":[111],"likely":[114],"its":[116],"SK3\u2013CaM":[120],"binding":[121],"site.":[122],"Mapping":[123],"for":[124,140],"interaction":[125],"sites":[126],"within":[127],"identified":[130],"strands":[134],"pore":[136],"residues":[137],"are":[138],"critical":[139],"functional":[142],"communication":[143],"SK3.":[145],"Moreover,":[146],"STIM1":[147,159],"bimodal":[150],"role":[151],"SK3\u2013Orai1":[153,164],"regulation.":[154],"Under":[155],"physiological":[156],"ionic":[157],"conditions,":[158],"able":[161],"impede":[163],"significantly":[167],"decreasing":[168],"Forced":[171],"STIM1\u2013Orai1":[172],"associated":[175],"influx":[177],"promote":[178],"dynamic":[183],"regulation":[184],"boost":[188],"endogenous":[189],"channels":[191],"was":[192],"also":[193],"determined":[194],"human":[197],"prostate":[198],"cell":[200],"line":[201],"LNCaP.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-12-31T00:00:00"}
