{"id":"https://openalex.org/W40876454","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.6034","title":"Regulation of cytoplasmic and nuclear PTEN levels by human papillomavirus (HPV) type 16 E6 and E7 oncogenes in HPV16+ oropharyngeal cancer cell line","display_name":"Regulation of cytoplasmic and nuclear PTEN levels by human papillomavirus (HPV) type 16 E6 and E7 oncogenes in HPV16+ oropharyngeal cancer cell line","publication_year":2008,"publication_date":"2008-05-20","ids":{"openalex":"https://openalex.org/W40876454","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.6034","mag":"40876454"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2008.26.15_suppl.6034","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.6034","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2008.26.15_suppl.6034","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063134810","display_name":"Amanda K. Psyrri","orcid":"https://orcid.org/0000-0002-4321-766X","observed_orcids":["https://orcid.org/0000-0002-4321-766X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Psyrri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C. Sasaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Sasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023000705","display_name":"Barbara Ann Burtness","orcid":"https://orcid.org/0000-0003-4660-1859","observed_orcids":["https://orcid.org/0000-0003-4660-1859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. A. Burtness","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082993144","display_name":"Theodoros N Rampias","orcid":"https://orcid.org/0000-0002-5460-5334","observed_orcids":["https://orcid.org/0000-0002-5460-5334"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Rampias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"15_suppl","first_page":"6034","last_page":"6034"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.5054000020027161,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.5054000020027161,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.43309998512268066,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpv16-e6","display_name":"HPV16 E6","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hpv16-e7","display_name":"HPV16 E7","score":1.0},{"id":"https://openalex.org/keywords/oropharyngeal-cancer","display_name":"oropharyngeal cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/p53-restoration","display_name":"p53 restoration","score":0.7509999871253967},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/phosphoinositide-3-kinase-akt-pathway","display_name":"phosphoinositide 3-kinase/Akt pathway","score":0.9279999732971191},{"id":"https://openalex.org/keywords/pten-mrna-expression","display_name":"PTEN mRNA expression","score":0.5649999976158142},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9586585760116577},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6593230962753296},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6249822378158569},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6203233599662781},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5966532826423645},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5431953072547913},{"id":"https://openalex.org/C2779549131","wikidata":"https://www.wikidata.org/wiki/Q83167294","display_name":"Tensin","level":5,"score":0.5070784091949463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49300524592399597},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4856473207473755},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.45914411544799805},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4560537040233612},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4234398603439331},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3723366856575012},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3241253197193146},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.31852591037750244},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2361193299293518},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19830527901649475},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18345269560813904},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05142220854759216},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.05139806866645813}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2008.26.15_suppl.6034","doi":"https://doi.org/10.1200/jco.2008.26.15_suppl.6034","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2008.26.15_suppl.6034","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2103493548","https://openalex.org/W2248319852","https://openalex.org/W2039922925","https://openalex.org/W2082145882","https://openalex.org/W2275892562","https://openalex.org/W2037296279","https://openalex.org/W1991889173","https://openalex.org/W1987987555","https://openalex.org/W2522650226","https://openalex.org/W2001830249"],"abstract_inverted_index":{"6034":[0],"Background:":[1],"We":[2,69,240],"have":[3],"previously":[4],"shown":[5],"that":[6,43,228,243,287,317],"repression":[7,293],"of":[8,28,75,84,145,180,191,205,220,255,299,304],"HPV":[9,76,100],"type":[10,101],"16":[11,102],"E6":[12,77,103,121],"and":[13,31,78,104,119,122,135,140,148,153,158,182,193,249,257,277,309],"E7":[14,79,105,123],"genes":[15,106],"using":[16],"short":[17],"hairpin":[18,97],"RNAs":[19,98],"to":[20,71,112,174,177,329],"HPV16+":[21,91,113,263],"oropharyngeal":[22,92,114],"cancer":[23,93,115,265],"cells":[24],"results":[25],"in":[26,62,81,90,156,216,253,262],"restoration":[27,298],"cellular":[29,39,297],"p53":[30,139,300],"pRb":[32],"tumor":[33,40,86],"suppressor":[34,41,87],"pathways.":[35],"PTEN":[36,58,85,149,183,195,206,229,259,268,288,307,318],"is":[37,59,285,294,312],"a":[38,46,214],"protein":[42,88,143,189,207,260,276,289],"functions":[44],"as":[45],"plasma":[47],"membrane":[48],"lipid":[49],"phosphatase":[50],"antagonizing":[51],"the":[52,66,73,82,217,244,275,280],"phosphoinositide":[53],"3-kinase/AKT":[54],"cell":[55,63,116,161,266],"survival":[56],"pathway.":[57],"also":[60,172,320],"found":[61],"nuclei":[64],"maintaining":[65],"chromosomal":[67],"stability.":[68],"sought":[70],"investigate":[72],"role":[74],"oncogenes":[80],"regulation":[83],"levels":[89,144,190,231,261],"cells.":[94],"Methods:":[95],"Short":[96],"targeting":[99],"were":[107,150,196,232],"delivered":[108],"by":[109,128,163],"retrovirus":[110],"infection":[111],"lines":[117,162],"147T":[118,157],"090.":[120],"mRNA":[124,178,230,281],"downregulation":[125,254,308],"was":[126,171,210],"assessed":[127],"quantitative":[129],"reverse":[130],"transcription":[131],"polymerase":[132],"chain":[133],"reaction":[134],"western":[136,164],"blotting":[137],"for":[138],"Rb.":[141],"The":[142,188,203,302],"AKT,":[146],"pAKT":[147],"analyzed":[151],"before":[152],"after":[154,184,199,208,236,270,291],"silencing":[155,209,272],"090":[159],"oropharygeal":[160,264],"blotting.":[165],"Quantitative":[166,222],"real":[167,223],"time":[168,224],"RT-PCR":[169,225],"analysis":[170,226],"used":[173],"detect":[175],"changes":[176],"expression":[179],"AKT":[181,310],"E6/E7":[185,200,237,271,292],"repression.":[186,238],"Results:":[187],"cytoplasmic":[192,256],"nuclear":[194,258],"significantly":[197,234],"upregulated":[198,235],"gene":[201],"silencing.":[202],"upregulation":[204,269],"not":[211,233,278],"associated":[212,295],"with":[213,296,314],"change":[215],"phosphorylated":[218],"status":[219],"AKT.":[221],"showed":[227],"Conclusions:":[239],"provide":[241],"evidence":[242],"principal":[245],"HPV16":[246],"oncoproteins":[247],"(E6":[248],"E7)":[250],"are":[251],"involved":[252],"lines.":[267],"occurs":[273,321],"at":[274,279],"level.":[282],"Thus,":[283],"it":[284],"possible":[286],"stabilization":[290],"protein.":[301],"lack":[303],"correlation":[305],"between":[306],"activation":[311],"consistent":[313],"data":[315],"showing":[316],"tumorigenesis":[319],"via":[322],"AKT-independent":[323],"mechanisms.":[324],"No":[325],"significant":[326],"financial":[327],"relationships":[328],"disclose.":[330]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
