{"id":"https://openalex.org/W41153680","doi":null,"title":"Enhancing T-cell responses to vaccination of HIV-1 infected subjects on antiretroviral therapy","display_name":"Enhancing T-cell responses to vaccination of HIV-1 infected subjects on antiretroviral therapy","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W41153680","mag":"41153680"},"language":"en","primary_location":{"id":"pmh:oai:repository.upenn.edu:edissertations-3225","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/1413","pdf_url":"https://repository.upenn.edu/edissertations/1413","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.upenn.edu/edissertations/1413","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108259671","display_name":"Lorenzo Ramirez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lorenzo Ramirez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108259671"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00451467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.7350000143051147},{"id":"https://openalex.org/keywords/therapeutic-vaccination","display_name":"therapeutic vaccination","score":0.6890000104904175},{"id":"https://openalex.org/keywords/hiv-1-dna-vaccine","display_name":"HIV-1 DNA vaccine","score":0.8709999918937683},{"id":"https://openalex.org/keywords/in-vivo-electroporation","display_name":"in vivo electroporation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.6850000023841858},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/influenza-vaccination","display_name":"influenza vaccination","score":0.5690000057220459},{"id":"https://openalex.org/keywords/cd4-t-cell-reconstitution","display_name":"CD4+ T cell recovery","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.824999988079071},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.859000027179718},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6729999780654907},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8109999895095825},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.5889999866485596},{"id":"https://openalex.org/keywords/immune-reconstitution","display_name":"immune reconstitution","score":0.49000000953674316},{"id":"https://openalex.org/keywords/opportunistic-infections","display_name":"opportunistic infections","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.6865862011909485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6532562971115112},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.596167266368866},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5917248129844666},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5479292273521423},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5116863250732422},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.5053151249885559},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.3334936499595642},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.23698928952217102}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:repository.upenn.edu:edissertations-3225","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/1413","pdf_url":"https://repository.upenn.edu/edissertations/1413","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},{"id":"pmh:oai:repository.upenn.edu:20.500.14332/28222","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/28222","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"published","raw_type":"Dissertation/Thesis"},{"id":"pmh:oai:repository.upenn.edu:dissertations-12614","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3670957","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},{"id":"mag:41153680","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=12614&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.upenn.edu:edissertations-3225","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/1413","pdf_url":"https://repository.upenn.edu/edissertations/1413","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W41153680.pdf","grobid_xml":"https://content.openalex.org/works/W41153680.grobid-xml"},"referenced_works_count":224,"referenced_works":["https://openalex.org/W227202595","https://openalex.org/W1501690710","https://openalex.org/W1506224745","https://openalex.org/W1507980006","https://openalex.org/W1513052585","https://openalex.org/W1530235393","https://openalex.org/W1530246149","https://openalex.org/W1531645323","https://openalex.org/W1534881087","https://openalex.org/W1546154494","https://openalex.org/W1558813989","https://openalex.org/W1568534433","https://openalex.org/W1607531254","https://openalex.org/W1608236599","https://openalex.org/W1621779329","https://openalex.org/W1648913866","https://openalex.org/W1655510925","https://openalex.org/W1703864506","https://openalex.org/W1786787856","https://openalex.org/W1869071094","https://openalex.org/W1912933271","https://openalex.org/W1964481529","https://openalex.org/W1964927614","https://openalex.org/W1965119593","https://openalex.org/W1965845165","https://openalex.org/W1966253033","https://openalex.org/W1967548282","https://openalex.org/W1967664818","https://openalex.org/W1967684158","https://openalex.org/W1970192083","https://openalex.org/W1970934635","https://openalex.org/W1971983469","https://openalex.org/W1974540435","https://openalex.org/W1977797184","https://openalex.org/W1978436252","https://openalex.org/W1978913285","https://openalex.org/W1978959016","https://openalex.org/W1979329648","https://openalex.org/W1980650718","https://openalex.org/W1980915827","https://openalex.org/W1981157257","https://openalex.org/W1982968177","https://openalex.org/W1983796858","https://openalex.org/W1985715136","https://openalex.org/W1986086086","https://openalex.org/W1986151024","https://openalex.org/W1988729025","https://openalex.org/W1990260535","https://openalex.org/W1992066198","https://openalex.org/W1992302496","https://openalex.org/W1993094357","https://openalex.org/W1993484328","https://openalex.org/W1995002272","https://openalex.org/W1995254193","https://openalex.org/W1995281119","https://openalex.org/W1995915978","https://openalex.org/W1997491414","https://openalex.org/W1998256809","https://openalex.org/W2001360631","https://openalex.org/W2001781773","https://openalex.org/W2001815433","https://openalex.org/W2002012748","https://openalex.org/W2003051762","https://openalex.org/W2003793276","https://openalex.org/W2005816484","https://openalex.org/W2006332998","https://openalex.org/W2007607803","https://openalex.org/W2007907525","https://openalex.org/W2007971001","https://openalex.org/W2008029670","https://openalex.org/W2009176907","https://openalex.org/W2009253992","https://openalex.org/W2010391664","https://openalex.org/W2011340131","https://openalex.org/W2012783935","https://openalex.org/W2014365032","https://openalex.org/W2015303879","https://openalex.org/W2016168268","https://openalex.org/W2017699847","https://openalex.org/W2018002636","https://openalex.org/W2018310724","https://openalex.org/W2018444159","https://openalex.org/W2019885309","https://openalex.org/W2020673372","https://openalex.org/W2021151285","https://openalex.org/W2023844808","https://openalex.org/W2024600835","https://openalex.org/W2026452856","https://openalex.org/W2027336565","https://openalex.org/W2029534804","https://openalex.org/W2030236537","https://openalex.org/W2031360844","https://openalex.org/W2032478431","https://openalex.org/W2032523448","https://openalex.org/W2032722583","https://openalex.org/W2036325663","https://openalex.org/W2037524921","https://openalex.org/W2037736746","https://openalex.org/W2038574980","https://openalex.org/W2039473791","https://openalex.org/W2039742816","https://openalex.org/W2045506129","https://openalex.org/W2046230726","https://openalex.org/W2046775408","https://openalex.org/W2047553535","https://openalex.org/W2047656594","https://openalex.org/W2049497180","https://openalex.org/W2051040572","https://openalex.org/W2052444641","https://openalex.org/W2053154066","https://openalex.org/W2053898412","https://openalex.org/W2055796578","https://openalex.org/W2059752094","https://openalex.org/W2059790979","https://openalex.org/W2060334940","https://openalex.org/W2061868430","https://openalex.org/W2062254741","https://openalex.org/W2063353079","https://openalex.org/W2065172977","https://openalex.org/W2067893593","https://openalex.org/W2068431093","https://openalex.org/W2070939667","https://openalex.org/W2072463965","https://openalex.org/W2073274550","https://openalex.org/W2074822525","https://openalex.org/W2075345074","https://openalex.org/W2075436742","https://openalex.org/W2077159378","https://openalex.org/W2078742755","https://openalex.org/W2078891878","https://openalex.org/W2081116633","https://openalex.org/W2082516444","https://openalex.org/W2085919513","https://openalex.org/W2086719710","https://openalex.org/W2087668602","https://openalex.org/W2088258412","https://openalex.org/W2089139305","https://openalex.org/W2090875077","https://openalex.org/W2091040274","https://openalex.org/W2091045718","https://openalex.org/W2092220076","https://openalex.org/W2092321761","https://openalex.org/W2093596177","https://openalex.org/W2094736478","https://openalex.org/W2095748010","https://openalex.org/W2095867033","https://openalex.org/W2100285658","https://openalex.org/W2101844985","https://openalex.org/W2102768133","https://openalex.org/W2105359832","https://openalex.org/W2105804574","https://openalex.org/W2107286925","https://openalex.org/W2107986169","https://openalex.org/W2110559078","https://openalex.org/W2111374555","https://openalex.org/W2111562199","https://openalex.org/W2114720145","https://openalex.org/W2114940577","https://openalex.org/W2115042155","https://openalex.org/W2115101818","https://openalex.org/W2116971894","https://openalex.org/W2117553644","https://openalex.org/W2117785982","https://openalex.org/W2117978224","https://openalex.org/W2118394718","https://openalex.org/W2118954661","https://openalex.org/W2119240876","https://openalex.org/W2123063882","https://openalex.org/W2125070883","https://openalex.org/W2125852723","https://openalex.org/W2126005292","https://openalex.org/W2126751198","https://openalex.org/W2126861692","https://openalex.org/W2127517680","https://openalex.org/W2128513949","https://openalex.org/W2128620327","https://openalex.org/W2129196237","https://openalex.org/W2130366757","https://openalex.org/W2130399622","https://openalex.org/W2130703905","https://openalex.org/W2131696465","https://openalex.org/W2131748930","https://openalex.org/W2133107090","https://openalex.org/W2133323910","https://openalex.org/W2134537454","https://openalex.org/W2135843416","https://openalex.org/W2138694347","https://openalex.org/W2139250164","https://openalex.org/W2139400179","https://openalex.org/W2141634817","https://openalex.org/W2143242765","https://openalex.org/W2144882745","https://openalex.org/W2145075050","https://openalex.org/W2148397464","https://openalex.org/W2148597851","https://openalex.org/W2148817537","https://openalex.org/W2149687555","https://openalex.org/W2150484278","https://openalex.org/W2151926553","https://openalex.org/W2152505869","https://openalex.org/W2153670011","https://openalex.org/W2153869022","https://openalex.org/W2154703325","https://openalex.org/W2159266143","https://openalex.org/W2161021146","https://openalex.org/W2163787552","https://openalex.org/W2163876717","https://openalex.org/W2165101346","https://openalex.org/W2168987719","https://openalex.org/W2169241566","https://openalex.org/W2169249122","https://openalex.org/W2169749417","https://openalex.org/W2169983987","https://openalex.org/W2184177170","https://openalex.org/W2184533357","https://openalex.org/W2252509073","https://openalex.org/W2316311853","https://openalex.org/W2318289184","https://openalex.org/W2319380801","https://openalex.org/W2334332481","https://openalex.org/W2343249020","https://openalex.org/W2897034676","https://openalex.org/W3048877846","https://openalex.org/W4313331142"],"related_works":["https://openalex.org/W2152077388","https://openalex.org/W2417153089","https://openalex.org/W2102808688","https://openalex.org/W1985547915","https://openalex.org/W2059547077","https://openalex.org/W2309734431","https://openalex.org/W1973187550","https://openalex.org/W2017136280","https://openalex.org/W7000868644","https://openalex.org/W1995782231"],"abstract_inverted_index":{"With":[0],"the":[1,15,29,117,196,258,271,283,294,301,328,346,353,387,391,397],"advancement":[2],"in":[3,14,36,49,71,152,157,175,195,206,267,335,339,352],"anti-retroviral":[4],"therapy":[5,221],"(ART)":[6],"regimens":[7],"there":[8],"has":[9],"been":[10],"a":[11,72,94,168,218,254],"significant":[12],"improvement":[13],"quality":[16],"of":[17,21,146,161,198,257,273,285,296,355,366,396,400,416],"life":[18],"and":[19,38,57,91,137,210,300,405],"survival":[20],"those":[22,356],"individuals":[23,43,82,159,227,275],"infected":[24,42,83,106,142,180,311,357],"with":[25,28,84,174,282,358,370],"HIV-1.":[26,215],"Even":[27],"benefits":[30],"to":[31,45,54,69,104,114,130,178,192,214,230,276,278,290,324,333,337,383,403],"CD4+":[32,287,297,305],"cell":[33],"counts,":[34],"decrease":[35],"viremia":[37],"inflammatory":[39],"biomarkers,":[40],"HIV-1":[41,85,96,141,170,179,223,310,359,401],"continue":[44,229],"exhibit":[46],"functional":[47],"issues":[48,79],"their":[50],"T-cell":[51,63,77,154,298,306],"immune":[52,133,155,188,212,373,409],"responses":[53,65,103,156,189,213,336],"recall":[55],"antigens":[56],"vaccines.":[58],"Additionally,":[59,363],"researchers":[60],"believe":[61],"that":[62,100,149,246,253,345],"mediated":[64],"will":[66],"be":[67,193,231,377],"important":[68,194,323],"elicit":[70,102,185,265],"therapeutic":[73,95,147,169,414],"vaccination":[74,279,338],"setting.":[75],"These":[76],"functionality":[78],"can":[80,101,150,331],"leave":[81],"at":[86,232],"risk":[87,233],"from":[88],"opportunistic":[89,236],"infections":[90],"co-morbidities.":[92],"Furthermore,":[93],"vaccine":[97,172,201,219,260],"is":[98,127,160,224,322],"needed":[99,129,412],"help":[105,299],"subjects":[107,181],"better":[108,304,394],"control":[109,197],"HIV":[110,126,136],"infection":[111,402],"so":[112],"as":[113,239],"potentially":[115],"reduce":[116],"need":[118,302,392],"for":[119,222,234,303,393,413],"long-term":[120],"therapy.":[121],"However,":[122,216],"basic":[123,398],"research":[124],"on":[125,182,248,361],"still":[128],"solidify":[131],"potential":[132,408],"correlates":[134,410],"against":[135],"other":[138,235],"pathogens":[139],"affecting":[140],"subjects.":[143],"Likewise,":[144],"investigation":[145],"targets":[148],"aid":[151],"enhancing":[153],"these":[158,226,274,340,417],"importance.\\nIn":[162],"this":[163],"thesis,":[164],"we":[165,251],"examined":[166],"whether":[167,326],"DNA":[171],"delivered":[173],"vivo":[176],"electroporation":[177],"ART":[183],"could":[184,376],"potent":[186],"cellular":[187,372],"previously":[190],"suggested":[191],"HIV.":[199],"This":[200],"strategy":[202],"demonstrated":[203],"an":[204,316],"enhancement":[205],"cell-mediated":[207],"IFN-\u03b3":[208],"production":[209],"cytotoxic":[211],"until":[217],"or":[220],"developed,":[225],"also":[228],"infections,":[237],"such":[238],"influenza":[240,249],"infection.":[241],"Supported":[242],"by":[243,379],"previous":[244],"studies":[245,388],"focus":[247],"vaccination,":[250,291],"found":[252,344],"standard":[255],"dose":[256],"H1N1":[259],"(15\u03bcg;":[261],"Novartis)":[262],"did":[263],"not":[264],"sero-protection":[266],"all":[268],"individuals.":[269,341,418],"Importantly,":[270],"ability":[272],"respond":[277],"was":[280,350],"associated":[281,369],"frequency":[284],"na\u00c3\u00afve":[286],"T-cells":[288],"prior":[289,382],"thereby":[292],"reinforcing":[293],"importance":[295],"reconstitution.":[307],"In":[308],"addition,":[309],"subjects,":[312],"despite":[313],"ART,":[314],"have":[315],"altered":[317],"cytokine/chemokine":[318],"environment.":[319],"Thereby":[320],"it":[321],"explore":[325],"targeting":[327],"cytokine":[329],"milieu":[330],"lead":[332],"improvements":[334],"We":[342],"specifically":[343],"pro-inflammatory":[347],"chemokine":[348],"IP-10":[349,367,381],"elevated":[351,364],"sera":[354],"while":[360],"ART.":[362],"levels":[365],"were":[368],"decreased":[371],"responses,":[374],"which":[375],"improved":[378],"neutralizing":[380],"antigen":[384],"stimulation.":[385],"Therefore,":[386],"herein":[389],"support":[390],"understanding":[395],"science":[399],"uncover":[404],"comprehend":[406],"what":[407],"are":[411],"treatment":[415]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}