{"id":"https://openalex.org/W41914890","doi":null,"title":"Synthetic nanoparticle-based vaccines against respiratory pathogens","display_name":"Synthetic nanoparticle-based vaccines against respiratory pathogens","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W41914890","mag":"41914890"},"language":"en","primary_location":{"id":"pmh:oai:lib.dr.iastate.edu:etd-4578","doi":null,"is_oa":true,"landing_page_url":"https://lib.dr.iastate.edu/etd/13571","pdf_url":"https://lib.dr.iastate.edu/etd/13571","source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lib.dr.iastate.edu/etd/13571","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014996238","display_name":"Kathleen A. Ross","orcid":"https://orcid.org/0000-0003-2510-6779","observed_orcids":["https://orcid.org/0000-0003-2510-6779"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kathleen A. Ross","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2510-6779","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5014996238"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00494058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyanhydride-nanoparticles","display_name":"polyanhydride nanoparticles","score":0.8859999775886536},{"id":"https://openalex.org/keywords/nanovaccines","display_name":"nanovaccines","score":0.8629999756813049},{"id":"https://openalex.org/keywords/h5n1-avian-influenza","display_name":"H5N1 avian influenza","score":0.9200000166893005},{"id":"https://openalex.org/keywords/influenza-vaccination","display_name":"influenza vaccination","score":0.6150000095367432},{"id":"https://openalex.org/keywords/intranasal-immunization","display_name":"intranasal immunization","score":0.8220000267028809},{"id":"https://openalex.org/keywords/protein-subunit-vaccines","display_name":"subunit vaccine","score":0.824999988079071},{"id":"https://openalex.org/keywords/sustained-antigen-release","display_name":"sustained antigen release","score":0.7950000166893005},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7929999828338623},{"id":"https://openalex.org/keywords/ovalbumin","display_name":"ovalbumin","score":0.7390000224113464},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.4970000088214874},{"id":"https://openalex.org/keywords/ph-sensitive-release","display_name":"pH-dependent release","score":0.3779999911785126},{"id":"https://openalex.org/keywords/virus-neutralizing-antibodies","display_name":"virus-neutralizing antibodies","score":0.7099999785423279},{"id":"https://openalex.org/keywords/respiratory-pathogens","display_name":"respiratory pathogens","score":0.7889999747276306},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5453885793685913},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4786178469657898},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4048171639442444},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09351876378059387}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:lib.dr.iastate.edu:etd-4578","doi":null,"is_oa":true,"landing_page_url":"https://lib.dr.iastate.edu/etd/13571","pdf_url":"https://lib.dr.iastate.edu/etd/13571","source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},{"id":"pmh:oai:dr.lib.iastate.edu:20.500.12876/27758","doi":null,"is_oa":false,"landing_page_url":"https://dr.lib.iastate.edu/handle/20.500.12876/27758","pdf_url":null,"source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"archive/lib.dr.iastate.edu/etd/13571/Ross_iastate_0097E_13944.pdf|||Fri Jan 14 19:55:43 UTC 2022","raw_type":"dissertation"},{"id":"mag:41914890","doi":null,"is_oa":false,"landing_page_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=4578&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:lib.dr.iastate.edu:etd-4578","doi":null,"is_oa":true,"landing_page_url":"https://lib.dr.iastate.edu/etd/13571","pdf_url":"https://lib.dr.iastate.edu/etd/13571","source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G316760780","display_name":null,"funder_award_id":"W81XWH-09-1-0386","funder_id":"https://openalex.org/F4320338280","funder_display_name":"Medical Research and Materiel Command"},{"id":"https://openalex.org/G3373200278","display_name":"Impact of polymer adjuvant chemistry on adaptive immune mechanisms","funder_award_id":"R56AI075026","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6988971791","display_name":null,"funder_award_id":"C76HF19578","funder_id":"https://openalex.org/F4320332175","funder_display_name":"Health Resources and Services Administration"},{"id":"https://openalex.org/G7031014169","display_name":null,"funder_award_id":"N00014-06-1-1176","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G8876996369","display_name":null,"funder_award_id":"N00014","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332175","display_name":"Health Resources and Services Administration","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320333591","display_name":"Multidisciplinary University Research Initiative","ror":null},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320338280","display_name":"Medical Research and Materiel Command","ror":"https://ror.org/03cd02q50"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W41914890.pdf","grobid_xml":"https://content.openalex.org/works/W41914890.grobid-xml"},"referenced_works_count":326,"referenced_works":["https://openalex.org/W3667498","https://openalex.org/W52794679","https://openalex.org/W73591399","https://openalex.org/W161788270","https://openalex.org/W177909858","https://openalex.org/W631888396","https://openalex.org/W1485088544","https://openalex.org/W1485224098","https://openalex.org/W1507800008","https://openalex.org/W1509793976","https://openalex.org/W1516518029","https://openalex.org/W1520434148","https://openalex.org/W1536496588","https://openalex.org/W1537962162","https://openalex.org/W1541571439","https://openalex.org/W1545924785","https://openalex.org/W1572881837","https://openalex.org/W1573590923","https://openalex.org/W1581510589","https://openalex.org/W1583785918","https://openalex.org/W1585164341","https://openalex.org/W1588690200","https://openalex.org/W1607922172","https://openalex.org/W1710049236","https://openalex.org/W1824220324","https://openalex.org/W1826726928","https://openalex.org/W1845088392","https://openalex.org/W1917091625","https://openalex.org/W1930642994","https://openalex.org/W1954030163","https://openalex.org/W1963749626","https://openalex.org/W1964334838","https://openalex.org/W1964375899","https://openalex.org/W1964564382","https://openalex.org/W1964715079","https://openalex.org/W1965647100","https://openalex.org/W1965655823","https://openalex.org/W1965793784","https://openalex.org/W1967434989","https://openalex.org/W1967938917","https://openalex.org/W1969038105","https://openalex.org/W1969941967","https://openalex.org/W1970785335","https://openalex.org/W1971611507","https://openalex.org/W1972012737","https://openalex.org/W1972888626","https://openalex.org/W1973986744","https://openalex.org/W1974737035","https://openalex.org/W1974876989","https://openalex.org/W1975296966","https://openalex.org/W1976623095","https://openalex.org/W1977473762","https://openalex.org/W1978355161","https://openalex.org/W1980785560","https://openalex.org/W1980825106","https://openalex.org/W1981002602","https://openalex.org/W1982019229","https://openalex.org/W1984024271","https://openalex.org/W1984928125","https://openalex.org/W1985117052","https://openalex.org/W1985786449","https://openalex.org/W1987034028","https://openalex.org/W1988626912","https://openalex.org/W1989509259","https://openalex.org/W1990711002","https://openalex.org/W1991701295","https://openalex.org/W1993391185","https://openalex.org/W1993798463","https://openalex.org/W1994238156","https://openalex.org/W1995405664","https://openalex.org/W1995607682","https://openalex.org/W1996125619","https://openalex.org/W1996176347","https://openalex.org/W1997606952","https://openalex.org/W1998121317","https://openalex.org/W1998429819","https://openalex.org/W1998552130","https://openalex.org/W2002283556","https://openalex.org/W2004037102","https://openalex.org/W2004754034","https://openalex.org/W2005164282","https://openalex.org/W2005174418","https://openalex.org/W2005788144","https://openalex.org/W2006143850","https://openalex.org/W2008610318","https://openalex.org/W2009472173","https://openalex.org/W2010222913","https://openalex.org/W2010585539","https://openalex.org/W2010866755","https://openalex.org/W2010896315","https://openalex.org/W2011297204","https://openalex.org/W2011879952","https://openalex.org/W2012308698","https://openalex.org/W2014902970","https://openalex.org/W2016148953","https://openalex.org/W2016198028","https://openalex.org/W2016471012","https://openalex.org/W2017148875","https://openalex.org/W2017834001","https://openalex.org/W2017873272","https://openalex.org/W2018058743","https://openalex.org/W2018702951","https://openalex.org/W2019759746","https://openalex.org/W2020355224","https://openalex.org/W2020782376","https://openalex.org/W2020829318","https://openalex.org/W2021158172","https://openalex.org/W2021617136","https://openalex.org/W2022294540","https://openalex.org/W2022549467","https://openalex.org/W2022959775","https://openalex.org/W2024032532","https://openalex.org/W2025100772","https://openalex.org/W2026335551","https://openalex.org/W2027434623","https://openalex.org/W2028189879","https://openalex.org/W2028232308","https://openalex.org/W2028889249","https://openalex.org/W2028915356","https://openalex.org/W2029369547","https://openalex.org/W2030226247","https://openalex.org/W2030883039","https://openalex.org/W2031898415","https://openalex.org/W2032015628","https://openalex.org/W2032353662","https://openalex.org/W2032658109","https://openalex.org/W2033150882","https://openalex.org/W2033330903","https://openalex.org/W2033471283","https://openalex.org/W2034029599","https://openalex.org/W2034293576","https://openalex.org/W2035376077","https://openalex.org/W2035757734","https://openalex.org/W2036525828","https://openalex.org/W2036989874","https://openalex.org/W2037164614","https://openalex.org/W2037868721","https://openalex.org/W2039027344","https://openalex.org/W2039386488","https://openalex.org/W2040097914","https://openalex.org/W2040344672","https://openalex.org/W2040440325","https://openalex.org/W2041658172","https://openalex.org/W2042301629","https://openalex.org/W2042433863","https://openalex.org/W2042728718","https://openalex.org/W2043706543","https://openalex.org/W2044227123","https://openalex.org/W2044414646","https://openalex.org/W2044430876","https://openalex.org/W2045633914","https://openalex.org/W2045866351","https://openalex.org/W2046656605","https://openalex.org/W2047366270","https://openalex.org/W2048340513","https://openalex.org/W2049579981","https://openalex.org/W2050223302","https://openalex.org/W2050285009","https://openalex.org/W2050503449","https://openalex.org/W2051367804","https://openalex.org/W2051459836","https://openalex.org/W2051717763","https://openalex.org/W2051993844","https://openalex.org/W2053869106","https://openalex.org/W2054209117","https://openalex.org/W2054480907","https://openalex.org/W2055604607","https://openalex.org/W2057700014","https://openalex.org/W2058039642","https://openalex.org/W2059044331","https://openalex.org/W2060489174","https://openalex.org/W2061969811","https://openalex.org/W2062274977","https://openalex.org/W2062378549","https://openalex.org/W2062784887","https://openalex.org/W2063128374","https://openalex.org/W2065441707","https://openalex.org/W2065949094","https://openalex.org/W2066218699","https://openalex.org/W2066685510","https://openalex.org/W2068076666","https://openalex.org/W2069749184","https://openalex.org/W2069820370","https://openalex.org/W2070156210","https://openalex.org/W2071629929","https://openalex.org/W2072424192","https://openalex.org/W2073102085","https://openalex.org/W2073133705","https://openalex.org/W2073262167","https://openalex.org/W2074399085","https://openalex.org/W2075649492","https://openalex.org/W2078446518","https://openalex.org/W2078799473","https://openalex.org/W2079876772","https://openalex.org/W2079893411","https://openalex.org/W2080270710","https://openalex.org/W2080484488","https://openalex.org/W2081083251","https://openalex.org/W2081182134","https://openalex.org/W2082450387","https://openalex.org/W2082461885","https://openalex.org/W2083067161","https://openalex.org/W2084009979","https://openalex.org/W2084483530","https://openalex.org/W2085535868","https://openalex.org/W2085827891","https://openalex.org/W2086748193","https://openalex.org/W2088200348","https://openalex.org/W2089376737","https://openalex.org/W2089773350","https://openalex.org/W2090846253","https://openalex.org/W2090848247","https://openalex.org/W2090928701","https://openalex.org/W2091080683","https://openalex.org/W2091527885","https://openalex.org/W2091976848","https://openalex.org/W2092778039","https://openalex.org/W2094827919","https://openalex.org/W2094977314","https://openalex.org/W2095521654","https://openalex.org/W2096148942","https://openalex.org/W2098330531","https://openalex.org/W2101262013","https://openalex.org/W2101490573","https://openalex.org/W2101954404","https://openalex.org/W2102335249","https://openalex.org/W2102847984","https://openalex.org/W2104096093","https://openalex.org/W2104289773","https://openalex.org/W2106127585","https://openalex.org/W2106811814","https://openalex.org/W2108075163","https://openalex.org/W2108573701","https://openalex.org/W2108594676","https://openalex.org/W2108728550","https://openalex.org/W2109491705","https://openalex.org/W2109541209","https://openalex.org/W2109757991","https://openalex.org/W2111050706","https://openalex.org/W2112170460","https://openalex.org/W2112333290","https://openalex.org/W2113209814","https://openalex.org/W2113888056","https://openalex.org/W2114347909","https://openalex.org/W2114555019","https://openalex.org/W2114582344","https://openalex.org/W2114918588","https://openalex.org/W2117212538","https://openalex.org/W2118965097","https://openalex.org/W2120143538","https://openalex.org/W2122399224","https://openalex.org/W2124696441","https://openalex.org/W2125930129","https://openalex.org/W2125994542","https://openalex.org/W2125996638","https://openalex.org/W2126623340","https://openalex.org/W2127920839","https://openalex.org/W2129860791","https://openalex.org/W2130480901","https://openalex.org/W2131170401","https://openalex.org/W2131513859","https://openalex.org/W2133106116","https://openalex.org/W2134599862","https://openalex.org/W2135360970","https://openalex.org/W2135426762","https://openalex.org/W2136890185","https://openalex.org/W2136931342","https://openalex.org/W2137870902","https://openalex.org/W2139372108","https://openalex.org/W2140644802","https://openalex.org/W2143209582","https://openalex.org/W2144902263","https://openalex.org/W2145330783","https://openalex.org/W2145825913","https://openalex.org/W2145850791","https://openalex.org/W2146982119","https://openalex.org/W2147193679","https://openalex.org/W2147851449","https://openalex.org/W2148111882","https://openalex.org/W2149087734","https://openalex.org/W2149145595","https://openalex.org/W2149711075","https://openalex.org/W2151695254","https://openalex.org/W2152758574","https://openalex.org/W2152779030","https://openalex.org/W2153021768","https://openalex.org/W2153511402","https://openalex.org/W2154262967","https://openalex.org/W2154481606","https://openalex.org/W2154767953","https://openalex.org/W2156166135","https://openalex.org/W2158055198","https://openalex.org/W2158112812","https://openalex.org/W2158767298","https://openalex.org/W2158843323","https://openalex.org/W2158855166","https://openalex.org/W2159679357","https://openalex.org/W2159761055","https://openalex.org/W2161301665","https://openalex.org/W2161771158","https://openalex.org/W2162543584","https://openalex.org/W2163009027","https://openalex.org/W2163960578","https://openalex.org/W2164684229","https://openalex.org/W2164949714","https://openalex.org/W2165426348","https://openalex.org/W2167115441","https://openalex.org/W2168028856","https://openalex.org/W2169383781","https://openalex.org/W2170066804","https://openalex.org/W2170287675","https://openalex.org/W2170410486","https://openalex.org/W2171059204","https://openalex.org/W2179974579","https://openalex.org/W2187686847","https://openalex.org/W2211875517","https://openalex.org/W2314076256","https://openalex.org/W2316512281","https://openalex.org/W2316650677","https://openalex.org/W2406500641","https://openalex.org/W2412079984","https://openalex.org/W2417130707","https://openalex.org/W2421395535","https://openalex.org/W2582398023","https://openalex.org/W2905693830","https://openalex.org/W3202912068"],"related_works":["https://openalex.org/W843683664","https://openalex.org/W2087983219","https://openalex.org/W4399204934","https://openalex.org/W2264241410","https://openalex.org/W1954030163","https://openalex.org/W1511813607","https://openalex.org/W4416451542","https://openalex.org/W2062784887","https://openalex.org/W4412559283","https://openalex.org/W2577508242"],"abstract_inverted_index":{"Avian":[0],"influenza":[1,13,53],"A":[2],"H5N1":[3,19,51,71,91,175,424],"is":[4,40,129],"rapidly":[5],"gaining":[6],"the":[7,11,76,80,99,105,111,116,120,135,196,199,206,221,242,273,284,301,317,366,374,390,393,406],"potential":[8],"to":[9,22,35,47,90,104,145,219,226,231,271,282,298,341,364],"be":[10,23,146,166],"next":[12,420],"pandemic":[14,50],"threat.":[15],"Human":[16],"cases":[17],"of":[18,31,82,95,101,110,119,137,181,198,202,208,223,234,246,257,275,280,289,319,392],"have":[20,142],"proven":[21],"approximately":[24],"60%":[25],"fatal":[26],"with":[27,153,191,397],"a":[28,41,49,58,83,147,263,290,326,343,361,415,419],"growing":[29],"number":[30],"strains":[32],"becoming":[33],"resistant":[34],"antiviral":[36],"treatments.":[37],"Therefore,":[38],"there":[39],"strong":[42],"need":[43],"for":[44,66,150,168,306,418],"new":[45],"research":[46],"develop":[48],"avian":[52,92,176,425],"vaccine.":[54],"In":[55,74],"this":[56],"work,":[57],"synthetic":[59],"polyanhydride":[60,303,314,412],"nanoparticle-based":[61],"vaccine":[62,85,422],"(or":[63],"nanovaccine)":[64],"platform":[65,149,417],"respiratory":[67,171],"pathogens":[68,172],"such":[69,173],"as":[70,174,381,383],"was":[72,189,354,371,395],"designed.":[73],"particular,":[75],"work":[77],"focused":[78],"on":[79,87,205,348],"design":[81],"subunit":[84],"based":[86,347],"antigens":[88,102],"specific":[89],"influenza.\\nIntranasal":[93],"administration":[94],"vaccines":[96,169,248],"can":[97,114],"increase":[98],"availability":[100],"due":[103],"large,":[106],"permeable":[107],"surface":[108],"area":[109],"lung":[112],"and":[113,133,162,179,212,238,262,286,369,401],"avoid":[115],"harsh":[117],"environments":[118],"gastrointestinal":[121],"tract.":[122],"Despite":[123],"these":[124,203,337],"advantages,":[125],"antigen":[126,224,265],"delivered":[127,183],"alone":[128],"often":[130],"not":[131],"immunogenic":[132],"requires":[134],"use":[136],"an":[138,192,232,253],"adjuvant.":[139],"Polyanhydride":[140,215,267],"nanoparticles":[141,216],"been":[143],"shown":[144,270],"promising":[148,416],"intranasal":[151],"immunization":[152],"many":[154],"beneficial":[155],"properties":[156],"including":[157],"sustained":[158],"release,":[159,322],"cell":[160,387],"internalization,":[161],"immunomodulation,":[163],"which":[164],"may":[165],"suitable":[167,305],"against":[170,423],"influenza.\\nThe":[177],"deposition":[178],"persistence":[180],"intranasally":[182],"nanovaccines":[184,268,413],"at":[185],"early":[186],"time":[187],"points":[188],"investigated":[190,297],"eye":[193],"towards":[194],"examining":[195],"role":[197],"initial":[200],"fate":[201],"particles":[204],"induction":[207],"long-lasting":[209,243],"memory":[210,244,276],"responses":[211,245],"protective":[213],"immunity.":[214],"were":[217,249,269,296,339],"found":[218],"prolong":[220],"presence":[222],"up":[225],"63":[227],"days":[228],"post-immunization":[229],"leading":[230],"enhancement":[233],"antibody":[235],"titer,":[236],"avidity,":[237],"epitope":[239],"specificity.":[240],"Furthermore,":[241],"particle-based":[247],"examined":[250],"by":[251],"utilizing":[252],"adoptive":[254],"transfer":[255],"model":[256,264,363],"antigen-specific":[258],"CD8+":[259],"T":[260,277,386],"cells":[261,278],"(ovalbumin).":[266],"enhance":[272],"development":[274],"capable":[279],"responding":[281],"challenge.\\nNext,":[283],"stability":[285],"release":[287],"kinetics":[288],"nanoparticle-encapsulated":[291],"H5":[292],"hemagglutinin":[293],"trimer":[294],"(H53)":[295],"rationally":[299],"determine":[300],"optimal":[302],"chemistries":[304,315],"protein":[307],"stabilization.":[308],"Results":[309],"suggested":[310],"that":[311,324,373,411],"while":[312],"several":[313],"preserved":[316],"antigenicity":[318],"H53":[320],"upon":[321],"formulations":[323],"provided":[325],"mildly":[327],"acidic":[328],"microenvironment":[329],"enhanced":[330,384],"structural":[331],"stability.":[332],"The":[333,350],"insights":[334],"gained":[335],"from":[336],"studies":[338,407],"utilized":[340],"identify":[342],"lead":[344,351],"candidate":[345,352],"nanovaccine":[346,353,375,394],"H53.":[349],"tested":[355],"using":[356],"in":[357,360],"vivo":[358],"experiments":[359],"rodent":[362],"define":[365],"immune":[367],"response":[368],"it":[370],"observed":[372],"formulation":[376],"induced":[377],"virus":[378],"neutralizing":[379],"titers":[380],"well":[382],"CD4+":[385],"responses.":[388],"Finally,":[389],"efficacy":[391],"evaluated":[396],"live":[398],"viral":[399],"challenge":[400],"demonstrated":[402],"full":[403],"protection.":[404],"Together,":[405],"described":[408],"herein":[409],"indicate":[410],"represent":[414],"generation":[421],"influenza.":[426]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2016-06-24T00:00:00"}