{"id":"https://openalex.org/W4086978","doi":null,"title":"Prostanoid receptor gene expression profile in human trabecular meshwork: a quantitative real-time PCR approach.","display_name":"Prostanoid receptor gene expression profile in human trabecular meshwork: a quantitative real-time PCR approach.","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W4086978","mag":"4086978","pmid":"https://pubmed.ncbi.nlm.nih.gov/11726624"},"language":"en","primary_location":{"id":"pmid:11726624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11726624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090136803","display_name":"Willem Kamphuis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Kamphuis","raw_affiliation_strings":["Glaucoma Research Group, Netherlands Ophthalmic Research Institute (NORI)-KNAW, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands. w.kamphuis@ioi.knaw.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaucoma Research Group, Netherlands Ophthalmic Research Institute (NORI)-KNAW, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands. w.kamphuis@ioi.knaw.nl","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017519493","display_name":"Andrea Schneemann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Schneemann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077396417","display_name":"L. M van Beek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L M van Beek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012301628","display_name":"Anne-Marie Smit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A B Smit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113480400","display_name":"Ph F. J. Hoyng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P F Hoyng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037127206","display_name":"Eisuke Koya","orcid":"https://orcid.org/0000-0002-5039-4875","observed_orcids":["https://orcid.org/0000-0002-5039-4875"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Koya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4246,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.91364224,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"42","issue":"13","first_page":"3209","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostanoid-receptors","display_name":"prostanoid receptors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/trabecular-meshwork","display_name":"trabecular meshwork","score":0.9049999713897705},{"id":"https://openalex.org/keywords/thromboxane-a2-receptor","display_name":"thromboxane A2 receptor","score":0.7179999947547913},{"id":"https://openalex.org/keywords/gene-expression-profiles","display_name":"gene expression profiles","score":0.656000018119812},{"id":"https://openalex.org/keywords/aqueous-humor-outflow","display_name":"aqueous humor outflow","score":0.9570000171661377},{"id":"https://openalex.org/keywords/schlemm-s-canal","display_name":"Schlemm's canal","score":0.9100000262260437},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7646474838256836},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.7047970294952393},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6833982467651367},{"id":"https://openalex.org/C2781121420","wikidata":"https://www.wikidata.org/wiki/Q750873","display_name":"Trabecular meshwork","level":3,"score":0.6555520296096802},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5935167670249939},{"id":"https://openalex.org/C33922130","wikidata":"https://www.wikidata.org/wiki/Q419232","display_name":"Housekeeping gene","level":4,"score":0.5831688046455383},{"id":"https://openalex.org/C2778266237","wikidata":"https://www.wikidata.org/wiki/Q962217","display_name":"Prostanoid","level":3,"score":0.5184130668640137},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4752117097377777},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.475147008895874},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.47466662526130676},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.46661511063575745},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45286697149276733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4224078357219696},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13900884985923767},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.10642710328102112},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014129","descriptor_name":"Trabecular Meshwork","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:11726624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11726624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:research.vu.nl:openaire_cris_publications/bfd2bf39-6b6a-472c-86a1-812041e0c9d8","doi":null,"is_oa":false,"landing_page_url":"https://research.vu.nl/en/publications/bfd2bf39-6b6a-472c-86a1-812041e0c9d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kamphuis, W, Schneemann, A, van Beek, J L, Smit, A B, Hoying, P F J & Koya, E 2001, 'Prostanoid receptor gene expression profile in human trabecular meshwork: A quantitative real-time PCR approach', Investigative Ophthalmology and Visual Science, vol. 42, no. 13, pp. 3209-3215.","raw_type":"article"},{"id":"pmh:vu:oai:research.vu.nl:publications/bfd2bf39-6b6a-472c-86a1-812041e0c9d8","doi":null,"is_oa":false,"landing_page_url":"https://research.vu.nl/en/publications/bfd2bf39-6b6a-472c-86a1-812041e0c9d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology and Visual Science, 42(13), 3209 - 3215. Association for Research in Vision and Ophthalmology","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:4086978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11726624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W37810882","https://openalex.org/W44351291","https://openalex.org/W45784375","https://openalex.org/W92602395","https://openalex.org/W128639338","https://openalex.org/W179828428","https://openalex.org/W289288819","https://openalex.org/W1497273958","https://openalex.org/W1501759973","https://openalex.org/W1510431736","https://openalex.org/W1542216122","https://openalex.org/W1563367972","https://openalex.org/W1754684850","https://openalex.org/W1967556106","https://openalex.org/W1971695370","https://openalex.org/W1976386525","https://openalex.org/W1997664154","https://openalex.org/W2022974805","https://openalex.org/W2028098651","https://openalex.org/W2038407307","https://openalex.org/W2041009121","https://openalex.org/W2047289728","https://openalex.org/W2050970383","https://openalex.org/W2056335999","https://openalex.org/W2056625902","https://openalex.org/W2059166883","https://openalex.org/W2064673207","https://openalex.org/W2079202995","https://openalex.org/W2111057887","https://openalex.org/W2118533330","https://openalex.org/W2125107554","https://openalex.org/W2129746956","https://openalex.org/W2143146123","https://openalex.org/W2258579859","https://openalex.org/W2313993513","https://openalex.org/W2400800535"],"related_works":["https://openalex.org/W1502766931","https://openalex.org/W2058550672","https://openalex.org/W2028098651","https://openalex.org/W1481697305","https://openalex.org/W2070340855","https://openalex.org/W102115212","https://openalex.org/W1157974692","https://openalex.org/W2059166883","https://openalex.org/W2460720372","https://openalex.org/W2109459807"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"assess":[2],"the":[3,29,38,76,119,124,147,155,189,193,206,214,224,227,240,256,261],"expression":[4,110,191],"pattern":[5],"of":[6,14,78,146,192,205,226,232],"prostanoid":[7,177,250],"receptor-encoding":[8,98,121],"genes":[9,87],"in":[10,43,115,123,184,216,221],"trabecular":[11],"meshwork":[12],"(TM)":[13],"human":[15,20,185],"donor":[16,21],"eyes.":[17],"METHODS:":[18],"Disposed":[19],"eyes":[22],"(n":[23],"=":[24],"10)":[25],"were":[26,100,137,153],"obtained":[27],"from":[28,37],"Cornea":[30],"Bank,":[31],"Amsterdam.":[32],"The":[33,51,108],"TM":[34,186,262],"was":[35,49,53,112],"dissected":[36],"scleral":[39],"tissue":[40],"and":[41,46,57,88,96,102,132,151,164,218,263],"homogenized":[42],"lysis":[44],"buffer,":[45],"total":[47],"RNA":[48,52],"isolated.":[50],"converted":[54],"into":[55],"cDNA":[56],"used":[58],"as":[59],"a":[60],"template":[61],"for":[62,84,104],"noncompetitive":[63],"quantitative":[64],"real-time":[65],"polymerase":[66],"chain":[67],"reaction":[68],"(PCR)":[69],"using":[70],"green":[71],"fluorescent":[72],"dye":[73],"to":[74,140,223,254],"quantify":[75],"accumulation":[77],"double-stranded":[79],"PCR":[80],"product.":[81],"Specific":[82],"primers":[83],"four":[85],"housekeeping":[86],"DP,":[89],"EP(1),":[90],"EP(2),":[91,169],"EP(3,)":[92],"EP(4),":[93],"FP,":[94,129],"IP,":[95,131],"TP":[97],"transcripts":[99],"developed":[101],"tested":[103],"their":[105],"efficiency.":[106],"RESULTS:":[107],"characterized":[109],"profile":[111],"highly":[113],"reproducible":[114],"all":[116,176],"samples,":[117],"with":[118],"EP(2)":[120,148,194,241],"transcript":[122],"highest":[125],"abundance,":[126],"followed":[127],"by":[128,230,239],"TP,":[130],"EP(4)":[133,207],"at":[134,154,181],"levels":[135,183,220],"that":[136,145,175,204,213],"approximately":[138],"10":[139],"15":[141,199],"times":[142,163,166,200],"lower":[143,167],"than":[144,168,203],"subtype.":[149],"DP":[150],"EP(3)":[152],"lowest":[156],"levels,":[157],"which":[158],"were,":[159],"on":[160,197],"average,":[161,198],"45":[162],"228":[165],"respectively.":[170],"CONCLUSIONS:":[171],"These":[172,243],"data":[173,244],"show":[174],"receptors":[178,229],"are":[179],"expressed":[180],"different":[182],"tissue.":[187],"Because":[188],"gene":[190],"receptor":[195,251],"is,":[196],"more":[201],"abundant":[202],"receptor,":[208],"it":[209],"may":[210],"be":[211,246],"expected":[212],"increase":[215],"flow":[217],"cAMP":[219],"response":[222],"activation":[225],"EP":[228],"application":[231],"prostaglandin":[233],"E(1)":[234],"(PGE(1)),":[235],"is":[236],"primarily":[237],"mediated":[238],"receptor.":[242],"should":[245],"considered":[247],"when":[248],"designing":[249],"mimetics":[252],"intended":[253],"enhance":[255],"aqueous":[257],"humor":[258],"outflow":[259],"through":[260],"Schlemm's":[264],"canal.":[265]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
