{"id":"https://openalex.org/W41752504","doi":null,"title":"Toll-like receptor 4-mediated apoptosis of pancreatic cells in cerulein-induced acute pancreatitis in mice.","display_name":"Toll-like receptor 4-mediated apoptosis of pancreatic cells in cerulein-induced acute pancreatitis in mice.","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W41752504","mag":"41752504","pmid":"https://pubmed.ncbi.nlm.nih.gov/21134836"},"language":"en","primary_location":{"id":"pmid:21134836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21134836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary & pancreatic diseases international : HBPD INT","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110827543","display_name":"Siqin Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-Qin Ding","raw_affiliation_strings":["Institute of Digestive Surgery, West China Hospital, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Digestive Surgery, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100409811","display_name":"Yuan Li","orcid":"https://orcid.org/0000-0002-5550-0307","observed_orcids":["https://orcid.org/0000-0002-5550-0307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026049732","display_name":"Zong\u2010Guang Zhou","orcid":"https://orcid.org/0000-0002-7616-1199","observed_orcids":["https://orcid.org/0000-0002-7616-1199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zong-Guang Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100736176","display_name":"Cun Wang","orcid":"https://orcid.org/0000-0002-1403-8806","observed_orcids":["https://orcid.org/0000-0002-1403-8806"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cun Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028859439","display_name":"Lan Zhan","orcid":"https://orcid.org/0000-0003-2568-3293","observed_orcids":["https://orcid.org/0000-0003-2568-3293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lan Zhan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007320512","display_name":"Bin Zhou","orcid":"https://orcid.org/0000-0003-3484-3340","observed_orcids":["https://orcid.org/0000-0003-3484-3340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7264,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.88417805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"6","first_page":"645","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-pancreatitis","display_name":"acute pancreatitis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/caerulein","display_name":"caerulein","score":0.7509999871253967},{"id":"https://openalex.org/keywords/tlr4-deficient-mice","display_name":"TLR4-deficient mice","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.968999981880188},{"id":"https://openalex.org/keywords/fadd","display_name":"FADD","score":0.996999979019165},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/extrinsic-apoptotic-pathway","display_name":"extrinsic apoptotic pathway","score":0.9950000047683716},{"id":"https://openalex.org/keywords/serum-amylase","display_name":"serum amylase","score":0.9100000262260437},{"id":"https://openalex.org/keywords/pancreatic-injury","display_name":"pancreatic injury","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.7388290166854858},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7092506289482117},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.703593373298645},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.7015324234962463},{"id":"https://openalex.org/C2776055636","wikidata":"https://www.wikidata.org/wiki/Q14907137","display_name":"FADD","level":5,"score":0.5301597714424133},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49264270067214966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4872356951236725},{"id":"https://openalex.org/C2776670229","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Acute pancreatitis","level":2,"score":0.4787101745605469},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.46993571519851685},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46334773302078247},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.4370126724243164},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3253750801086426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21257585287094116},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.19827982783317566},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.19202008843421936},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.14846819639205933},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11922004818916321}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000681","descriptor_name":"Amylases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002108","descriptor_name":"Ceruletide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053200","descriptor_name":"Fas-Associated Death Domain Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053200","descriptor_name":"Fas-Associated Death Domain Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21134836","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21134836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatobiliary & pancreatic diseases international : HBPD INT","raw_type":"Journal Article"},{"id":"mag:41752504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21134836","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1483162601","https://openalex.org/W1533387869","https://openalex.org/W1542238822","https://openalex.org/W1633097546","https://openalex.org/W1924734199","https://openalex.org/W1971701051","https://openalex.org/W1978926805","https://openalex.org/W1987036220","https://openalex.org/W1990122501","https://openalex.org/W1992616811","https://openalex.org/W2003030880","https://openalex.org/W2008838298","https://openalex.org/W2018020666","https://openalex.org/W2025715974","https://openalex.org/W2037225657","https://openalex.org/W2058839281","https://openalex.org/W2059887601","https://openalex.org/W2065276651","https://openalex.org/W2092783134","https://openalex.org/W2093062831","https://openalex.org/W2099249565","https://openalex.org/W2108244474","https://openalex.org/W2110215475","https://openalex.org/W2114226866","https://openalex.org/W2129319296","https://openalex.org/W2140375278","https://openalex.org/W2153534897","https://openalex.org/W2154069286","https://openalex.org/W2171033479"],"related_works":["https://openalex.org/W1992108049","https://openalex.org/W2154069286","https://openalex.org/W4235990590","https://openalex.org/W1975044867","https://openalex.org/W2044584052","https://openalex.org/W2072903264","https://openalex.org/W1982142818","https://openalex.org/W2070103616","https://openalex.org/W2364773499","https://openalex.org/W1992616811"],"abstract_inverted_index":{"BACKGROUND:":[0],"Toll-like":[1],"receptor":[2],"4":[3],"(TLR4)":[4],"plays":[5],"an":[6],"important":[7],"role":[8],"in":[9,36,55,141,186,225,232,248,256],"the":[10,26,56,149,155,187,202,226,236,257,278,284],"occurrence":[11],"and":[12,40,53,67,78,91,132,153,161,170,209,223,243,289],"development":[13],"of":[14,19,28,44,58,63,102,114,117,121,136,138,158,189,220,228,246,260,274,281,286],"acute":[15],"pancreatitis":[16],"(AP).":[17],"Apoptosis":[18],"pancreatic":[20,122,139,249,275],"cells":[21,140,276],"is":[22,31,43],"closely":[23],"related":[24],"to":[25,33,46,143,182,195,253],"severity":[27,120,245],"AP.":[29,59],"TLR4":[30,51,270],"known":[32],"induce":[34],"apoptosis":[35,54,137,273],"some":[37],"cell":[38],"types":[39],"therefore":[41],"it":[42],"importance":[45],"investigate":[47],"potential":[48],"associations":[49],"between":[50,168],"activity":[52],"setting":[57],"METHODS:":[60],"A":[61],"total":[62],"50":[64,103],"wild-type":[65],"(C57BL/10J)":[66],"TLR4-deficient":[68,92,171,190,229],"(C57BL/10ScNJ)":[69],"mice":[70,90,110,172,191,197,230,261],"were":[71,251],"divided":[72,84],"into":[73,85],"three":[74],"groups:":[75],"2-hour,":[76],"4-hour,":[77],"control":[79],"groups.":[80],"Each":[81],"group":[82],"was":[83,95,126,145,180],"two":[86,199,258],"equal":[87,115],"subgroups:":[88],"TLR4-wild-type":[89,169,196,233],"mice.":[93],"AP":[94,125,144,193,247],"experimentally":[96],"induced":[97],"by":[98,128,147],"7":[99,112],"intraperitoneal":[100],"injections":[101,113],"\u03bcg/kg":[104],"cerulein":[105],"at":[106,173,198,235,262],"hourly":[107],"intervals.":[108],"Control":[109],"received":[111],"volumes":[116],"saline.":[118],"The":[119,134,178],"injury":[123],"during":[124,277],"assessed":[127],"serum":[129],"amylase":[130,241],"concentration":[131,242],"histopathology.":[133],"level":[135],"response":[142],"evaluated":[146],"calculating":[148],"apoptotic":[150,291],"index":[151],"(AI)":[152],"comparing":[154],"expression":[156,219],"levels":[157],"cytochrome":[159,221],"C":[160,222],"Fas-associated":[162],"protein":[163],"with":[164,192],"death":[165],"domain":[166],"(FADD)":[167],"2":[174],"time":[175,238,264],"points.":[176,265],"RESULTS:":[177],"AI":[179],"found":[181,252],"be":[183,254],"significantly":[184,217],"lower":[185,218],"pancreas":[188,227],"compared":[194],"hours":[200],"after":[201],"last":[203],"treatment":[204],"injection.":[205],"Enzyme-linked":[206],"immunosorbent":[207],"assay":[208],"real-time":[210],"reverse":[211],"transcription-polymerase":[212],"chain":[213],"reaction":[214],"also":[215],"revealed":[216],"FADD":[224],"than":[231],"animals":[234],"same":[237],"point.":[239],"Serum":[240],"morphological":[244],"tissue":[250],"similar":[255],"strains":[259],"both":[263,287],"CONCLUSION:":[266],"We":[267],"postulate":[268],"that":[269],"can":[271],"mediate":[272],"early":[279],"stages":[280],"AP,":[282],"via":[283],"activation":[285],"intrinsic":[288],"extrinsic":[290],"signaling":[292],"pathways.":[293]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}