{"id":"https://openalex.org/W4087442","doi":null,"title":"Distinct overexpression of Fas ligand on T lymphocytes in aplastic anemia.","display_name":"Distinct overexpression of Fas ligand on T lymphocytes in aplastic anemia.","publication_year":2004,"publication_date":"2004-04-01","ids":{"openalex":"https://openalex.org/W4087442","mag":"4087442","pmid":"https://pubmed.ncbi.nlm.nih.gov/16212902"},"language":"en","primary_location":{"id":"pmid:16212902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16212902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular & molecular immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100397202","display_name":"Wenxin Li","orcid":"https://orcid.org/0000-0001-6660-477X","observed_orcids":["https://orcid.org/0000-0001-6660-477X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenxin Li","raw_affiliation_strings":["Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047368627","display_name":"Jinxiang Fu","orcid":"https://orcid.org/0000-0001-8709-9290","observed_orcids":["https://orcid.org/0000-0001-8709-9290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinxiang Fu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064214589","display_name":"Wang Fengming","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fengming Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100972886","display_name":"Gehua Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gehua Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100604633","display_name":"Yong Wang","orcid":"https://orcid.org/0000-0003-0989-9764","observed_orcids":["https://orcid.org/0000-0003-0989-9764"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5115588092","display_name":"Xueguang Zhang","orcid":"https://orcid.org/0000-0002-3519-4277","observed_orcids":["https://orcid.org/0000-0002-3519-4277","https://orcid.org/0000-0002-8322-1073"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xueguang Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.00026619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"1","issue":"2","first_page":"142","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.14319999516010284,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.05810000002384186,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.9359999895095825},{"id":"https://openalex.org/keywords/aplastic-anemia","display_name":"aplastic anemia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/fas-fasl-system","display_name":"Fas/FasL system","score":0.671999990940094},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6169999837875366},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.6359999775886536},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7099999785423279},{"id":"https://openalex.org/keywords/pancytopenia","display_name":"pancytopenia","score":0.7929999828338623},{"id":"https://openalex.org/keywords/phytohemagglutinin-stimulation","display_name":"phytohemagglutinin stimulation","score":0.9240000247955322}],"concepts":[{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.9522659182548523},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.6634779572486877},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5184111595153809},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.4947778582572937},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4859958589076996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48026227951049805},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.47978073358535767},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.46312081813812256},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43401777744293213},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.42810988426208496},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3870738446712494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3475881516933441},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.21911191940307617},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.20388999581336975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1729639768600464},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.14519912004470825},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.12687912583351135}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000741","descriptor_name":"Anemia, Aplastic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010835","descriptor_name":"Phytohemagglutinins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048069","descriptor_name":"Tumor Necrosis Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048069","descriptor_name":"Tumor Necrosis Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053222","descriptor_name":"Fas Ligand Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:16212902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16212902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular & molecular immunology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.517.1091","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.517.1091","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cmi.ustc.edu.cn/1/2/142.pdf","raw_type":"text"},{"id":"mag:2273143250","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/87787X/200402/9686601.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541443","display_name":"\u4e2d\u56fd\u514d\u75ab\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u514d\u75ab\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null},{"id":"mag:4087442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16212902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W127851043","https://openalex.org/W321209973","https://openalex.org/W1561516029","https://openalex.org/W1567676800","https://openalex.org/W1615638781","https://openalex.org/W1642763135","https://openalex.org/W1889489351","https://openalex.org/W1969275768","https://openalex.org/W1970022901","https://openalex.org/W1978873196","https://openalex.org/W1993256311","https://openalex.org/W2029158188","https://openalex.org/W2032463909","https://openalex.org/W2052300492","https://openalex.org/W2054369619","https://openalex.org/W2064632541","https://openalex.org/W2078035670","https://openalex.org/W2115871172","https://openalex.org/W2127993518","https://openalex.org/W2141080152","https://openalex.org/W2166787386","https://openalex.org/W3134477994","https://openalex.org/W3146127625","https://openalex.org/W4246372926"],"related_works":["https://openalex.org/W2381839253","https://openalex.org/W1982793898","https://openalex.org/W2392326674","https://openalex.org/W2371731814","https://openalex.org/W155287138","https://openalex.org/W2017975318","https://openalex.org/W1970022901","https://openalex.org/W2129099628","https://openalex.org/W2368797253","https://openalex.org/W2351187989"],"abstract_inverted_index":{"Increased":[0],"expression":[1],"of":[2,24,76,83,164,171,205],"Fas":[3],"by":[4,92,117,130,169],"hematopoietic":[5,206],"progenitors":[6],"in":[7,21,122,182,208],"aplastic":[8],"anemia":[9],"(AA)":[10],"suggests":[11],"that":[12,68,157,198],"Fas/Fas":[13],"ligand":[14],"(FasL)":[15],"system":[16],"plays":[17],"a":[18,123,162],"key":[19],"role":[20],"the":[22,30,100,147,196,203],"formation":[23],"severe":[25],"pancytopenia.":[26],"To":[27],"further":[28,191],"confirm":[29],"above":[31,133],"hypothesis,":[32],"T":[33,57,62,70,103,140,152,159,166,199],"cells":[34,58,71,104,200],"from":[35,99],"8":[36],"patients":[37],"with":[38,54],"AA":[39,69,102,158,209],"were":[40],"systematically":[41],"studied":[42],"for":[43,195],"their":[44],"FasL's":[45],"distribution":[46],"pattern,":[47],"releasing":[48],"manner":[49],"and":[50,59,79,192],"proapoptotic":[51],"activity,":[52],"compared":[53],"normal":[55,150],"resting":[56,151],"artificially":[60,138],"activated":[61,139],"cell":[63,141,160],"blasts.":[64],"The":[65,97,132],"results":[66,155],"demonstrated":[67],"abnormally":[72],"expressed":[73],"low":[74],"levels":[75,82],"membrane-bound":[77],"FasL":[78,85,121,175],"contained":[80],"high":[81],"intracellular":[84,174],"which":[86,112,176],"could":[87,113],"be":[88,114,178],"triggered":[89],"to":[90,180],"release":[91,181],"high-dose":[93],"phytohemagglutinin":[94],"(PHA)":[95],"pulse-stimulation.":[96],"supernatants":[98],"PHA-stimulated":[101],"had":[105],"apparent":[106],"cytotoxicity":[107],"against":[108,120],"FasL-sensitive":[109],"Jurkat":[110],"cells,":[111],"significantly":[115],"inhibited":[116],"monoclonal":[118],"antibody":[119],"dose-dependent":[124],"manner,":[125],"or":[126],"nearly":[127],"completely":[128],"abrogated":[129],"ultracentrifugation.":[131],"phenomena":[134],"also":[135],"appeared":[136],"on":[137,149],"blasts,":[142],"but":[143],"this":[144],"was":[145],"not":[146],"case":[148],"cells.":[153],"These":[154],"indicate":[156],"is":[161],"type":[163],"\"preactivated\"":[165],"lymphocyte,":[167],"characterized":[168],"overexpression":[170],"FasL,":[172],"especially":[173],"can":[177],"stimulated":[179],"bioactive":[183],"exosomes-bound":[184],"form.":[185],"Taken":[186],"together,":[187],"our":[188],"data":[189],"provide":[190],"direct":[193],"evidence":[194],"hypothesis":[197],"might":[201],"mediate":[202],"destruction":[204],"progenitor":[207],"through":[210],"Fas/FasL":[211],"system.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}