{"id":"https://openalex.org/W41777855","doi":null,"title":"Modelling and treating dysregulated fibrosis in primary open angle glaucoma","display_name":"Modelling and treating dysregulated fibrosis in primary open angle glaucoma","publication_year":2015,"publication_date":"2015-07-01","ids":{"openalex":"https://openalex.org/W41777855","mag":"41777855"},"language":"en","primary_location":{"id":"pmh:oai:etheses.bham.ac.uk:5683","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/5683/1/Hill15PhD.pdf","pdf_url":"http://etheses.bham.ac.uk/5683/1/Hill15PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://etheses.bham.ac.uk/5683/1/Hill15PhD.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104019052","display_name":"Lisa Jayne Hill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lisa Jayne Hill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5104019052"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-open-angle-glaucoma","display_name":"primary open-angle glaucoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/trabecular-meshwork-fibrosis","display_name":"trabecular meshwork fibrosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/decorin","display_name":"decorin","score":0.6980000138282776},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.8460000157356262},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.6919999718666077},{"id":"https://openalex.org/keywords/retinal-ganglion-cell-loss","display_name":"retinal ganglion cell death","score":0.9509999752044678},{"id":"https://openalex.org/keywords/ocular-fibrosis","display_name":"ocular fibrosis","score":0.6259999871253967},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.7940000295639038},{"id":"https://openalex.org/keywords/rodent-models","display_name":"rodent models","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2781121420","wikidata":"https://www.wikidata.org/wiki/Q750873","display_name":"Trabecular meshwork","level":3,"score":0.9653880596160889},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.8051731586456299},{"id":"https://openalex.org/C2779794767","wikidata":"https://www.wikidata.org/wiki/Q18248676","display_name":"Decorin","level":4,"score":0.7929766178131104},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.7041517496109009},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.6429771184921265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6240378618240356},{"id":"https://openalex.org/C2779984381","wikidata":"https://www.wikidata.org/wiki/Q827681","display_name":"Aqueous humour","level":3,"score":0.6001968383789062},{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.5758808255195618},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5613754391670227},{"id":"https://openalex.org/C2991803831","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Open angle glaucoma","level":3,"score":0.4970610439777374},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.4769250750541687},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31676626205444336},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.17974135279655457},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.061505019664764404},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etheses.bham.ac.uk:5683","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/5683/1/Hill15PhD.pdf","pdf_url":"http://etheses.bham.ac.uk/5683/1/Hill15PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:41777855","doi":null,"is_oa":false,"landing_page_url":"https://etheses.bham.ac.uk/id/eprint/5683/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etheses.bham.ac.uk:5683","doi":null,"is_oa":true,"landing_page_url":"http://etheses.bham.ac.uk/5683/1/Hill15PhD.pdf","pdf_url":"http://etheses.bham.ac.uk/5683/1/Hill15PhD.pdf","source":{"id":"https://openalex.org/S4306402357","display_name":"University of Birmingham Institutional Research Archive (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W41777855.pdf","grobid_xml":"https://content.openalex.org/works/W41777855.grobid-xml"},"referenced_works_count":133,"referenced_works":["https://openalex.org/W4657569","https://openalex.org/W1142561399","https://openalex.org/W1500275217","https://openalex.org/W1512574313","https://openalex.org/W1547404510","https://openalex.org/W1595226323","https://openalex.org/W1624294703","https://openalex.org/W1847735666","https://openalex.org/W1964003114","https://openalex.org/W1966908061","https://openalex.org/W1966910690","https://openalex.org/W1968109847","https://openalex.org/W1968169793","https://openalex.org/W1968576558","https://openalex.org/W1969824248","https://openalex.org/W1971547370","https://openalex.org/W1972041825","https://openalex.org/W1973633538","https://openalex.org/W1974939259","https://openalex.org/W1976386525","https://openalex.org/W1976500011","https://openalex.org/W1979055188","https://openalex.org/W1982118682","https://openalex.org/W1984656953","https://openalex.org/W1986278788","https://openalex.org/W1986362585","https://openalex.org/W1986862398","https://openalex.org/W1987469308","https://openalex.org/W1987574116","https://openalex.org/W1987986784","https://openalex.org/W1989857510","https://openalex.org/W1993722458","https://openalex.org/W1996764985","https://openalex.org/W1998908120","https://openalex.org/W2000685772","https://openalex.org/W2003287355","https://openalex.org/W2003959496","https://openalex.org/W2003960557","https://openalex.org/W2005174791","https://openalex.org/W2006796007","https://openalex.org/W2007992196","https://openalex.org/W2012231507","https://openalex.org/W2012974800","https://openalex.org/W2016750941","https://openalex.org/W2018189356","https://openalex.org/W2018822666","https://openalex.org/W2021933371","https://openalex.org/W2022118535","https://openalex.org/W2024475596","https://openalex.org/W2024533971","https://openalex.org/W2025416157","https://openalex.org/W2030349544","https://openalex.org/W2030353509","https://openalex.org/W2032065302","https://openalex.org/W2033076859","https://openalex.org/W2033152479","https://openalex.org/W2034661839","https://openalex.org/W2035820903","https://openalex.org/W2036683334","https://openalex.org/W2037960211","https://openalex.org/W2038575959","https://openalex.org/W2040024127","https://openalex.org/W2043243292","https://openalex.org/W2043771487","https://openalex.org/W2044092679","https://openalex.org/W2044270182","https://openalex.org/W2045477439","https://openalex.org/W2046227429","https://openalex.org/W2048385853","https://openalex.org/W2048937408","https://openalex.org/W2050530435","https://openalex.org/W2051900610","https://openalex.org/W2052476475","https://openalex.org/W2052577034","https://openalex.org/W2053352199","https://openalex.org/W2054705053","https://openalex.org/W2056879548","https://openalex.org/W2057266151","https://openalex.org/W2060928333","https://openalex.org/W2065397811","https://openalex.org/W2066478570","https://openalex.org/W2069512783","https://openalex.org/W2070013317","https://openalex.org/W2071067998","https://openalex.org/W2071113974","https://openalex.org/W2072365851","https://openalex.org/W2073589440","https://openalex.org/W2074274145","https://openalex.org/W2075073611","https://openalex.org/W2078093695","https://openalex.org/W2079202995","https://openalex.org/W2081858916","https://openalex.org/W2083515846","https://openalex.org/W2085002639","https://openalex.org/W2085097624","https://openalex.org/W2087749727","https://openalex.org/W2091212002","https://openalex.org/W2092404030","https://openalex.org/W2093247746","https://openalex.org/W2093856903","https://openalex.org/W2094273610","https://openalex.org/W2095407038","https://openalex.org/W2096930304","https://openalex.org/W2099842384","https://openalex.org/W2100556262","https://openalex.org/W2110913084","https://openalex.org/W2114271694","https://openalex.org/W2114975414","https://openalex.org/W2120711134","https://openalex.org/W2122434993","https://openalex.org/W2123550509","https://openalex.org/W2126429003","https://openalex.org/W2127260441","https://openalex.org/W2128540764","https://openalex.org/W2128889275","https://openalex.org/W2130105499","https://openalex.org/W2132398409","https://openalex.org/W2133989466","https://openalex.org/W2135138000","https://openalex.org/W2135382592","https://openalex.org/W2136722967","https://openalex.org/W2137221550","https://openalex.org/W2139676825","https://openalex.org/W2142605112","https://openalex.org/W2143062759","https://openalex.org/W2146819974","https://openalex.org/W2148131708","https://openalex.org/W2148890166","https://openalex.org/W2149065838","https://openalex.org/W2160307430","https://openalex.org/W2161893149","https://openalex.org/W2163509101","https://openalex.org/W2339764100"],"related_works":["https://openalex.org/W2341403492","https://openalex.org/W2470989924","https://openalex.org/W3130558270","https://openalex.org/W4408223755","https://openalex.org/W4388760526","https://openalex.org/W2775321364","https://openalex.org/W4382393724","https://openalex.org/W3081312355","https://openalex.org/W2914850059","https://openalex.org/W3014529144"],"abstract_inverted_index":{"Introduction":[0],"\\nA":[1],"risk":[2],"factor":[3],"for":[4,76],"POAG":[5],"is":[6],"elevated":[7],"intraocular":[8,38,61,97,165],"pressure":[9,39,98,166],"induced":[10,129,158],"by":[11,40,111],"reduced":[12],"outflow":[13],"of":[14,36,49,78,131,150],"aqueous":[15],"humour":[16],"through":[17],"the":[18,47,50,81,132,151,156,161,179],"fibrosed":[19],"trabecular":[20,42,56,133,162],"meshwork,":[21,163],"causing":[22],"retinal":[23,123,139,170],"ganglion":[24,117,140,171],"cell":[25,118,141,172],"death.":[26,173],"This":[27],"study":[28],"aimed":[29],"to:":[30],"1)":[31],"create":[32],"a":[33,145],"rodent":[34],"model":[35,149],"increased":[37],"inducing":[41],"meshwork":[43,57,134],"fibrosis;":[44],"2)":[45],"evaluate":[46],"ability":[48],"anti-fibrotic":[51],"agent,":[52],"Decorin":[53,79,104,154,174],"to":[54,67,93,178,195],"diminish":[55],"fibrosis":[58,95,130,159],"and":[59,70,96,113,138,167],"lower":[60],"pressure;":[62],"3)":[63],"correlate":[64],"these":[65],"findings":[66],"RCG":[68],"survival":[69],"4)":[71],"investigate":[72],"alternative":[73],"translational":[74],"methods":[75],"delivery":[77],"into":[80],"eye.":[82],"\\n":[83,126,187,203],"\\nMethods":[84],"\\nFibrotic":[85],"agents,":[86],"kaolin":[87],"or":[88],"TGF-\u03b2,":[89],"were":[90,120],"intracamerally":[91],"injected":[92],"induce":[94],"elevation.":[99],"Following":[100],"this":[101],"human":[102],"recombinant":[103],"was":[105,109,175],"administered":[106],"intracamerally.":[107],"Fibrosis":[108],"measured":[110],"immunohistochemistry":[112],"electron":[114],"microscopy.":[115],"Retinal":[116],"counts":[119],"performed":[121],"from":[122],"whole":[124],"mounts.":[125],"\\nResults":[127],"\\nTGF-\u03b2":[128],"leading":[135],"IOP":[136],"elevation":[137],"death,":[142],"thus":[143],"providing":[144],"reliable":[146],"in":[147,160,182,199],"vivo":[148],"ocular":[152],"fibrosis.":[153],"reversed":[155],"TGF-\u03b2":[157],"lowered":[164],"indirectly":[168],"prevented":[169],"successfully":[176],"delivered":[177],"anterior":[180],"chamber":[181],"an":[183,192],"eye":[184],"drop":[185],"formulation.":[186],"\\nConclusion":[188],"\\nDecorin":[189],"may":[190],"be":[191],"effective":[193],"treatment":[194],"preserving":[196],"visual":[197],"function":[198],"patients":[200],"with":[201],"POAG.":[202]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}