{"id":"https://openalex.org/W41343876","doi":null,"title":"Antitumor activity of polysaccharide fractions from pine cone extract of Pinus parviflora Sieb. et Zucc.","display_name":"Antitumor activity of polysaccharide fractions from pine cone extract of Pinus parviflora Sieb. et Zucc.","publication_year":1987,"publication_date":"1987-11-01","ids":{"openalex":"https://openalex.org/W41343876","mag":"41343876","pmid":"https://pubmed.ncbi.nlm.nih.gov/3481681"},"language":"en","primary_location":{"id":"pmid:3481681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3481681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003433490","display_name":"Hiroshi Sakagami","orcid":"https://orcid.org/0000-0001-8001-2121","observed_orcids":["https://orcid.org/0000-0001-8001-2121"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Sakagami","raw_affiliation_strings":["First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Ikeda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ikeda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020945332","display_name":"Senwa Unten","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Unten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055554576","display_name":"Ken Takeda","orcid":"https://orcid.org/0000-0002-2906-5575","observed_orcids":["https://orcid.org/0000-0002-2906-5575"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Takeda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018719486","display_name":"Jun\u2010Ichiro Murayama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Murayama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005740649","display_name":"Afaf Mohamed Hamada","orcid":"https://orcid.org/0000-0002-0700-2696","observed_orcids":["https://orcid.org/0000-0002-0700-2696"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Hamada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072438384","display_name":"Keitarou Kimura","orcid":"https://orcid.org/0000-0003-4641-4041","observed_orcids":["https://orcid.org/0000-0003-4641-4041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Kimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109942260","display_name":"Naoto Komatsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Komatsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108777319","display_name":"Kiju Konno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Konno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0699,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.89925987,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"7","issue":"6","first_page":"1153","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.33739998936653137,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.33739998936653137,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.2971000075340271,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.13830000162124634,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pinus-parviflora","display_name":"Pinus parviflora","score":0.9879999756813049},{"id":"https://openalex.org/keywords/acidic-polysaccharides","display_name":"acidic polysaccharides","score":0.9490000009536743},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ascites-tumor","display_name":"ascites tumor","score":0.859000027179718},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/polysaccharide-fractionation","display_name":"polysaccharide fractionation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/uronic-acid","display_name":"uronic acid","score":0.6610000133514404},{"id":"https://openalex.org/keywords/survival-time","display_name":"survival time","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.8727977275848389},{"id":"https://openalex.org/C2776084176","wikidata":"https://www.wikidata.org/wiki/Q71240623","display_name":"Arabinose","level":4,"score":0.7580048441886902},{"id":"https://openalex.org/C2775887612","wikidata":"https://www.wikidata.org/wiki/Q10809118","display_name":"Mannose","level":2,"score":0.5873690843582153},{"id":"https://openalex.org/C2778284416","wikidata":"https://www.wikidata.org/wiki/Q412056","display_name":"Uronic acid","level":3,"score":0.5608845949172974},{"id":"https://openalex.org/C2778173381","wikidata":"https://www.wikidata.org/wiki/Q66589593","display_name":"Galactose","level":2,"score":0.5571844577789307},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5179914236068726},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.481344074010849},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.4647507071495056},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4581618905067444},{"id":"https://openalex.org/C2776841590","wikidata":"https://www.wikidata.org/wiki/Q66589589","display_name":"Fucose","level":3,"score":0.430705189704895},{"id":"https://openalex.org/C2780294150","wikidata":"https://www.wikidata.org/wiki/Q66589603","display_name":"Xylose","level":3,"score":0.40695151686668396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36714664101600647},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.13967818021774292},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13041117787361145},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07930213212966919},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001089","descriptor_name":"Arabinose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001201","descriptor_name":"Ascites","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012510","descriptor_name":"Sarcoma 180","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3481681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3481681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:41343876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3481681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2378172098","https://openalex.org/W2394913098","https://openalex.org/W2438405884","https://openalex.org/W2356332929","https://openalex.org/W4282925817","https://openalex.org/W358326561","https://openalex.org/W2390397889","https://openalex.org/W2077711802","https://openalex.org/W2461168260","https://openalex.org/W1992372996"],"abstract_inverted_index":{"Hot":[0],"water":[1],"extract":[2],"of":[3,7,27,34,46,67,112,118],"pine":[4],"cone":[5],"(PCE)":[6],"Pinus":[8],"parviflora":[9],"Sieb.":[10],"et":[11],"Zucc.":[12],"dose-dependently":[13],"suppressed":[14,64],"both":[15],"solid":[16,68],"and":[17,40,75,77,115],"ascites":[18,37],"tumor":[19,38,69,73,86],"cells":[20],"transplanted":[21],"into":[22],"various":[23],"mice.":[24],"Acidic":[25],"polysaccharides":[26,90,114],"PCE":[28],"significantly":[29,63],"increased":[30,42],"the":[31,47,56,65,109],"survival":[32],"time":[33],"mice":[35],"bearing":[36],"cells,":[39,70],"activity":[41,111],"with":[43,71,78],"acidity.":[44],"One":[45],"four":[48],"polysaccharide":[49],"fractions":[50],"obtained":[51],"by":[52],"NaOH":[53],"extraction":[54],"showed":[55],"most":[57],"potent":[58],"antitumor":[59,110],"activity.":[60],"This":[61],"fraction":[62],"growth":[66],"occasional":[72],"regression":[74],"necrosis,":[76],"little":[79],"or":[80,125],"no":[81],"cytocidal":[82],"effect":[83],"on":[84],"cultured":[85],"cells.":[87],"All":[88],"acidic":[89],"were":[91],"able":[92],"to":[93,104],"activate":[94],"mouse":[95],"macrophage-like":[96],"cell":[97],"line":[98],"J774.1.":[99],"There":[100],"did":[101],"not":[102],"appear":[103],"be":[105],"any":[106],"correlation":[107],"between":[108],"these":[113],"their":[116],"content":[117],"arabinose":[119],"(or":[120],"fucose),":[121],"mannose,":[122],"galactose,":[123],"glucose,":[124],"uronic":[126],"acid.":[127]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}