{"id":"https://openalex.org/W413457353","doi":null,"title":"Co-ordinate regulation of cilia and the cell cycle in Chlamydomonas reinhardtii","display_name":"Co-ordinate regulation of cilia and the cell cycle in Chlamydomonas reinhardtii","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W413457353","mag":"413457353"},"language":"en","primary_location":{"id":"pmh:oai:summit.sfu.ca:9260","doi":null,"is_oa":true,"landing_page_url":"http://summit.sfu.ca/item/9260","pdf_url":"http://summit.sfu.ca/item/9260","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://summit.sfu.ca/item/9260","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065988146","display_name":"Jeremy Parker","orcid":"https://orcid.org/0000-0001-8319-5891","observed_orcids":["https://orcid.org/0000-0001-8319-5891"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jeremy Parker","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8319-5891","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5065988146"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cilia","display_name":"cilia","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.8149999976158142},{"id":"https://openalex.org/keywords/chlamydomonas-reinhardtii","display_name":"Chlamydomonas reinhardtii","score":0.9869999885559082},{"id":"https://openalex.org/keywords/basal-bodies","display_name":"basal bodies","score":0.8259999752044678},{"id":"https://openalex.org/keywords/ciliary-assembly","display_name":"ciliary assembly","score":0.6349999904632568},{"id":"https://openalex.org/keywords/ciliary-disassembly","display_name":"ciliary disassembly","score":0.8140000104904175},{"id":"https://openalex.org/keywords/deflagellation","display_name":"deflagellation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/katanin","display_name":"katanin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/microtubule-severing","display_name":"microtubule severing","score":0.9190000295639038},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/nek-kinases","display_name":"Nek kinases","score":0.8069999814033508},{"id":"https://openalex.org/keywords/nek8","display_name":"NEK8","score":0.8569999933242798},{"id":"https://openalex.org/keywords/transition-zone","display_name":"transition zone","score":0.5389999747276306},{"id":"https://openalex.org/keywords/mitotic-spindle","display_name":"mitotic spindle","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2777727519","wikidata":"https://www.wikidata.org/wiki/Q291827","display_name":"Chlamydomonas reinhardtii","level":4,"score":0.9798980951309204},{"id":"https://openalex.org/C2776580309","wikidata":"https://www.wikidata.org/wiki/Q133008","display_name":"Chlamydomonas","level":4,"score":0.6325805187225342},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.6229222416877747},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5062009692192078},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3839988112449646},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36274254322052},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18337902426719666},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07514491677284241},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:summit.sfu.ca:9260","doi":null,"is_oa":true,"landing_page_url":"http://summit.sfu.ca/item/9260","pdf_url":"http://summit.sfu.ca/item/9260","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:summit.sfu.ca:node-9260","doi":null,"is_oa":true,"landing_page_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/9260/etd4215.pdf","pdf_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/9260/etd4215.pdf","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:413457353","doi":null,"is_oa":false,"landing_page_url":"https://summit.sfu.ca/system/files/iritems1/9260/etd4215.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:summit.sfu.ca:9260","doi":null,"is_oa":true,"landing_page_url":"http://summit.sfu.ca/item/9260","pdf_url":"http://summit.sfu.ca/item/9260","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W413457353.pdf","grobid_xml":"https://content.openalex.org/works/W413457353.grobid-xml"},"referenced_works_count":112,"referenced_works":["https://openalex.org/W178469598","https://openalex.org/W186411712","https://openalex.org/W1501468947","https://openalex.org/W1587592813","https://openalex.org/W1605541801","https://openalex.org/W1827733533","https://openalex.org/W1835644365","https://openalex.org/W1902250508","https://openalex.org/W1963759286","https://openalex.org/W1964718989","https://openalex.org/W1968391872","https://openalex.org/W1968860396","https://openalex.org/W1973153764","https://openalex.org/W1973347338","https://openalex.org/W1973791049","https://openalex.org/W1976588897","https://openalex.org/W1985117787","https://openalex.org/W1987849943","https://openalex.org/W1988632377","https://openalex.org/W1989140036","https://openalex.org/W1991454115","https://openalex.org/W1995916420","https://openalex.org/W1999722591","https://openalex.org/W2000068229","https://openalex.org/W2000808410","https://openalex.org/W2003383185","https://openalex.org/W2004394768","https://openalex.org/W2009001010","https://openalex.org/W2021421164","https://openalex.org/W2024811660","https://openalex.org/W2024995840","https://openalex.org/W2030590806","https://openalex.org/W2033123653","https://openalex.org/W2036982993","https://openalex.org/W2041804034","https://openalex.org/W2051508195","https://openalex.org/W2052815101","https://openalex.org/W2055043387","https://openalex.org/W2057470782","https://openalex.org/W2058336798","https://openalex.org/W2060198945","https://openalex.org/W2060562600","https://openalex.org/W2065922392","https://openalex.org/W2068561300","https://openalex.org/W2070484339","https://openalex.org/W2070658365","https://openalex.org/W2071588572","https://openalex.org/W2072416931","https://openalex.org/W2074897318","https://openalex.org/W2075364453","https://openalex.org/W2075688601","https://openalex.org/W2080402857","https://openalex.org/W2080628311","https://openalex.org/W2086703813","https://openalex.org/W2097382368","https://openalex.org/W2099304384","https://openalex.org/W2101345103","https://openalex.org/W2101457064","https://openalex.org/W2101598422","https://openalex.org/W2102424043","https://openalex.org/W2102753929","https://openalex.org/W2103678187","https://openalex.org/W2104389902","https://openalex.org/W2106423726","https://openalex.org/W2108087670","https://openalex.org/W2108450599","https://openalex.org/W2111152287","https://openalex.org/W2111229238","https://openalex.org/W2113325631","https://openalex.org/W2113447712","https://openalex.org/W2115964608","https://openalex.org/W2116079099","https://openalex.org/W2116207011","https://openalex.org/W2117577561","https://openalex.org/W2119449193","https://openalex.org/W2119509468","https://openalex.org/W2119931639","https://openalex.org/W2119979825","https://openalex.org/W2120964958","https://openalex.org/W2120965368","https://openalex.org/W2124285343","https://openalex.org/W2126661153","https://openalex.org/W2127637426","https://openalex.org/W2128126810","https://openalex.org/W2128156628","https://openalex.org/W2128818346","https://openalex.org/W2133334674","https://openalex.org/W2134780731","https://openalex.org/W2139098279","https://openalex.org/W2139695148","https://openalex.org/W2143929717","https://openalex.org/W2144273979","https://openalex.org/W2144515265","https://openalex.org/W2145300367","https://openalex.org/W2146058063","https://openalex.org/W2146982832","https://openalex.org/W2148151206","https://openalex.org/W2148242921","https://openalex.org/W2148299087","https://openalex.org/W2150297520","https://openalex.org/W2152492039","https://openalex.org/W2155080027","https://openalex.org/W2155820436","https://openalex.org/W2156354211","https://openalex.org/W2159407840","https://openalex.org/W2161155561","https://openalex.org/W2161444534","https://openalex.org/W2165148994","https://openalex.org/W2166385580","https://openalex.org/W2166400533","https://openalex.org/W2171253503","https://openalex.org/W2240476799"],"related_works":["https://openalex.org/W1558863555","https://openalex.org/W90155001","https://openalex.org/W2143811575","https://openalex.org/W7095530098","https://openalex.org/W647910402","https://openalex.org/W3010129669","https://openalex.org/W2517659650","https://openalex.org/W1975738538","https://openalex.org/W4322576396","https://openalex.org/W2182167651"],"abstract_inverted_index":{"Cilia":[0,9],"are":[1,17,56,63,203,272],"multifunctional":[2],"organelles":[3],"implicated":[4,177],"in":[5,22,89,137,142,147,178,180,183,185,221,255,292],"many":[6],"human":[7,326],"diseases.":[8],"project":[10],"from":[11],"the":[12,52,83,93,125,161,194,214,217,222,248,264,288,302,317,325],"cell":[13,79,115,166,223,310],"surface":[14],"and":[15,24,49,73,145,165,170,182,258,278,284,295,307],"thus":[16],"well-situated":[18],"for":[19,37,128],"roles":[20],"both":[21],"motility":[23],"sensory":[25],"reception.":[26],"The":[27,270],"green":[28],"alga":[29],"Chlamydomonas":[30,318],"reinhardtii":[31],"is":[32,225,253,260,297],"a":[33,68,103,109,174,261,273],"useful":[34],"model":[35],"system":[36],"studies":[38],"of":[39,45,54,201,219,233,263,267,276,304,324],"cilia":[40,55,66,245],"due":[41],"to":[42,91,212,227,246,333],"its":[43,228],"combination":[44],"genetics,":[46],"molecular":[47],"biology,":[48],"biochemistry.":[50],"At":[51],"base":[53],"modified":[57],"centrioles":[58],"called":[59],"basal":[60,84,249],"bodies,":[61],"which":[62,205],"connected":[64],"with":[65,78,135,309],"via":[67],"transition":[69],"zone.":[70],"Ciliary":[71,96],"assembly":[72,139,306],"disassembly":[74,97],"must":[75,86],"be":[76,87,122],"co-ordinated":[77],"cycle":[80,224,303,311],"progression":[81],"because":[82],"bodies":[85],"freed":[88],"order":[90],"organize":[92],"mitotic":[94,268],"spindle.":[95],"can":[98,198],"occur":[99],"either":[100],"by":[101],"deflagellation,":[102],"drastic":[104],"stress":[105],"response,":[106],"or":[107],"resorption,":[108],"gradual":[110],"process":[111],"normally":[112],"occurring":[113],"before":[114],"division.":[116],"I":[117,131,171,236,285],"hypothesized":[118],"that":[119,133,193,197,216,238,287,299],"there":[120],"might":[121],"commonality":[123],"between":[124,163],"two":[126],"pathways":[127],"ciliary":[129,138,305],"loss.":[130],"discovered":[132,286],"cells":[134,196,240],"mutations":[136],"invoke":[140],"deflagellation":[141,164,179,252],"some":[143],"circumstances,":[144],"resorption":[146,153],"others.":[148],"Deflagellation":[149],"mutants":[150,204],"also":[151,315],"exhibited":[152],"defects,":[154],"supporting":[155],"my":[156],"hypothesis.":[157],"To":[158],"further":[159,334],"explore":[160],"relationship":[162],"cycle,":[167],"Qasim":[168],"Rasi":[169],"examined":[172],"katanin,":[173],"microtubule-severing":[175],"protein":[176],"Chlamydomonas,":[181],"mitosis":[184,242],"mammalian":[186],"cells.":[187],"A":[188],"reverse":[189],"genetics":[190],"approach":[191],"revealed":[192],"only":[195],"survive":[199],"knock-down":[200],"katanin":[202,220],"already":[206],"lack":[207],"cilia.":[208],"This":[209,313],"led":[210],"us":[211],"form":[213],"hypothesis":[215],"role":[218],"related":[226],"cilia-severing":[229],"activity.":[230],"In":[231],"support":[232],"this":[234],"idea,":[235],"observed":[237],"wild-type":[239],"entering":[241],"sever":[243],"their":[244],"free":[247],"bodies.":[250],"Katanin-mediated":[251],"defective":[254],"fa2":[256],"mutants,":[257],"FA2":[259],"member":[262],"Nek":[265,319],"family":[266,275,289],"kinases.":[269],"Neks":[271,300],"large":[274],"kinases":[277],"through":[279],"evolutionary":[280],"analyses,":[281],"Brian":[282],"Bradley":[283],"expanded":[290],"early":[291],"eukaryotic":[293],"evolution":[294],"it":[296],"likely":[298],"co-ordinate":[301],"dissasemby":[308],"progression.":[312],"study":[314],"identified":[316],"CNK3":[320],"as":[321],"an":[322,331],"orthologue":[323],"disease":[327],"gene":[328],"Nek8,":[329],"suggesting":[330],"avenue":[332],"disease-related":[335],"research.":[336]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2016-06-24T00:00:00"}
