{"id":"https://openalex.org/W4200013221","doi":"https://doi.org/10.1038/s41541-021-00407-3","title":"Malaria transmission-blocking conjugate vaccine in ALFQ adjuvant induces durable functional immune responses in rhesus macaques","display_name":"Malaria transmission-blocking conjugate vaccine in ALFQ adjuvant induces durable functional immune responses in rhesus macaques","publication_year":2021,"publication_date":"2021-12-09","ids":{"openalex":"https://openalex.org/W4200013221","doi":"https://doi.org/10.1038/s41541-021-00407-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/34887448","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8660773"},"language":"en","primary_location":{"id":"doi:10.1038/s41541-021-00407-3","doi":"https://doi.org/10.1038/s41541-021-00407-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41541-021-00407-3","pdf_url":"https://www.nature.com/articles/s41541-021-00407-3.pdf","source":{"id":"https://openalex.org/S4210235625","display_name":"npj Vaccines","issn_l":"2059-0105","issn":["2059-0105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Vaccines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41541-021-00407-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111458225","display_name":"Puthupparampil V. Scaria","orcid":"https://orcid.org/0000-0002-7521-6514","observed_orcids":["https://orcid.org/0000-0002-7521-6514"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Puthupparampil V. Scaria","raw_affiliation_strings":["Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Charles Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Anderson","raw_affiliation_strings":["Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083887946","display_name":"Olga V. Muratova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Muratova","raw_affiliation_strings":["Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054063398","display_name":"Nada Alani","orcid":"https://orcid.org/0009-0005-3094-025X","observed_orcids":["https://orcid.org/0009-0005-3094-025X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nada Alani","raw_affiliation_strings":["Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005664607","display_name":"Hung V. Trinh","orcid":"https://orcid.org/0000-0001-8014-9291","observed_orcids":["https://orcid.org/0000-0001-8014-9291"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hung V. Trinh","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, 6720A Rockledge Drive, Bethesda, MD, 20817, USA","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, 6720A Rockledge Drive, Bethesda, MD, 20817, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069366223","display_name":"Steven T. Nadakal","orcid":"https://orcid.org/0000-0002-4584-4325","observed_orcids":["https://orcid.org/0000-0002-4584-4325"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven T. Nadakal","raw_affiliation_strings":["Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050112210","display_name":"Irfan Zaidi","orcid":"https://orcid.org/0000-0001-9161-2050","observed_orcids":["https://orcid.org/0000-0001-9161-2050","https://orcid.org/0000-0002-9847-2115"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irfan Zaidi","raw_affiliation_strings":["Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044942708","display_name":"Lynn Lambert","orcid":"https://orcid.org/0000-0002-3428-2347","observed_orcids":["https://orcid.org/0000-0002-3428-2347"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn Lambert","raw_affiliation_strings":["Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076380897","display_name":"Zolt\u00e1n Beck","orcid":"https://orcid.org/0000-0003-3818-7475","observed_orcids":["https://orcid.org/0000-0003-3818-7475"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]},{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zoltan Beck","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine, 6720A Rockledge Drive, Bethesda, MD, 20817, USA","Pfizer, Vaccine Research and Development, Pearl River, NY, USA","U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine, 6720A Rockledge Drive, Bethesda, MD, 20817, USA","institution_ids":["https://openalex.org/I1280259254"]},{"raw_affiliation_string":"Pfizer, Vaccine Research and Development, Pearl River, NY, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074916958","display_name":"Emma K. Barnafo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma K. Barnafo","raw_affiliation_strings":["Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102308797","display_name":"Kelly M. Rausch","orcid":"https://orcid.org/0000-0003-2270-4319","observed_orcids":["https://orcid.org/0000-0003-2270-4319"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly M. Rausch","raw_affiliation_strings":["Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070662012","display_name":"Christopher G. Rowe","orcid":"https://orcid.org/0009-0007-9269-1249","observed_orcids":["https://orcid.org/0009-0007-9269-1249"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Rowe","raw_affiliation_strings":["Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017293849","display_name":"Beth Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth Chen","raw_affiliation_strings":["Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019474861","display_name":"Gary R. Matyas","orcid":"https://orcid.org/0000-0002-2074-2373","observed_orcids":["https://orcid.org/0000-0002-2074-2373"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary R. Matyas","raw_affiliation_strings":["U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA"],"raw_orcid":"https://orcid.org/0000-0002-2074-2373","affiliations":[{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107139162","display_name":"Mangala Rao","orcid":"https://orcid.org/0000-0001-9553-4969","observed_orcids":["https://orcid.org/0000-0001-9553-4969"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mangala Rao","raw_affiliation_strings":["U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA"],"raw_orcid":"https://orcid.org/0000-0001-9553-4969","affiliations":[{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007536314","display_name":"Carl R. Alving","orcid":"https://orcid.org/0000-0002-1913-3909","observed_orcids":["https://orcid.org/0000-0002-1913-3909"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl R. Alving","raw_affiliation_strings":["U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056139240","display_name":"David L. Narum","orcid":"https://orcid.org/0000-0003-3041-5402","observed_orcids":["https://orcid.org/0000-0003-3041-5402"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Narum","raw_affiliation_strings":["Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA"],"raw_orcid":"https://orcid.org/0000-0003-3041-5402","affiliations":[{"raw_affiliation_string":"Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049967604","display_name":"Patrick  Emmet Duffy","orcid":"https://orcid.org/0000-0002-4483-5005","observed_orcids":["https://orcid.org/0000-0002-4483-5005"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrick E. Duffy","raw_affiliation_strings":["Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA. patrick.duffy@nih.gov","Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA"],"raw_orcid":"https://orcid.org/0000-0002-4483-5005","affiliations":[{"raw_affiliation_string":"Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA. patrick.duffy@nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"Laboratory of Malaria Immunology and Vaccinology, NIAID/NIH, 29 Lincoln Drive, Building 29B, Bethesda, MD, 20892-2903, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5049967604"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":{"value":3170,"currency":"USD","value_usd":3170},"fwci":3.9544,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.94119019,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":98},"biblio":{"volume":"6","issue":"1","first_page":"148","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malaria-transmission-blocking-vaccine","display_name":"malaria transmission-blocking vaccine","score":0.9300000071525574},{"id":"https://openalex.org/keywords/liposomal-adjuvant","display_name":"liposomal adjuvant","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tlr4-agonist","display_name":"TLR4 agonist","score":0.843999981880188},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.8140000104904175},{"id":"https://openalex.org/keywords/antibody-avidity","display_name":"antibody avidity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/functional-immunity","display_name":"functional immunity","score":0.5189999938011169},{"id":"https://openalex.org/keywords/igg-subclasses","display_name":"IgG subclasses","score":0.8159999847412109},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.7390000224113464},{"id":"https://openalex.org/keywords/vaccine-durability","display_name":"vaccine durability","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.795525074005127},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.7278207540512085},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6471031308174133},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6379850506782532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6211722493171692},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5333737134933472},{"id":"https://openalex.org/C179223381","wikidata":"https://www.wikidata.org/wiki/Q419425","display_name":"Avidity","level":3,"score":0.5183130502700806},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.49102139472961426},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4829406142234802},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.46205464005470276},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3791853189468384},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41541-021-00407-3","doi":"https://doi.org/10.1038/s41541-021-00407-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41541-021-00407-3","pdf_url":"https://www.nature.com/articles/s41541-021-00407-3.pdf","source":{"id":"https://openalex.org/S4210235625","display_name":"npj Vaccines","issn_l":"2059-0105","issn":["2059-0105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Vaccines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8660773","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8660773","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Vaccines","raw_type":"Text"},{"id":"pmid:34887448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34887448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ vaccines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5f059d573321402aaaf06cc772fda055","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5f059d573321402aaaf06cc772fda055","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41541-021-00407-3","doi":"https://doi.org/10.1038/s41541-021-00407-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41541-021-00407-3","pdf_url":"https://www.nature.com/articles/s41541-021-00407-3.pdf","source":{"id":"https://openalex.org/S4210235625","display_name":"npj Vaccines","issn_l":"2059-0105","issn":["2059-0105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Vaccines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1600240610","display_name":"ADDRESSING THE THREATS OF HIV AND EMERGING INFECTIOUS DISEASE TO THE MILITARY AND GLOBAL COMMUNITY THROUGH INNOVATIVE RESEARCH","funder_award_id":"W81XWH1820040","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G633733221","display_name":null,"funder_award_id":"W81XWH-18-2-0040","funder_id":"https://openalex.org/F4320307611","funder_display_name":"Henry M. Jackson Foundation"},{"id":"https://openalex.org/G7617460357","display_name":null,"funder_award_id":"W81XWH-18-2-0040","funder_id":"https://openalex.org/F4320338325","funder_display_name":"Walter Reed Army Institute of Research"},{"id":"https://openalex.org/G8093122957","display_name":null,"funder_award_id":"W81XWH-18-2-0040","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8166743225","display_name":null,"funder_award_id":"W81XWH-18","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320307611","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320338325","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4200013221.pdf","grobid_xml":"https://content.openalex.org/works/W4200013221.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W27723882","https://openalex.org/W1135375943","https://openalex.org/W1483396785","https://openalex.org/W1631727505","https://openalex.org/W1971408348","https://openalex.org/W1984658883","https://openalex.org/W1988696596","https://openalex.org/W1994101226","https://openalex.org/W2003002296","https://openalex.org/W2006196213","https://openalex.org/W2021868497","https://openalex.org/W2026923014","https://openalex.org/W2027088291","https://openalex.org/W2027259868","https://openalex.org/W2034728213","https://openalex.org/W2049209126","https://openalex.org/W2049579981","https://openalex.org/W2074096962","https://openalex.org/W2074472697","https://openalex.org/W2074905094","https://openalex.org/W2080689553","https://openalex.org/W2120404094","https://openalex.org/W2131082270","https://openalex.org/W2132243766","https://openalex.org/W2138623605","https://openalex.org/W2146636691","https://openalex.org/W2146998582","https://openalex.org/W2151313894","https://openalex.org/W2159984475","https://openalex.org/W2160654020","https://openalex.org/W2169656611","https://openalex.org/W2223960065","https://openalex.org/W2297951781","https://openalex.org/W2413417242","https://openalex.org/W2484762910","https://openalex.org/W2527986880","https://openalex.org/W2536285012","https://openalex.org/W2557596101","https://openalex.org/W2566478247","https://openalex.org/W2578705601","https://openalex.org/W2616844168","https://openalex.org/W2739289028","https://openalex.org/W2778723308","https://openalex.org/W2800786251","https://openalex.org/W2801278005","https://openalex.org/W2808217454","https://openalex.org/W2883266876","https://openalex.org/W2883669154","https://openalex.org/W2885422062","https://openalex.org/W2894608512","https://openalex.org/W2917115977","https://openalex.org/W2921951804","https://openalex.org/W2931641461","https://openalex.org/W2936579903","https://openalex.org/W2946248791","https://openalex.org/W2947693660","https://openalex.org/W2953851754","https://openalex.org/W2972772084","https://openalex.org/W2995668389","https://openalex.org/W3011663072","https://openalex.org/W3013273499","https://openalex.org/W3037750127","https://openalex.org/W3044518652","https://openalex.org/W3082923610","https://openalex.org/W3091948925","https://openalex.org/W3092466836","https://openalex.org/W3110330792","https://openalex.org/W3122399033","https://openalex.org/W3217177726","https://openalex.org/W4240350981"],"related_works":["https://openalex.org/W3110330792","https://openalex.org/W4417493615","https://openalex.org/W3037750127","https://openalex.org/W2947693660","https://openalex.org/W2803463081","https://openalex.org/W2578705601","https://openalex.org/W2007829789","https://openalex.org/W2074096962","https://openalex.org/W4401485855","https://openalex.org/W3120681435"],"abstract_inverted_index":{"developed":[0],"functional":[1,42,77,92,109],"immunity":[2],"in":[3,19,22,67],"humans,":[4],"with":[5,13,25,102,108,125],"limited":[6],"durability.":[7],"Pfs230":[8],"conjugated":[9],"to":[10,36],"EPA":[11],"(Pfs230D1-EPA)":[12],"liposomal":[14,52],"adjuvant":[15,53],"AS01":[16],"is":[17],"currently":[18],"clinical":[20],"trials":[21],"Mali.":[23],"Studies":[24],"these":[26],"conjugates":[27,71],"revealed":[28],"that":[29,123],"non-human":[30],"primates":[31],"are":[32],"better":[33],"than":[34],"mice":[35],"recapitulate":[37],"the":[38,47,61],"human":[39],"immunogenicity":[40,62],"and":[41,58,65,76,105,118],"activity.":[43,110,126],"Here,":[44],"we":[45],"evaluated":[46],"effect":[48],"of":[49,55,63,89,116],"ALFQ,":[50],"a":[51],"consisting":[54],"TLR4":[56],"agonist":[57],"QS21,":[59],"on":[60],"Pfs25-EPA":[64],"Pfs230D1-EPA":[66,90],"Rhesus":[68],"macaques.":[69],"Both":[70],"generated":[72],"strong":[73],"antibody":[74,121],"responses":[75],"activity":[78,83,93],"after":[79],"two":[80],"vaccinations":[81],"though":[82],"declined":[84],"rapidly.":[85],"A":[86],"third":[87],"vaccination":[88,104],"induced":[91],"lasting":[94],"at":[95],"least":[96],"9":[97],"months.":[98],"Antibody":[99],"avidity":[100],"increased":[101],"each":[103],"correlated":[106,124],"strongly":[107],"IgG":[111],"subclass":[112,120],"analysis":[113],"showed":[114],"induction":[115],"Th1":[117],"Th2":[119],"levels":[122]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2021-12-31T00:00:00"}