{"id":"https://openalex.org/W405629025","doi":null,"title":"A Novel Mechanism for Mechanosensing by Endothelial Cells","display_name":"A Novel Mechanism for Mechanosensing by Endothelial Cells","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W405629025","mag":"405629025"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.umaine.edu:honors-1128","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.umaine.edu/honors/135","pdf_url":"https://digitalcommons.library.umaine.edu/cgi/viewcontent.cgi?article=1128&context=honors","source":{"id":"https://openalex.org/S4306402196","display_name":"DigitalCommons (California Polytechnic State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149919469","host_organization_name":"California Polytechnic State University","host_organization_lineage":["https://openalex.org/I149919469"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honors College","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.umaine.edu/cgi/viewcontent.cgi?article=1128&context=honors","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059078972","display_name":"Jennifer MacDowell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer MacDowell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059078972"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanosensing","display_name":"mechanosensing","score":0.8450000286102295},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.8650000095367432},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.8650000095367432},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7630000114440918},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7279999852180481},{"id":"https://openalex.org/keywords/traction-force","display_name":"traction force","score":0.5989999771118164},{"id":"https://openalex.org/keywords/polyacrylamide-hydrogel","display_name":"polyacrylamide hydrogel","score":0.859000027179718},{"id":"https://openalex.org/keywords/fluorescent-microspheres","display_name":"fluorescent microspheres","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cell-spreading","display_name":"cell spreading","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5534678101539612},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4120143949985504},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40219008922576904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34697985649108887},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34078484773635864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26199108362197876},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1812460720539093},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.umaine.edu:honors-1128","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.umaine.edu/honors/135","pdf_url":"https://digitalcommons.library.umaine.edu/cgi/viewcontent.cgi?article=1128&context=honors","source":{"id":"https://openalex.org/S4306402196","display_name":"DigitalCommons (California Polytechnic State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149919469","host_organization_name":"California Polytechnic State University","host_organization_lineage":["https://openalex.org/I149919469"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honors College","raw_type":"text"},{"id":"mag:405629025","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.umaine.edu/cgi/viewcontent.cgi?article=1128&context=honors","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.umaine.edu:honors-1128","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.umaine.edu/honors/135","pdf_url":"https://digitalcommons.library.umaine.edu/cgi/viewcontent.cgi?article=1128&context=honors","source":{"id":"https://openalex.org/S4306402196","display_name":"DigitalCommons (California Polytechnic State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149919469","host_organization_name":"California Polytechnic State University","host_organization_lineage":["https://openalex.org/I149919469"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honors College","raw_type":"text"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W405629025.pdf","grobid_xml":"https://content.openalex.org/works/W405629025.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1990711717","https://openalex.org/W1992112921","https://openalex.org/W1993323132","https://openalex.org/W2007154529","https://openalex.org/W2011206112","https://openalex.org/W2016576487","https://openalex.org/W2024250498","https://openalex.org/W2029773366","https://openalex.org/W2040142478","https://openalex.org/W2042953526","https://openalex.org/W2054635074","https://openalex.org/W2055334948","https://openalex.org/W2064977142","https://openalex.org/W2068092779","https://openalex.org/W2069366060","https://openalex.org/W2087624790","https://openalex.org/W2092778532","https://openalex.org/W2093126111","https://openalex.org/W2102283558","https://openalex.org/W2105809801","https://openalex.org/W2125644189","https://openalex.org/W2136657825","https://openalex.org/W2147023756","https://openalex.org/W2156713309","https://openalex.org/W2164495477","https://openalex.org/W2181430260"],"related_works":["https://openalex.org/W2605610376","https://openalex.org/W2586733264","https://openalex.org/W2125217376","https://openalex.org/W2019384864","https://openalex.org/W4391537698","https://openalex.org/W2029991360","https://openalex.org/W2153688789","https://openalex.org/W4406029485","https://openalex.org/W2125047490","https://openalex.org/W2161054601"],"abstract_inverted_index":{"The":[0,118],"formation":[1],"of":[2,22,75,80,120,149,152,168],"new":[3],"vasculature":[4],"is":[5,33],"an":[6],"essential":[7],"process,":[8],"but":[9],"can":[10],"also":[11],"be":[12],"utilized":[13],"by":[14,36],"cancerous":[15],"cells.":[16],"Angiogenesis":[17],"requires":[18],"the":[19,23,27,44,51,69,76,123,147,166],"directed":[20],"migration":[21],"endothelial":[24],"cells":[25,101],"lining":[26],"nascent":[28],"blood":[29],"vessels.":[30],"This":[31],"process":[32,60],"largely":[34],"mediated":[35],"integrin,":[37],"which":[38],"plays":[39],"a":[40,48,59],"key":[41],"role":[42,156],"in":[43,50,157,165],"interplay":[45],"between":[46],"sensing":[47],"force":[49,140],"extracellular":[52],"matrix":[53],"(ECM)":[54],"and":[55,73,83,87,112,134,154,159,172],"transducing":[56],"this":[57],"signal,":[58],"termed":[61],"mechanotransduction.":[62],"Through":[63],"cell-ECM":[64],"focal":[65,81,93],"adhesions,":[66],"integrin":[67,121,153],"mediates":[68],"signaling":[70],"both":[71,169],"into":[72],"out":[74],"cell,":[77],"promoting":[78],"growth":[79],"adhesions":[82],"subsequent":[84],"cell":[85,138],"spreading":[86],"migration.":[88,160],"In":[89],"order":[90],"to":[91,97,145],"study":[92],"adhesion":[94],"dynamics":[95],"related":[96],"force,":[98],"we":[99],"observed":[100],"on":[102,122],"three":[103],"different":[104,124],"substrates:":[105],"polyacrylamide":[106,113],"gels,":[107],"polydimethylsiloxane":[108],"(PDMS)":[109],"micro":[110],"pillars,":[111],"gels":[114],"containing":[115],"fluorescent":[116,129],"beads.":[117],"mobility":[119],"substrates":[125],"was":[126],"assessed":[127],"using":[128],"recovery":[130],"after":[131],"photo-bleaching":[132],"(FRAP)":[133],"analyzed":[135],"along":[136],"with":[137],"traction":[139],"measurements.":[141],"These":[142],"studies":[143],"serve":[144],"further":[146],"understanding":[148],"our":[150],"knowledge":[151],"its":[155],"mechanotransduction":[158],"It":[161],"will,":[162],"therefore,":[163],"aid":[164],"advancement":[167],"tissue":[170],"engineering":[171],"cancer":[173],"treatment":[174],"research.":[175]},"counts_by_year":[],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2016-06-24T00:00:00"}