{"id":"https://openalex.org/W41847044","doi":null,"title":"Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles.","display_name":"Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles.","publication_year":1994,"publication_date":"1994-04-01","ids":{"openalex":"https://openalex.org/W41847044","mag":"41847044","pmid":"https://pubmed.ncbi.nlm.nih.gov/7518802","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1422380"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1422380","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1422380","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1422380","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078371513","display_name":"Kevin Joseph Maloy","orcid":"https://orcid.org/0000-0001-5795-7688","observed_orcids":["https://orcid.org/0000-0001-5795-7688"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K J Maloy","raw_affiliation_strings":["Department of Immunology, University of Glasgow, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Glasgow, U.K","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072389992","display_name":"Anne M. Donachie","orcid":"https://orcid.org/0000-0001-8339-7258","observed_orcids":["https://orcid.org/0000-0001-8339-7258"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A M Donachie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110000817","display_name":"Derek T. O\u2019Hagan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D T O'Hagan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086268399","display_name":"Allan McI. Mowat","orcid":"https://orcid.org/0000-0001-9389-3079","observed_orcids":["https://orcid.org/0000-0001-9389-3079"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A M Mowat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0307,"has_fulltext":false,"cited_by_count":182,"citation_normalized_percentile":{"value":0.94602961,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"81","issue":"4","first_page":"661","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.15469999611377716,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovalbumin","display_name":"ovalbumin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/oral-immunization","display_name":"oral immunization","score":0.7720000147819519},{"id":"https://openalex.org/keywords/subcutaneous-vaccination","display_name":"subcutaneous immunization","score":0.7730000019073486},{"id":"https://openalex.org/keywords/mucosal-immune-response","display_name":"mucosal immune response","score":0.609000027179718},{"id":"https://openalex.org/keywords/systemic-immune-response","display_name":"systemic immune response","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9340000152587891},{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.9419999718666077},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.531000018119812},{"id":"https://openalex.org/keywords/iga","display_name":"IgA","score":0.8080000281333923},{"id":"https://openalex.org/keywords/iscoms","display_name":"ISCOMs","score":0.7599999904632568},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.859000027179718},{"id":"https://openalex.org/keywords/oral-vaccine","display_name":"oral vaccine","score":0.6489999890327454},{"id":"https://openalex.org/keywords/antigen-delivery","display_name":"antigen delivery","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.8532118201255798},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.827437698841095},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7261357307434082},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.7135384678840637},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.6674294471740723},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6569471955299377},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.49598178267478943},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.49101734161376953},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.44866877794265747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3975578248500824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32761138677597046},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2715170383453369},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.13677233457565308},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006968","descriptor_name":"Hypersensitivity, Delayed","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016882","descriptor_name":"ISCOMs","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1422380","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1422380","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:7518802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7518802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:41847044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7518802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1422380","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1422380","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W23296051","https://openalex.org/W24264733","https://openalex.org/W59541110","https://openalex.org/W255711577","https://openalex.org/W1261650543","https://openalex.org/W1486736995","https://openalex.org/W1509443850","https://openalex.org/W1536081943","https://openalex.org/W1570752474","https://openalex.org/W1576684487","https://openalex.org/W1915092098","https://openalex.org/W1918084043","https://openalex.org/W1981872132","https://openalex.org/W1984511441","https://openalex.org/W1984512389","https://openalex.org/W2007121055","https://openalex.org/W2012260545","https://openalex.org/W2030880018","https://openalex.org/W2042470561","https://openalex.org/W2061452227","https://openalex.org/W2074061180","https://openalex.org/W2080667413","https://openalex.org/W2107462139","https://openalex.org/W2156918343"],"related_works":["https://openalex.org/W2107462139","https://openalex.org/W2020355224","https://openalex.org/W2156918343","https://openalex.org/W2047599016","https://openalex.org/W1261650543","https://openalex.org/W2409929920","https://openalex.org/W2033939437","https://openalex.org/W2071217697","https://openalex.org/W2313604704","https://openalex.org/W2079235500"],"abstract_inverted_index":{"We":[0],"have":[1],"examined":[2],"the":[3,119,166],"range":[4],"of":[5,44,153,188],"mucosal":[6,191],"and":[7,35,84,109,139,178,190],"systemic":[8,189],"immune":[9,192],"responses":[10,42,74,88,117,138,175,193],"induced":[11],"by":[12],"oral":[13,124,200],"or":[14,131],"parenteral":[15],"immunization":[16,28,83],"with":[17,29,126],"ovalbumin":[18],"(OVA)":[19],"entrapped":[20],"in":[21,71,75,99,118,128,132,135,155,176,198],"poly(D,L-lactide-co-glycolide)":[22],"(PLG)":[23],"microparticles.":[24],"A":[25],"single":[26,82],"subcutaneous":[27],"OVA-PLG":[30],"primed":[31,69],"significant":[32,159],"OVA-specific":[33,70,86,115,136,160],"IgG":[34,64],"delayed-type":[36],"hypersensitivity":[37],"(DTH)":[38],"responses.":[39,65,163],"The":[40],"DTH":[41],"were":[43,89,96,148],"similar":[45],"magnitude":[46],"to":[47,184],"those":[48],"obtained":[49],"using":[50],"immunostimulating":[51],"complexes":[52],"(ISCOMS)":[53],"as":[54,145],"a":[55,81,186],"potent":[56,144],"control":[57],"adjuvant,":[58],"although":[59],"ISCOMS":[60,95,111,133,141],"stimulated":[61],"higher":[62],"serum":[63],"Both":[66],"vectors":[67],"also":[68],"vitro":[72],"proliferative":[73],"draining":[76,120],"lymph":[77,121],"node":[78],"cells":[79],"following":[80],"strong":[85],"CTL":[87,116,137,174],"found":[90],"after":[91],"intraperitoneal":[92],"(i.p.)":[93],"immunization.":[94],"more":[97,143],"efficient":[98],"inducing":[100],"cytotoxic":[101],"T":[102],"lymphocytes":[103],"(CTL),":[104],"requiring":[105],"much":[106],"less":[107],"antigen":[108],"only":[110],"could":[112],"stimulate":[113,173],"primary":[114],"nodes.":[122],"Multiple":[123],"immunizations":[125],"OVA":[127,154],"PLG":[129,156,170],"microparticles":[130,157,171],"resulted":[134],"again":[140],"seemed":[142],"fewer":[146],"feeds":[147,152],"necessary.":[149],"Lastly,":[150],"multiple":[151],"generated":[158],"intestinal":[161],"IgA":[162],"This":[164],"is":[165],"first":[167],"demonstration":[168],"that":[169],"can":[172],"vivo":[177],"our":[179],"results":[180],"highlight":[181],"their":[182],"ability":[183],"prime":[185],"variety":[187],"which":[194],"may":[195],"be":[196],"useful":[197],"future":[199],"vaccine":[201],"development.":[202]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}