{"id":"https://openalex.org/W412427334","doi":null,"title":"Regulation and function of the mitochondrial protease HtrA2/Omi in the control of cell death","display_name":"Regulation and function of the mitochondrial protease HtrA2/Omi in the control of cell death","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W412427334","mag":"412427334"},"language":"en","primary_location":{"id":"pmh:hdl:10068/1005456","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/1005456","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018372885","display_name":"Kristina Klupsch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kristina Klupsch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5018372885"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.6406000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.6406000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.2433999925851822,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.05660000070929527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/htra2-omi","display_name":"Omi/HtrA2","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mitochondrial-protease","display_name":"mitochondrial protease","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.734000027179718},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6660000085830688},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.6930000185966492},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.75},{"id":"https://openalex.org/keywords/pink1","display_name":"PINK1","score":0.6660000085830688},{"id":"https://openalex.org/keywords/chop","display_name":"CHOP","score":0.8790000081062317},{"id":"https://openalex.org/keywords/atf4","display_name":"ATF4","score":0.9070000052452087},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9210000038146973},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8360000252723694},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6593225002288818},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5319117903709412},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5256030559539795},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.5085619688034058},{"id":"https://openalex.org/C2780900454","wikidata":"https://www.wikidata.org/wiki/Q21102119","display_name":"ATF4","level":4,"score":0.4902215600013733},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.48059341311454773},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.46582624316215515},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4270184338092804},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.41669535636901855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3760839104652405},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.333745539188385},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.33131474256515503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23447784781455994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13425064086914062},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.11729788780212402},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09293687343597412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0769878625869751},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06852865219116211},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/1005456","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/1005456","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1444896","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1444896/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, University of London.","raw_type":"Thesis"},{"id":"mag:412427334","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582648","pdf_url":null,"source":{"id":"https://openalex.org/S4306508234","display_name":"Doctoral thesis, University of London.","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, University of London.","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9294000267982483}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2059492848","https://openalex.org/W2087290491","https://openalex.org/W2060470131","https://openalex.org/W2001977333","https://openalex.org/W2115687796","https://openalex.org/W7011701675","https://openalex.org/W2028968291","https://openalex.org/W2754171710","https://openalex.org/W2293572648","https://openalex.org/W2115282304"],"abstract_inverted_index":{"The":[0,107],"serine":[1],"protease":[2,65],"HtrA2":[3,15,34,49,68,83,131,154,179,203,225,262,281,295],"is":[4,80,84,263],"released":[5],"from":[6],"mitochondria":[7,298],"following":[8],"apoptotic":[9],"stimuli.":[10],"Once":[11],"in":[12,19,69,77,89,91,102,153,160,178,191,211,224,235,265,276,296],"the":[13,45,64,70,78,136,192,195,245,257,292,297],"cytosol,":[14,79],"has":[16],"been":[17],"implicated":[18],"promoting":[20],"cell":[21,42,105],"death":[22],"by":[23],"a":[24,55,92,115,169,187,227,266],"caspase-dependent":[25],"and":[26,72,130,282],"-independent":[27],"mechanism.":[28],"However,":[29],"mice":[30],"lacking":[31],"expression":[32,209],"of":[33,38,41,48,67,121,127,165,171,194,202,238,280,285,294,303],"show":[35],"no":[36],"evidence":[37],"reduced":[39],"rates":[40],"death.":[43],"On":[44],"contrary,":[46],"loss":[47,201,237],"causes":[50],"mitochondrial":[51,145,246,306],"dysfunction":[52],"leading":[53,118,217],"to":[54,87,95,119,218,272,300,305],"neurodegenerative":[56],"disorder":[57],"with":[58,250,256],"parkinsonian":[59],"features.":[60],"This":[61],"suggests":[62],"that":[63,244],"function":[66,88,293],"mitochondria,":[71],"not":[73,159],"its":[74,96,286],"pro-apoptotic":[75],"action":[76],"critical.":[81],"Mammalian":[82],"therefore":[85],"likely":[86],"vivo":[90],"manner":[93,268],"similar":[94],"bacterial":[97,108],"homologues,":[98],"which":[99],"are":[100,226,254],"involved":[101],"protection":[103],"against":[104],"stress.":[106,307],"DegS":[109],"homologue":[110],"senses":[111],"unfolded":[112],"proteins,":[113],"activating":[114],"proteolytic":[116,239,287],"cascade":[117],"induction":[120],"stress":[122,146],"response":[123],"genes.":[124],"Transcriptional":[125,163],"profiling":[126,164],"wild":[128],"type":[129],"knockout":[132],"(KO)":[133],"cells":[134,304],"identified":[135,186],"stress-inducible":[137],"transcription":[138],"factor":[139,229],"CHOP":[140,149],"being":[141,176],"differentially":[142],"regulated":[143],"when":[144],"was":[147,151],"triggered.":[148],"up-regulation":[150],"found":[152,274],"KO":[155],"mouse":[156],"brains":[157],"but":[158],"other":[161],"tissues.":[162],"brain":[166],"tissue":[167],"revealed":[168],"number":[170],"putative":[172],"ATF4":[173],"target":[174],"genes":[175,196],"up-regulated":[177],"KO,":[180],"among":[181],"these":[182],"CHOP.":[183],"Promoter":[184],"analysis":[185],"C/EBP-ATF":[188],"composite":[189],"site":[190],"majority":[193],"within":[197],"this":[198],"signature.":[199],"Therefore,":[200],"might":[204],"impact":[205],"on":[206],"nuclear":[207],"gene":[208],"specifically":[210],"brain,":[212],"subverting":[213],"normal":[214],"cellular":[215],"homeostasis":[216],"disease.":[219],"In":[220],"humans,":[221],"point":[222],"mutations":[223,253],"susceptibility":[228,260],"for":[230,291],"Parkinson's":[231],"disease":[232],"(PD)":[233],"resulting":[234],"partial":[236],"activity.":[240],"Affinity":[241],"purification":[242],"shows":[243],"kinase":[247],"PINK1":[248,252],"interacts":[249],"HtrA2.":[251],"associated":[255],"PARK6":[258],"PD":[259,277],"locus.":[261],"phosphorylated":[264],"PINK1-dependent":[267],"at":[269],"residues":[270],"adjacent":[271],"positions":[273],"mutated":[275],"patients.":[278],"Phosphorylation":[279],"thereby":[283],"modulation":[284],"activity":[288],"seems":[289],"necessary":[290],"contributing":[299],"increased":[301],"resistance":[302]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}
