{"id":"https://openalex.org/W4200210903","doi":"https://doi.org/10.3390/cancers13246295","title":"PARP1 Inhibitor and Trabectedin Combination Does Not Increase Tumor Mutational Burden in Advanced Sarcomas\u2014A Preclinical and Translational Study","display_name":"PARP1 Inhibitor and Trabectedin Combination Does Not Increase Tumor Mutational Burden in Advanced Sarcomas\u2014A Preclinical and Translational Study","publication_year":2021,"publication_date":"2021-12-15","ids":{"openalex":"https://openalex.org/W4200210903","doi":"https://doi.org/10.3390/cancers13246295","pmid":"https://pubmed.ncbi.nlm.nih.gov/34944915","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8699802"},"language":"en","primary_location":{"id":"doi:10.3390/cancers13246295","doi":"https://doi.org/10.3390/cancers13246295","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13246295","pdf_url":"https://www.mdpi.com/2072-6694/13/24/6295/pdf?version=1639742349","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/13/24/6295/pdf?version=1639742349","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052120219","display_name":"Ymera Pignochino","orcid":"https://orcid.org/0000-0001-5073-8618","observed_orcids":["https://orcid.org/0000-0001-5073-8618"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ymera Pignochino","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","Department of Clinical and Biological Sciences, University of Torino, 10100 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Clinical and Biological Sciences, University of Torino, 10100 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016649801","display_name":"Giovanni Crisafulli","orcid":"https://orcid.org/0000-0002-5511-1555","observed_orcids":["https://orcid.org/0000-0002-5511-1555"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Crisafulli","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","Department of Oncology, University of Torino, 10100 Torino, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5511-1555","affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Oncology, University of Torino, 10100 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Giorgia Giordano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgia Giordano","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","Department of Oncology, University of Torino, 10100 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Oncology, University of Torino, 10100 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030044022","display_name":"Alessandra Merlini","orcid":"https://orcid.org/0000-0002-5280-1411","observed_orcids":["https://orcid.org/0000-0002-5280-1411"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alessandra Merlini","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","Department of Oncology, University of Torino, 10100 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Oncology, University of Torino, 10100 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021452701","display_name":"Enrico Berrino","orcid":"https://orcid.org/0000-0001-6728-5619","observed_orcids":["https://orcid.org/0000-0001-6728-5619"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Berrino","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","Department of Medical Sciences, University of Torino, 10100 Torino, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6728-5619","affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Medical Sciences, University of Torino, 10100 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024450006","display_name":"Maria Laura Centomo","orcid":"https://orcid.org/0000-0003-1812-7192","observed_orcids":["https://orcid.org/0000-0003-1812-7192"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Laura Centomo","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","Department of Oncology, University of Torino, 10100 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Oncology, University of Torino, 10100 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014527748","display_name":"Giulia Chiabotto","orcid":"https://orcid.org/0000-0002-1420-3517","observed_orcids":["https://orcid.org/0000-0002-1420-3517"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Chiabotto","raw_affiliation_strings":["Department of Medical Sciences, University of Torino, 10100 Torino, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1420-3517","affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, University of Torino, 10100 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031479484","display_name":"Silvia Brusco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Brusco","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","Department of Oncology, University of Torino, 10100 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Oncology, University of Torino, 10100 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079227239","display_name":"Marco Basiric\u00f2","orcid":"https://orcid.org/0000-0002-3059-7501","observed_orcids":["https://orcid.org/0000-0002-3059-7501"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Basiric\u00f2","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083263060","display_name":"Elena Maldi","orcid":"https://orcid.org/0000-0002-8094-820X","observed_orcids":["https://orcid.org/0000-0002-8094-820X"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Maldi","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy"],"raw_orcid":"https://orcid.org/0000-0002-8094-820X","affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075529367","display_name":"Alberto Maria Pisacane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Pisacane","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086890383","display_name":"Valeria Leuci","orcid":"https://orcid.org/0000-0003-3592-9779","observed_orcids":["https://orcid.org/0000-0003-3592-9779"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria Leuci","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3592-9779","affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041240875","display_name":"Dario Sangiolo","orcid":"https://orcid.org/0000-0002-7163-7071","observed_orcids":["https://orcid.org/0000-0002-7163-7071"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Dario Sangiolo","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","Department of Oncology, University of Torino, 10100 Torino, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7163-7071","affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Oncology, University of Torino, 10100 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052085580","display_name":"Lorenzo D\u2019Ambrosio","orcid":"https://orcid.org/0000-0003-3294-8819","observed_orcids":["https://orcid.org/0000-0003-3294-8819"]},"institutions":[{"id":"https://openalex.org/I4210111911","display_name":"Azienda Sanitaria Locale di Asti","ror":"https://ror.org/019z87133","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210111911"]},{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo D\u2019Ambrosio","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","Cardinal Massaia Hospital, 14100 Asti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Cardinal Massaia Hospital, 14100 Asti, Italy","institution_ids":["https://openalex.org/I4210111911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056702454","display_name":"Massimo Aglietta","orcid":"https://orcid.org/0000-0002-2255-7972","observed_orcids":["https://orcid.org/0000-0002-2255-7972"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Aglietta","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","Department of Oncology, University of Torino, 10100 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Oncology, University of Torino, 10100 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076043217","display_name":"Bernd Kasper","orcid":"https://orcid.org/0000-0001-8425-8356","observed_orcids":["https://orcid.org/0000-0001-8425-8356"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210156450"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd Kasper","raw_affiliation_strings":["Sarcoma Unit, Mannheim University Medical Center, University of Heidelberg, 68167 Mannheim, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8425-8356","affiliations":[{"raw_affiliation_string":"Sarcoma Unit, Mannheim University Medical Center, University of Heidelberg, 68167 Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064011158","display_name":"Alberto Bardelli","orcid":"https://orcid.org/0000-0003-1647-5070","observed_orcids":["https://orcid.org/0000-0003-1647-5070"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Bardelli","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","Department of Oncology, University of Torino, 10100 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]},{"raw_affiliation_string":"Department of Oncology, University of Torino, 10100 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050031420","display_name":"Giovanni Grignani","orcid":"https://orcid.org/0000-0001-5515-569X","observed_orcids":["https://orcid.org/0000-0001-5515-569X"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Grignani","raw_affiliation_strings":["Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5515-569X","affiliations":[{"raw_affiliation_string":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy","institution_ids":["https://openalex.org/I4210151091"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5030044022"],"corresponding_institution_ids":["https://openalex.org/I4210151091","https://openalex.org/I55143463"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":0.3994,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.57706478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"24","first_page":"6295","last_page":"6295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parp1-inhibitors","display_name":"PARP-1 inhibitors","score":0.8320000171661377},{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.9800000190734863},{"id":"https://openalex.org/keywords/trabectedin","display_name":"trabectedin","score":1.0},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.9330000281333923},{"id":"https://openalex.org/keywords/advanced-sarcoma","display_name":"advanced sarcoma","score":0.8289999961853027},{"id":"https://openalex.org/keywords/dna-repair-genes","display_name":"DNA repair genes","score":0.6200000047683716},{"id":"https://openalex.org/keywords/mutational-signatures","display_name":"mutational signatures","score":0.9789999723434448},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":0.902999997138977},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.3580000102519989},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.7020000219345093},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C2780752271","wikidata":"https://www.wikidata.org/wiki/Q2637746","display_name":"Trabectedin","level":4,"score":0.9597369432449341},{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.9587388634681702},{"id":"https://openalex.org/C2778480876","wikidata":"https://www.wikidata.org/wiki/Q21112674","display_name":"PARP1","level":5,"score":0.7337019443511963},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6546308398246765},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.6247023344039917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6228326559066772},{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.6098967790603638},{"id":"https://openalex.org/C2781312401","wikidata":"https://www.wikidata.org/wiki/Q7919041","display_name":"Veliparib","level":5,"score":0.545003354549408},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.420238733291626},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3363465964794159},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.22648176550865173},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.2108170986175537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19734275341033936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12226596474647522},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10097110271453857},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.07509395480155945},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/cancers13246295","doi":"https://doi.org/10.3390/cancers13246295","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13246295","pdf_url":"https://www.mdpi.com/2072-6694/13/24/6295/pdf?version=1639742349","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmid:34944915","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34944915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8699802","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8699802/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmh:oai:iris.polito.it:11583/2996362","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11583/2996362","pdf_url":"https://iris.polito.it/bitstream/11583/2996362/1/cancers-13-06295-v2.pdf","source":{"id":"https://openalex.org/S7407055329","display_name":"PORTO@Iris","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unito.it:2318/1835722","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1835722","pdf_url":"https://iris.unito.it/bitstream/2318/1835722/1/cancers-13-06295.pdf","source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/cancers13246295","doi":"https://doi.org/10.3390/cancers13246295","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13246295","pdf_url":"https://www.mdpi.com/2072-6694/13/24/6295/pdf?version=1639742349","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G156594879","display_name":null,"funder_award_id":"IG-2018","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G163181597","display_name":null,"funder_award_id":"GR-2016-02362726.","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G1855991024","display_name":null,"funder_award_id":"IG-2017","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G1924445280","display_name":null,"funder_award_id":"23104","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G2297922352","display_name":null,"funder_award_id":"RC-2021","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G255694563","display_name":null,"funder_award_id":"5\u00d71000","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G387172998","display_name":null,"funder_award_id":"\u201c5\u00d71000\u201d","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G4458958805","display_name":null,"funder_award_id":"IG-2019","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G6297372918","display_name":null,"funder_award_id":"AIRC IG 2018","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G6400499238","display_name":null,"funder_award_id":"FPRC 5xmille","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G6476675656","display_name":null,"funder_award_id":"AIRC IG 23104","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G6562031730","display_name":null,"funder_award_id":"AIRC IG 2017","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G7756906289","display_name":null,"funder_award_id":"21091","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G801137187","display_name":null,"funder_award_id":"5 x mille","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G8066471175","display_name":null,"funder_award_id":"21923","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G8701425265","display_name":null,"funder_award_id":"ARS01_00492","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G934622242","display_name":null,"funder_award_id":"ID.21091","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200210903.pdf","grobid_xml":"https://content.openalex.org/works/W4200210903.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1566328614","https://openalex.org/W1759669640","https://openalex.org/W1816802498","https://openalex.org/W1914351667","https://openalex.org/W1970898535","https://openalex.org/W1992332625","https://openalex.org/W2039123767","https://openalex.org/W2049491375","https://openalex.org/W2049553585","https://openalex.org/W2057888466","https://openalex.org/W2068402552","https://openalex.org/W2075561524","https://openalex.org/W2096616470","https://openalex.org/W2104885590","https://openalex.org/W2107429737","https://openalex.org/W2108976255","https://openalex.org/W2120426523","https://openalex.org/W2139471935","https://openalex.org/W2152061559","https://openalex.org/W2160609925","https://openalex.org/W2291298003","https://openalex.org/W2292067704","https://openalex.org/W2560367415","https://openalex.org/W2605942164","https://openalex.org/W2609248852","https://openalex.org/W2737389832","https://openalex.org/W2761575992","https://openalex.org/W2770647635","https://openalex.org/W2800002600","https://openalex.org/W2808484886","https://openalex.org/W2828180271","https://openalex.org/W2883000607","https://openalex.org/W2891251861","https://openalex.org/W2900082702","https://openalex.org/W2902524594","https://openalex.org/W2902666606","https://openalex.org/W2903718866","https://openalex.org/W2909679049","https://openalex.org/W2914335731","https://openalex.org/W2922492752","https://openalex.org/W2924124844","https://openalex.org/W2924359886","https://openalex.org/W2952477280","https://openalex.org/W2969503240","https://openalex.org/W2970967145","https://openalex.org/W2972939290","https://openalex.org/W2981790403","https://openalex.org/W2987148655","https://openalex.org/W2987694236","https://openalex.org/W2988447335","https://openalex.org/W2989904606","https://openalex.org/W3000282923","https://openalex.org/W3004480399","https://openalex.org/W3008245293","https://openalex.org/W3009789321","https://openalex.org/W3011208784","https://openalex.org/W3016983055","https://openalex.org/W3089056851","https://openalex.org/W3113077828","https://openalex.org/W3166072320","https://openalex.org/W3167445921","https://openalex.org/W3168360437","https://openalex.org/W4235857807","https://openalex.org/W4236289131","https://openalex.org/W6680769451"],"related_works":["https://openalex.org/W2072062775","https://openalex.org/W2609248852","https://openalex.org/W2032386131","https://openalex.org/W6977546711","https://openalex.org/W4296012087","https://openalex.org/W2891791014","https://openalex.org/W2078783276","https://openalex.org/W7136052214","https://openalex.org/W2605942164","https://openalex.org/W2603911269"],"abstract_inverted_index":{"Drug-induced":[0],"tumor":[1,69,139],"mutational":[2,55,110],"burden":[3],"(TMB)":[4],"may":[5],"contribute":[6],"to":[7,80,151,184,210],"unleashing":[8],"the":[9,26,31,43,109,165,194,202],"immune":[10],"response":[11],"in":[12,35,51,59,124,131,138,164,201],"relatively":[13],"\"immune-cold\"":[14],"tumors,":[15],"such":[16],"as":[17],"sarcomas.":[18],"We":[19],"previously":[20],"showed":[21],"that":[22,88,99],"PARP1":[23,211],"inhibition":[24],"perpetuates":[25],"DNA":[27,52,112],"damage":[28],"induced":[29,159],"by":[30],"chemotherapeutic":[32],"agent":[33,87],"trabectedin":[34,75,103,172],"both":[36,123],"preclinical":[37],"models":[38],"and":[39,57,68,76,92,104,127,144,173,181],"sarcoma":[40],"patients.":[41],"In":[42,169],"present":[44],"work,":[45],"we":[46],"explored":[47],"acquired":[48],"genetic":[49],"changes":[50],"repair":[53,113],"genes,":[54],"signatures,":[56],"TMB":[58,122,134,162,191],"a":[60,160,171],"translational":[61],"platform":[62],"composed":[63],"of":[64,102,205],"cell":[65],"lines,":[66],"xenografts,":[67],"samples":[70],"from":[71,142],"patients":[72,146],"treated":[73,82],"with":[74,83,157],"olaparib":[77,105,174],"combination,":[78],"compared":[79,150],"cells":[81,129],"temozolomide,":[84],"an":[85],"alkylating":[86],"induces":[89],"hypermutation.":[90],"Whole-exome":[91],"targeted":[93],"panel":[94],"sequencing":[95],"data":[96],"analyses":[97],"revealed":[98],"three":[100],"cycles":[101],"combination":[106,175],"neither":[107],"affected":[108],"profiles,":[111],"gene":[114],"status,":[115],"or":[116,130],"copy":[117],"number":[118],"alterations,":[119],"nor":[120],"increased":[121,137],"homologous":[125],"recombinant-defective":[126],"proficient":[128],"xenografts.":[132],"Moreover,":[133],"was":[135],"not":[136,177],"specimens":[140],"derived":[141],"trabectedin-":[143],"olaparib-treated":[145],"(5-6":[147],"cycles)":[148],"when":[149],"pre-treatment":[152],"biopsies.":[153],"Conversely,":[154],"repeated":[155],"treatments":[156],"temozolomide":[158],"massive":[161],"increase":[163],"SJSA-1":[166],"osteosarcoma":[167],"model.":[168],"conclusion,":[170],"did":[176],"show":[178],"mutagenic":[179],"effects":[180],"is":[182],"unlikely":[183],"prime":[185],"subsequent":[186],"immune-therapeutic":[187],"interventions":[188],"based":[189],"on":[190],"increase.":[192],"On":[193],"other":[195],"hand,":[196],"these":[197],"findings":[198],"are":[199],"reassuring":[200],"increasing":[203],"warning":[204],"treatment-induced":[206],"hematologic":[207],"malignancies":[208],"correlated":[209],"inhibitor":[212],"use.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-12-31T00:00:00"}
