{"id":"https://openalex.org/W41721175","doi":null,"title":"Modulation of oxidative stress-induced changes in hypertension and atherosclerosis by antioxidants.","display_name":"Modulation of oxidative stress-induced changes in hypertension and atherosclerosis by antioxidants.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W41721175","mag":"41721175","pmid":"https://pubmed.ncbi.nlm.nih.gov/18651033","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2276159"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2276159","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2276159","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Clin Cardiol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2276159","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037779063","display_name":"Sudesh Vasdev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130438778","display_name":"Memorial University of Newfoundland","ror":"https://ror.org/04haebc03","country_code":"CA","type":"education","lineage":["https://openalex.org/I130438778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sudesh Vasdev","raw_affiliation_strings":["Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John's, Newfoundland and Labrador"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St John's, Newfoundland and Labrador","institution_ids":["https://openalex.org/I130438778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103456062","display_name":"Vicki D. Gill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vicki D Gill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048278410","display_name":"Pawan K. Singal","orcid":"https://orcid.org/0000-0001-8818-9239","observed_orcids":["https://orcid.org/0000-0001-8818-9239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pawan K Singal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0049,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.80550674,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"3","first_page":"206","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.30149999260902405,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8569999933242798},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":1.0},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.9919999837875366},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9390000104904175},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9779999852180481},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9610000252723694},{"id":"https://openalex.org/keywords/protein-glycation","display_name":"protein glycation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.7149999737739563},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.6290000081062317},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9390000104904175}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.911952018737793},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.8931000828742981},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7850111722946167},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.6889539957046509},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5622264742851257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5610052943229675},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.48761239647865295},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.48163145780563354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4591602087020874},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4345923066139221},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4272151589393616},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3760577440261841},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3471885919570923},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3274746537208557}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2276159","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2276159","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Clin Cardiol","raw_type":"Text"},{"id":"pmid:18651033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18651033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and clinical cardiology","raw_type":"Journal Article"},{"id":"mag:41721175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18651033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2276159","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2276159","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Clin Cardiol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":158,"referenced_works":["https://openalex.org/W68743804","https://openalex.org/W113714250","https://openalex.org/W134133824","https://openalex.org/W151020393","https://openalex.org/W172036993","https://openalex.org/W184906826","https://openalex.org/W309415132","https://openalex.org/W1512889873","https://openalex.org/W1532750448","https://openalex.org/W1538844921","https://openalex.org/W1559813904","https://openalex.org/W1678920698","https://openalex.org/W1792726538","https://openalex.org/W1825417295","https://openalex.org/W1887156662","https://openalex.org/W1901604221","https://openalex.org/W1964051905","https://openalex.org/W1966051421","https://openalex.org/W1966330450","https://openalex.org/W1968357287","https://openalex.org/W1972299046","https://openalex.org/W1975781920","https://openalex.org/W1976075200","https://openalex.org/W1976616659","https://openalex.org/W1977857737","https://openalex.org/W1978793468","https://openalex.org/W1978896699","https://openalex.org/W1984513597","https://openalex.org/W1987401718","https://openalex.org/W1992385339","https://openalex.org/W1993143422","https://openalex.org/W1994738775","https://openalex.org/W1994863097","https://openalex.org/W1995697203","https://openalex.org/W1997259202","https://openalex.org/W1998155352","https://openalex.org/W2001565942","https://openalex.org/W2003589653","https://openalex.org/W2003949605","https://openalex.org/W2004496421","https://openalex.org/W2005244961","https://openalex.org/W2006284844","https://openalex.org/W2007435006","https://openalex.org/W2007918875","https://openalex.org/W2008219736","https://openalex.org/W2009771629","https://openalex.org/W2010919246","https://openalex.org/W2011955651","https://openalex.org/W2015788490","https://openalex.org/W2019841328","https://openalex.org/W2019983337","https://openalex.org/W2020988577","https://openalex.org/W2025679035","https://openalex.org/W2031379379","https://openalex.org/W2032515919","https://openalex.org/W2033704972","https://openalex.org/W2034525236","https://openalex.org/W2034559254","https://openalex.org/W2035772760","https://openalex.org/W2037000525","https://openalex.org/W2038613674","https://openalex.org/W2039031441","https://openalex.org/W2040567895","https://openalex.org/W2040923416","https://openalex.org/W2042038416","https://openalex.org/W2042250109","https://openalex.org/W2042769297","https://openalex.org/W2046112813","https://openalex.org/W2048659753","https://openalex.org/W2049225059","https://openalex.org/W2050814649","https://openalex.org/W2051625732","https://openalex.org/W2051786840","https://openalex.org/W2052124418","https://openalex.org/W2053355173","https://openalex.org/W2056429367","https://openalex.org/W2060052300","https://openalex.org/W2061968178","https://openalex.org/W2063024150","https://openalex.org/W2063747608","https://openalex.org/W2064858030","https://openalex.org/W2065801590","https://openalex.org/W2067140776","https://openalex.org/W2067185786","https://openalex.org/W2067422331","https://openalex.org/W2070216509","https://openalex.org/W2073913852","https://openalex.org/W2079580148","https://openalex.org/W2080142407","https://openalex.org/W2083259478","https://openalex.org/W2083281709","https://openalex.org/W2085983395","https://openalex.org/W2088955890","https://openalex.org/W2089660664","https://openalex.org/W2092810872","https://openalex.org/W2094941678","https://openalex.org/W2096057450","https://openalex.org/W2096535920","https://openalex.org/W2097099550","https://openalex.org/W2097155911","https://openalex.org/W2098827026","https://openalex.org/W2099753885","https://openalex.org/W2101537600","https://openalex.org/W2101736229","https://openalex.org/W2101802428","https://openalex.org/W2104330486","https://openalex.org/W2106071968","https://openalex.org/W2107262676","https://openalex.org/W2116775994","https://openalex.org/W2119458555","https://openalex.org/W2119603369","https://openalex.org/W2121527030","https://openalex.org/W2122751858","https://openalex.org/W2122920228","https://openalex.org/W2123799914","https://openalex.org/W2123818872","https://openalex.org/W2126085531","https://openalex.org/W2127072099","https://openalex.org/W2129497087","https://openalex.org/W2130791935","https://openalex.org/W2130904954","https://openalex.org/W2132133918","https://openalex.org/W2134260386","https://openalex.org/W2136037976","https://openalex.org/W2136614806","https://openalex.org/W2140795515","https://openalex.org/W2141436159","https://openalex.org/W2144473676","https://openalex.org/W2147515295","https://openalex.org/W2156599039","https://openalex.org/W2157051245","https://openalex.org/W2157316647","https://openalex.org/W2157490824","https://openalex.org/W2157552205","https://openalex.org/W2158020124","https://openalex.org/W2159959895","https://openalex.org/W2161112776","https://openalex.org/W2164967692","https://openalex.org/W2172057670","https://openalex.org/W2177617345","https://openalex.org/W2314490642","https://openalex.org/W2319850088","https://openalex.org/W2324841714","https://openalex.org/W2328364118","https://openalex.org/W2334903440","https://openalex.org/W2394484217","https://openalex.org/W2396622574","https://openalex.org/W2402553165","https://openalex.org/W2409370607","https://openalex.org/W2413576654","https://openalex.org/W2417699621","https://openalex.org/W2418810104","https://openalex.org/W2420170690","https://openalex.org/W2469543797","https://openalex.org/W2469785480","https://openalex.org/W2481667321","https://openalex.org/W2511464528","https://openalex.org/W4299315071"],"related_works":["https://openalex.org/W2022647504","https://openalex.org/W4391813086","https://openalex.org/W2079580148","https://openalex.org/W4214882019","https://openalex.org/W4318215083","https://openalex.org/W2281422803","https://openalex.org/W4389630119","https://openalex.org/W2085005037","https://openalex.org/W2373920073","https://openalex.org/W7096295083"],"abstract_inverted_index":{"An":[0,135],"imbalance":[1],"between":[2],"reactive":[3,74,110],"oxygen":[4,111],"species":[5,112],"and":[6,19,24,32,62,67,82,109,125],"antioxidant":[7,98],"reserve,":[8],"referred":[9],"to":[10,64,87,102,131],"as":[11],"oxidative":[12,103,150],"stress,":[13],"results":[14],"in":[15,56,73],"the":[16,53,57,80,118,147],"altered":[17],"structure":[18],"function":[20],"of":[21,59,85,123,149],"proteins,":[22,96],"lipids":[23],"DNA.":[25],"Oxidative":[26],"stress":[27],"is":[28,36,40,52],"associated":[29],"with":[30,70,79],"hypertension":[31,124],"atherosclerosis,":[33],"but":[34],"it":[35,39],"unknown":[37],"whether":[38],"a":[41,114],"causative":[42],"or":[43],"resultant":[44],"factor.":[45],"The":[46],"authors":[47],"suggest":[48],"that":[49,120],"insulin":[50,145],"resistance":[51],"key":[54],"element":[55],"pathogenesis":[58],"these":[60,133,139],"diseases,":[61],"leads":[63,101],"abnormal":[65],"glucose":[66],"lipid":[68],"metabolism":[69],"an":[71],"increase":[72],"aldehydes.":[75],"These":[76],"aldehydes":[77],"react":[78],"sulfhydryl":[81],"amino":[83],"groups":[84],"proteins":[86],"form":[88],"advanced":[89],"glycation":[90,106],"end":[91,107],"products,":[92],"adversely":[93],"affecting":[94],"body":[95],"including":[97],"enzymes.":[99],"This":[100],"stress.":[104,151],"Advanced":[105],"products":[108],"perpetuate":[113],"pro-oxidant":[115],"state,":[116],"producing":[117],"changes":[119],"are":[121],"characteristic":[122],"atherosclerosis.":[126],"Antioxidants":[127],"have":[128],"been":[129],"shown":[130],"modulate":[132],"changes.":[134],"ideal":[136],"therapy":[137],"for":[138],"diseases":[140],"includes":[141],"antioxidants,":[142],"which":[143],"attenuate":[144],"resistance,":[146],"source":[148]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}