{"id":"https://openalex.org/W4200015342","doi":"https://doi.org/10.1007/s00005-021-00640-7","title":"Prospects for Development of Induced Pluripotent Stem Cell-Derived CAR-Targeted Immunotherapies","display_name":"Prospects for Development of Induced Pluripotent Stem Cell-Derived CAR-Targeted Immunotherapies","publication_year":2021,"publication_date":"2021-12-12","ids":{"openalex":"https://openalex.org/W4200015342","doi":"https://doi.org/10.1007/s00005-021-00640-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/34897554","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8666432"},"language":"en","primary_location":{"id":"doi:10.1007/s00005-021-00640-7","doi":"https://doi.org/10.1007/s00005-021-00640-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00005-021-00640-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00005-021-00640-7.pdf","source":{"id":"https://openalex.org/S25199142","display_name":"Archivum Immunologiae et Therapiae Experimentalis","issn_l":"0004-069X","issn":["0004-069X","1661-4917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivum Immunologiae et Therapiae Experimentalis","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00005-021-00640-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012431032","display_name":"Roberta Mazza","orcid":"https://orcid.org/0000-0002-0497-5994","observed_orcids":["https://orcid.org/0000-0002-0497-5994"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I4405272435","display_name":"Leucid Bio (United Kingdom)","ror":"https://ror.org/045pe3119","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405272435"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roberta Mazza","raw_affiliation_strings":["Leucid Bio Ltd, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leucid Bio Ltd, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I4405272435"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053670839","display_name":"John F. Maher","orcid":"https://orcid.org/0000-0001-8275-8488","observed_orcids":["https://orcid.org/0000-0001-8275-8488"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210106427","display_name":"Eastbourne District General Hospital","ror":"https://ror.org/01pjjvq50","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210106427","https://openalex.org/I4210136757"]},{"id":"https://openalex.org/I4405272435","display_name":"Leucid Bio (United Kingdom)","ror":"https://ror.org/045pe3119","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405272435"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"John Maher","raw_affiliation_strings":["Department of Immunology, Eastbourne Hospital, Kings Drive, Eastbourne, BN21 2UD, East Sussex, UK. john.maher@kcl.ac.uk","King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London, SE1 9RT, UK. john.maher@kcl.ac.uk","Leucid Bio Ltd, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK. john.maher@kcl.ac.uk","Leucid Bio Ltd, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK"],"raw_orcid":"https://orcid.org/0000-0001-8275-8488","affiliations":[{"raw_affiliation_string":"Department of Immunology, Eastbourne Hospital, Kings Drive, Eastbourne, BN21 2UD, East Sussex, UK. john.maher@kcl.ac.uk","institution_ids":["https://openalex.org/I4210106427"]},{"raw_affiliation_string":"King's College London, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, Great Maze Pond, London, SE1 9RT, UK. john.maher@kcl.ac.uk","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Leucid Bio Ltd, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK. john.maher@kcl.ac.uk","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I4405272435"]},{"raw_affiliation_string":"Leucid Bio Ltd, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I4405272435"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5053670839"],"corresponding_institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753","https://openalex.org/I4210106427","https://openalex.org/I4405272435"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":{"value":3860,"currency":"USD","value_usd":3860},"fwci":0.6958,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.62674191,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"70","issue":"1","first_page":"2","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.11599999666213989,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.7879999876022339},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.765999972820282},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.8029999732971191},{"id":"https://openalex.org/keywords/ipsc-derived-t-cells","display_name":"iPSC-derived T cells","score":0.8100000023841858},{"id":"https://openalex.org/keywords/ex-vivo-t-cell-engineering","display_name":"ex vivo T cell engineering","score":0.7170000076293945},{"id":"https://openalex.org/keywords/genetic-modification","display_name":"genetic modification","score":0.5260000228881836},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.578000009059906},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.807746946811676},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.750274121761322},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5990955829620361},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.47627824544906616},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4745950400829315},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.43180060386657715},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.41629576683044434},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4157608151435852},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4023655354976654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3850090205669403},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3732355237007141},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37301158905029297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33942553400993347},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32940205931663513},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31214308738708496},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.14808917045593262},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11485865712165833},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08225411176681519},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00005-021-00640-7","doi":"https://doi.org/10.1007/s00005-021-00640-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00005-021-00640-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00005-021-00640-7.pdf","source":{"id":"https://openalex.org/S25199142","display_name":"Archivum Immunologiae et Therapiae Experimentalis","issn_l":"0004-069X","issn":["0004-069X","1661-4917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivum Immunologiae et Therapiae Experimentalis","raw_type":"journal-article"},{"id":"pmid:34897554","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34897554","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivum immunologiae et therapiae experimentalis","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8666432","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8666432/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arch Immunol Ther Exp (Warsz)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s00005-021-00640-7","doi":"https://doi.org/10.1007/s00005-021-00640-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00005-021-00640-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00005-021-00640-7.pdf","source":{"id":"https://openalex.org/S25199142","display_name":"Archivum Immunologiae et Therapiae Experimentalis","issn_l":"0004-069X","issn":["0004-069X","1661-4917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivum Immunologiae et Therapiae Experimentalis","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5726036687","display_name":"Phase 1 trial: T4 immunotherapy of head and neck cancer.","funder_award_id":"104802/Z/14/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6160881927","display_name":null,"funder_award_id":"MESOUK18-2 INT 1","funder_id":"https://openalex.org/F4320320055","funder_display_name":"British Lung Foundation"}],"funders":[{"id":"https://openalex.org/F2655170654","display_name":"Leucid Bio","ror":"https://ror.org/045pe3119"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320055","display_name":"British Lung Foundation","ror":"https://ror.org/05qnwyb92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200015342.pdf","grobid_xml":"https://content.openalex.org/works/W4200015342.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W1574443686","https://openalex.org/W1939360714","https://openalex.org/W1964294710","https://openalex.org/W1966128754","https://openalex.org/W1990416052","https://openalex.org/W1991494425","https://openalex.org/W1991936258","https://openalex.org/W1994142477","https://openalex.org/W2003624697","https://openalex.org/W2010607826","https://openalex.org/W2013205740","https://openalex.org/W2017240932","https://openalex.org/W2028460943","https://openalex.org/W2030173131","https://openalex.org/W2035180813","https://openalex.org/W2039648189","https://openalex.org/W2080860848","https://openalex.org/W2084894578","https://openalex.org/W2087209798","https://openalex.org/W2092166052","https://openalex.org/W2098372175","https://openalex.org/W2102560467","https://openalex.org/W2108992451","https://openalex.org/W2109427914","https://openalex.org/W2115228434","https://openalex.org/W2119207148","https://openalex.org/W2121158936","https://openalex.org/W2121934915","https://openalex.org/W2138977668","https://openalex.org/W2140347191","https://openalex.org/W2142046859","https://openalex.org/W2142291912","https://openalex.org/W2163846766","https://openalex.org/W2165580475","https://openalex.org/W2165813814","https://openalex.org/W2182452189","https://openalex.org/W2221432805","https://openalex.org/W2315749684","https://openalex.org/W2395532360","https://openalex.org/W2401987785","https://openalex.org/W2550226908","https://openalex.org/W2552702590","https://openalex.org/W2580253009","https://openalex.org/W2583070206","https://openalex.org/W2589417329","https://openalex.org/W2739484648","https://openalex.org/W2750982243","https://openalex.org/W2770028022","https://openalex.org/W2794125175","https://openalex.org/W2795256310","https://openalex.org/W2804977060","https://openalex.org/W2810715813","https://openalex.org/W2889646458","https://openalex.org/W2890955229","https://openalex.org/W2893050608","https://openalex.org/W2895644365","https://openalex.org/W2896659686","https://openalex.org/W2900794929","https://openalex.org/W2903960245","https://openalex.org/W2904940919","https://openalex.org/W2906302782","https://openalex.org/W2913136103","https://openalex.org/W2913902534","https://openalex.org/W2917035693","https://openalex.org/W2922288722","https://openalex.org/W2925851255","https://openalex.org/W2948047060","https://openalex.org/W2949407488","https://openalex.org/W2955975697","https://openalex.org/W2967773781","https://openalex.org/W2976402945","https://openalex.org/W2978325726","https://openalex.org/W2982460272","https://openalex.org/W2984549776","https://openalex.org/W2987673820","https://openalex.org/W2988443210","https://openalex.org/W2989253463","https://openalex.org/W2995447672","https://openalex.org/W3004611567","https://openalex.org/W3009933121","https://openalex.org/W3015094526","https://openalex.org/W3021971416","https://openalex.org/W3022006417","https://openalex.org/W3029598682","https://openalex.org/W3034974614","https://openalex.org/W3039313607","https://openalex.org/W3039988661","https://openalex.org/W3048398491","https://openalex.org/W3083271094","https://openalex.org/W3094688588","https://openalex.org/W3095958987","https://openalex.org/W3097052250","https://openalex.org/W3097128992","https://openalex.org/W3106079805","https://openalex.org/W3112437255","https://openalex.org/W3113171896","https://openalex.org/W3122702917","https://openalex.org/W3132255011","https://openalex.org/W3139396124","https://openalex.org/W3158278756","https://openalex.org/W3160669634","https://openalex.org/W3163192972","https://openalex.org/W3164374695","https://openalex.org/W3165646149","https://openalex.org/W3166276852","https://openalex.org/W3172565803","https://openalex.org/W3179913768","https://openalex.org/W3191387132","https://openalex.org/W4206384507"],"related_works":["https://openalex.org/W4225253937","https://openalex.org/W4404476926","https://openalex.org/W4417022332","https://openalex.org/W4415279736","https://openalex.org/W4321435675","https://openalex.org/W4409619648","https://openalex.org/W3172565803","https://openalex.org/W4387245987","https://openalex.org/W4411058299","https://openalex.org/W7159979656"],"abstract_inverted_index":{"Technologies":[0],"required":[1],"to":[2,19,60,81,143,162,178],"generate":[3,144],"induced":[4],"pluripotent":[5],"stem":[6],"cells":[7,58],"(iPSC)":[8],"were":[9],"first":[10],"described":[11],"15":[12],"years":[13],"ago,":[14],"providing":[15],"a":[16,32,114],"strong":[17],"impetus":[18],"the":[20,87,94,110,122,141,173],"field":[21],"of":[22,36,73,125,147,172],"regenerative":[23],"medicine.":[24],"In":[25,39],"parallel,":[26],"immunotherapy":[27],"has":[28,43],"finally":[29],"emerged":[30],"as":[31],"clinically":[33],"meaningful":[34],"modality":[35],"cancer":[37],"therapy.":[38],"particular,":[40],"impressive":[41],"efficacy":[42],"been":[44,160],"achieved":[45],"in":[46,93,109,121,152,176],"patients":[47],"with":[48],"selected":[49],"haematological":[50],"malignancies":[51],"using":[52],"ex":[53],"vivo":[54],"expanded":[55],"autologous":[56],"T":[57],"engineered":[59],"express":[61],"chimeric":[62],"antigen":[63],"receptors":[64],"(CARs).":[65],"While":[66],"solid":[67,105],"tumours":[68,106],"account":[69],"for":[70,103],"over":[71],"90%":[72],"human":[74],"cancer,":[75],"they":[76],"currently":[77],"are":[78],"largely":[79],"refractory":[80],"this":[82],"therapeutic":[83],"approach.":[84],"Nonetheless,":[85],"given":[86],"considerable":[88],"innovation":[89],"taking":[90],"place":[91],"worldwide":[92],"CAR":[95],"field,":[96],"it":[97],"is":[98],"likely":[99],"that":[100,136],"effective":[101],"solutions":[102],"common":[104],"will":[107,116],"emerge":[108],"near":[111],"future.":[112],"Such":[113],"development":[115],"create":[117],"significant":[118],"new":[119],"challenges":[120],"scalable":[123],"delivery":[124],"these":[126],"complex,":[127],"costly":[128],"and":[129,166],"individualised":[130],"therapies.":[131],"CAR-engineered":[132],"immune":[133],"cell":[134,150],"products":[135,151],"originate":[137],"from":[138],"iPSCs":[139],"offer":[140],"potential":[142],"unlimited":[145],"numbers":[146],"homogeneous,":[148],"standardised":[149],"which":[153],"multiple":[154],"defined":[155],"gene":[156],"modification":[157],"events":[158],"have":[159],"introduced":[161],"ensure":[163],"safety,":[164],"potency":[165],"reproducibility.":[167],"Here,":[168],"we":[169],"review":[170],"some":[171],"emerging":[174],"strategies":[175],"use":[177],"engineer":[179],"CAR-expressing":[180],"iPSC-derived":[181],"drug":[182],"products.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-12-31T00:00:00"}