{"id":"https://openalex.org/W415555683","doi":null,"title":"A prospective study showing poor prognosis in Japanese NASH patients with fibrosis stage F3-4","display_name":"A prospective study showing poor prognosis in Japanese NASH patients with fibrosis stage F3-4","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W415555683","mag":"415555683"},"language":"en","primary_location":{"id":"pmh:oai:irdb.nii.ac.jp:01278:0002639414","doi":null,"is_oa":true,"landing_page_url":"https://kwmed.repo.nii.ac.jp/records/1614","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kawasaki medical journal","raw_type":"journal article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://kwmed.repo.nii.ac.jp/records/1614","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016064473","display_name":"Miwa Kawanaka","orcid":"https://orcid.org/0000-0003-2341-5199","observed_orcids":["https://orcid.org/0000-0003-2341-5199"]},"institutions":[{"id":"https://openalex.org/I189996419","display_name":"Kawasaki Medical School","ror":"https://ror.org/059z11218","country_code":"JP","type":"education","lineage":["https://openalex.org/I189996419"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miwa Kawanaka","raw_affiliation_strings":["Kawasaki Medical School;"],"raw_orcid":"https://orcid.org/0000-0003-2341-5199","affiliations":[{"raw_affiliation_string":"Kawasaki Medical School;","institution_ids":["https://openalex.org/I189996419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081252831","display_name":"Ken Nishino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ken Nishino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054134672","display_name":"Takahito Oka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takahito Oka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036591947","display_name":"Noriyo Urata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noriyo Urata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101639792","display_name":"Jun Nakamura","orcid":"https://orcid.org/0000-0002-9345-3740","observed_orcids":["https://orcid.org/0000-0002-9345-3740"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Nakamura","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9345-3740","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Daisuke Goto","orcid":"https://orcid.org/0000-0003-4921-3851","observed_orcids":["https://orcid.org/0000-0003-4921-3851"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daisuke Goto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4921-3851","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072364978","display_name":"Mitsuhiko Suehiro","orcid":"https://orcid.org/0000-0003-4703-2192","observed_orcids":["https://orcid.org/0000-0003-4703-2192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitsuhiko Suehiro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4703-2192","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023301990","display_name":"Hirofumi Kawamoto","orcid":"https://orcid.org/0000-0002-9650-3555","observed_orcids":["https://orcid.org/0000-0002-9650-3555"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hirofumi Kawamoto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9650-3555","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5053294093","display_name":"Gotaro Yamada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gotaro Yamada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1792,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57226881,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"38","issue":"3","first_page":"119","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/advanced-fibrosis","display_name":"advanced fibrosis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7649999856948853},{"id":"https://openalex.org/keywords/hepatic-decompensation","display_name":"hepatic decompensation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.8830000162124634},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.4350000023841858},{"id":"https://openalex.org/keywords/fibrosis-markers","display_name":"fibrosis biomarkers","score":0.609000027179718},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.9010000228881836},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.7710000276565552},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8395659327507019},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7354670763015747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7145360708236694},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.698935866355896},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6619205474853516},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5544219017028809},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5473570227622986},{"id":"https://openalex.org/C2778721985","wikidata":"https://www.wikidata.org/wiki/Q1183680","display_name":"Decompensation","level":2,"score":0.5411381721496582},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5317614674568176},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.5105829834938049},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.4766745865345001},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.4303014278411865},{"id":"https://openalex.org/C2779102576","wikidata":"https://www.wikidata.org/wiki/Q5113984","display_name":"Chronic liver disease","level":3,"score":0.421977698802948},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.41673150658607483},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.4030773341655731},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3260911703109741},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.315578818321228},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.23806583881378174},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1084042489528656}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:irdb.nii.ac.jp:01278:0002639414","doi":null,"is_oa":true,"landing_page_url":"https://kwmed.repo.nii.ac.jp/records/1614","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kawasaki medical journal","raw_type":"journal article"},{"id":"mag:415555683","doi":null,"is_oa":false,"landing_page_url":"http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2012/KMJ(3)119-127.2012.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306548151","display_name":"\u5ddd\u5d0e\u533b\u5b66\u4f1a\u8a8c","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u5ddd\u5d0e\u533b\u5b66\u4f1a\u8a8c","raw_type":null}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01278:0002639414","doi":null,"is_oa":true,"landing_page_url":"https://kwmed.repo.nii.ac.jp/records/1614","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kawasaki medical journal","raw_type":"journal article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1983586642","https://openalex.org/W1985958297","https://openalex.org/W1999950621","https://openalex.org/W2001454915","https://openalex.org/W2001837599","https://openalex.org/W2064387090","https://openalex.org/W2069553469","https://openalex.org/W2072751592","https://openalex.org/W2074594336","https://openalex.org/W2087829753","https://openalex.org/W2095426577","https://openalex.org/W2120397203","https://openalex.org/W2123650181","https://openalex.org/W2131117941","https://openalex.org/W2153997209","https://openalex.org/W2412264811","https://openalex.org/W3149847267"],"related_works":["https://openalex.org/W4385514817","https://openalex.org/W2074594336","https://openalex.org/W2743667261","https://openalex.org/W2115176557","https://openalex.org/W3214207239","https://openalex.org/W2888519594","https://openalex.org/W2411298825","https://openalex.org/W3216705632","https://openalex.org/W2885412276","https://openalex.org/W2042953929"],"abstract_inverted_index":{"Nonalcoholic":[0],"fatty":[1],"liver":[2,14,47,133,144,152,157],"disease":[3,23,86,125],"(NAFLD)":[4],"is":[5,213],"one":[6,122,155],"of":[7,11,22,34,84,96,104,174,208],"the":[8,97,105,110,162,185],"most":[9],"prevalent":[10],"all":[12],"chronic":[13],"diseases":[15],"in":[16,24,92,128,161],"Japan.":[17],"The":[18,49,82,148,178],"course":[19,83],"and":[20,72,87,121,140,146,172,196,200,211],"prognosis":[21],"Japanese":[25,40],"patients":[26,41,50,56,73,114,150,176,226],"with":[27,42,57,65,76,132,136,142,151,227],"NAFLD":[28,43],"remains":[29],"unclear.":[30],"For":[31],"a":[32,202,205],"period":[33],"5.2\u00b12.4":[35],"years,":[36],"we":[37],"followed":[38],"274":[39],"who":[44],"had":[45,181,201],"undergone":[46],"biopsy.":[48],"were":[51],"divided":[52],"into":[53],"two":[54,94],"groups:":[55],"simple":[58],"steatosis":[59],"(SS)":[60],"or":[61,169],"nonalcoholic":[62],"steatohepatitis":[63],"(NASH)":[64],"fibrosis":[66,70,77,189,221],"Stages":[67,78],"0-2":[68],"(mild-":[69],"group),":[71],"having":[74],"NASH":[75,222],"3-4":[79],"(advanced-fibrosis":[80],"group).":[81],"hepatic":[85,170],"cerebro-cardiovascular":[88,117,167],"events":[89,118,168],"was":[90,100],"evaluated":[91],"these":[93,175],"groups.\u3000Survival":[95],"advanced-fibrosis":[98,111,179],"group":[99,107,164,180,187],"lower":[101,197],"than":[102,184],"that":[103],"mild-fibrosis":[106,163,186],"(p=0.001).":[108],"In":[109],"group,":[112],"7":[113],"(8.5%)":[115],"experienced":[116,165],"after":[119],"diagnosis,":[120],"died.":[123,177],"Hepatic":[124],"(9.8%)":[126],"occurred":[127],"8":[129],"patients:":[130],"4":[131],"decompensation,":[134],"3":[135,149],"hepatocellular":[137],"carcinoma":[138],"(HCC),":[139],"1":[141],"both":[143],"decompensation":[145,153],"HCC.":[147],"died;":[154],"underwent":[156],"transplantation.":[158],"No":[159],"patient":[160],"any":[166],"disease,":[171],"none":[173],"higher":[182,206],"values":[183],"for":[188],"marker,":[190],"HOMA-IR,":[191],"hemoglobin":[192],"A1c,":[193],"leptin,":[194],"hs-CRP":[195],"platelet":[198],"count,":[199],"tendency":[203],"toward":[204],"incidence":[207],"diabetes":[209],"mellitus":[210],"hypertension.\u3000It":[212],"important":[214],"to":[215,218],"understand":[216],"how":[217],"diagnosis":[219],"advance":[220],"among":[223],"so":[224],"many":[225],"NAFLD.":[228]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
