{"id":"https://openalex.org/W4047603","doi":null,"title":"Effects of long term consumption of sugar as part of meal on serotonin 1-a receptor dependent responses.","display_name":"Effects of long term consumption of sugar as part of meal on serotonin 1-a receptor dependent responses.","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W4047603","mag":"4047603","pmid":"https://pubmed.ncbi.nlm.nih.gov/16751117"},"language":"en","primary_location":{"id":"pmid:16751117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16751117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074487498","display_name":"Qurrat-ul-Aen Inam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Qurrat-Ul-Aen Inam","raw_affiliation_strings":["Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Unit, University of Karachi, Karachi-75270, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Unit, University of Karachi, Karachi-75270, Pakistan","institution_ids":["https://openalex.org/I193670377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078279462","display_name":"Mohammed A Haleem","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Abdul Haleem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019048394","display_name":"Darakhshan Jabeen Haleem","orcid":"https://orcid.org/0000-0003-4800-2198","observed_orcids":["https://orcid.org/0000-0003-4800-2198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darakhshan Jabeen Haleem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.00043641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"19","issue":"2","first_page":"94","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.03480000048875809,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sugar-intake","display_name":"sugar consumption","score":0.7350000143051147},{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.7689999938011169},{"id":"https://openalex.org/keywords/8-oh-dpat","display_name":"8-OH-DPAT","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hyperphagia","display_name":"hyperphagia","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hyperlocomotion","display_name":"hyperlocomotion","score":0.7950000166893005},{"id":"https://openalex.org/keywords/appetite-regulation","display_name":"appetite regulation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/stress-adaptation","display_name":"stress adaptation","score":0.5849999785423279},{"id":"https://openalex.org/keywords/mood","display_name":"mood","score":0.7250000238418579},{"id":"https://openalex.org/keywords/high-sugar-diet","display_name":"high-sugar diet","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.7950969934463501},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7187865972518921},{"id":"https://openalex.org/C2777108408","wikidata":"https://www.wikidata.org/wiki/Q11002","display_name":"Sugar","level":2,"score":0.7052891254425049},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.673745334148407},{"id":"https://openalex.org/C75908981","wikidata":"https://www.wikidata.org/wiki/Q28578","display_name":"Appetite","level":2,"score":0.6388753056526184},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.5444494485855103},{"id":"https://openalex.org/C2778345441","wikidata":"https://www.wikidata.org/wiki/Q6460735","display_name":"Meal","level":2,"score":0.5151975750923157},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.4859517812728882},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47720012068748474},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4644826352596283},{"id":"https://openalex.org/C3017811646","wikidata":"https://www.wikidata.org/wiki/Q227870","display_name":"Sugar consumption","level":3,"score":0.44037479162216187},{"id":"https://openalex.org/C2776238416","wikidata":"https://www.wikidata.org/wiki/Q4644282","display_name":"8-OH-DPAT","level":5,"score":0.43927186727523804},{"id":"https://openalex.org/C2778914748","wikidata":"https://www.wikidata.org/wiki/Q10850","display_name":"Rodent","level":2,"score":0.42592352628707886},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4014318287372589},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31318628787994385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2890750765800476},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.1660725474357605},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.07235834002494812}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006963","descriptor_name":"Hyperphagia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006963","descriptor_name":"Hyperphagia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017371","descriptor_name":"8-Hydroxy-2-(di-n-propylamino)tetralin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019422","descriptor_name":"Dietary Sucrose","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D020230","descriptor_name":"Serotonin Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020230","descriptor_name":"Serotonin Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044282","descriptor_name":"Receptor, Serotonin, 5-HT1A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058825","descriptor_name":"Serotonin 5-HT1 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16751117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16751117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Comparative Study"},{"id":"mag:2338616858","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Darakhshan_Haleem/publication/7032078_Effects_of_long_term_consumption_of_sugar_as_part_of_meal_on_serotonin_1-a_receptor_dependent_responses/links/0046353646f8feef89000000.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W53955850","https://openalex.org/W1566149803","https://openalex.org/W1944697741","https://openalex.org/W1968220189","https://openalex.org/W1970174017","https://openalex.org/W1992241048","https://openalex.org/W1995241918","https://openalex.org/W1996833453","https://openalex.org/W2002193260","https://openalex.org/W2016134350","https://openalex.org/W2052350817","https://openalex.org/W2069267673","https://openalex.org/W2095017885","https://openalex.org/W2096665699","https://openalex.org/W2118928934","https://openalex.org/W2131601623","https://openalex.org/W2475124104"],"related_works":["https://openalex.org/W2338616858","https://openalex.org/W2187607367","https://openalex.org/W1982343074","https://openalex.org/W2290757569","https://openalex.org/W2475124104","https://openalex.org/W4211093776","https://openalex.org/W2000569639","https://openalex.org/W2386542060","https://openalex.org/W4220955403","https://openalex.org/W2078801407"],"abstract_inverted_index":{"In":[0],"view":[1],"of":[2,5,8,18,23,46,50,68,98,109,190,204,208],"an":[3],"effect":[4],"high":[6],"intake":[7],"sugar":[9,47,65,135,147,159,178,205],"on":[10,76,87,212],"brain":[11],"serotonin":[12,19,209],"(5-hydroxytryptamine,":[13],"5-HT)":[14],"and":[15,30,63,71,117,129,214],"a":[16,34,96,185],"role":[17],"in":[20,52,66,134,146,158,169,177,187],"the":[21,25,104,110,188],"regulation":[22],"appetite,":[24],"present":[26],"study":[27],"concerns":[28],"pre":[29,191],"postsynaptic":[31,195],"responses":[32,199],"to":[33,102,106,112,217],"selective":[35],"5-HT-1A":[36,196],"receptor":[37,197,210],"agonist":[38],"8-hydroxy-2-(di-n-propylamino)":[39],"tetralin":[40],"(8-OH-DPAT)":[41],"following":[42,200],"long":[43,201],"term":[44,202],"consumption":[45,155,203],"as":[48,192,194],"part":[49],"meal":[51],"rats.":[53,140,152,181],"Sugar":[54],"diet":[55,62,78,138,150,162,171,179],"was":[56,100,144,156,174],"prepared":[57],"by":[58],"mixing":[59],"standard":[60,88],"rodent":[61,89],"table":[64],"ratio":[67],"3:1":[69],"(w/w)":[70],"rats":[72,83,164,173],"were":[73,84,132],"fed":[74,85],"freely":[75,86],"this":[77],"for":[79],"five":[80,92],"weeks.":[81],"Control":[82],"diet.":[90,206],"After":[91],"weeks":[93],"8-OH-DPAT":[94],"at":[95],"dose":[97],"0.5mg/kg/ml":[99],"injected":[101],"both":[103],"groups":[105],"compare":[107],"effectiveness":[108,189],"drug":[111],"elicit":[113],"hyperphagia":[114,167],"(presynaptic":[115],"response)":[116],"elicited":[118],"hyperactivity":[119],"syndrome":[120],"(postsynaptic":[121],"response).":[122],"Results":[123],"showed":[124],"that":[125],"8-OH-DPAT-induced":[126,142,166],"forepaw":[127],"treading":[128],"flatbody":[130],"posture":[131],"smaller":[133],"than":[136,148,160],"normal":[137,149,161,170],"treated":[139,151,163,172,180],"Conversely":[141],"hyperlocomotion":[143],"greater":[145,157],"4h":[153],"Food":[154],"while":[165],"significant":[168],"not":[175],"observed":[176],"The":[182],"results":[183],"show":[184],"decrease":[186],"well":[193],"dependent":[198],"Role":[207],"responsiveness":[211],"mood":[213],"impaired":[215],"adaptation":[216],"stress":[218],"is":[219],"discussed.":[220]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
