{"id":"https://openalex.org/W41858242","doi":"https://doi.org/10.1007/978-1-4419-7037-4_11","title":"Adult Stem Cels and Their Niches","display_name":"Adult Stem Cels and Their Niches","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W41858242","doi":"https://doi.org/10.1007/978-1-4419-7037-4_11","mag":"41858242","pmid":"https://pubmed.ncbi.nlm.nih.gov/21222205","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4020242"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4419-7037-4_11","doi":"https://doi.org/10.1007/978-1-4419-7037-4_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4419-7037-4_11","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W619271028","display_name":"The Cell Biology of Stem Cells"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC4020242","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076251065","display_name":"Francesca Ferraro","orcid":"https://orcid.org/0000-0002-6016-3819","observed_orcids":["https://orcid.org/0000-0002-6016-3819"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francesca Ferraro","raw_affiliation_strings":["Harvard Stem Cell Institute, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077166294","display_name":"Cristina Lo Celso","orcid":"https://orcid.org/0000-0002-1163-4207","observed_orcids":["https://orcid.org/0000-0002-1163-4207"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cristina Lo Celso","raw_affiliation_strings":["Division of Cell and Molecular Biology, Imperial College London, London, England UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell and Molecular Biology, Imperial College London, London, England UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083648953","display_name":"David T. Scadden","orcid":"https://orcid.org/0000-0001-9821-7133","observed_orcids":["https://orcid.org/0000-0001-9821-7133"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Scadden","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard University, 185 Cambridge Street, Boston, Massachusetts, USA","Harvard Stem Cell Institute, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University, 185 Cambridge Street, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083648953"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"],"apc_list":null,"apc_paid":null,"fwci":22.4902,"has_fulltext":false,"cited_by_count":198,"citation_normalized_percentile":{"value":0.99665552,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"695","issue":null,"first_page":"155","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.57669997215271,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.57669997215271,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.11940000206232071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.10689999908208847,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adult-stem-cells","display_name":"adult stem cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.9760000109672546},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9900000095367432},{"id":"https://openalex.org/keywords/stem-cell-regulation","display_name":"stem cell regulation","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7765741348266602},{"id":"https://openalex.org/C164794517","wikidata":"https://www.wikidata.org/wiki/Q16729831","display_name":"Stem cell niche","level":4,"score":0.6666343212127686},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5912144184112549},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.5245495438575745},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5232499837875366},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.5159121751785278},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5032405257225037},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4333399534225464},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43260568380355835},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.19154053926467896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13778582215309143},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.077450692653656},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/978-1-4419-7037-4_11","doi":"https://doi.org/10.1007/978-1-4419-7037-4_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4419-7037-4_11","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:21222205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21222205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2997783","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC4020242","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4020242","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4020242","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Exp Med Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2997783","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC4020242","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1133759245","display_name":"Microenvironmental control of progenitors in organ dysfunction and repair","funder_award_id":"U01HL100402","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1540324531","display_name":"Mechanisms of Hematopoiesis in AIDS","funder_award_id":"R01HL044851","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4391658258","display_name":"Stem Cell Engagement of the Niche","funder_award_id":"R01HL097794","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W1643680178","https://openalex.org/W1820902015","https://openalex.org/W1861988602","https://openalex.org/W1910697241","https://openalex.org/W1963759977","https://openalex.org/W1965681567","https://openalex.org/W1969103012","https://openalex.org/W1971100182","https://openalex.org/W1972224144","https://openalex.org/W1973508705","https://openalex.org/W1973697421","https://openalex.org/W1975025595","https://openalex.org/W1975247371","https://openalex.org/W1976222351","https://openalex.org/W1977480736","https://openalex.org/W1980332250","https://openalex.org/W1982174586","https://openalex.org/W1982603620","https://openalex.org/W1983952522","https://openalex.org/W1985727076","https://openalex.org/W1986932941","https://openalex.org/W1988393390","https://openalex.org/W1990959960","https://openalex.org/W1992591328","https://openalex.org/W1992811953","https://openalex.org/W1993076246","https://openalex.org/W1996623272","https://openalex.org/W1997184614","https://openalex.org/W2001296918","https://openalex.org/W2003855139","https://openalex.org/W2005675957","https://openalex.org/W2006123040","https://openalex.org/W2011174877","https://openalex.org/W2011202983","https://openalex.org/W2011842366","https://openalex.org/W2015809080","https://openalex.org/W2015964634","https://openalex.org/W2016840131","https://openalex.org/W2017907565","https://openalex.org/W2018264362","https://openalex.org/W2020622102","https://openalex.org/W2020964731","https://openalex.org/W2021276131","https://openalex.org/W2022487205","https://openalex.org/W2024968355","https://openalex.org/W2029221763","https://openalex.org/W2029675195","https://openalex.org/W2030956730","https://openalex.org/W2031316068","https://openalex.org/W2035287163","https://openalex.org/W2035538797","https://openalex.org/W2037048003","https://openalex.org/W2041897873","https://openalex.org/W2043757927","https://openalex.org/W2046006021","https://openalex.org/W2046578266","https://openalex.org/W2048994674","https://openalex.org/W2053995696","https://openalex.org/W2054674800","https://openalex.org/W2056265113","https://openalex.org/W2058839233","https://openalex.org/W2061262594","https://openalex.org/W2064236697","https://openalex.org/W2067298584","https://openalex.org/W2067553572","https://openalex.org/W2069290496","https://openalex.org/W2070793750","https://openalex.org/W2073495853","https://openalex.org/W2077330278","https://openalex.org/W2079657320","https://openalex.org/W2080274993","https://openalex.org/W2084289371","https://openalex.org/W2085379791","https://openalex.org/W2086243699","https://openalex.org/W2086265207","https://openalex.org/W2087025782","https://openalex.org/W2087442979","https://openalex.org/W2087803244","https://openalex.org/W2093409245","https://openalex.org/W2093818708","https://openalex.org/W2093885717","https://openalex.org/W2100063372","https://openalex.org/W2104852357","https://openalex.org/W2118453722","https://openalex.org/W2120372000","https://openalex.org/W2123318803","https://openalex.org/W2124153237","https://openalex.org/W2124326407","https://openalex.org/W2129619539","https://openalex.org/W2131263031","https://openalex.org/W2134195865","https://openalex.org/W2134208433","https://openalex.org/W2141837666","https://openalex.org/W2142018200","https://openalex.org/W2143758178","https://openalex.org/W2147784618","https://openalex.org/W2148693026","https://openalex.org/W2153338840","https://openalex.org/W2157155777","https://openalex.org/W2163819958","https://openalex.org/W2165867905","https://openalex.org/W2168649860","https://openalex.org/W2415647814","https://openalex.org/W2587692411","https://openalex.org/W2625471798","https://openalex.org/W3151704361","https://openalex.org/W4256386089"],"related_works":["https://openalex.org/W1996623272","https://openalex.org/W595403773","https://openalex.org/W1587848884","https://openalex.org/W1990574061","https://openalex.org/W4377138718","https://openalex.org/W2473664292","https://openalex.org/W2056082704","https://openalex.org/W2165716414","https://openalex.org/W2170330851","https://openalex.org/W2066936218"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":26},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}