{"id":"https://openalex.org/W40463610","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.758.2","title":"Cerium oxide nanoparticles decrease inflammation in J774 cells","display_name":"Cerium oxide nanoparticles decrease inflammation in J774 cells","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W40463610","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.758.2","mag":"40463610"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.22.1_supplement.758.2","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.758.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.758.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083931427","display_name":"Suzanne Marie Hirst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Marie Hirst","raw_affiliation_strings":["Biomedical Sciences Virginia Tech Blacksburg VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Virginia Tech Blacksburg VA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046074716","display_name":"Abby D Peairs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I896114043","display_name":"Edward Via College of Osteopathic Medicine","ror":"https://ror.org/00sda2672","country_code":"US","type":"education","lineage":["https://openalex.org/I896114043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abby D Peairs","raw_affiliation_strings":["Physiology Virginia College of Osteopathic Medicine Blacksburg VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Virginia College of Osteopathic Medicine Blacksburg VA","institution_ids":["https://openalex.org/I896114043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027621059","display_name":"Robert M. Gogal","orcid":"https://orcid.org/0000-0002-3213-4906","observed_orcids":["https://orcid.org/0000-0002-3213-4906"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Gogal","raw_affiliation_strings":["Biomedical Sciences Virginia Tech Blacksburg VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Virginia Tech Blacksburg VA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026168431","display_name":"Sudipta Seal","orcid":"https://orcid.org/0000-0002-0963-3344","observed_orcids":["https://orcid.org/0000-0002-0963-3344"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudipta Seal","raw_affiliation_strings":["AMPAC &amp; Mechanical Materials and Aerospace Engineering University of Central Florida Orlando FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AMPAC &amp; Mechanical Materials and Aerospace Engineering University of Central Florida Orlando FL","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102862582","display_name":"Christopher M. Reilly","orcid":"https://orcid.org/0000-0003-4787-7750","observed_orcids":["https://orcid.org/0000-0003-4787-7750"]},"institutions":[{"id":"https://openalex.org/I896114043","display_name":"Edward Via College of Osteopathic Medicine","ror":"https://ror.org/00sda2672","country_code":"US","type":"education","lineage":["https://openalex.org/I896114043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M Reilly","raw_affiliation_strings":["Physiology Virginia College of Osteopathic Medicine Blacksburg VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Virginia College of Osteopathic Medicine Blacksburg VA","institution_ids":["https://openalex.org/I896114043"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.1699,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.48076765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"22","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12302","display_name":"Advanced Nanomaterials in Catalysis","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12302","display_name":"Advanced Nanomaterials in Catalysis","score":0.5717999935150146,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.20100000500679016,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10192","display_name":"Catalytic Processes in Materials Science","score":0.11349999904632568,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerium-oxide-nanoparticles","display_name":"cerium oxide nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6290000081062317},{"id":"https://openalex.org/keywords/j774-macrophages","display_name":"J774 macrophages","score":0.8600000143051147},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9890000224113464},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lps-ifn-gamma-stimulation","display_name":"LPS/IFN-\u03b3 stimulation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mitochondrial-localization","display_name":"mitochondrial localization","score":0.5899999737739563},{"id":"https://openalex.org/keywords/nanoparticle-uptake","display_name":"nanoparticle uptake","score":0.7979999780654907},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.5370000004768372},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C2780657402","wikidata":"https://www.wikidata.org/wiki/Q1055570","display_name":"Cerium oxide","level":3,"score":0.9167934656143188},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.713655948638916},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.6775606870651245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6181487441062927},{"id":"https://openalex.org/C523597863","wikidata":"https://www.wikidata.org/wiki/Q1385","display_name":"Cerium","level":2,"score":0.6172821521759033},{"id":"https://openalex.org/C127445965","wikidata":"https://www.wikidata.org/wiki/Q2518429","display_name":"Nanotoxicology","level":3,"score":0.5733320116996765},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5690910816192627},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.549651026725769},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5452431440353394},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5265296697616577},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.4622156023979187},{"id":"https://openalex.org/C138631740","wikidata":"https://www.wikidata.org/wiki/Q967847","display_name":"Nanomaterials","level":2,"score":0.42927539348602295},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42186206579208374},{"id":"https://openalex.org/C2779851234","wikidata":"https://www.wikidata.org/wiki/Q50690","display_name":"Oxide","level":2,"score":0.34728437662124634},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2688891291618347},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.23782995343208313},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23311972618103027},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1692732274532318},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.15912947058677673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13508301973342896},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.22.1_supplement.758.2","doi":"https://doi.org/10.1096/fasebj.22.1_supplement.758.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.22.1_supplement.758.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2022556212","https://openalex.org/W2792604743","https://openalex.org/W4200108629","https://openalex.org/W195635648","https://openalex.org/W3137374266","https://openalex.org/W7030331912","https://openalex.org/W1981761304","https://openalex.org/W2161067130","https://openalex.org/W2165743023","https://openalex.org/W4248227276"],"abstract_inverted_index":{"The":[0,122],"use":[1],"of":[2,64,93,132,203],"nanomaterials":[3],"in":[4,78,83,134,171,186],"biological":[5],"systems":[6],"has":[7,34],"gained":[8],"attention":[9],"due":[10,50],"to":[11,37,51,68,100],"the":[12,31,62,127,135,201],"unique":[13],"properties":[14],"that":[15,106,180],"these":[16,177],"materials":[17],"possess.":[18],"Cerium":[19,41,149],"oxide":[20,28,42,150,182],"(CeO":[21],"2":[22,66,95,111,140,163],")":[23],"is":[24],"a":[25,45,129,196],"rare":[26],"earth":[27],"that,":[29],"on":[30],"nanomolar":[32],"scale,":[33],"been":[35],"reported":[36],"exhibit":[38],"antioxidant":[39],"properties.":[40],"acts":[43],"as":[44,113],"regenerative":[46],"free":[47],"radical":[48],"scavenger":[49],"its":[52],"valence":[53],"and":[54,74,118,169,189,193],"oxygen":[55,71],"defects.":[56],"In":[57],"this":[58],"study,":[59],"we":[60],"investigated":[61],"ability":[63],"CeO":[65,94,110,139,162],"nanoparticles":[67,96,183],"reduce":[69],"reactive":[70],"species":[72],"(ROS)":[73],"inflammatory":[75,166,190],"mediator":[76,191],"production":[77],"J774":[79,86,107],"murine":[80],"macrophage":[81],"cells":[82,87,108],"vitro":[84],".":[85],"were":[88],"pretreated":[89,151],"with":[90,138,155],"various":[91],"concentrations":[92,142],"24":[97],"hr":[98],"prior":[99],"LPS/IFN\u2010\u03b3":[101,172],"stimulation.":[102],"Our":[103],"results":[104],"showed":[105,157],"internalized":[109],"particles":[112,124],"assessed":[114],"by":[115],"electron":[116],"microscopy":[117],"atomic":[119],"force":[120],"microscopy.":[121],"cerium":[123,181],"localized":[125],"around":[126],"mitochondria,":[128],"major":[130],"producer":[131],"ROS":[133,188],"cell.":[136],"Treatment":[137],"at":[141],"under":[143],"1":[144],"uM":[145],"caused":[146],"no":[147],"toxicity.":[148],"cells,":[152],"when":[153],"stimulated":[154,173],"LPS/IFN\u2010\u03b3,":[156],"decreased":[158,165],"oxidative":[159],"stress.":[160],"Furthermore,":[161],"pretreatment":[164],"cytokines":[167],"IL\u20106":[168],"TNF\u2010\u03b1":[170],"cells.":[174],"Taken":[175],"together,":[176],"studies":[178],"suggest":[179],"are":[184],"effective":[185],"reducing":[187],"production,":[192],"may":[194],"constitute":[195],"novel":[197],"therapeutic":[198],"tool":[199],"for":[200],"treatment":[202],"inflammation.":[204]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
