{"id":"https://openalex.org/W40471780","doi":"https://doi.org/10.1007/978-1-4899-0703-5_11","title":"Toxicity of Bilirubin and Detoxification by PEG-Bilirubin Oxidase Conjugate","display_name":"Toxicity of Bilirubin and Detoxification by PEG-Bilirubin Oxidase Conjugate","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W40471780","doi":"https://doi.org/10.1007/978-1-4899-0703-5_11","mag":"40471780"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4899-0703-5_11","doi":"https://doi.org/10.1007/978-1-4899-0703-5_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4899-0703-5_11","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poly(Ethylene Glycol) Chemistry","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2482531400","display_name":"Poly(Ethylene Glycol) Chemistry"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112020437","display_name":"Hiroshi Maeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Maeda","raw_affiliation_strings":["Kumamoto University Medical School, Kumamoto 860, Japan","Kumamoto University MEdical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kumamoto University Medical School, Kumamoto 860, Japan","institution_ids":["https://openalex.org/I96036126"]},{"raw_affiliation_string":"Kumamoto University MEdical School","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112620306","display_name":"Masami Kimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masami Kimura","raw_affiliation_strings":["Kumamoto University Medical School, Kumamoto 860, Japan","Kumamoto University MEdical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kumamoto University Medical School, Kumamoto 860, Japan","institution_ids":["https://openalex.org/I96036126"]},{"raw_affiliation_string":"Kumamoto University MEdical School","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079409188","display_name":"Ikuharu Sasaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ikuharu Sasaki","raw_affiliation_strings":["Amano Pharmaceutical Co., Ltd., Nagoya 481, Japan","Amano Pharmaceutical Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amano Pharmaceutical Co., Ltd., Nagoya 481, Japan","institution_ids":[]},{"raw_affiliation_string":"Amano Pharmaceutical Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101055433","display_name":"Yoshihiko Hirose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshihiko Hirose","raw_affiliation_strings":["Amano Pharmaceutical Co., Ltd., Nagoya 481, Japan","Amano Pharmaceutical Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amano Pharmaceutical Co., Ltd., Nagoya 481, Japan","institution_ids":[]},{"raw_affiliation_string":"Amano Pharmaceutical Co., Ltd","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111564601","display_name":"Toshimitsu Konno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshimitsu Konno","raw_affiliation_strings":["Kumamoto University Medical School, Kumamoto 860, Japan","Kumamoto University MEdical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kumamoto University Medical School, Kumamoto 860, Japan","institution_ids":["https://openalex.org/I96036126"]},{"raw_affiliation_string":"Kumamoto University MEdical School","institution_ids":["https://openalex.org/I96036126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4925,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.88412017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"153","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bilirubin-toxicity","display_name":"bilirubin toxicity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bilirubin-oxidase","display_name":"bilirubin oxidase","score":0.9430000185966492},{"id":"https://openalex.org/keywords/enzyme-conjugation","display_name":"enzyme conjugation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/kernicterus","display_name":"kernicterus","score":0.8880000114440918},{"id":"https://openalex.org/keywords/unconjugated-bilirubin","display_name":"unconjugated bilirubin","score":0.8320000171661377},{"id":"https://openalex.org/keywords/jaundice-treatment","display_name":"jaundice treatment","score":0.7300000190734863},{"id":"https://openalex.org/keywords/glucuronidation","display_name":"glucuronidation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.4359999895095825},{"id":"https://openalex.org/keywords/fulminant-hepatitis","display_name":"fulminant hepatitis","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.8497767448425293},{"id":"https://openalex.org/C2778083895","wikidata":"https://www.wikidata.org/wiki/Q861845","display_name":"Kernicterus","level":3,"score":0.7995861768722534},{"id":"https://openalex.org/C2778456037","wikidata":"https://www.wikidata.org/wiki/Q133244","display_name":"Jaundice","level":2,"score":0.5108346939086914},{"id":"https://openalex.org/C2911188197","wikidata":"https://www.wikidata.org/wiki/Q419543","display_name":"Unconjugated hyperbilirubinemia","level":3,"score":0.4988837242126465},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.4801566004753113},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4686678647994995},{"id":"https://openalex.org/C2776648616","wikidata":"https://www.wikidata.org/wiki/Q409216","display_name":"Glucuronic acid","level":3,"score":0.4668259024620056},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.44366446137428284},{"id":"https://openalex.org/C2777915509","wikidata":"https://www.wikidata.org/wiki/Q3165913","display_name":"Bilirubin oxidase","level":3,"score":0.44207778573036194},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4345172941684723},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35691016912460327},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3467447757720947},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.280265748500824},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4899-0703-5_11","doi":"https://doi.org/10.1007/978-1-4899-0703-5_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4899-0703-5_11","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Poly(Ethylene Glycol) Chemistry","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1821438013","https://openalex.org/W1842081329","https://openalex.org/W1965443536","https://openalex.org/W1968896643","https://openalex.org/W1970330748","https://openalex.org/W1970652782","https://openalex.org/W1972992205","https://openalex.org/W1977404966","https://openalex.org/W1981444990","https://openalex.org/W1990073986","https://openalex.org/W2008139109","https://openalex.org/W2010412191","https://openalex.org/W2018960634","https://openalex.org/W2022537484","https://openalex.org/W2023634255","https://openalex.org/W2023727702","https://openalex.org/W2026393879","https://openalex.org/W2028211453","https://openalex.org/W2053996331","https://openalex.org/W2064328220","https://openalex.org/W2078263947","https://openalex.org/W2079276084","https://openalex.org/W2084375725","https://openalex.org/W2086059798","https://openalex.org/W2086183765","https://openalex.org/W2086357134","https://openalex.org/W2088622312","https://openalex.org/W2126307919","https://openalex.org/W2269476838","https://openalex.org/W2325849963","https://openalex.org/W2336924892","https://openalex.org/W2341238468","https://openalex.org/W2412312222"],"related_works":["https://openalex.org/W2320178969","https://openalex.org/W2086059798","https://openalex.org/W4229833868","https://openalex.org/W1972403258","https://openalex.org/W2325849963","https://openalex.org/W4404614618","https://openalex.org/W2345580618","https://openalex.org/W27951376","https://openalex.org/W1978014416","https://openalex.org/W2338340657"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}