{"id":"https://openalex.org/W413992285","doi":null,"title":"Dextrofenfluramine in the treatment of refractory obesity","display_name":"Dextrofenfluramine in the treatment of refractory obesity","publication_year":1985,"publication_date":"1985-12-01","ids":{"openalex":"https://openalex.org/W413992285","mag":"413992285"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1357449","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1357449/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL , 38 (6) pp. 847-854. (1985)","raw_type":"Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018535962","display_name":"Nick Finer","orcid":"https://orcid.org/0000-0003-2468-6804","observed_orcids":["https://orcid.org/0000-0003-2468-6804"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nick Finer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2468-6804","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046219789","display_name":"D Craddock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Craddock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111483851","display_name":"Rodolphe Lavielle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Lavielle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074177680","display_name":"Helen Isobel Keen","orcid":"https://orcid.org/0000-0002-8469-2424","observed_orcids":["https://orcid.org/0000-0002-8469-2424"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen Keen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8469-2424","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3939,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.56951266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"6","first_page":"847","last_page":"854"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/refractory-obesity","display_name":"refractory obesity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/anti-obesity-drugs","display_name":"anti-obesity drugs","score":0.7639999985694885},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.9860000014305115},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.6600000262260437},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6779999732971191},{"id":"https://openalex.org/keywords/daytime-drowsiness","display_name":"daytime drowsiness","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8483734130859375},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8427666425704956},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.7567959427833557},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.7401422262191772},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6727689504623413},{"id":"https://openalex.org/C3017583242","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Placebo group","level":4,"score":0.6370316743850708},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6008968949317932},{"id":"https://openalex.org/C2779638493","wikidata":"https://www.wikidata.org/wiki/Q418928","display_name":"Fenfluramine","level":4,"score":0.54536372423172},{"id":"https://openalex.org/C2911106879","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Severe obesity","level":4,"score":0.4717605710029602},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.454999715089798},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37388765811920166},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34651774168014526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3211973309516907},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0614660382270813},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1357449","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1357449/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL , 38 (6) pp. 847-854. (1985)","raw_type":"Article"},{"id":"mag:413992285","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1357449/","pdf_url":null,"source":{"id":"https://openalex.org/S160239940","display_name":"Current Therapeutic Research","issn_l":"0011-393X","issn":["0011-393X","1879-0313"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Current Therapeutic Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2402849891","https://openalex.org/W2412768264","https://openalex.org/W2433472835","https://openalex.org/W2414499916","https://openalex.org/W2020482290","https://openalex.org/W7160225883","https://openalex.org/W2059527062","https://openalex.org/W2071607902","https://openalex.org/W2519574456","https://openalex.org/W2010010974"],"abstract_inverted_index":{"89":[0],"patients":[1,49,54],"with":[2,71],"refractory":[3,123],"obesity":[4,35],"entered":[5],"a":[6,28,33],"trial":[7],"to":[8,66,74,95,113,129],"assess":[9],"the":[10,17,21,51,56,61,114],"efficacy":[11],"and":[12,32,58,105],"acceptability":[13],"of":[14,20,80],"dextrofenfluramine":[15,39,57,72,96],"-":[16],"active":[18],"stereoisomer":[19],"antiobesity":[22],"drug":[23],"fenfluramine.":[24],"Patients,":[25],"recruited":[26],"from":[27,100],"general":[29],"practice":[30],"surgery":[31],"hospital":[34],"clinic,":[36],"received":[37],"either":[38],"15mg":[40],"twice":[41],"daily":[42],"or":[43],"placebo":[44,62,115],"for":[45],"12":[46,90],"weeks.":[47,91],"76":[48],"completed":[50],"study:":[52],"4":[53],"in":[55,60,122],"1":[59],"group":[63],"withdrew":[64],"due":[65],"side":[67],"effects.":[68],"Patients":[69],"treated":[70],"continued":[73],"lose":[75],"weight":[76,84,120],"throughout":[77],"twelve":[78],"weeks":[79],"treatment;":[81],"their":[82,106],"mean":[83],"loss":[85,121],"was":[86,108],"4.1":[87],"kg":[88],"after":[89],"Side":[92],"effects":[93],"attributable":[94],"were":[97],"infrequent":[98],"(apart":[99],"daytime":[101],"drowsiness),":[102],"mainly":[103],"transient":[104],"incidence":[107],"not":[109],"statistically":[110],"different":[111],"compared":[112],"group.":[116],"Dextrofenfluramine":[117],"effectively":[118],"induces":[119],"obesity.":[124],"Longer-term":[125],"studies":[126],"are":[127],"needed":[128],"evaluate":[130],"its":[131],"potential":[132],"clinical":[133],"uses.":[134]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
