{"id":"https://openalex.org/W405815093","doi":null,"title":"Folate Nutrition In Human Skin: Implications For Cancer Prevention","display_name":"Folate Nutrition In Human Skin: Implications For Cancer Prevention","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W405815093","mag":"405815093"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/195167","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/195167","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044838343","display_name":"Joshua D. Williams","orcid":"https://orcid.org/0000-0002-3462-0158","observed_orcids":["https://orcid.org/0000-0002-3462-0158"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joshua D. Williams","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3462-0158","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044838343"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-skin","display_name":"human skin","score":0.8169999718666077},{"id":"https://openalex.org/keywords/skin-cancer-prevention","display_name":"skin cancer prevention","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/folate-deficiency","display_name":"folate deficiency","score":0.9660000205039978},{"id":"https://openalex.org/keywords/folate-degradation","display_name":"folate degradation","score":0.925000011920929},{"id":"https://openalex.org/keywords/folic-acid-supplementation","display_name":"folic acid supplementation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8259999752044678},{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.8479999899864197},{"id":"https://openalex.org/keywords/uracil-misincorporation","display_name":"uracil misincorporation","score":0.984000027179718},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5051901936531067},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5049765706062317},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.4435592293739319},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.4287271201610565},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15887364745140076}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/195167","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/195167","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:405815093","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/195167","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":207,"referenced_works":["https://openalex.org/W36624856","https://openalex.org/W42797104","https://openalex.org/W100528328","https://openalex.org/W117048748","https://openalex.org/W143330005","https://openalex.org/W198012563","https://openalex.org/W1497616291","https://openalex.org/W1513564968","https://openalex.org/W1515990224","https://openalex.org/W1539234395","https://openalex.org/W1552354790","https://openalex.org/W1564732968","https://openalex.org/W1565425041","https://openalex.org/W1565839821","https://openalex.org/W1581455991","https://openalex.org/W1589372977","https://openalex.org/W1604877397","https://openalex.org/W1605154757","https://openalex.org/W1656308601","https://openalex.org/W1838116823","https://openalex.org/W1841577196","https://openalex.org/W1846108463","https://openalex.org/W1853068488","https://openalex.org/W1872501262","https://openalex.org/W1904895329","https://openalex.org/W1919851123","https://openalex.org/W1960649918","https://openalex.org/W1961807673","https://openalex.org/W1964175376","https://openalex.org/W1964388566","https://openalex.org/W1965256036","https://openalex.org/W1967629365","https://openalex.org/W1969383125","https://openalex.org/W1971470223","https://openalex.org/W1971683155","https://openalex.org/W1972024904","https://openalex.org/W1976104819","https://openalex.org/W1979276428","https://openalex.org/W1981487444","https://openalex.org/W1982597283","https://openalex.org/W1983204623","https://openalex.org/W1983768725","https://openalex.org/W1983797787","https://openalex.org/W1985158717","https://openalex.org/W1985228353","https://openalex.org/W1985447236","https://openalex.org/W1985463131","https://openalex.org/W1985734471","https://openalex.org/W1985975702","https://openalex.org/W1986404752","https://openalex.org/W1986643596","https://openalex.org/W1986795920","https://openalex.org/W1987821354","https://openalex.org/W1988104611","https://openalex.org/W1988505861","https://openalex.org/W1988760590","https://openalex.org/W1992768845","https://openalex.org/W1999732266","https://openalex.org/W2003775843","https://openalex.org/W2003896768","https://openalex.org/W2005029249","https://openalex.org/W2005202534","https://openalex.org/W2006044879","https://openalex.org/W2006901345","https://openalex.org/W2007779552","https://openalex.org/W2008893599","https://openalex.org/W2008991190","https://openalex.org/W2010011130","https://openalex.org/W2011834328","https://openalex.org/W2015333781","https://openalex.org/W2018200333","https://openalex.org/W2020842094","https://openalex.org/W2027523943","https://openalex.org/W2030301615","https://openalex.org/W2035010751","https://openalex.org/W2035029439","https://openalex.org/W2036009794","https://openalex.org/W2036810287","https://openalex.org/W2036956155","https://openalex.org/W2039850131","https://openalex.org/W2041172237","https://openalex.org/W2042590400","https://openalex.org/W2042912904","https://openalex.org/W2043990654","https://openalex.org/W2046251366","https://openalex.org/W2051359919","https://openalex.org/W2053362484","https://openalex.org/W2053558823","https://openalex.org/W2054083814","https://openalex.org/W2055602534","https://openalex.org/W2056167765","https://openalex.org/W2058058614","https://openalex.org/W2059841058","https://openalex.org/W2059959643","https://openalex.org/W2060459188","https://openalex.org/W2062118620","https://openalex.org/W2063073228","https://openalex.org/W2063450593","https://openalex.org/W2064372980","https://openalex.org/W2065243562","https://openalex.org/W2066542880","https://openalex.org/W2067894172","https://openalex.org/W2067947422","https://openalex.org/W2068944232","https://openalex.org/W2069007939","https://openalex.org/W2071921882","https://openalex.org/W2073142030","https://openalex.org/W2073235279","https://openalex.org/W2073471880","https://openalex.org/W2074106591","https://openalex.org/W2074137845","https://openalex.org/W2076098889","https://openalex.org/W2078636121","https://openalex.org/W2079615960","https://openalex.org/W2080156186","https://openalex.org/W2081078216","https://openalex.org/W2081265985","https://openalex.org/W2083607134","https://openalex.org/W2083791611","https://openalex.org/W2084201616","https://openalex.org/W2084702387","https://openalex.org/W2085164570","https://openalex.org/W2085363005","https://openalex.org/W2085780393","https://openalex.org/W2087355759","https://openalex.org/W2090811567","https://openalex.org/W2091307455","https://openalex.org/W2092410657","https://openalex.org/W2092629964","https://openalex.org/W2093273285","https://openalex.org/W2094505351","https://openalex.org/W2095243203","https://openalex.org/W2095559553","https://openalex.org/W2095892417","https://openalex.org/W2096207257","https://openalex.org/W2097778420","https://openalex.org/W2098022635","https://openalex.org/W2099614709","https://openalex.org/W2100561376","https://openalex.org/W2100946491","https://openalex.org/W2101259585","https://openalex.org/W2101741084","https://openalex.org/W2102368871","https://openalex.org/W2103085707","https://openalex.org/W2104885191","https://openalex.org/W2105806351","https://openalex.org/W2107772901","https://openalex.org/W2108225402","https://openalex.org/W2108640565","https://openalex.org/W2109544293","https://openalex.org/W2110822325","https://openalex.org/W2112288850","https://openalex.org/W2113665122","https://openalex.org/W2114181787","https://openalex.org/W2114600768","https://openalex.org/W2114758163","https://openalex.org/W2115135910","https://openalex.org/W2118205902","https://openalex.org/W2118937700","https://openalex.org/W2119391957","https://openalex.org/W2120518693","https://openalex.org/W2121099849","https://openalex.org/W2122287106","https://openalex.org/W2122843121","https://openalex.org/W2123411656","https://openalex.org/W2125809877","https://openalex.org/W2125872031","https://openalex.org/W2127426062","https://openalex.org/W2127935571","https://openalex.org/W2128481501","https://openalex.org/W2130097072","https://openalex.org/W2134159453","https://openalex.org/W2134693324","https://openalex.org/W2134947521","https://openalex.org/W2136125035","https://openalex.org/W2136865578","https://openalex.org/W2140203288","https://openalex.org/W2141011149","https://openalex.org/W2142544310","https://openalex.org/W2143464311","https://openalex.org/W2145121588","https://openalex.org/W2146016400","https://openalex.org/W2149508506","https://openalex.org/W2150555170","https://openalex.org/W2150763392","https://openalex.org/W2151595202","https://openalex.org/W2151965640","https://openalex.org/W2156154580","https://openalex.org/W2158294624","https://openalex.org/W2161649724","https://openalex.org/W2161927091","https://openalex.org/W2162463371","https://openalex.org/W2164079972","https://openalex.org/W2166353874","https://openalex.org/W2166775467","https://openalex.org/W2168284337","https://openalex.org/W2171654958","https://openalex.org/W2176671673","https://openalex.org/W2184391500","https://openalex.org/W2218713096","https://openalex.org/W2236805842","https://openalex.org/W2266990620","https://openalex.org/W2287326366","https://openalex.org/W2290815490","https://openalex.org/W2323783182","https://openalex.org/W2328999771","https://openalex.org/W2418387125"],"related_works":["https://openalex.org/W2024014605","https://openalex.org/W1802482190","https://openalex.org/W1529404138","https://openalex.org/W1907675431","https://openalex.org/W7095926521","https://openalex.org/W2207149705","https://openalex.org/W3120022184","https://openalex.org/W3170995282","https://openalex.org/W3170465845","https://openalex.org/W1495178179"],"abstract_inverted_index":{"The":[0,20,291],"folates":[1],"are":[2,95,219,228,238,283,289],"a":[3,80,134,346],"family":[4],"of":[5,23,43,54,77,101,118,140,194,203,330,340],"structurally":[6],"similar,":[7],"water-soluble,":[8],"B":[9],"vitamins,":[10],"documented":[11],"to":[12,51,67,99,121,126,157,173,182,230,242,257,305],"play":[13],"prominently":[14],"in":[15,74,187,216,245,252,278,320,333],"human":[16,150,188,226,253,321,334],"health":[17],"and":[18,32,56,85,116,129,165,198,206,221,240,276,301,309,336],"disease.":[19],"potential":[21,259],"impact":[22],"folate":[24,38,86,93,127,131,147,159,176,185,208,214,233,248,286,299,318,331,341],"nutrition":[25,148,160,332,342],"has":[26,87],"been":[27],"demonstrated":[28,212],"by":[29,97],"large-scale":[30],"epidemiological":[31],"nutritional":[33],"studies":[34,90],"indicating":[35],"that":[36,60,92,111,130,213,338],"decreased":[37],"intake":[39],"increases":[40],"the":[41,52,68,75,105,112,138,192,295],"risk":[42,63],"cancer":[44,62,308,347],"development.":[45],"Human":[46],"skin":[47,61,119,123,141,151,196,217,307,335],"is":[48,58,109,133,211,255],"particularly":[49],"prone":[50,125],"development":[53],"carcinomas":[55],"it":[57],"established":[59],"correlates":[64],"with":[65],"exposure":[66,98,241],"complete":[69],"carcinogen":[70],"ultraviolet":[71],"radiation":[72],"(UVR)":[73],"form":[76],"sunlight.":[78],"Recently":[79],"link":[81],"between":[82,297],"skin,":[83],"sunlight,":[84],"emerged":[88],"from":[89],"demonstrating":[91],"species":[94,186,300],"degraded":[96],"wavelengths":[100],"UVR":[102,243],"contained":[103],"within":[104,149],"solar":[106],"spectrum.":[107],"It":[108,210],"hypothesized":[110],"unique":[113],"physiology,":[114],"function,":[115],"environment":[117],"combine":[120],"make":[122],"tissue":[124,197,218],"deficiencies":[128,215,277],"supplementation":[132,313],"promising":[135],"strategy":[136],"for":[137,191,315],"prevention":[139],"cancer.":[142],"However,":[143],"many":[144],"questions":[145],"regarding":[146],"must":[152],"be":[153,162],"answered":[154],"before":[155],"strategies":[156,314],"modulate":[158],"may":[161],"rationally":[163],"designed":[164],"safely":[166],"implemented.":[167],"This":[168],"work":[169,293],"presents":[170],"novel":[171],"means":[172],"examine":[174],"skin-specific":[175],"nutrition,":[177],"including":[178,262],"an":[179],"analytical":[180],"method":[181],"quantify":[183],"individual":[184],"keratinocytes":[189,227,254],"adaptable":[190],"analysis":[193],"intact":[195],"innovative":[199],"cultured":[200],"keratinocyte":[201],"models":[202],"both":[204],"acute":[205],"chronic":[207],"deficiencies.":[209],"possible":[220],"even":[222],"likely":[223],"as":[224,345],"proliferating":[225],"unable":[229],"maintain":[231],"intracellular":[232,298],"concentrations":[234],"when":[235,285],"nutrient":[236,287],"conditions":[237],"limited":[239],"results":[244],"biologically":[246],"relevant":[247],"degradation.":[249],"Folate":[250],"deficiency":[251],"observed":[256],"have":[258],"pro-carcinogenic":[260],"consequences":[261],"S-phase":[263],"proliferation":[264],"arrest,":[265],"increased":[266,271],"inherent":[267],"DNA":[268,279],"strand":[269],"breaks,":[270],"uracil":[272],"misincorporation":[273],"into":[274],"DNA,":[275],"damage":[280],"repair,":[281],"which":[282],"reversed":[284],"levels":[288],"optimized.":[290],"presented":[292],"characterizes":[294],"relationship":[296],"environmental":[302],"carcinogens":[303],"known":[304],"induce":[306],"addresses":[310],"challenges":[311],"facing":[312],"specifically":[316],"improving":[317],"nutriture":[319],"skin.":[322],"In":[323],"total,":[324],"this":[325],"report":[326],"broadens":[327],"our":[328],"understanding":[329],"demonstrates":[337],"optimization":[339],"holds":[343],"promise":[344],"preventive":[348],"strategy.":[349]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}