{"id":"https://openalex.org/W41504529","doi":null,"title":"The evaluation of hyaluronic acid, with and without lidocaine, in the filling of nasolabial folds as measured by ultrastructural changes and pain management.","display_name":"The evaluation of hyaluronic acid, with and without lidocaine, in the filling of nasolabial folds as measured by ultrastructural changes and pain management.","publication_year":2013,"publication_date":"2013-03-01","ids":{"openalex":"https://openalex.org/W41504529","mag":"41504529","pmid":"https://pubmed.ncbi.nlm.nih.gov/23545926"},"language":"en","primary_location":{"id":"pmid:23545926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23545926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062859490","display_name":"Josefina Royo de la Torre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Josefina Royo de la Torre","raw_affiliation_strings":["Servicio de Dermatolog\u00eda, Instituto M\u00e9dico L\u00e1ser, Madrid, Spain. consulta@iml.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Dermatolog\u00eda, Instituto M\u00e9dico L\u00e1ser, Madrid, Spain. consulta@iml.es","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069769349","display_name":"Javier Moreno\u2010Moraga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Moreno-Moraga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031429153","display_name":"Mar\u00eda J. Isarr\u00eda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria J Isarr\u00eda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102100043","display_name":"Estefan\u00eda Mu\u00f1oz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Estefania Mu\u00f1oz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101145398","display_name":"Irene Cruz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irene Cruz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Gema P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gema P\u00e9rez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5056836136","display_name":"Paloma Cornejo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paloma Cornejo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1688,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.76868552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"3","first_page":"e46","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11322","display_name":"Facial Rejuvenation and Surgery Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11322","display_name":"Facial Rejuvenation and Surgery Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11258","display_name":"Breast Implant and Reconstruction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9179999828338623},{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.9800000190734863},{"id":"https://openalex.org/keywords/nasolabial-fold","display_name":"nasolabial fold","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dermal-fillers","display_name":"dermal fillers","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.6859999895095825},{"id":"https://openalex.org/keywords/reflectance-confocal-microscopy","display_name":"reflectance confocal microscopy","score":0.9129999876022339},{"id":"https://openalex.org/keywords/dermal-epidermal-junction","display_name":"basement membrane zone","score":0.9710000157356262},{"id":"https://openalex.org/keywords/skin-rejuvenation","display_name":"skin rejuvenation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/aesthetic-satisfaction","display_name":"aesthetic satisfaction","score":0.5},{"id":"https://openalex.org/keywords/erythema","display_name":"erythema","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hematoma","display_name":"hematoma","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9485688805580139},{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.7083461284637451},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.678745448589325},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5995258688926697},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.5177627801895142},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.5121586322784424},{"id":"https://openalex.org/C2777872592","wikidata":"https://www.wikidata.org/wiki/Q349185","display_name":"Wrinkle","level":2,"score":0.46134594082832336},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4474032521247864},{"id":"https://openalex.org/C2775935860","wikidata":"https://www.wikidata.org/wiki/Q1425611","display_name":"Nasolabial fold","level":2,"score":0.4297170341014862},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.42922329902648926},{"id":"https://openalex.org/C2779121184","wikidata":"https://www.wikidata.org/wiki/Q1166142","display_name":"Erythema","level":2,"score":0.4152841567993164},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.34138262271881104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2063119113445282},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003357","descriptor_name":"Cosmetic Techniques","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012060","descriptor_name":"Rejuvenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017060","descriptor_name":"Patient Satisfaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060052","descriptor_name":"Nasolabial Fold","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23545926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23545926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Comparative Study"},{"id":"mag:41504529","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23545926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3024508519","https://openalex.org/W2348674570","https://openalex.org/W2803080562","https://openalex.org/W4400678813","https://openalex.org/W2159794557","https://openalex.org/W4409203746","https://openalex.org/W2417676904","https://openalex.org/W1968023957","https://openalex.org/W2584188592","https://openalex.org/W2146874008"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pain":[1,123],"management":[2],"is":[3],"an":[4,85],"important":[5],"objective":[6],"in":[7,103,107,112,169,209,224,276,284,290],"procedures":[8],"involving":[9],"dermal":[10],"fillers":[11],"composed":[12],"of":[13,24,32,49,92,165,212,256,269],"hyaluronic":[14],"acid":[15],"(HA).":[16],"OBJECTIVE:":[17],"To":[18],"compare":[19],"the":[20,26,47,60,90,100,137,143,192,210,213,232,267,274,277,285],"1-year":[21],"clinical":[22],"results":[23,289],"filling":[25],"nasolabial":[27,101],"fold":[28,102],"with":[29,84,172,205,287],"2":[30,193],"types":[31],"filler:":[33],"large-gel":[34,38],"particle":[35,39],"HA":[36,40],"and":[37,53,58,62,66,110,121,132,142,155,159,178,185,199,241],"plus":[41],"0.3%":[42],"lidocaine":[43],"(HA+L).":[44],"We":[45,77],"compared":[46],"level":[48],"pain":[50,166,259],"during":[51],"treatment":[52,57,93],"10":[54,179],"minutes":[55,180],"after":[56],"assessed":[59],"safety":[61],"efficacy":[63],"profile,":[64],"satisfaction,":[65,264],"histological":[67,282],"findings":[68],"(using":[69],"reflectance":[70],"confocal":[71],"microscopy":[72],"[RCM]).":[73],"MATERIALS":[74],"AND":[75],"METHODS:":[76],"performed":[78],"a":[79,127,206,281],"comparative,":[80],"parallel-group,":[81],"double-blind":[82],"trial":[83],"external":[86],"observer":[87],"(blinded":[88],"to":[89,99],"type":[91],"administered).":[94],"The":[95,163,254],"filler":[96],"was":[97,124,167,222],"applied":[98],"119":[104],"patients":[105,109,170],"(HA":[106],"62":[108],"HA+L":[111,173,257],"57).":[113],"Patients":[114],"were":[115,134,151,238,246],"followed":[116],"at":[117,153,156,195,216,248],"months":[118,157,196,249],"3,":[119,197,231],"9,":[120,198],"12.":[122,160,200,252],"evaluated":[125,135],"using":[126,136],"visual":[128],"analog":[129],"scale.":[130],"Efficacy":[131,184],"satisfaction":[133],"Wrinkle":[138],"Severity":[139],"Rating":[140],"Scale":[141],"Global":[144],"Aesthetic":[145],"Improvement":[146],"Scale.":[147],"RCM":[148,271],"images":[149],"(n=32)":[150],"taken":[152],"baseline":[154],"3":[158],"RESULTS:":[161],"Pain:":[162],"severity":[164],"decreased":[168],"treated":[171],"on":[174],"application":[175],"(P":[176,219],"<.001)":[177],"later":[181],"(":[182],"P=.008).":[183],"satisfaction:":[186],"No":[187,244],"significant":[188],"differences":[189],"existed":[190],"between":[191],"groups":[194],"RCM:":[201],"Skin":[202],"rejuvenation":[203],"occurred":[204],"32%":[207],"increase":[208],"height":[211],"dermoepidermal":[214,278],"junction":[215,279],"month":[217,230],"12":[218],"<.001),":[220],"which":[221],"similar":[223,288],"both":[225,291],"groups.":[226,292],"Adverse":[227],"events:":[228],"At":[229],"most":[233],"common":[234],"adverse":[235],"events":[236],"(AEs)":[237],"erythema":[239],"(68%)":[240],"hematoma":[242],"(11%).":[243],"AEs":[245],"recorded":[247],"9":[250],"or":[251,266],"CONCLUSION:":[253],"use":[255],"provides":[258],"relief":[260],"without":[261],"affecting":[262],"efficacy,":[263],"safety,":[265],"duration":[268],"results.":[270],"showed":[272],"that":[273],"changes":[275],"represented":[280],"improvement":[283],"skin":[286]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}