{"id":"https://openalex.org/W4200213654","doi":"https://doi.org/10.1093/eurheartj/suab136.001","title":"459 Evaluation of LDL-C reductions by siRNA treatment with inclisiran in patients with diabetes mellitus, metabolic syndrome or neither","display_name":"459 Evaluation of LDL-C reductions by siRNA treatment with inclisiran in patients with diabetes mellitus, metabolic syndrome or neither","publication_year":2021,"publication_date":"2021-12-01","ids":{"openalex":"https://openalex.org/W4200213654","doi":"https://doi.org/10.1093/eurheartj/suab136.001"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/suab136.001","doi":"https://doi.org/10.1093/eurheartj/suab136.001","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/suab136.001","pdf_url":"https://academic.oup.com/eurheartjsupp/article-pdf/23/Supplement_G/suab136.001/41683318/suab136.001.pdf","source":{"id":"https://openalex.org/S81127","display_name":"European Heart Journal Supplements","issn_l":"1520-765X","issn":["1520-765X","1554-2815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal Supplements","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/eurheartjsupp/article-pdf/23/Supplement_G/suab136.001/41683318/suab136.001.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062745101","display_name":"R. Scott Wright","orcid":"https://orcid.org/0000-0002-0625-0444","observed_orcids":["https://orcid.org/0000-0002-0625-0444"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Scott Wright","raw_affiliation_strings":["Division of Preventive Cardiology and the Department Of Cardiology, Mayo Clinic, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preventive Cardiology and the Department Of Cardiology, Mayo Clinic, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075595313","display_name":"David G. Kallend","orcid":"https://orcid.org/0000-0003-3680-285X","observed_orcids":["https://orcid.org/0000-0003-3680-285X"]},"institutions":[{"id":"https://openalex.org/I4405270399","display_name":"DalCor Pharmaceuticals (Canada)","ror":"https://ror.org/00m33qn53","country_code":"CA","type":"company","lineage":["https://openalex.org/I4405270399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David Kallend","raw_affiliation_strings":["Dalcor Pharmaceuticals, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dalcor Pharmaceuticals, Canada","institution_ids":["https://openalex.org/I4405270399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006206326","display_name":"Kausik Kumar Ray","orcid":"https://orcid.org/0000-0003-0508-0954","observed_orcids":["https://orcid.org/0000-0003-0508-0954","https://orcid.org/0000-0002-7166-060X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kausik K Ray","raw_affiliation_strings":["Imperial Center for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Center for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080414941","display_name":"Lawrence A. Leiter","orcid":"https://orcid.org/0000-0002-1040-6229","observed_orcids":["https://orcid.org/0000-0002-1040-6229"]},"institutions":[{"id":"https://openalex.org/I1297363086","display_name":"St. Michael's Hospital","ror":"https://ror.org/04skqfp25","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1297363086","https://openalex.org/I4399598460"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lawrence Leiter","raw_affiliation_strings":["Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital, University of Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital, University of Toronto, Canada","institution_ids":["https://openalex.org/I1297363086","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028480812","display_name":"Wolfgang K\u00f6enig","orcid":"https://orcid.org/0000-0002-2064-9603","observed_orcids":["https://orcid.org/0000-0002-2064-9603"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Koenig","raw_affiliation_strings":["Deutsches Herzentrum Munchen, Technische Universitat Munchen, and German Center for Cardiovascular Research, Munich Heart Alliance, Munich, and The Institute of Epidemiology and Medical Biometry, University Of Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deutsches Herzentrum Munchen, Technische Universitat Munchen, and German Center for Cardiovascular Research, Munich Heart Alliance, Munich, and The Institute of Epidemiology and Medical Biometry, University Of Ulm, Germany","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044425699","display_name":"Frederick Johan Raal","orcid":"https://orcid.org/0000-0002-9170-7938","observed_orcids":["https://orcid.org/0000-0002-9170-7938"]},"institutions":[{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Frederick Raal","raw_affiliation_strings":["Faculty of Health Sciences, University of the Witwatersrand, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, University of the Witwatersrand, South Africa","institution_ids":["https://openalex.org/I192619145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110586871","display_name":"Peter L. J. Wijngaard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152963","display_name":"Medicines Company (United States)","ror":"https://ror.org/0564rh245","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619","https://openalex.org/I4387152963"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Wijngaard","raw_affiliation_strings":["Medicines Company, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicines Company, USA","institution_ids":["https://openalex.org/I4387152963"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077848934","display_name":"John J.P. Kastelein","orcid":"https://orcid.org/0000-0003-2018-4532","observed_orcids":["https://orcid.org/0000-0003-2018-4532"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"John J.P Kastelein","raw_affiliation_strings":["Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1747,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44217204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"23","issue":"Supplement_G","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inclisiran","display_name":"inclisiran","score":1.0},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.675000011920929},{"id":"https://openalex.org/keywords/ldl-cholesterol-lowering","display_name":"LDL cholesterol lowering","score":0.9589999914169312},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9639999866485596},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":1.0},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease","display_name":"atherosclerotic cardiovascular disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/statin-therapy","display_name":"statin therapy","score":0.7250000238418579},{"id":"https://openalex.org/keywords/ezetimibe","display_name":"ezetimibe","score":0.972000002861023},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9138460755348206},{"id":"https://openalex.org/C2778657065","wikidata":"https://www.wikidata.org/wiki/Q417997","display_name":"Ezetimibe","level":3,"score":0.7834216952323914},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.6929808855056763},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6857011914253235},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6681959629058838},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6620429754257202},{"id":"https://openalex.org/C2780084366","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demographics","level":2,"score":0.5040058493614197},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.484454870223999},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47275716066360474},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4274282455444336},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.42516791820526123},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.34252965450286865},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08165156841278076},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/eurheartj/suab136.001","doi":"https://doi.org/10.1093/eurheartj/suab136.001","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/suab136.001","pdf_url":"https://academic.oup.com/eurheartjsupp/article-pdf/23/Supplement_G/suab136.001/41683318/suab136.001.pdf","source":{"id":"https://openalex.org/S81127","display_name":"European Heart Journal Supplements","issn_l":"1520-765X","issn":["1520-765X","1554-2815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal Supplements","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/eurheartj/suab136.001","doi":"https://doi.org/10.1093/eurheartj/suab136.001","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/suab136.001","pdf_url":"https://academic.oup.com/eurheartjsupp/article-pdf/23/Supplement_G/suab136.001/41683318/suab136.001.pdf","source":{"id":"https://openalex.org/S81127","display_name":"European Heart Journal Supplements","issn_l":"1520-765X","issn":["1520-765X","1554-2815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal Supplements","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200213654.pdf","grobid_xml":"https://content.openalex.org/works/W4200213654.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3011538699","https://openalex.org/W3110249077","https://openalex.org/W2903347258","https://openalex.org/W4409523417","https://openalex.org/W7143508528","https://openalex.org/W7170087737","https://openalex.org/W2809459554","https://openalex.org/W4388666456","https://openalex.org/W4385378074","https://openalex.org/W3215673038"],"abstract_inverted_index":{"Abstract":[0],"Aims":[1],"Patients":[2],"with":[3,34,65,218,223,244],"diabetes":[4,37],"(DM)":[5],"and":[6,29,78,121,135,140,148,161,170,197,212,221,228,246],"metabolic":[7,39],"syndrome":[8,40],"(MS)":[9,41],"have":[10],"elevated":[11],"risks":[12],"for":[13,71,242],"atherosclerotic":[14],"cardiovascular":[15],"disease":[16],"(ASCVD).":[17],"Aggressive":[18],"LDL-C":[19,28,106,177,215,239],"lowering":[20,72,240],"reduces":[21,214],"risks.":[22],"Inclisiran,":[23],"a":[24,54,237],"new":[25],"siRNA,":[26],"lowers":[27],"was":[30,53],"evaluated":[31,100],"in":[32,47,62,105,112,132,145,157,166,185,201],"patients":[33,64,82,217],"Type":[35],"2":[36],"(DM),":[38],"without":[42],"DM":[43,113,245],"or":[44],"neither":[45],"(N)":[46],"the":[48,101],"ORION-10":[49,52],"trial.":[50],"Methods":[51],"double-blind,":[55],"randomized,":[56],"placebo":[57,80],"controlled":[58],"trial":[59],"evaluating":[60],"inclisiran":[61,75],"1561":[63],"ASCVD":[66],"on":[67],"maximally":[68],"tolerated":[69],"therapy":[70],"LDL-C.":[73],"781":[74],"(INC)":[76],"participants":[77,123],"780":[79],"(P)":[81],"received":[83],"1.5":[84],"mL":[85],"SQ":[86],"tx":[87],"at":[88],"Days":[89,110],"1,":[90],"90,":[91],"then":[92],"every":[93],"6":[94],"months":[95],"until":[96],"Day":[97],"540.":[98],"We":[99],"time":[102],"adjusted":[103],"change":[104],"from":[107],"baseline":[108,133],"after":[109],"90\u2013540":[111],"(n":[114,118,124],"=":[115,119,125],"702),":[116],"MS":[117,220],"455)":[120],"N":[122,202],"404).":[126],"Results":[127],"There":[128],"were":[129,143,155],"no":[130],"differences":[131],"demographics":[134],"background":[136],"therapies":[137],"between":[138],"INC":[139,147,160,175],"P.":[141,151],"Statins":[142],"utilized":[144,156],"89.8%":[146],"88.7%":[149],"of":[150,159,163,168,172],"High":[152],"intensity":[153],"statins":[154],"67.2%":[158],"68.8%":[162],"P;":[164],"ezetimibe":[165],"10.2%":[167],"NC":[169],"9.5%":[171],"P":[173,193,204],"participants.":[174],"reduced":[176],"by":[178],"\u2212":[179],"54.4%":[180],"(\u221258.3,":[181],"\u221250.6":[182],"95%":[183],"CI)":[184],"DM,":[186,219],"(P":[187],"<":[188,194,205],"0.001),":[189],"\u221258.6%":[190],"(\u221262.3,":[191],"\u221254.8),":[192],"0.001":[195,206],"in-MS":[196],"\u221256.0%":[198],"(\u221260.2,":[199],"\u221251.7),":[200],"subjects":[203],"(see":[207],"Figure).":[208],"Conclusions":[209],"Inclisiran":[210,233],"potently":[211],"durably":[213],"across":[216,230],"those":[222,243],"neither,":[224],"demonstrating":[225],"potent":[226,238],"efficacy":[227],"durability":[229],"glycaemic":[231],"categories.":[232],"may":[234],"also":[235],"represent":[236],"treatment":[241],"MS.":[247]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-12-31T00:00:00"}
