{"id":"https://openalex.org/W41409171","doi":null,"title":"A Morpholino Strategy to Assess TSC Gene Function in Zebrafish","display_name":"A Morpholino Strategy to Assess TSC Gene Function in Zebrafish","publication_year":2006,"publication_date":"2006-11-01","ids":{"openalex":"https://openalex.org/W41409171","mag":"41409171"},"language":"en","primary_location":{"id":"pmh:ADA462962","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA462962","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000296959","display_name":"Scott C. Baraban","orcid":"https://orcid.org/0000-0003-1975-9781","observed_orcids":["https://orcid.org/0000-0003-1975-9781"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Scott C. Baraban","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1975-9781","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5000296959"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00376375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberous-sclerosis-complex","display_name":"tuberous sclerosis complex","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tsc1","display_name":"TSC1","score":0.953000009059906},{"id":"https://openalex.org/keywords/neuronal-hyperexcitability","display_name":"neuronal hyperexcitability","score":0.8960000276565552},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.7310000061988831},{"id":"https://openalex.org/keywords/morpholino-knockdown","display_name":"morpholino knockdown","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cortical-tubers","display_name":"cortical tubers","score":0.8930000066757202},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tor-kinase","display_name":"TOR kinase","score":0.6949999928474426},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.9679999947547913},{"id":"https://openalex.org/keywords/seizure-susceptibility","display_name":"seizure susceptibility","score":0.4729999899864197},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.9288716912269592},{"id":"https://openalex.org/C2776773979","wikidata":"https://www.wikidata.org/wiki/Q898669","display_name":"TSC1","level":4,"score":0.8541955947875977},{"id":"https://openalex.org/C2778980267","wikidata":"https://www.wikidata.org/wiki/Q1362721","display_name":"Tuberous sclerosis","level":2,"score":0.8327486515045166},{"id":"https://openalex.org/C136571751","wikidata":"https://www.wikidata.org/wiki/Q424607","display_name":"Morpholino","level":4,"score":0.7534817457199097},{"id":"https://openalex.org/C2779422105","wikidata":"https://www.wikidata.org/wiki/Q21109261","display_name":"TSC2","level":4,"score":0.7366150617599487},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7339038848876953},{"id":"https://openalex.org/C2780384893","wikidata":"https://www.wikidata.org/wiki/Q901804","display_name":"Danio","level":4,"score":0.5451436042785645},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.5200816988945007},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4981272220611572},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.47048309445381165},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4512941539287567},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4399036169052124},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36214250326156616},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2908209562301636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2602888345718384},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24201786518096924},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2149164378643036},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.13245761394500732},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.08937439322471619},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:ADA462962","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&amp;verb=getRecord&amp;metadataPrefix=html&amp;identifier=ADA462962","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC","raw_type":"Text"},{"id":"mag:41409171","doi":null,"is_oa":false,"landing_page_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a462962.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W57038779","https://openalex.org/W66960383","https://openalex.org/W257891185","https://openalex.org/W1515372146","https://openalex.org/W1761007799","https://openalex.org/W1877075148","https://openalex.org/W1923381385","https://openalex.org/W1952006903","https://openalex.org/W1963035817","https://openalex.org/W1975420381","https://openalex.org/W1980754624","https://openalex.org/W1986025484","https://openalex.org/W1986137336","https://openalex.org/W1995441742","https://openalex.org/W1997199005","https://openalex.org/W1997557640","https://openalex.org/W1998756807","https://openalex.org/W2001891026","https://openalex.org/W2008377803","https://openalex.org/W2013258896","https://openalex.org/W2014372892","https://openalex.org/W2018293173","https://openalex.org/W2021207380","https://openalex.org/W2029810183","https://openalex.org/W2032403871","https://openalex.org/W2032555040","https://openalex.org/W2041115099","https://openalex.org/W2045748542","https://openalex.org/W2049458280","https://openalex.org/W2050980183","https://openalex.org/W2051611889","https://openalex.org/W2054347313","https://openalex.org/W2057106513","https://openalex.org/W2063268783","https://openalex.org/W2064813976","https://openalex.org/W2069056717","https://openalex.org/W2072320653","https://openalex.org/W2074077310","https://openalex.org/W2076352446","https://openalex.org/W2081584046","https://openalex.org/W2089632625","https://openalex.org/W2109263914","https://openalex.org/W2114859236","https://openalex.org/W2119979409","https://openalex.org/W2127956748","https://openalex.org/W2129585918","https://openalex.org/W2140657162","https://openalex.org/W2145804860","https://openalex.org/W2149498611","https://openalex.org/W2163140784","https://openalex.org/W2171884143","https://openalex.org/W2235106477","https://openalex.org/W2303631713","https://openalex.org/W2316048374","https://openalex.org/W2383259826","https://openalex.org/W2481087048"],"related_works":["https://openalex.org/W3000389316","https://openalex.org/W2751034821","https://openalex.org/W2070667172","https://openalex.org/W2090137651","https://openalex.org/W4310558170","https://openalex.org/W2037139204","https://openalex.org/W4399107953","https://openalex.org/W4286250823","https://openalex.org/W2911644334","https://openalex.org/W4392498953"],"abstract_inverted_index":{"Tuberous":[0],"sclerosis":[1],"complex":[2],"(TSC)":[3],"is":[4,68],"a":[5,145],"genetic":[6],"disorder":[7],"associated":[8],"with":[9,131],"severe":[10],"neurological":[11],"symptoms":[12],"including":[13],"mental":[14],"retardation,":[15],"autism,":[16],"infantile":[17],"spasms,":[18],"and":[19,29,92],"epilepsy.":[20],"Seizures":[21],"occur":[22],"in":[23,41,48,82,115,129,144,152],"the":[24,38,53,63,135],"majority":[25],"of":[26,55,65,104,112,124,134],"TSC":[27,56,80],"patients":[28],"are":[30],"often":[31],"refractory":[32],"to":[33,59,78],"antiepileptic":[34],"drugs.":[35],"Cortical":[36],"tubers,":[37],"primary":[39],"neuropathology":[40],"these":[42],"patients,":[43],"were":[44],"identified":[45],"as":[46],"epileptogenic":[47],"several":[49],"clinical":[50],"studies.":[51,117],"However,":[52],"contribution":[54],"gene":[57],"inactivation":[58],"altered":[60],"excitability":[61],"(in":[62],"absence":[64],"tuber":[66,113],"formation)":[67],"not":[69],"fully":[70],"understood.":[71],"Here":[72],"we":[73,96],"used":[74],"antisense":[75],"morpholino":[76],"oligonucleotides":[77],"knockdown":[79,143],"genes":[81],"developing":[83],"zebrafish":[84,90,130],"(Danio":[85],"rerio).":[86],"Using":[87],"intact":[88],"agar-immobilized":[89],"larvae":[91],"extracellular":[93],"recording":[94],"techniques,":[95],"present":[97],"evidence":[98,111],"for":[99],"neuronal":[100],"hyperexcitability":[101],"following":[102],"loss":[103],"Tsc1.":[105],"Importantly,":[106],"Tsc1":[107,142],"morphants":[108],"show":[109],"no":[110,132],"formation":[114],"histological":[116],"In":[118],"addition,":[119],"rapamycin":[120,125],"effectively":[121],"inhibited":[122],"target":[123],"(TOR)":[126],"kinase":[127],"activity":[128],"amelioration":[133],"hyperexcitable":[136],"phenotype.":[137],"Our":[138],"study":[139],"demonstrates":[140],"that":[141],"relatively":[146],"simple":[147],"brain":[148],"structure":[149],"can":[150],"result":[151],"hyperexcitability.":[153]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
