{"id":"https://openalex.org/W409063523","doi":null,"title":"Broccoli bioactives: impact on enzyme induction, estrogen metabolism and human cancer cell growth","display_name":"Broccoli bioactives: impact on enzyme induction, estrogen metabolism and human cancer cell growth","publication_year":2012,"publication_date":"2012-06-27","ids":{"openalex":"https://openalex.org/W409063523","mag":"409063523"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/32034","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/32034","pdf_url":"https://www.ideals.illinois.edu/items/32299/bitstreams/105883/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ideals.illinois.edu/items/32299/bitstreams/105883/data.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008599640","display_name":"Sonja E. Volker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sonja E. Volker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008599640"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02283829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/broccoli","display_name":"broccoli","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cruciferous-vegetables","display_name":"cruciferous vegetables","score":0.8700000047683716},{"id":"https://openalex.org/keywords/glucosinolates","display_name":"glucosinolates","score":0.8730000257492065},{"id":"https://openalex.org/keywords/indole-3-carbinol","display_name":"indole-3-carbinol","score":0.9160000085830688},{"id":"https://openalex.org/keywords/sulforaphane","display_name":"sulforaphane","score":0.9990000128746033},{"id":"https://openalex.org/keywords/2-methoxyestradiol","display_name":"2-methoxyestradiol","score":0.8830000162124634},{"id":"https://openalex.org/keywords/estrogen-metabolism","display_name":"estrogen metabolism","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cyp1a","display_name":"CYP1A","score":0.6819999814033508},{"id":"https://openalex.org/keywords/nqo1","display_name":"NQO1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5519999861717224},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8740000128746033},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":1.0},{"id":"https://openalex.org/keywords/selenium-enrichment","display_name":"selenium enrichment","score":0.6039999723434448},{"id":"https://openalex.org/keywords/neoglucobrassicin","display_name":"neoglucobrassicin","score":0.9089999794960022},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.925000011920929},{"id":"https://openalex.org/keywords/kaempferol","display_name":"kaempferol","score":1.0}],"concepts":[{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6277778148651123},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.515617311000824},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4712912142276764},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4476279616355896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44422686100006104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4385947585105896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4376446604728699},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.436280757188797},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21643418073654175},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19228950142860413}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/32034","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/32034","pdf_url":"https://www.ideals.illinois.edu/items/32299/bitstreams/105883/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:409063523","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/32034","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/32034","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/32034","pdf_url":"https://www.ideals.illinois.edu/items/32299/bitstreams/105883/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W409063523.pdf","grobid_xml":"https://content.openalex.org/works/W409063523.grobid-xml"},"referenced_works_count":233,"referenced_works":["https://openalex.org/W23010048","https://openalex.org/W107140107","https://openalex.org/W1231794540","https://openalex.org/W1558003391","https://openalex.org/W1758017998","https://openalex.org/W1785455093","https://openalex.org/W1816432249","https://openalex.org/W1820568833","https://openalex.org/W1847813277","https://openalex.org/W1891709130","https://openalex.org/W1911795670","https://openalex.org/W1914622032","https://openalex.org/W1963768364","https://openalex.org/W1963995164","https://openalex.org/W1967077010","https://openalex.org/W1968269032","https://openalex.org/W1968555772","https://openalex.org/W1969418532","https://openalex.org/W1969606544","https://openalex.org/W1970203467","https://openalex.org/W1970708444","https://openalex.org/W1970739279","https://openalex.org/W1971545670","https://openalex.org/W1972283659","https://openalex.org/W1972802699","https://openalex.org/W1972833991","https://openalex.org/W1972958544","https://openalex.org/W1975773180","https://openalex.org/W1975827192","https://openalex.org/W1976707722","https://openalex.org/W1976932448","https://openalex.org/W1977101823","https://openalex.org/W1980067078","https://openalex.org/W1980513621","https://openalex.org/W1980537841","https://openalex.org/W1980812423","https://openalex.org/W1982804638","https://openalex.org/W1983380926","https://openalex.org/W1983824549","https://openalex.org/W1984017436","https://openalex.org/W1984061460","https://openalex.org/W1984183031","https://openalex.org/W1984254637","https://openalex.org/W1984543805","https://openalex.org/W1984799211","https://openalex.org/W1986553386","https://openalex.org/W1988090278","https://openalex.org/W1989027116","https://openalex.org/W1989565001","https://openalex.org/W1990584786","https://openalex.org/W1990753012","https://openalex.org/W1991263862","https://openalex.org/W1991395966","https://openalex.org/W1993083361","https://openalex.org/W1995458344","https://openalex.org/W1995612090","https://openalex.org/W1997506075","https://openalex.org/W1997567914","https://openalex.org/W1997888279","https://openalex.org/W2001178223","https://openalex.org/W2001984564","https://openalex.org/W2002817997","https://openalex.org/W2004897757","https://openalex.org/W2005009329","https://openalex.org/W2005382866","https://openalex.org/W2005804312","https://openalex.org/W2006957836","https://openalex.org/W2010728788","https://openalex.org/W2011984268","https://openalex.org/W2012599300","https://openalex.org/W2012631275","https://openalex.org/W2012757692","https://openalex.org/W2012921202","https://openalex.org/W2014135975","https://openalex.org/W2014580896","https://openalex.org/W2015411576","https://openalex.org/W2016823780","https://openalex.org/W2019623380","https://openalex.org/W2020687059","https://openalex.org/W2021270662","https://openalex.org/W2022586351","https://openalex.org/W2023056191","https://openalex.org/W2025041464","https://openalex.org/W2025944270","https://openalex.org/W2026322528","https://openalex.org/W2027782293","https://openalex.org/W2027977447","https://openalex.org/W2028204224","https://openalex.org/W2028902040","https://openalex.org/W2031249491","https://openalex.org/W2031306701","https://openalex.org/W2033187407","https://openalex.org/W2039139292","https://openalex.org/W2039495159","https://openalex.org/W2041195664","https://openalex.org/W2041623257","https://openalex.org/W2043130298","https://openalex.org/W2043888893","https://openalex.org/W2044259466","https://openalex.org/W2044261960","https://openalex.org/W2045538216","https://openalex.org/W2045965817","https://openalex.org/W2047439832","https://openalex.org/W2047539719","https://openalex.org/W2047687060","https://openalex.org/W2047705797","https://openalex.org/W2048734658","https://openalex.org/W2049969105","https://openalex.org/W2050737891","https://openalex.org/W2051097020","https://openalex.org/W2051240128","https://openalex.org/W2052184908","https://openalex.org/W2052902977","https://openalex.org/W2053222990","https://openalex.org/W2053344338","https://openalex.org/W2054039401","https://openalex.org/W2054211750","https://openalex.org/W2055732427","https://openalex.org/W2055824301","https://openalex.org/W2056966248","https://openalex.org/W2058474213","https://openalex.org/W2060638322","https://openalex.org/W2060645387","https://openalex.org/W2062120476","https://openalex.org/W2065840609","https://openalex.org/W2066504626","https://openalex.org/W2067561231","https://openalex.org/W2067670440","https://openalex.org/W2068080536","https://openalex.org/W2070867753","https://openalex.org/W2071595592","https://openalex.org/W2073553779","https://openalex.org/W2075488301","https://openalex.org/W2075581750","https://openalex.org/W2075884509","https://openalex.org/W2076030128","https://openalex.org/W2077033018","https://openalex.org/W2077620426","https://openalex.org/W2077914981","https://openalex.org/W2078604774","https://openalex.org/W2079434650","https://openalex.org/W2079591143","https://openalex.org/W2079605491","https://openalex.org/W2079614648","https://openalex.org/W2079808944","https://openalex.org/W2080985370","https://openalex.org/W2081976043","https://openalex.org/W2086619383","https://openalex.org/W2087962059","https://openalex.org/W2089480413","https://openalex.org/W2090220368","https://openalex.org/W2091340779","https://openalex.org/W2094254201","https://openalex.org/W2094879937","https://openalex.org/W2095963384","https://openalex.org/W2096330673","https://openalex.org/W2097634036","https://openalex.org/W2099299146","https://openalex.org/W2102073771","https://openalex.org/W2102475188","https://openalex.org/W2103023937","https://openalex.org/W2104036878","https://openalex.org/W2106572206","https://openalex.org/W2106787323","https://openalex.org/W2107846985","https://openalex.org/W2111789508","https://openalex.org/W2112392983","https://openalex.org/W2113422684","https://openalex.org/W2114770772","https://openalex.org/W2116488093","https://openalex.org/W2116895128","https://openalex.org/W2118400439","https://openalex.org/W2118745028","https://openalex.org/W2118905557","https://openalex.org/W2121794675","https://openalex.org/W2123242153","https://openalex.org/W2124094791","https://openalex.org/W2124524961","https://openalex.org/W2125472410","https://openalex.org/W2126401328","https://openalex.org/W2126837402","https://openalex.org/W2128635872","https://openalex.org/W2132704642","https://openalex.org/W2134008152","https://openalex.org/W2134184434","https://openalex.org/W2134699561","https://openalex.org/W2135513887","https://openalex.org/W2135657957","https://openalex.org/W2136196488","https://openalex.org/W2136613613","https://openalex.org/W2136700586","https://openalex.org/W2136798908","https://openalex.org/W2138122919","https://openalex.org/W2138597496","https://openalex.org/W2140068099","https://openalex.org/W2140236760","https://openalex.org/W2140443079","https://openalex.org/W2145311089","https://openalex.org/W2146252974","https://openalex.org/W2147036069","https://openalex.org/W2147339968","https://openalex.org/W2147651641","https://openalex.org/W2147874539","https://openalex.org/W2154208846","https://openalex.org/W2154766974","https://openalex.org/W2155794145","https://openalex.org/W2156597720","https://openalex.org/W2157317294","https://openalex.org/W2157607726","https://openalex.org/W2157933551","https://openalex.org/W2158280263","https://openalex.org/W2159298094","https://openalex.org/W2160259836","https://openalex.org/W2160525662","https://openalex.org/W2162085688","https://openalex.org/W2162756556","https://openalex.org/W2166435019","https://openalex.org/W2166601591","https://openalex.org/W2167257317","https://openalex.org/W2168229293","https://openalex.org/W2168298835","https://openalex.org/W2168392848","https://openalex.org/W2168737016","https://openalex.org/W2172018104","https://openalex.org/W2188497247","https://openalex.org/W2301361857","https://openalex.org/W2399475545","https://openalex.org/W2404021914","https://openalex.org/W2406460631","https://openalex.org/W2409693006","https://openalex.org/W4245684785","https://openalex.org/W4294307372","https://openalex.org/W4301042653"],"related_works":["https://openalex.org/W434901022","https://openalex.org/W1504922522","https://openalex.org/W1983672530","https://openalex.org/W2339852765","https://openalex.org/W2760960824","https://openalex.org/W2025054234","https://openalex.org/W2070634758","https://openalex.org/W4232081307","https://openalex.org/W2763321376","https://openalex.org/W2048342707"],"abstract_inverted_index":{"Estrogen-associated":[0],"cancers":[1,60,105],"are":[2,40,391],"a":[3,202,247,337],"leading":[4],"cause":[5],"of":[6,16,38,46,56,66,71,89,109,117,124,137,152,165,174,183,220,237,259,264,274,292,300,314,327,349,399,419],"mortality":[7],"and":[8,13,23,32,48,146,168,193,207,211,241,261,302,311,336,342,380],"morbidity":[9],"in":[10,101,133,144,246,250,267,279,308,324,332,340,345,361,406,411],"U.S.":[11],"men":[12],"women.":[14],"Consumption":[15],"cruciferous":[17,62,110],"vegetables,":[18],"such":[19],"as":[20],"broccoli,":[21,390],"cauliflower":[22],"cabbage,":[24],"is":[25,64,255],"associated":[26],"with":[27,76,93,106],"reduced":[28],"risk":[29,102],"for":[30,103,357,395],"these":[31,375],"other":[33,402],"cancers.":[34],"The":[35,231],"chemoprotective":[36],"properties":[37],"crucifers":[39],"traditionally":[41],"attributed":[42],"to":[43,86,114,181,186,201,217,287,355,370,415],"high":[44],"levels":[45,326],"glucosinolates":[47],"their":[49,364],"bioactive":[50,384,403],"breakdown":[51,79,130,190,386],"products.":[52],"A":[53],"proposed":[54],"mechanism":[55,296],"protection":[57],"against":[58],"estrogen-associated":[59,104],"by":[61],"vegetables":[63,111],"alteration":[65],"estrogen":[67,91],"metabolism":[68,123],"toward":[69],"formation":[70,88,116,136,182],"less":[72],"estrogenic":[73,95],"metabolites.":[74],"Supplementation":[75],"the":[77,98,140,153,187,208,221,262,268,280,289,328,333,358,382,396,407,416,420],"glucosinolate":[78,129,189,330,385],"product":[80],"indole-3-carbinol":[81],"(I3C)":[82],"has":[83,284],"been":[84,214,285],"shown":[85,215,286],"increase":[87,339,360],"2-hydroxyestrogens,":[90],"metabolites":[92],"weak":[94],"activity.":[96],"However,":[97],"observed":[99,359],"reduction":[100],"increased":[107,115,243,325],"consumption":[108],"may":[112,271,297,306,413],"relate":[113],"anticarcinogenic":[118,290],"2-methoxyestrogens":[119],"derived":[120,388],"from":[121,139,389],"further":[122],"2-hydroxyestrogens.":[125],"In":[126,318],"this":[127,177,265,319],"study,":[128,320],"products":[131,191,348,387],"found":[132],"broccoli":[134,196],"enhanced":[135,309],"2-methoxyestradiol":[138],"parent":[141],"compound":[142],"17\u03b2-estradiol":[143],"vitro":[145],"ex":[147],"vivo,":[148],"mainly":[149],"via":[150,172],"upregulation":[151,299],"phase":[154,222],"I":[155],"detoxification":[156,224],"enzyme":[157,225],"cytochrome":[158],"P450":[159],"(CYP)":[160],"1A.":[161],"Broccoli":[162,254],"inhibited":[163,197],"growth":[164,200],"human":[166],"prostate":[167],"ovarian":[169],"cancer":[170,198],"cells":[171],"induction":[173],"apoptosis,":[175],"but":[176,351],"was":[178],"not":[179,352,392],"due":[180],"2-methoxyestradiol.":[184],"Compared":[185],"purified":[188,238],"I3C":[192,379],"sulforaphane":[194],"(SF),":[195],"cell":[199],"greater":[203,276],"extent.":[204],"Both":[205],"SF":[206],"flavonols":[209],"quercetin":[210,240],"kaempferol":[212,242],"have":[213],"individually":[216],"upregulate":[218],"activity":[219,245,368],"II":[223],"NAD(P)H":[226],"dehydrogenase,":[227],"quinone":[228],"1":[229],"(NQO1).":[230],"present":[232,405],"study":[233],"demonstrated":[234],"that":[235,278,378],"combinations":[236],"SF,":[239,381],"NQO1":[244,303,343,367],"synergistic":[248],"manner":[249],"murine":[251],"hepatoma":[252],"cells.":[253],"an":[256],"active":[257],"accumulator":[258],"selenium,":[260,353],"concentration":[263],"mineral":[266],"plant":[269,334],"tissue":[270],"be":[272,298,371],"orders":[273],"magnitude":[275],"than":[277],"soil.":[281],"Selenium":[282],"enrichment":[283,322],"enhance":[288],"property":[291],"broccoli.":[293,400],"An":[294],"underlying":[295],"CYP1A":[301,341,362],"activities,":[304],"which":[305],"result":[307],"inactivation":[310],"subsequent":[312],"excretion":[313],"potentially":[315],"carcinogenic":[316],"compounds.":[317],"selenium":[321],"resulted":[323],"indole":[329],"neoglucobrassicin":[331],"tissue,":[335],"concomitant":[338],"activities":[344],"vitro.":[346],"Breakdown":[347],"neoglucobrassicin,":[350],"appear":[354],"account":[356],"activity;":[363],"effect":[365],"on":[366],"remains":[369],"determined.":[372],"Taken":[373],"together,":[374],"results":[376],"show":[377],"main":[383],"solely":[393],"responsible":[394],"anticancer":[397],"effects":[398],"Rather,":[401],"compounds":[404],"vegetable,":[408],"alone":[409],"or":[410],"combination,":[412],"contribute":[414],"chemopreventive":[417],"potential":[418],"vegetable.":[421]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
