{"id":"https://openalex.org/W412787087","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.673","title":"Neoadjuvant chemotherapy (NCT) in 710 patients for operable breast cancer: Variation changing in hormonal receptors (HR) status","display_name":"Neoadjuvant chemotherapy (NCT) in 710 patients for operable breast cancer: Variation changing in hormonal receptors (HR) status","publication_year":2006,"publication_date":"2006-06-20","ids":{"openalex":"https://openalex.org/W412787087","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.673","mag":"412787087"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2006.24.18_suppl.673","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.673","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.673","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036644613","display_name":"Olivier Tacca","orcid":"https://orcid.org/0000-0003-1996-4195","observed_orcids":["https://orcid.org/0000-0003-1996-4195"]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"O. Tacca","raw_affiliation_strings":["Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061340891","display_name":"Frederique Madeleine Penault-Llorca","orcid":"https://orcid.org/0000-0002-4279-5492","observed_orcids":["https://orcid.org/0000-0002-4279-5492"]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F. Penault-Llorca","raw_affiliation_strings":["Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029086962","display_name":"Catherine Abrial","orcid":"https://orcid.org/0000-0002-1759-9457","observed_orcids":["https://orcid.org/0000-0002-1759-9457"]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Abrial","raw_affiliation_strings":["Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073726565","display_name":"In\u00e8s Raoelfils","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"I. Raoelfils","raw_affiliation_strings":["Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069540694","display_name":"Marie\u2010Ange Mouret\u2010Reynier","orcid":"https://orcid.org/0000-0001-6981-1678","observed_orcids":["https://orcid.org/0000-0001-6981-1678","https://orcid.org/0000-0001-5542-5813"]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. A. Mouret-Reynier","raw_affiliation_strings":["Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079609936","display_name":"Philippe Bougnoux","orcid":"https://orcid.org/0000-0002-8717-055X","observed_orcids":["https://orcid.org/0000-0002-8717-055X"]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Bougnoux","raw_affiliation_strings":["Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113527248","display_name":"J.L. Achard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. L. Achard","raw_affiliation_strings":["Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111675900","display_name":"J Dauplat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Dauplat","raw_affiliation_strings":["Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072502548","display_name":"Philippe J. M. Chollet","orcid":"https://orcid.org/0000-0001-8457-7568","observed_orcids":["https://orcid.org/0000-0001-8457-7568"]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Chollet","raw_affiliation_strings":["Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France","institution_ids":["https://openalex.org/I4210124119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046469470","display_name":"H. Cur\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124119","display_name":"Centre Jean Perrin","ror":"https://ror.org/02pwnhd33","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210124119"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H. Cure\u0301","raw_affiliation_strings":["Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Jean Perrin, Clermont-Ferrand, France; CHU Bretonneau, Tours, France","institution_ids":["https://openalex.org/I4210124119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210124119"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"18_suppl","first_page":"673","last_page":"673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/operable-breast-cancer","display_name":"operable breast cancer","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hormone-receptor-status","display_name":"hormone receptor status","score":0.9100000262260437},{"id":"https://openalex.org/keywords/oestrogen-receptor","display_name":"oestrogen receptor","score":0.8370000123977661},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.9800000190734863},{"id":"https://openalex.org/keywords/receptor-switching","display_name":"receptor switching","score":0.5680000185966492},{"id":"https://openalex.org/keywords/residual-disease","display_name":"residual disease","score":0.6610000133514404},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8880000114440918},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9769999980926514},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7279999852180481},{"id":"https://openalex.org/keywords/adjuvant-endocrine-therapy","display_name":"adjuvant endocrine therapy","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.930962324142456},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6846065521240234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6456120610237122},{"id":"https://openalex.org/C2778311097","wikidata":"https://www.wikidata.org/wiki/Q5903784","display_name":"Hormonal therapy","level":4,"score":0.6154260039329529},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5625966191291809},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5597215890884399},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5473109483718872},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.4992494583129883},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.44708871841430664},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4411046802997589},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.43230491876602173},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39887717366218567}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2006.24.18_suppl.673","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.673","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.673","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2149579505","https://openalex.org/W2030002770","https://openalex.org/W1740277143","https://openalex.org/W2164288737","https://openalex.org/W2145054184","https://openalex.org/W2791287855","https://openalex.org/W2087182221","https://openalex.org/W3157031786","https://openalex.org/W2031042189","https://openalex.org/W4407643026"],"abstract_inverted_index":{"673":[0],"Background:":[1],"Positive":[2],"HR":[3,26,65,163,171,183,186,189,205,210,239,280],"constitutes":[4],"by":[5,24,63,73],"their":[6],"presence":[7],"a":[8,70,117,121,130,143,196,286,290],"favourable":[9],"prognosis":[10],"factor":[11],"and":[12,43,58,123,141,165,227],"predicts":[13],"response":[14],"to":[15,31,301],"an":[16],"adjuvant":[17,231],"hormonal":[18,230],"therapy.":[19],"In":[20],"breast":[21],"cancer":[22],"treated":[23],"NCT,":[25,247,262],"expression":[27],"has":[28],"been":[29],"shown":[30,257],"be":[32,234,271],"modified":[33],"in":[34,69,175,279,282],"residual":[35,259],"disease":[36,218,260],"after":[37,142,246,261],"induction":[38],"chemotherapy":[39],"(":[40],"Miyoshi":[41],"Y":[42],"al.,":[44],"Clin":[45],"Cancer":[46,101],"Res.":[47],"2004":[48],").":[49],"Methods:":[50],"A":[51],"second":[52],"centralized":[53],"comparative":[54],"lecture":[55],"of":[56,79,108,133,146,150,284],"oestrogenic":[57],"progestative":[59],"receptors":[60],"was":[61,67,93,110,137,173,192,289],"realized":[62],"IHC.":[64],"status":[66,172,226,281],"evaluated":[68,138,266],"blinded":[71],"fashion":[72],"two":[74],"pathologists,":[75],"on":[76,216,229,250,267],"414":[77],"out":[78],"710":[80],"patients":[81,109,115,177,180,295],"from":[82],"several":[83],"prospective":[84],"phase":[85],"II":[86],"trials.":[87],"Cut":[88],"off":[89],"value":[90],"for":[91,273,294],"positivity":[92],"10%":[94],"tumor":[95],"cells":[96],"(Amat":[97],"et":[98],"al,":[99],"Breast":[100],"Res":[102],"Treat":[103],"2005)":[104],".":[105],"Median":[106],"age":[107],"49.5":[111],"years.":[112],"555":[113],"(78%)":[114],"had":[116,213],"ductal,":[118],"90":[119],"(13%)":[120],"lobular":[122],"65":[124],"(9%)":[125],"other":[126],"type":[127],"carcinoma,":[128],"with":[129,195,202],"median":[131,144],"size":[132],"40":[134],"mm.":[135],"Response":[136],"before,":[139],"during":[140],"number":[145],"6":[147],"courses":[148],"(1\u20139)":[149],"NCT.":[151,170],"Study":[152],"is":[153],"curently":[154],"ongoing.":[155],"Results:":[156],"Among":[157,236],"these414":[158],"tumors,":[159,241],"157":[160],"(38%)":[161],"were":[162],"negative":[164,184,206,245],"257":[166,238],"(62%)":[167],"positive":[168,190,211,240,287],"before":[169],"changed":[174],"105":[176],"(25%):":[178],"75":[179],"(48%)":[181],"initially":[182],"became":[185,244],"positive.":[187],"This":[188],"switch":[191,212,288],"significantly":[193],"correlated":[194],"better":[197],"overall":[198],"survival":[199,220],"(OS),":[200],"compared":[201],"the":[203,217,237],"unchanged":[204],"tumors":[207],"(p=0.032).":[208],"However,":[209],"no":[214],"effect":[215,228,249],"free":[219],"(p=0.085).":[221],"More":[222],"details":[223],"concerning":[224],"RH":[225],"treatment":[232],"will":[233],"presented.Conversely,":[235],"30":[242],"(12%)":[243],"without":[248],"OS":[251],"(p=0.28).":[252],"Conclusions:":[253],"We":[254],"have":[255],"previously":[256],"that":[258],"rather":[263],"than":[264],"parameters":[265],"initial":[268],"biopsy,":[269],"must":[270],"considered":[272],"patients\u2019":[274],"prognosis.":[275],"NCT":[276],"induced":[277],"variations":[278],"25%":[283],"patients;":[285],"strong":[291],"prognostic":[292],"indicator":[293],"outcome.":[296],"No":[297],"significant":[298],"financial":[299],"relationships":[300],"disclose.":[302]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}