{"id":"https://openalex.org/W415270004","doi":null,"title":"Approche environnementale et g\u00e9n\u00e9tique de la sensibilit\u00e9 comportementale et mol\u00e9culaire \u00e0 deux psychotropes : la coca\u00efne et la fluox\u00e9tine","display_name":"Approche environnementale et g\u00e9n\u00e9tique de la sensibilit\u00e9 comportementale et mol\u00e9culaire \u00e0 deux psychotropes : la coca\u00efne et la fluox\u00e9tine","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W415270004","mag":"415270004"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/778255","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/778255","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/778255","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085907726","display_name":"Claire Crozatier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Claire Crozatier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5085907726"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cocaine","display_name":"cocaine","score":0.6899999976158142},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.6140000224113464},{"id":"https://openalex.org/keywords/prenatal-cocaine-exposure","display_name":"prenatal cocaine exposure","score":0.8450000286102295},{"id":"https://openalex.org/keywords/behavioral-sensitization","display_name":"behavioral sensitization","score":0.6510000228881836},{"id":"https://openalex.org/keywords/calcineurin","display_name":"calcineurin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/glutamate-receptor-subunits","display_name":"glutamate receptor subunits","score":0.7919999957084656},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.8799999952316284},{"id":"https://openalex.org/keywords/animal-models-of-psychiatric-disorders","display_name":"animal models of psychiatric disorders","score":0.7450000047683716},{"id":"https://openalex.org/keywords/psychostimulants","display_name":"psychostimulants","score":0.800000011920929},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.3817828297615051},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.37282490730285645}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/778255","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/778255","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:415270004","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/2005PA120066","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:hdl:10068/778255","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/778255","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":227,"referenced_works":["https://openalex.org/W58243263","https://openalex.org/W198756773","https://openalex.org/W1486548360","https://openalex.org/W1487599137","https://openalex.org/W1489716577","https://openalex.org/W1490397123","https://openalex.org/W1496714476","https://openalex.org/W1502137679","https://openalex.org/W1506117520","https://openalex.org/W1511265793","https://openalex.org/W1519847602","https://openalex.org/W1524081744","https://openalex.org/W1525839404","https://openalex.org/W1557569458","https://openalex.org/W1592885676","https://openalex.org/W1593383161","https://openalex.org/W1599746996","https://openalex.org/W1609834322","https://openalex.org/W1634913020","https://openalex.org/W1642086117","https://openalex.org/W1644438397","https://openalex.org/W1662277789","https://openalex.org/W1671833268","https://openalex.org/W1674012705","https://openalex.org/W1681161665","https://openalex.org/W1714786400","https://openalex.org/W1802874590","https://openalex.org/W1828572233","https://openalex.org/W1830398839","https://openalex.org/W1845046061","https://openalex.org/W1872569578","https://openalex.org/W1919332923","https://openalex.org/W1928329059","https://openalex.org/W1934456309","https://openalex.org/W1945010036","https://openalex.org/W1950744654","https://openalex.org/W1959245327","https://openalex.org/W1963956528","https://openalex.org/W1964408740","https://openalex.org/W1965435203","https://openalex.org/W1966879038","https://openalex.org/W1966998460","https://openalex.org/W1968008729","https://openalex.org/W1968046285","https://openalex.org/W1968213313","https://openalex.org/W1969133295","https://openalex.org/W1969819088","https://openalex.org/W1970290214","https://openalex.org/W1971303103","https://openalex.org/W1972037461","https://openalex.org/W1973072038","https://openalex.org/W1974587599","https://openalex.org/W1975485558","https://openalex.org/W1976289522","https://openalex.org/W1977237592","https://openalex.org/W1978559408","https://openalex.org/W1978583734","https://openalex.org/W1980620165","https://openalex.org/W1980719669","https://openalex.org/W1981433880","https://openalex.org/W1982591896","https://openalex.org/W1983285634","https://openalex.org/W1983706324","https://openalex.org/W1983775298","https://openalex.org/W1983914274","https://openalex.org/W1986782732","https://openalex.org/W1986817593","https://openalex.org/W1989306631","https://openalex.org/W1989505370","https://openalex.org/W1989639507","https://openalex.org/W1991036207","https://openalex.org/W1993091614","https://openalex.org/W1994302329","https://openalex.org/W1995556701","https://openalex.org/W1996443737","https://openalex.org/W1997008818","https://openalex.org/W1997774782","https://openalex.org/W1998033984","https://openalex.org/W1998218335","https://openalex.org/W1998896933","https://openalex.org/W1999570014","https://openalex.org/W1999721756","https://openalex.org/W2000967843","https://openalex.org/W2002597268","https://openalex.org/W2005594217","https://openalex.org/W2005657014","https://openalex.org/W2006123903","https://openalex.org/W2006459253","https://openalex.org/W2008264529","https://openalex.org/W2008780733","https://openalex.org/W2009449932","https://openalex.org/W2010451755","https://openalex.org/W2011412551","https://openalex.org/W2012447446","https://openalex.org/W2014463262","https://openalex.org/W2015318843","https://openalex.org/W2018312069","https://openalex.org/W2019563294","https://openalex.org/W2020174502","https://openalex.org/W2021733070","https://openalex.org/W2022406556","https://openalex.org/W2022419428","https://openalex.org/W2022791210","https://openalex.org/W2023877903","https://openalex.org/W2027436298","https://openalex.org/W2030221131","https://openalex.org/W2030249389","https://openalex.org/W2033587421","https://openalex.org/W2033884201","https://openalex.org/W2034424952","https://openalex.org/W2034533563","https://openalex.org/W2035336615","https://openalex.org/W2035487171","https://openalex.org/W2035862236","https://openalex.org/W2039548187","https://openalex.org/W2041561931","https://openalex.org/W2043961643","https://openalex.org/W2046737437","https://openalex.org/W2046929321","https://openalex.org/W2048557710","https://openalex.org/W2049668076","https://openalex.org/W2050526587","https://openalex.org/W2052435357","https://openalex.org/W2052655524","https://openalex.org/W2053020627","https://openalex.org/W2053374916","https://openalex.org/W2053472601","https://openalex.org/W2054072520","https://openalex.org/W2056722870","https://openalex.org/W2057778600","https://openalex.org/W2057942805","https://openalex.org/W2060018802","https://openalex.org/W2061014473","https://openalex.org/W2061065257","https://openalex.org/W2061575992","https://openalex.org/W2062007331","https://openalex.org/W2062429423","https://openalex.org/W2064225780","https://openalex.org/W2065478328","https://openalex.org/W2068215811","https://openalex.org/W2070019933","https://openalex.org/W2070554778","https://openalex.org/W2074073259","https://openalex.org/W2075620663","https://openalex.org/W2076059783","https://openalex.org/W2076717931","https://openalex.org/W2077320328","https://openalex.org/W2079004695","https://openalex.org/W2079302576","https://openalex.org/W2080155879","https://openalex.org/W2080557221","https://openalex.org/W2082308885","https://openalex.org/W2084107364","https://openalex.org/W2084169314","https://openalex.org/W2085459673","https://openalex.org/W2086048722","https://openalex.org/W2088264073","https://openalex.org/W2089770153","https://openalex.org/W2089977938","https://openalex.org/W2090623565","https://openalex.org/W2090966488","https://openalex.org/W2090975570","https://openalex.org/W2092416261","https://openalex.org/W2093541378","https://openalex.org/W2093906292","https://openalex.org/W2094063881","https://openalex.org/W2094284473","https://openalex.org/W2095302640","https://openalex.org/W2095536802","https://openalex.org/W2097152162","https://openalex.org/W2097241494","https://openalex.org/W2100384166","https://openalex.org/W2101744311","https://openalex.org/W2102256305","https://openalex.org/W2108652301","https://openalex.org/W2111431369","https://openalex.org/W2111478092","https://openalex.org/W2112768057","https://openalex.org/W2113889584","https://openalex.org/W2114272370","https://openalex.org/W2116848628","https://openalex.org/W2119035790","https://openalex.org/W2120258938","https://openalex.org/W2121651624","https://openalex.org/W2122305414","https://openalex.org/W2122836762","https://openalex.org/W2123099861","https://openalex.org/W2125347442","https://openalex.org/W2125813097","https://openalex.org/W2131224021","https://openalex.org/W2132277863","https://openalex.org/W2133565799","https://openalex.org/W2137180357","https://openalex.org/W2137725292","https://openalex.org/W2138570586","https://openalex.org/W2140178312","https://openalex.org/W2141998004","https://openalex.org/W2145592505","https://openalex.org/W2146439993","https://openalex.org/W2146918064","https://openalex.org/W2147028713","https://openalex.org/W2148239264","https://openalex.org/W2149823377","https://openalex.org/W2150255019","https://openalex.org/W2152390421","https://openalex.org/W2154809561","https://openalex.org/W2162045483","https://openalex.org/W2162602904","https://openalex.org/W2163334673","https://openalex.org/W2165398609","https://openalex.org/W2165463566","https://openalex.org/W2165510883","https://openalex.org/W2167088399","https://openalex.org/W2168950597","https://openalex.org/W2170155163","https://openalex.org/W2171321056","https://openalex.org/W2171691063","https://openalex.org/W2172196619","https://openalex.org/W2330883289","https://openalex.org/W2396576979","https://openalex.org/W2399783354","https://openalex.org/W2405353726","https://openalex.org/W2418379574","https://openalex.org/W2419144483","https://openalex.org/W2511181468","https://openalex.org/W2609550033","https://openalex.org/W4294810261"],"related_works":["https://openalex.org/W7037634210","https://openalex.org/W2883556164","https://openalex.org/W2987646428","https://openalex.org/W7208872699","https://openalex.org/W2896051088","https://openalex.org/W2060938535","https://openalex.org/W7058164441","https://openalex.org/W7164616355","https://openalex.org/W4392329072","https://openalex.org/W7166944749"],"abstract_inverted_index":{"Ce":[0],"travail":[1],"de":[2,28,50,61,68,76,106,126,128],"th\u00e8se":[3],"porte":[4],"sur":[5,34],"la":[6,35,40,62,86,89,94],"sensibilit\u00e9":[7],"\u00e0":[8,39,73,85],"deux":[9,70],"psychotropes":[10,71],":":[11],"un":[12,17,74,118],"psychostimulant":[13],"(la":[14,19],"coca\u00efne)":[15],"et":[16,83,88,93],"antid\u00e9presseur":[18],"fluox\u00e9tine).":[20],"Nous":[21,42,54],"avons":[22,43,55],"d'abord":[23],"explor\u00e9":[24],"l'impact":[25],"d'une":[26,97],"perturbation":[27],"l'environnement":[29],"pr\u00e9natal":[30],"(coca\u00efne":[31],"in":[32],"utero)":[33],"sensibilisation":[36,51],"comportementale":[37],"adulte":[38],"coca\u00efne.":[41],"observ\u00e9":[44],"une":[45],"modification":[46],"du":[47],"profil":[48],"comportemental":[49],"des":[52,130,135],"souris.":[53],"par":[56,117],"ailleurs":[57],"\u00e9tudi\u00e9":[58],"le":[59,65],"r\u00f4le":[60],"calcineurine":[63],"dans":[64],"mode":[66],"d'action":[67],"ces":[69,111],"gr\u00e2ce":[72],"mod\u00e8le":[75],"surexpression":[77],"g\u00e9n\u00e9tique":[78],"(CN98).":[79],"Les":[80],"r\u00e9ponses":[81],"comportementales":[82],"mol\u00e9culaires":[84],"coca\u00efne":[87],"fluox\u00e9tine":[90],"\u00e9taient":[91],"potentialis\u00e9es":[92],"localisation":[95],"sub-cellulaire":[96],"sous-unit\u00e9":[98],"d'un":[99],"r\u00e9cepteur":[100],"au":[101,121],"glutamate":[102],"\u00e9tait":[103],"perturb\u00e9e.":[104],"Finalement,":[105],"nombreux":[107],"ph\u00e9notypes":[108],"modifi\u00e9s":[109],"chez":[110],"souris":[112],"ont":[113],"pu":[114],"\u00eatre":[115],"normalis\u00e9s":[116],"traitement":[119],"thymor\u00e9gulateur":[120],"valproate,":[122],"ce":[123],"qui":[124],"permet":[125],"discuter":[127],"l'utilisation":[129],"mod\u00e8les":[131],"animaux":[132],"pour":[133],"l'\u00e9tude":[134],"maladies":[136],"psychiatriques.":[137]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}