{"id":"https://openalex.org/W40622382","doi":null,"title":"Coexpression of type I and type II human macrophage scavenger receptors in macrophages of various organs and foam cells in atherosclerotic lesions.","display_name":"Coexpression of type I and type II human macrophage scavenger receptors in macrophages of various organs and foam cells in atherosclerotic lesions.","publication_year":1992,"publication_date":"1992-09-01","ids":{"openalex":"https://openalex.org/W40622382","mag":"40622382","pmid":"https://pubmed.ncbi.nlm.nih.gov/1519666","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886699"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886699","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886699","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886699","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056132715","display_name":"Makoto Naito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Naito","raw_affiliation_strings":["Second Department of Pathology, Kumamoto University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Pathology, Kumamoto University Medical School, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Suzuki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Suzuki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Mori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Mori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Matsumoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Matsumoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107007603","display_name":"Tatsuhiko Kodama","orcid":"https://orcid.org/0000-0003-3747-7956","observed_orcids":["https://orcid.org/0000-0003-3747-7956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kodama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001798874","display_name":"Ken I. Takahashi","orcid":"https://orcid.org/0000-0003-3670-2939","observed_orcids":["https://orcid.org/0000-0003-3670-2939","https://orcid.org/0000-0001-6533-0228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Takahashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3382,"has_fulltext":false,"cited_by_count":140,"citation_normalized_percentile":{"value":0.93474895,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"141","issue":"3","first_page":"591","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-scavenger-receptor","display_name":"macrophage scavenger receptor","score":0.9539999961853027},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/foam-cells","display_name":"foam cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/fatty-streaks","display_name":"fatty streaks","score":0.906000018119812},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cholesterol-deposition","display_name":"cholesterol deposition","score":0.6949999928474426},{"id":"https://openalex.org/keywords/endosomes","display_name":"endosomes","score":0.7710000276565552},{"id":"https://openalex.org/keywords/receptor-coexpression","display_name":"receptor co-expression","score":0.7820000052452087},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C41443022","wikidata":"https://www.wikidata.org/wiki/Q27796666","display_name":"Scavenger receptor","level":4,"score":0.9582977294921875},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.808200478553772},{"id":"https://openalex.org/C2776205754","wikidata":"https://www.wikidata.org/wiki/Q6750945","display_name":"Mannose receptor","level":4,"score":0.6771576404571533},{"id":"https://openalex.org/C2777895019","wikidata":"https://www.wikidata.org/wiki/Q1425962","display_name":"Foam cell","level":4,"score":0.6157652139663696},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6078116297721863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5756415724754333},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4971518814563751},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4561946988105774},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44960644841194153},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.43078261613845825},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2837327718734741},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25006359815597534},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.21282657980918884},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.19148308038711548},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07499176263809204}],"mesh":[{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005487","descriptor_name":"Foam Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016253","descriptor_name":"Microscopy, Immunoelectron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019038","descriptor_name":"Platelet Glycoprotein GPIb-IX Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051117","descriptor_name":"Scavenger Receptors, Class A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1886699","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886699","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:1519666","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1519666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:40622382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1519666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886699","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886699","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W105501348","https://openalex.org/W130410760","https://openalex.org/W165426504","https://openalex.org/W295866172","https://openalex.org/W1535615765","https://openalex.org/W1857052429","https://openalex.org/W1939864570","https://openalex.org/W1974790290","https://openalex.org/W2024352183","https://openalex.org/W2037599912","https://openalex.org/W2038484123","https://openalex.org/W2040550208","https://openalex.org/W2049401036","https://openalex.org/W2050795431","https://openalex.org/W2055184058","https://openalex.org/W2058060182","https://openalex.org/W2063813098","https://openalex.org/W2064244952","https://openalex.org/W2065790541","https://openalex.org/W2095160367","https://openalex.org/W2162458714","https://openalex.org/W2269289618","https://openalex.org/W2402153245"],"related_works":["https://openalex.org/W2058060182","https://openalex.org/W2001112073","https://openalex.org/W2004687242","https://openalex.org/W2095266423","https://openalex.org/W2079404954","https://openalex.org/W7096977335","https://openalex.org/W2022865224","https://openalex.org/W2135364407","https://openalex.org/W7207993803","https://openalex.org/W2158789950"],"abstract_inverted_index":{"Macrophage":[0],"scavenger":[1,48,131],"receptors":[2,26,132],"are":[3,133],"trimeric":[4],"membrane":[5,116],"glycoproteins":[6],"implicated":[7],"in":[8,14,75,78,85,99,119,138],"the":[9,38,43,90,107,112,115],"pathologic":[10,141],"deposition":[11],"of":[12,21,40,81,89,93,101,106,117],"cholesterol":[13],"arterial":[15],"walls":[16],"during":[17],"atherogenesis.":[18],"Two":[19],"types":[20,92,105],"cDNAs":[22],"for":[23],"functional":[24],"human":[25],"have":[27],"been":[28],"cloned,":[29],"but":[30],"their":[31],"physiologic":[32,139],"roles":[33],"remain":[34],"obscure.":[35],"To":[36],"study":[37],"expression":[39],"these":[41,56],"receptors,":[42],"authors":[44],"generated":[45],"antibodies":[46,57,62],"against":[47],"receptor":[49,61,70,94],"type-specific":[50],"synthetic":[51],"peptide.":[52],"Immunohistochemical":[53],"examination":[54],"using":[55],"and":[58,67,114,128,135,140],"other":[59],"anti-human":[60],"shows":[63],"that":[64,124],"type":[65,68,126,129],"I":[66,127],"II":[69,130],"proteins":[71],"can":[72],"be":[73],"detected":[74,98,110],"foam":[76],"cells":[77],"various":[79,102],"stages":[80],"atherosclerosis,":[82],"most":[83],"evidently":[84],"fatty":[86],"streaks.":[87],"Co-expression":[88],"two":[91],"protein":[95,108],"was":[96],"also":[97],"macrophages":[100],"organs.":[103],"Both":[104],"were":[109],"on":[111],"surface":[113],"endosomes":[118],"macrophages.":[120],"These":[121],"results":[122],"indicate":[123],"both":[125],"expressed":[134],"functionally":[136],"active":[137],"conditions.":[142]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}