{"id":"https://openalex.org/W41952500","doi":null,"title":"Molecular mapping of a recombination hotspot located in the second intron of the human TAP2 locus.","display_name":"Molecular mapping of a recombination hotspot located in the second intron of the human TAP2 locus.","publication_year":1995,"publication_date":"1995-06-01","ids":{"openalex":"https://openalex.org/W41952500","mag":"41952500","pmid":"https://pubmed.ncbi.nlm.nih.gov/7762558","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1801095"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1801095","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1801095","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1801095","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Cullen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Cullen","raw_affiliation_strings":["Biological Carcinogenesis and Development Program, NCI-Frederick Cancer Research and Development Program, MD 21702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Carcinogenesis and Development Program, NCI-Frederick Cancer Research and Development Program, MD 21702, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Erlich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Erlich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081541099","display_name":"William Klitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Klitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015541994","display_name":"Mary N Carrington","orcid":"https://orcid.org/0000-0002-2692-2180","observed_orcids":["https://orcid.org/0000-0002-2692-2180"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Carrington","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9496,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.93827968,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"56","issue":"6","first_page":"1350","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombination-hotspots","display_name":"recombination hotspots","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tap2","display_name":"TAP2","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tap1","display_name":"TAP1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/hla-class-ii-region","display_name":"HLA class II region","score":0.8550000190734863},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.7300000190734863},{"id":"https://openalex.org/keywords/crossover-sites","display_name":"crossover sites","score":0.6909999847412109},{"id":"https://openalex.org/keywords/second-intron","display_name":"second intron","score":0.6660000085830688},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.8180000185966492},{"id":"https://openalex.org/keywords/lmp","display_name":"LMP","score":0.41499999165534973},{"id":"https://openalex.org/keywords/dob","display_name":"DOB","score":0.9610000252723694},{"id":"https://openalex.org/keywords/recombinant-chromosomes","display_name":"recombinant chromosomes","score":0.6790000200271606},{"id":"https://openalex.org/keywords/familial-transmission","display_name":"family transmission","score":0.5609999895095825},{"id":"https://openalex.org/keywords/polymorphic-markers","display_name":"polymorphic markers","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7817096710205078},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.729608952999115},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.700385332107544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6828017830848694},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6360058784484863},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.48699599504470825},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.45591577887535095},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.44140657782554626},{"id":"https://openalex.org/C122735190","wikidata":"https://www.wikidata.org/wiki/Q715789","display_name":"Gene mapping","level":4,"score":0.4218064844608307},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4155057668685913},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3374651074409485},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.23392927646636963},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.08992207050323486}],"mesh":[{"descriptor_ui":"D000071450","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002877","descriptor_name":"Chromosomes, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003434","descriptor_name":"Crossing Over, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005802","descriptor_name":"Genes, MHC Class II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006681","descriptor_name":"HLA-D Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1801095","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1801095","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},{"id":"pmid:7762558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7762558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},{"id":"mag:41952500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7762558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1801095","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1801095","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Hum Genet","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G7458575326","display_name":"Population Genetics of the HLA Region","funder_award_id":"5r01gm035326-16","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W102829956","https://openalex.org/W1517583758","https://openalex.org/W1556309461","https://openalex.org/W1596798861","https://openalex.org/W1763760366","https://openalex.org/W1922541632","https://openalex.org/W1977379640","https://openalex.org/W1978046386","https://openalex.org/W1980854129","https://openalex.org/W1989085879","https://openalex.org/W1992591472","https://openalex.org/W1995700119","https://openalex.org/W2005494552","https://openalex.org/W2006564826","https://openalex.org/W2020490067","https://openalex.org/W2024378229","https://openalex.org/W2026798364","https://openalex.org/W2027773962","https://openalex.org/W2028087834","https://openalex.org/W2029927400","https://openalex.org/W2033613795","https://openalex.org/W2037214758","https://openalex.org/W2041933388","https://openalex.org/W2042398646","https://openalex.org/W2044154275","https://openalex.org/W2051026611","https://openalex.org/W2055989490","https://openalex.org/W2063474005","https://openalex.org/W2065864253","https://openalex.org/W2073507902","https://openalex.org/W2082191940","https://openalex.org/W2088635433","https://openalex.org/W2090631526","https://openalex.org/W2091292572","https://openalex.org/W2094764172","https://openalex.org/W2104195358","https://openalex.org/W2108293016","https://openalex.org/W2113405278","https://openalex.org/W2139308657","https://openalex.org/W2244387419","https://openalex.org/W2464503457"],"related_works":["https://openalex.org/W1879817911","https://openalex.org/W2133272121","https://openalex.org/W2113405278","https://openalex.org/W1979534428","https://openalex.org/W2588526578","https://openalex.org/W1966098214","https://openalex.org/W1534769413","https://openalex.org/W1730861791","https://openalex.org/W1965070657","https://openalex.org/W4246072099"],"abstract_inverted_index":{"Recombination":[0],"across":[1],"the":[2,19,23,33,58,68,90,97,107,113,119,125,141,145,154,159,167],"HLA":[3],"class":[4,74],"II":[5,75],"region":[6,56,131,163],"is":[7],"not":[8],"randomly":[9],"distributed,":[10],"as":[11],"indicated":[12],"by":[13],"both":[14],"strong":[15],"linkage":[16],"disequilibrium":[17],"within":[18,85,153],"100":[20],"kb":[21],"encompassing":[22,57],"DRB1-DQA1-DQB1":[24],"loci":[25],"and":[26,31,61,102,136],"complete":[27],"equilibrium":[28],"between":[29],"TAP1":[30,101],"TAP2,":[32,94],"closest":[34],"variant":[35,98],"sites":[36,99],"of":[37,70,93,100,109,121,132,140,164],"which":[38,95],"are":[39],"<":[40],"15":[41],"kb.":[42],"In":[43],"an":[44,86],"attempt":[45],"to":[46,66,115,148],"explain":[47],"these":[48],"observations,":[49],"39":[50],"novel":[51],"polymorphic":[52],"markers":[53],"in":[54,72,89,124,166],"a":[55,110,149],"TAP,":[59],"LMP,":[60],"DOB":[62],"genes":[63],"were":[64],"used":[65],"delineate":[67],"site":[69,147],"crossover":[71,133,146],"11":[73],"recombinant":[76],"chromosomes.":[77],"SSCP":[78],"demonstrated":[79],"that":[80],"two":[81],"recombination":[82,111,165],"events":[83],"occurred":[84],"850-bp":[87,155],"interval":[88],"second":[91],"intron":[92],"separates":[96],"TAP2.":[103],"These":[104],"data":[105],"indicate":[106],"presence":[108],"hotspot,":[112],"first":[114],"be":[116],"identified":[117],"from":[118,138],"analysis":[120],"familial":[122],"transmission":[123],"human":[126,168],"major":[127],"histocompatibility":[128],"complex.":[129],"The":[130],"was":[134],"cloned":[135],"sequenced":[137],"one":[139],"recombinants,":[142],"further":[143],"defining":[144],"138-bp":[150],"segment":[151],"nested":[152],"region.":[156],"This":[157],"represents":[158],"most":[160],"precisely":[161],"defined":[162],"genome.":[169]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
