{"id":"https://openalex.org/W4200212362","doi":"https://doi.org/10.3390/ecmc2021-11485","title":"Antiviral activity of polyhydrated fullerenes against influenza \u0410 virus H1N1","display_name":"Antiviral activity of polyhydrated fullerenes against influenza \u0410 virus H1N1","publication_year":2021,"publication_date":"2021-11-03","ids":{"openalex":"https://openalex.org/W4200212362","doi":"https://doi.org/10.3390/ecmc2021-11485"},"language":"en","primary_location":{"id":"doi:10.3390/ecmc2021-11485","doi":"https://doi.org/10.3390/ecmc2021-11485","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ecmc2021-11485","pdf_url":null,"source":{"id":"https://openalex.org/S4363608807","display_name":"International Electronic Conference on Medicinal Chemistry (ECMC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of 7th International Electronic Conference on Medicinal Chemistry","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3390/ecmc2021-11485","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081001433","display_name":"Polina Yu. Zaremba","orcid":"https://orcid.org/0000-0001-7253-0404","observed_orcids":["https://orcid.org/0000-0001-7253-0404"]},"institutions":[{"id":"https://openalex.org/I4210120336","display_name":"Danylo Zabolotny Institute of Microbiology and Virology","ror":"https://ror.org/02qqsgs30","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210120336"]}],"countries":["UA"],"is_corresponding":true,"raw_author_name":"Polina Zaremba","raw_affiliation_strings":["Zabolotny Institute of Microbiology and Virology of the NAS of Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zabolotny Institute of Microbiology and Virology of the NAS of Ukraine","institution_ids":["https://openalex.org/I4210120336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020884697","display_name":"Krystyna Naumenko","orcid":"https://orcid.org/0000-0003-4635-0690","observed_orcids":["https://orcid.org/0000-0003-4635-0690"]},"institutions":[{"id":"https://openalex.org/I4210120336","display_name":"Danylo Zabolotny Institute of Microbiology and Virology","ror":"https://ror.org/02qqsgs30","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210120336"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Krystyna Naumenko","raw_affiliation_strings":["Zabolotny Institute of Microbiology and Virology of the NAS of Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zabolotny Institute of Microbiology and Virology of the NAS of Ukraine","institution_ids":["https://openalex.org/I4210120336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111616200","display_name":"Sv\u0456tlana Zagorodnya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120336","display_name":"Danylo Zabolotny Institute of Microbiology and Virology","ror":"https://ror.org/02qqsgs30","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210120336"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Svitlana Zagorodnya","raw_affiliation_strings":["Zabolotny Institute of Microbiology and Virology of the NAS of Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zabolotny Institute of Microbiology and Virology of the NAS of Ukraine","institution_ids":["https://openalex.org/I4210120336"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081975284","display_name":"Mykhailo Yelipashev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mykhailo Yelipashev","raw_affiliation_strings":["Private Research Laboratory Yelipashev"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Private Research Laboratory Yelipashev","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081001433"],"corresponding_institution_ids":["https://openalex.org/I4210120336"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"11485","last_page":"11485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10956","display_name":"Fullerene Chemistry and Applications","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10956","display_name":"Fullerene Chemistry and Applications","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.164900004863739,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h1n1-influenza","display_name":"H1N1 influenza","score":0.9369999766349792},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9629999995231628},{"id":"https://openalex.org/keywords/oseltamivir","display_name":"oseltamivir","score":0.8199999928474426},{"id":"https://openalex.org/keywords/virus-infectivity","display_name":"viral infectivity","score":0.5709999799728394},{"id":"https://openalex.org/keywords/mdck-cells","display_name":"MDCK cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/viral-replication-inhibition","display_name":"viral replication inhibition","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.8158822059631348},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.7766368389129639},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7709762454032898},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6723945140838623},{"id":"https://openalex.org/C70913881","wikidata":"https://www.wikidata.org/wiki/Q2296803","display_name":"Virus quantification","level":3,"score":0.6267048716545105},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5701999664306641},{"id":"https://openalex.org/C2780374985","wikidata":"https://www.wikidata.org/wiki/Q211509","display_name":"Oseltamivir","level":5,"score":0.5379882454872131},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.5137127637863159},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.4519668221473694},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4216662645339966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38583287596702576},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.37693148851394653},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24258637428283691},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2028566300868988},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.14403992891311646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12181559205055237},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.11635398864746094},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/ecmc2021-11485","doi":"https://doi.org/10.3390/ecmc2021-11485","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ecmc2021-11485","pdf_url":null,"source":{"id":"https://openalex.org/S4363608807","display_name":"International Electronic Conference on Medicinal Chemistry (ECMC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of 7th International Electronic Conference on Medicinal Chemistry","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.3390/ecmc2021-11485","doi":"https://doi.org/10.3390/ecmc2021-11485","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ecmc2021-11485","pdf_url":null,"source":{"id":"https://openalex.org/S4363608807","display_name":"International Electronic Conference on Medicinal Chemistry (ECMC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of 7th International Electronic Conference on Medicinal Chemistry","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4383264325","https://openalex.org/W4323569288","https://openalex.org/W2063983669","https://openalex.org/W4312480473","https://openalex.org/W1983955245","https://openalex.org/W1566677148","https://openalex.org/W2061040945","https://openalex.org/W1553721340","https://openalex.org/W4395956493","https://openalex.org/W2084640403"],"abstract_inverted_index":{"Today,":[0],"the":[1,28,34,42,48,80,86,109,156,183,187,201,215,241],"development":[2],"of":[3,30,36,47,59,63,92,114,129,141,143,159,171,193,217,240,243,245],"drugs":[4],"against":[5,69],"influenza":[6,70,93,218],"viruses":[7],"remains":[8],"an":[9,55],"urgent":[10],"problem.":[11],"Hydrated":[12,148],"fullerenes":[13,64,149,207],"have":[14],"high":[15,152,211],"stability":[16],"and":[17,44,66,116,121,138,165,198,238],"relatively":[18],"low":[19],"toxicity,":[20],"which":[21],"undoubtedly":[22],"makes":[23],"them":[24],"attractive":[25],"candidates":[26],"for":[27,163,167,195,235],"role":[29],"antiviral":[31,45],"agents.":[32],"Therefore,":[33,200],"aim":[35],"this":[37],"work":[38],"was":[39,77,83,95,118,132],"to":[40],"study":[41,170],"cytotoxicity":[43,113],"activity":[46,145,212],"drug":[49,137],"K050":[50],"(manufactured":[51],"in":[52,79,179,213,226],"Ukraine)":[53],"-":[54,68],"aqueous":[56],"colloidal":[57],"solution":[58],"a":[60,127,135,151,177,224,232],"polyhydrated":[61,206],"mixture":[62],"HyFn5":[65,115,164,197],"HyFn6":[67,117],"A":[71,169],"virus":[72,94,174,184,219],"H1N1.":[73],"Cell":[74],"culture":[75],"MDCK":[76],"used":[78,133],"experiments.":[81],"Cytotoxicity":[82],"determined":[84,96],"using":[85],"MTT":[87],"assay.":[88],"De":[89],"novo":[90,173],"infectivity":[91,175],"by":[97,108,161,190],"Median":[98],"Tissue":[99],"Culture":[100],"Infectious":[101],"Dose":[102],"assay,":[103],"TCID50":[104],"titers":[105],"were":[106],"calculated":[107],"Reed-Muench":[110],"method.":[111],"The":[112],"11.79":[119],"mg/ml":[120,131],"16.03":[122],"mg/ml,":[123],"respectively.":[124],"Oseltamivir":[125],"at":[126],"concentration":[128],"0.15":[130],"as":[134],"reference":[136],"showed":[139,150,176],"22.33%":[140],"inhibition":[142],"viral":[144],"(or":[146],"AVA).":[147],"dose-dependent":[153],"effect,":[154],"with":[155,182,186],"highest":[157],"rates":[158],"AVA":[160],"96.48%":[162],"96.54%":[166],"HyFn6.":[168,199],"de":[172],"decrease":[178,225],"titer,":[180],"compared":[181],"control":[185],"largest":[188],"reduction":[189],"4":[191],"orders":[192],"magnitude":[194],"both":[196],"obtained":[202],"results":[203],"show":[204,208],"that":[205],"not":[209],"only":[210],"inhibiting":[214],"reproduction":[216],"type":[220],"H1N1,":[221],"but":[222],"also":[223],"its":[227],"infectious":[228],"titer.":[229],"This":[230],"gives":[231],"good":[233],"start":[234],"further":[236],"research":[237],"determination":[239],"mechanisms":[242],"action":[244],"these":[246],"fullerenes.":[247]},"counts_by_year":[],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2021-12-31T00:00:00"}