{"id":"https://openalex.org/W41398435","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.599.3","title":"Caveolin\u20101 negatively regulates a metalloprotease\u2010dependent EGF receptor transactivation by angiotensin II","display_name":"Caveolin\u20101 negatively regulates a metalloprotease\u2010dependent EGF receptor transactivation by angiotensin II","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W41398435","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.599.3","mag":"41398435"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.24.1_supplement.599.3","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.599.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.599.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051212660","display_name":"Akira Takaguri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akira Takaguri","raw_affiliation_strings":["Cardiovascular Research Center and Department of Physiology Temple University School of Medicine Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Department of Physiology Temple University School of Medicine Philadelphia PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111921231","display_name":"Heigoro Shirai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heigoro Shirai","raw_affiliation_strings":["Cardiovascular Research Center and Department of Physiology Temple University School of Medicine Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Department of Physiology Temple University School of Medicine Philadelphia PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003631795","display_name":"Akinari Hinoki","orcid":"https://orcid.org/0000-0001-6878-2043","observed_orcids":["https://orcid.org/0000-0001-6878-2043"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akinari Hinoki","raw_affiliation_strings":["Cardiovascular Research Center and Department of Physiology Temple University School of Medicine Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Department of Physiology Temple University School of Medicine Philadelphia PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001908946","display_name":"Victor Rizzo","orcid":"https://orcid.org/0000-0002-5705-5462","observed_orcids":["https://orcid.org/0000-0002-5705-5462"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Rizzo","raw_affiliation_strings":["Cardiovascular Research Center and Department of Physiology Temple University School of Medicine Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Department of Physiology Temple University School of Medicine Philadelphia PA","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011779254","display_name":"Satoru Eguchi","orcid":"https://orcid.org/0000-0002-8407-7501","observed_orcids":["https://orcid.org/0000-0002-8407-7501"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satoru Eguchi","raw_affiliation_strings":["Cardiovascular Research Center and Department of Physiology Temple University School of Medicine Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Department of Physiology Temple University School of Medicine Philadelphia PA","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00410994,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":1.0},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9269999861717224},{"id":"https://openalex.org/keywords/egf-receptor-transactivation","display_name":"EGF receptor transactivation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/adam17","display_name":"ADAM17","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metalloproteinases","display_name":"metalloproteinases","score":0.7580000162124634},{"id":"https://openalex.org/keywords/caveolae","display_name":"caveolae","score":0.8479999899864197},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.9350000023841858},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cellular-hypertrophy","display_name":"cell hypertrophy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9350000023841858},{"id":"https://openalex.org/keywords/methyl-beta-cyclodextrin","display_name":"methyl-\u03b2-cyclodextrin","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C49866891","wikidata":"https://www.wikidata.org/wiki/Q1051872","display_name":"Caveolae","level":3,"score":0.7759380340576172},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.7210144400596619},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.7129146456718445},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6675361394882202},{"id":"https://openalex.org/C2780870201","wikidata":"https://www.wikidata.org/wiki/Q17855958","display_name":"Caveolin 1","level":2,"score":0.6657767295837402},{"id":"https://openalex.org/C79266657","wikidata":"https://www.wikidata.org/wiki/Q424178","display_name":"Lipid raft","level":3,"score":0.6009137630462646},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5760536193847656},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5759264826774597},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.535662055015564},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42652058601379395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3050210773944855},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23936757445335388},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1637844741344452},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.09006020426750183},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.24.1_supplement.599.3","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.599.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.599.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2061223293","https://openalex.org/W2486045871","https://openalex.org/W2759613807","https://openalex.org/W4395039458","https://openalex.org/W3177002110","https://openalex.org/W2557318830","https://openalex.org/W4236920950","https://openalex.org/W2079710576","https://openalex.org/W2116309149","https://openalex.org/W2131760832"],"abstract_inverted_index":{"Objective":[0],"The":[1],"EGF":[2],"receptor":[3],"(EGFR)":[4],"transactivation":[5],"pathway":[6],"via":[7],"an":[8,150],"ADAM17\u2010dependent":[9],"ligand":[10,86,139],"shedding":[11,140],"is":[12,54,174],"the":[13,30,34,45,57,66,124,133,137],"key":[14],"signaling":[15,67],"step":[16],"by":[17,178],"which":[18,179],"angiotensin":[19],"II":[20],"(AngII)":[21],"induces":[22,181],"vascular":[23,162],"smooth":[24],"muscle":[25],"cell":[26],"(VSMC)":[27],"remodeling.":[28,163],"However,":[29],"molecular":[31],"mechanism":[32,177],"of":[33,49,65,78,106,115,156,170],"ADAM17":[35,99,173,182],"regulation":[36],"remains":[37],"largely":[38],"unclear.":[39],"We":[40],"hypothesized":[41],"that":[42,109,168],"caveolin\u20101":[43],"(Cav1),":[44],"major":[46],"structural":[47],"protein":[48],"a":[50,112,129,175],"membrane":[51],"microdomain,":[52],"caveolae,":[53],"involved":[55],"in":[56,71,101,123,145],"regulation.":[58],"Methods":[59],"&":[60],"Results":[61],"Phosphorylation":[62],"and":[63,91,108,141],"expression":[64],"proteins":[68],"were":[69],"evaluated":[70],"VSMCs":[72],"prepared":[73],"from":[74,118,172],"rat":[75],"aorta.":[76],"Infection":[77],"adenovirus":[79],"encoding":[80],"Cav1":[81,171],"markedly":[82],"inhibited":[83],"AngII\u2010induced":[84],"EGFR":[85,88,138,143],"shedding,":[87],"transactivation,":[89],"hypertrophy":[90],"migration,":[92],"but":[93],"not":[94],"intracellular":[95],"Ca2+":[96],"elevation.":[97],"Interestingly,":[98],"localized":[100],"Cav1\u2010rich":[102],"lipid":[103],"raft":[104],"fractions":[105],"VSMCs,":[107],"AngII":[110,157,180],"induced":[111],"fraction":[113],"shift":[114],"ADAM":[116],"17":[117],"low":[119],"to":[120,131,161],"high":[121],"density":[122],"fractions.":[125],"In":[126],"addition,":[127],"methyl\u2010beta\u2010cyclodextrin,":[128],"reagent":[130],"disrupt":[132],"caveolae":[134],"structure,":[135],"stimulates":[136],"subsequent":[142],"activation":[144,155],"VSMCs.":[146],"Conclusion":[147],"Caveolae":[148],"provides":[149],"indispensable":[151],"base":[152],"environment":[153],"for":[154],"signal":[158],"transduction":[159],"linked":[160],"Moreover,":[164],"our":[165],"data":[166],"indicate":[167],"dissociation":[169],"crucial":[176],"activation.":[183]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}