{"id":"https://openalex.org/W41924415","doi":null,"title":"Differential stimulatory and inhibitory responses of human MCF-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture.","display_name":"Differential stimulatory and inhibitory responses of human MCF-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture.","publication_year":1992,"publication_date":"1992-11-01","ids":{"openalex":"https://openalex.org/W41924415","mag":"41924415","pmid":"https://pubmed.ncbi.nlm.nih.gov/1295460"},"language":"en","primary_location":{"id":"pmid:1295460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1295460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111465329","display_name":"Terry D. Shultz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T D Shultz","raw_affiliation_strings":["Department of Food Science and Human Nutrition, Washington State University, Pullman 99164-6376"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science and Human Nutrition, Washington State University, Pullman 99164-6376","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067829486","display_name":"Boon P. Chew","orcid":"https://orcid.org/0000-0003-4869-9845","observed_orcids":["https://orcid.org/0000-0003-4869-9845"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B P Chew","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042150569","display_name":"Wanda R. Seaman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W R Seaman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.734,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.79820569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"12","issue":"6B","first_page":"2143","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conjugated-linoleic-acid","display_name":"conjugated linoleic acid","score":0.9869999885559082},{"id":"https://openalex.org/keywords/linoleic-acid","display_name":"linoleic acid","score":1.0},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cytostasis","display_name":"cytostasis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/dietary-fat","display_name":"dietary fat","score":0.5490000247955322},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.8818524479866028},{"id":"https://openalex.org/C2779780233","wikidata":"https://www.wikidata.org/wiki/Q56696202","display_name":"Conjugated linoleic acid","level":4,"score":0.8699898719787598},{"id":"https://openalex.org/C2780809830","wikidata":"https://www.wikidata.org/wiki/Q407426","display_name":"Linoleic acid","level":3,"score":0.8636875152587891},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5824898481369019},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5569926500320435},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5225664973258972},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5027332305908203},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46916255354881287},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44491448998451233},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43481960892677307},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.42954200506210327},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4283732771873474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40089985728263855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4002179205417633},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3749399781227112},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.37281981110572815},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.252638041973114},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.1986035406589508},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12434181571006775},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008041","descriptor_name":"Linoleic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019787","descriptor_name":"Linoleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1295460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1295460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Comparative Study"},{"id":"mag:41924415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1295460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W47474394","https://openalex.org/W164682661","https://openalex.org/W116477296","https://openalex.org/W757023499","https://openalex.org/W1976616876","https://openalex.org/W2150604017","https://openalex.org/W4239038406","https://openalex.org/W2186673570","https://openalex.org/W4250067465","https://openalex.org/W2056571384"],"abstract_inverted_index":{"Consumption":[0],"of":[1,11,52,71,87,137,149],"dietary":[2],"fat":[3],"has":[4,17],"been":[5],"linked":[6],"to":[7,94,126,130,134,166],"the":[8,116],"high":[9],"incidence":[10],"certain":[12],"cancers.":[13],"However,":[14],"recent":[15],"research":[16],"stimulated":[18,61],"interest":[19],"in":[20,41,158],"conjugated":[21],"linoleic":[22,53],"acid":[23,54,59],"(CLA),":[24],"a":[25],"newly":[26],"recognized":[27],"anticarcinogenic":[28],"fatty":[29],"acid.":[30],"Human":[31],"MCF-7":[32,62,167],"breast":[33],"cancer":[34,95],"cells":[35],"were":[36,151],"incubated":[37],"for":[38],"12":[39,85,135],"d":[40,86,136],"culture":[42],"medium":[43],"supplemented":[44],"with":[45,65],"various":[46],"concentrations":[47,70,81,100,121],"(1.78-7.14":[48],"x":[49,73],"10(-5)":[50,74],"M)":[51],"(LA)":[55],"or":[56],"CLA.":[57],"Linoleic":[58],"initially":[60],"cell":[63,96],"growth":[64,97,105],"an":[66],"optimal":[67],"effect":[68],"at":[69,79,98,115],"3.57-7.14":[72],"M,":[75],"but":[76],"was":[77,92,109],"inhibitory":[78,93],"similar":[80,140],"after":[82],"8":[83,133],"and":[84,101,111,119,128,142,146],"incubation.":[88],"In":[89],"contrast,":[90],"CLA":[91,108,120,143,150,163],"all":[99],"times":[102],"tested.":[103],"Cell":[104],"inhibition":[106],"by":[107],"dose-":[110],"time-dependent.":[112],"Growth":[113],"retardation":[114],"prescribed":[117],"LA":[118,141],"ranged,":[122],"respectively,":[123],"from":[124],"4":[125],"33%":[127],"54":[129],"100%":[131],"following":[132],"treatment.":[138],"At":[139],"concentrations,":[144],"cytostatic":[145],"cytotoxic":[147,165],"effects":[148],"more":[152],"pronounced":[153],"(8-81%)":[154],"than":[155],"LA.":[156],"These":[157],"vitro":[159],"results":[160],"suggest":[161],"that":[162],"is":[164],"cells.":[168]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
