{"id":"https://openalex.org/W4200200743","doi":"https://doi.org/10.1128/mbio.02980-21","title":"A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency","display_name":"A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency","publication_year":2021,"publication_date":"2021-12-07","ids":{"openalex":"https://openalex.org/W4200200743","doi":"https://doi.org/10.1128/mbio.02980-21","pmid":"https://pubmed.ncbi.nlm.nih.gov/34872356","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8649776"},"language":"en","primary_location":{"id":"doi:10.1128/mbio.02980-21","doi":"https://doi.org/10.1128/mbio.02980-21","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.02980-21","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1128/mbio.02980-21","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070604966","display_name":"Michael D. R\u00f6ling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michael R\u00f6ling","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007846185","display_name":"Mahsa Mollapour Sisakht","orcid":"https://orcid.org/0000-0003-0396-676X","observed_orcids":["https://orcid.org/0000-0003-0396-676X"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR","NL"],"is_corresponding":false,"raw_author_name":"Mahsa Mollapour Sisakht","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","Stem Cell and Regenerative Medicine Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Stem Cell and Regenerative Medicine Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030332517","display_name":"Enrico Ne","orcid":"https://orcid.org/0000-0002-9450-6736","observed_orcids":["https://orcid.org/0000-0002-9450-6736"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Enrico Ne","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079422639","display_name":"Panagiotis Moulos","orcid":"https://orcid.org/0000-0002-4199-0333","observed_orcids":["https://orcid.org/0000-0002-4199-0333"]},"institutions":[{"id":"https://openalex.org/I6820528","display_name":"Alexander Fleming Biomedical Sciences Research Center","ror":"https://ror.org/013x0ky90","country_code":"GR","type":"facility","lineage":["https://openalex.org/I6820528"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis Moulos","raw_affiliation_strings":["Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece","institution_ids":["https://openalex.org/I6820528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048367579","display_name":"Raquel Crespo","orcid":"https://orcid.org/0000-0002-6751-6621","observed_orcids":["https://orcid.org/0000-0002-6751-6621"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Raquel Crespo","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014259692","display_name":"Mateusz Stoszko","orcid":"https://orcid.org/0000-0002-0629-2492","observed_orcids":["https://orcid.org/0000-0002-0629-2492"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mateusz Stoszko","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002888060","display_name":"Elisa De Crignis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Elisa De Crignis","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063764542","display_name":"Helen C. Bodmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Helen Bodmer","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077692179","display_name":"Tsung Wai Kan","orcid":"https://orcid.org/0009-0001-0013-8486","observed_orcids":["https://orcid.org/0009-0001-0013-8486"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tsung Wai Kan","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013314623","display_name":"Maryam Akbarzadeh","orcid":"https://orcid.org/0000-0002-4054-6396","observed_orcids":["https://orcid.org/0000-0002-4054-6396"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR","NL"],"is_corresponding":false,"raw_author_name":"Maryam Akbarzadeh","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","Stem Cell and Regenerative Medicine Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Stem Cell and Regenerative Medicine Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108146140","display_name":"Vaggelis Harokopos","orcid":"https://orcid.org/0000-0001-9260-8459","observed_orcids":["https://orcid.org/0000-0001-9260-8459"]},"institutions":[{"id":"https://openalex.org/I6820528","display_name":"Alexander Fleming Biomedical Sciences Research Center","ror":"https://ror.org/013x0ky90","country_code":"GR","type":"facility","lineage":["https://openalex.org/I6820528"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vaggelis Harokopos","raw_affiliation_strings":["Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece","institution_ids":["https://openalex.org/I6820528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069153102","display_name":"Pantelis Hatzis","orcid":"https://orcid.org/0000-0001-5002-7728","observed_orcids":["https://orcid.org/0000-0001-5002-7728"]},"institutions":[{"id":"https://openalex.org/I6820528","display_name":"Alexander Fleming Biomedical Sciences Research Center","ror":"https://ror.org/013x0ky90","country_code":"GR","type":"facility","lineage":["https://openalex.org/I6820528"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Pantelis Hatzis","raw_affiliation_strings":["Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece","institution_ids":["https://openalex.org/I6820528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022876579","display_name":"Robert-Jan T. S. Palstra","orcid":"https://orcid.org/0000-0003-4600-2303","observed_orcids":["https://orcid.org/0000-0003-4600-2303"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Robert-Jan Palstra","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","Department of Pathology, Erasmus University Medical Center, Rotterdam, the Netherlands","Department of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Department of Pathology, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Department of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077282469","display_name":"Tokameh Mahmoudi","orcid":"https://orcid.org/0000-0002-2060-9353","observed_orcids":["https://orcid.org/0000-0002-2060-9353"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Tokameh Mahmoudi","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","Department of Pathology, Erasmus University Medical Center, Rotterdam, the Netherlands","Department of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-2060-9353","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Department of Pathology, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Department of Urology, Erasmus University Medical Center, Rotterdam, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022876579","https://openalex.org/A5077282469"],"corresponding_institution_ids":["https://openalex.org/I2801952686"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":0.702,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.60229561,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"12","issue":"6","first_page":"e0298021","last_page":"e0298021"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-latency","display_name":"HIV-1 latency","score":0.9980000257492065},{"id":"https://openalex.org/keywords/host-factors","display_name":"host factors","score":0.609000027179718},{"id":"https://openalex.org/keywords/latent-hiv-1-reservoir","display_name":"latent HIV-1 reservoir","score":0.6740000247955322},{"id":"https://openalex.org/keywords/viral-reactivation","display_name":"viral reactivation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/hiv-1-provirus","display_name":"HIV-1 provirus","score":0.7350000143051147},{"id":"https://openalex.org/keywords/cure-strategies","display_name":"cure strategies","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2778852064","wikidata":"https://www.wikidata.org/wiki/Q4115619","display_name":"Virus latency","level":4,"score":0.6682665944099426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5954511761665344},{"id":"https://openalex.org/C179138559","wikidata":"https://www.wikidata.org/wiki/Q24740158","display_name":"Chromodomain","level":5,"score":0.5265593528747559},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.49717405438423157},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.4915259778499603},{"id":"https://openalex.org/C2776915012","wikidata":"https://www.wikidata.org/wiki/Q17125871","display_name":"PRC2","level":5,"score":0.45818012952804565},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39515745639801025},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.38663995265960693},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35297638177871704},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3495906591415405},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3171558678150177},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.30275797843933105},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.2846127152442932},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.23655065894126892},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.16782647371292114},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.12520533800125122},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.09792077541351318}],"mesh":[{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006238","descriptor_name":"Haploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014775","descriptor_name":"Virus Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018092","descriptor_name":"Kainic Acid Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018092","descriptor_name":"Kainic Acid Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064570","descriptor_name":"Ubiquitin-Specific Proteases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064570","descriptor_name":"Ubiquitin-Specific Proteases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1128/mbio.02980-21","doi":"https://doi.org/10.1128/mbio.02980-21","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.02980-21","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},{"id":"doi:10.1101/2021.01.20.427543","doi":"https://doi.org/10.1101/2021.01.20.427543","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.01.20.427543","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/01/22/2021.01.20.427543.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:34872356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34872356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8649776","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8649776/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"Text"},{"id":"pmh:oai:pure.eur.nl:openaire/990d5449-35d0-444d-84b2-3df50eea54d9","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/990d5449-35d0-444d-84b2-3df50eea54d9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"R\u00f6ling, M, Sisakht, M M, Ne, E, Moulos, P, Crespo, R, Stoszko, M, de Crignis, E, Bodmer, H, Kan, T W, Akbarzadeh, M, Harokopos, V, Hatzis, P, Palstra, R J & Mahmoudi, T 2021, 'A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency', mBio, vol. 12, no. 6, e02980-21. https://doi.org/10.1128/mBio.02980-21","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/990d5449-35d0-444d-84b2-3df50eea54d9","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/990d5449-35d0-444d-84b2-3df50eea54d9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mBio, 12(6):e02980-21. American Society for Microbiology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:2f729d806387452999a3c9f51ee0ea9f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2f729d806387452999a3c9f51ee0ea9f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mBio, Vol 12, Iss 6 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/mbio.02980-21","doi":"https://doi.org/10.1128/mbio.02980-21","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.02980-21","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G59611650","display_name":null,"funder_award_id":"446002508","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"},{"id":"https://openalex.org/G6119232506","display_name":null,"funder_award_id":"FP/2007-2013 STG 337116 Trxn-PURGE","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"},{"id":"https://openalex.org/G7546946110","display_name":null,"funder_award_id":"FP/2007-2013)/ERC","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8440449467","display_name":null,"funder_award_id":"2016014","funder_id":"https://openalex.org/F4320309881","funder_display_name":"Aids Fonds"},{"id":"https://openalex.org/G896728979","display_name":null,"funder_award_id":"FP/2007/2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G966257856","display_name":null,"funder_award_id":"2014021","funder_id":"https://openalex.org/F4320309881","funder_display_name":"Aids Fonds"}],"funders":[{"id":"https://openalex.org/F4320309881","display_name":"Aids Fonds","ror":"https://ror.org/00j04c011"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200200743.pdf","grobid_xml":"https://content.openalex.org/works/W4200200743.grobid-xml"},"referenced_works_count":107,"referenced_works":["https://openalex.org/W1527634862","https://openalex.org/W1964660012","https://openalex.org/W1965952845","https://openalex.org/W1966121663","https://openalex.org/W1971112771","https://openalex.org/W1973491611","https://openalex.org/W1980853691","https://openalex.org/W1982410222","https://openalex.org/W1983186759","https://openalex.org/W1996604523","https://openalex.org/W1997232062","https://openalex.org/W2000337153","https://openalex.org/W2001356550","https://openalex.org/W2002124740","https://openalex.org/W2003787610","https://openalex.org/W2006487962","https://openalex.org/W2012608856","https://openalex.org/W2018875143","https://openalex.org/W2022773122","https://openalex.org/W2028613789","https://openalex.org/W2037524921","https://openalex.org/W2041184937","https://openalex.org/W2051879794","https://openalex.org/W2051951150","https://openalex.org/W2055796578","https://openalex.org/W2058486365","https://openalex.org/W2063628696","https://openalex.org/W2064743809","https://openalex.org/W2065609322","https://openalex.org/W2065613238","https://openalex.org/W2066013688","https://openalex.org/W2066741833","https://openalex.org/W2067849510","https://openalex.org/W2069554621","https://openalex.org/W2069765786","https://openalex.org/W2074794487","https://openalex.org/W2081651784","https://openalex.org/W2083322751","https://openalex.org/W2088281838","https://openalex.org/W2098560279","https://openalex.org/W2098612555","https://openalex.org/W2098766227","https://openalex.org/W2105343273","https://openalex.org/W2110951885","https://openalex.org/W2111589020","https://openalex.org/W2114570899","https://openalex.org/W2122745942","https://openalex.org/W2127467277","https://openalex.org/W2128009957","https://openalex.org/W2129305656","https://openalex.org/W2135493913","https://openalex.org/W2138164217","https://openalex.org/W2145246179","https://openalex.org/W2146632088","https://openalex.org/W2146926782","https://openalex.org/W2147447587","https://openalex.org/W2158520397","https://openalex.org/W2163855841","https://openalex.org/W2164223256","https://openalex.org/W2168822770","https://openalex.org/W2174686320","https://openalex.org/W2252780427","https://openalex.org/W2328075981","https://openalex.org/W2339647598","https://openalex.org/W2564084609","https://openalex.org/W2575376556","https://openalex.org/W2578584536","https://openalex.org/W2606675097","https://openalex.org/W2614033948","https://openalex.org/W2745732448","https://openalex.org/W2761486126","https://openalex.org/W2762873154","https://openalex.org/W2767749422","https://openalex.org/W2769609079","https://openalex.org/W2783821082","https://openalex.org/W2787103295","https://openalex.org/W2790372871","https://openalex.org/W2800435599","https://openalex.org/W2802681989","https://openalex.org/W2804663340","https://openalex.org/W2807231680","https://openalex.org/W2885704283","https://openalex.org/W2888206159","https://openalex.org/W2901557802","https://openalex.org/W2911100007","https://openalex.org/W2914484956","https://openalex.org/W2918786033","https://openalex.org/W2941845540","https://openalex.org/W2946439345","https://openalex.org/W2955106731","https://openalex.org/W2961032267","https://openalex.org/W2968540016","https://openalex.org/W2981535855","https://openalex.org/W2996586428","https://openalex.org/W3005570285","https://openalex.org/W3013091596","https://openalex.org/W3035082673","https://openalex.org/W3037233756","https://openalex.org/W3046236678","https://openalex.org/W3048917395","https://openalex.org/W3080636052","https://openalex.org/W3086046890","https://openalex.org/W3087731538","https://openalex.org/W3108668483","https://openalex.org/W3109857251","https://openalex.org/W3135683720","https://openalex.org/W4295332804"],"related_works":["https://openalex.org/W2736822140","https://openalex.org/W2296362429","https://openalex.org/W2177546552","https://openalex.org/W4362590271","https://openalex.org/W2036958568","https://openalex.org/W2610073991","https://openalex.org/W2012065621","https://openalex.org/W3131097798","https://openalex.org/W3010708378","https://openalex.org/W2005062239"],"abstract_inverted_index":{"A":[0],"reservoir":[1],"of":[2,10,23,30,38],"latently":[3],"HIV-1-infected":[4],"cells":[5],"persists":[6],"in":[7],"the":[8,24,39],"presence":[9],"combination":[11],"antiretroviral":[12],"therapy":[13],"(cART),":[14],"representing":[15],"a":[16],"major":[17],"obstacle":[18],"for":[19],"viral":[20],"eradication.":[21],"Reactivation":[22],"latent":[25],"HIV-1":[26],"provirus":[27],"is":[28],"part":[29],"curative":[31],"strategies":[32],"which":[33],"aim":[34],"to":[35],"promote":[36],"clearance":[37],"infected":[40],"cells.":[41]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-12-31T00:00:00"}
