{"id":"https://openalex.org/W40454542","doi":null,"title":"SHP-1 and PDK1 Form a Phosphotyrosine-Dependent Nucleo-Cytoplasmic Shuttling Complex: Implications for Differentiation","display_name":"SHP-1 and PDK1 Form a Phosphotyrosine-Dependent Nucleo-Cytoplasmic Shuttling Complex: Implications for Differentiation","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W40454542","mag":"40454542"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.usask.ca:10388/etd-06282007-113751","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/etd-06282007-113751","pdf_url":"http://hdl.handle.net/10388/etd-06282007-113751","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10388/etd-06282007-113751","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021982269","display_name":"Chantelle F. Sephton","orcid":"https://orcid.org/0000-0002-9839-0611","observed_orcids":["https://orcid.org/0000-0002-9839-0611"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chantelle F. Sephton","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9839-0611","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5021982269"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/shp-1","display_name":"SHP-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pdk1","display_name":"PDK1","score":0.972000002861023},{"id":"https://openalex.org/keywords/nucleocytoplasmic-shuttling","display_name":"nucleocytoplasmic shuttling","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.859000027179718},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nuclear-localization-signal","display_name":"nuclear localization signal","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nuclear-export-signal","display_name":"nuclear export signal","score":0.878000020980835},{"id":"https://openalex.org/keywords/nuclear-import","display_name":"nuclear import","score":0.42500001192092896},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor-receptor","display_name":"platelet-derived growth factor receptor","score":0.7300000190734863},{"id":"https://openalex.org/keywords/c6-glioma-cells","display_name":"C6 glioma cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.7829999923706055},{"id":"https://openalex.org/keywords/nuclear-export","display_name":"nuclear export","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.577815055847168},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5191782712936401},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3509708046913147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34642404317855835}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ecommons.usask.ca:10388/etd-06282007-113751","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/etd-06282007-113751","pdf_url":"http://hdl.handle.net/10388/etd-06282007-113751","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:harvest.usask.ca:10388/etd-06282007-113751","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10388/etd-06282007-113751","pdf_url":null,"source":{"id":"https://openalex.org/S7407063267","display_name":"HARVEST (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:40454542","doi":null,"is_oa":false,"landing_page_url":"https://harvest.usask.ca/bitstream/10388/etd-06282007-113751/1/sephton_c.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ecommons.usask.ca:10388/etd-06282007-113751","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10388/etd-06282007-113751","pdf_url":"http://hdl.handle.net/10388/etd-06282007-113751","source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W40454542.pdf","grobid_xml":"https://content.openalex.org/works/W40454542.grobid-xml"},"referenced_works_count":403,"referenced_works":["https://openalex.org/W3488583","https://openalex.org/W22834613","https://openalex.org/W49790523","https://openalex.org/W67399661","https://openalex.org/W164293537","https://openalex.org/W179263153","https://openalex.org/W208766157","https://openalex.org/W228957167","https://openalex.org/W1491625645","https://openalex.org/W1495179683","https://openalex.org/W1495346616","https://openalex.org/W1511628891","https://openalex.org/W1513743142","https://openalex.org/W1572891678","https://openalex.org/W1573413160","https://openalex.org/W1574140047","https://openalex.org/W1575276040","https://openalex.org/W1576918670","https://openalex.org/W1585385265","https://openalex.org/W1594992262","https://openalex.org/W1631158375","https://openalex.org/W1643628872","https://openalex.org/W1654498070","https://openalex.org/W1665416055","https://openalex.org/W1688381890","https://openalex.org/W1705381357","https://openalex.org/W1726025741","https://openalex.org/W1791888878","https://openalex.org/W1819429396","https://openalex.org/W1838131144","https://openalex.org/W1841094009","https://openalex.org/W1846395924","https://openalex.org/W1863238068","https://openalex.org/W1868324460","https://openalex.org/W1870135658","https://openalex.org/W1877328105","https://openalex.org/W1885849736","https://openalex.org/W1900810111","https://openalex.org/W1908445283","https://openalex.org/W1908945397","https://openalex.org/W1931293178","https://openalex.org/W1941291890","https://openalex.org/W1955217315","https://openalex.org/W1965118916","https://openalex.org/W1965835768","https://openalex.org/W1966099522","https://openalex.org/W1966631711","https://openalex.org/W1966930760","https://openalex.org/W1967407315","https://openalex.org/W1967410234","https://openalex.org/W1967548980","https://openalex.org/W1968365451","https://openalex.org/W1969134590","https://openalex.org/W1969166125","https://openalex.org/W1969283023","https://openalex.org/W1969634414","https://openalex.org/W1969918683","https://openalex.org/W1970575840","https://openalex.org/W1970587959","https://openalex.org/W1970735844","https://openalex.org/W1971695868","https://openalex.org/W1972172786","https://openalex.org/W1973837499","https://openalex.org/W1973875557","https://openalex.org/W1974241409","https://openalex.org/W1975290731","https://openalex.org/W1975464455","https://openalex.org/W1975623017","https://openalex.org/W1975823509","https://openalex.org/W1975987716","https://openalex.org/W1976242955","https://openalex.org/W1976382352","https://openalex.org/W1976460971","https://openalex.org/W1976564408","https://openalex.org/W1976805459","https://openalex.org/W1977156769","https://openalex.org/W1978019490","https://openalex.org/W1979046411","https://openalex.org/W1979906352","https://openalex.org/W1981072221","https://openalex.org/W1981188183","https://openalex.org/W1982436712","https://openalex.org/W1983671474","https://openalex.org/W1984418041","https://openalex.org/W1984453879","https://openalex.org/W1986273917","https://openalex.org/W1988069145","https://openalex.org/W1989294105","https://openalex.org/W1989820489","https://openalex.org/W1989885576","https://openalex.org/W1990065094","https://openalex.org/W1990738958","https://openalex.org/W1990841830","https://openalex.org/W1990918868","https://openalex.org/W1991276398","https://openalex.org/W1991359253","https://openalex.org/W1991750814","https://openalex.org/W1992423002","https://openalex.org/W1993216157","https://openalex.org/W1993326304","https://openalex.org/W1993948601","https://openalex.org/W1994527192","https://openalex.org/W1995088117","https://openalex.org/W1995725370","https://openalex.org/W1996401524","https://openalex.org/W1997848361","https://openalex.org/W1998908508","https://openalex.org/W1998945528","https://openalex.org/W1999012962","https://openalex.org/W1999163644","https://openalex.org/W1999892621","https://openalex.org/W1999903313","https://openalex.org/W1999975236","https://openalex.org/W2001081096","https://openalex.org/W2001163784","https://openalex.org/W2001853125","https://openalex.org/W2002054992","https://openalex.org/W2002375890","https://openalex.org/W2003044215","https://openalex.org/W2003168434","https://openalex.org/W2004078164","https://openalex.org/W2004199183","https://openalex.org/W2004756723","https://openalex.org/W2004939857","https://openalex.org/W2005023357","https://openalex.org/W2005189737","https://openalex.org/W2007142448","https://openalex.org/W2008123630","https://openalex.org/W2008193652","https://openalex.org/W2008408111","https://openalex.org/W2008779407","https://openalex.org/W2009976155","https://openalex.org/W2011417221","https://openalex.org/W2012219375","https://openalex.org/W2012333696","https://openalex.org/W2012347775","https://openalex.org/W2012610188","https://openalex.org/W2013105209","https://openalex.org/W2013355944","https://openalex.org/W2014709915","https://openalex.org/W2015239877","https://openalex.org/W2015561849","https://openalex.org/W2017394099","https://openalex.org/W2018118610","https://openalex.org/W2018380860","https://openalex.org/W2018826402","https://openalex.org/W2019802189","https://openalex.org/W2019890837","https://openalex.org/W2020018765","https://openalex.org/W2020329164","https://openalex.org/W2020931266","https://openalex.org/W2020972524","https://openalex.org/W2021384128","https://openalex.org/W2021406365","https://openalex.org/W2021647600","https://openalex.org/W2022090845","https://openalex.org/W2023034760","https://openalex.org/W2023934239","https://openalex.org/W2024306318","https://openalex.org/W2024850434","https://openalex.org/W2025654786","https://openalex.org/W2026460320","https://openalex.org/W2026738139","https://openalex.org/W2027202090","https://openalex.org/W2027981450","https://openalex.org/W2028415754","https://openalex.org/W2028672566","https://openalex.org/W2029172416","https://openalex.org/W2029225125","https://openalex.org/W2030788598","https://openalex.org/W2030793757","https://openalex.org/W2031793223","https://openalex.org/W2032346440","https://openalex.org/W2033063936","https://openalex.org/W2033630329","https://openalex.org/W2037196975","https://openalex.org/W2037439089","https://openalex.org/W2037729579","https://openalex.org/W2037831105","https://openalex.org/W2037835657","https://openalex.org/W2038060467","https://openalex.org/W2039193709","https://openalex.org/W2039899736","https://openalex.org/W2040524146","https://openalex.org/W2041467442","https://openalex.org/W2041603493","https://openalex.org/W2041806676","https://openalex.org/W2041926656","https://openalex.org/W2042122259","https://openalex.org/W2042209841","https://openalex.org/W2042434971","https://openalex.org/W2042629507","https://openalex.org/W2043617798","https://openalex.org/W2044579944","https://openalex.org/W2045082605","https://openalex.org/W2045567387","https://openalex.org/W2045777034","https://openalex.org/W2046077454","https://openalex.org/W2047132622","https://openalex.org/W2047187392","https://openalex.org/W2047526959","https://openalex.org/W2048832148","https://openalex.org/W2050343039","https://openalex.org/W2051507092","https://openalex.org/W2051774115","https://openalex.org/W2053151896","https://openalex.org/W2053156270","https://openalex.org/W2053640261","https://openalex.org/W2053799953","https://openalex.org/W2054582733","https://openalex.org/W2054929655","https://openalex.org/W2054943275","https://openalex.org/W2056158543","https://openalex.org/W2057786093","https://openalex.org/W2058068390","https://openalex.org/W2058882614","https://openalex.org/W2058885870","https://openalex.org/W2058924545","https://openalex.org/W2059072734","https://openalex.org/W2060252228","https://openalex.org/W2060408446","https://openalex.org/W2061088682","https://openalex.org/W2064373926","https://openalex.org/W2065033398","https://openalex.org/W2065286099","https://openalex.org/W2065652048","https://openalex.org/W2065812567","https://openalex.org/W2066113694","https://openalex.org/W2066368611","https://openalex.org/W2066469176","https://openalex.org/W2066565605","https://openalex.org/W2067099248","https://openalex.org/W2067405360","https://openalex.org/W2067546158","https://openalex.org/W2068427129","https://openalex.org/W2069088275","https://openalex.org/W2069602875","https://openalex.org/W2070139659","https://openalex.org/W2070224555","https://openalex.org/W2072531102","https://openalex.org/W2072835510","https://openalex.org/W2073410553","https://openalex.org/W2073754783","https://openalex.org/W2074725166","https://openalex.org/W2075121503","https://openalex.org/W2075767774","https://openalex.org/W2075776349","https://openalex.org/W2076193535","https://openalex.org/W2076421143","https://openalex.org/W2077430113","https://openalex.org/W2077950605","https://openalex.org/W2079559486","https://openalex.org/W2081441817","https://openalex.org/W2082448876","https://openalex.org/W2082770517","https://openalex.org/W2083480719","https://openalex.org/W2084065981","https://openalex.org/W2085530715","https://openalex.org/W2086725260","https://openalex.org/W2086795846","https://openalex.org/W2087095360","https://openalex.org/W2087930947","https://openalex.org/W2088007882","https://openalex.org/W2088363390","https://openalex.org/W2088472722","https://openalex.org/W2088481957","https://openalex.org/W2088589733","https://openalex.org/W2089908364","https://openalex.org/W2091016640","https://openalex.org/W2091275711","https://openalex.org/W2092328154","https://openalex.org/W2092354039","https://openalex.org/W2092871680","https://openalex.org/W2093074547","https://openalex.org/W2094068658","https://openalex.org/W2094174069","https://openalex.org/W2094701037","https://openalex.org/W2095376376","https://openalex.org/W2096286606","https://openalex.org/W2097557938","https://openalex.org/W2097558464","https://openalex.org/W2097613725","https://openalex.org/W2097767970","https://openalex.org/W2098712968","https://openalex.org/W2098997742","https://openalex.org/W2099389441","https://openalex.org/W2099717623","https://openalex.org/W2099735526","https://openalex.org/W2101073455","https://openalex.org/W2104593771","https://openalex.org/W2104682649","https://openalex.org/W2104812730","https://openalex.org/W2105347265","https://openalex.org/W2106415942","https://openalex.org/W2107546866","https://openalex.org/W2109519875","https://openalex.org/W2111062014","https://openalex.org/W2111478988","https://openalex.org/W2112948888","https://openalex.org/W2113757627","https://openalex.org/W2114303931","https://openalex.org/W2114943013","https://openalex.org/W2114998237","https://openalex.org/W2117029515","https://openalex.org/W2118719170","https://openalex.org/W2118989312","https://openalex.org/W2119361990","https://openalex.org/W2119483030","https://openalex.org/W2119785019","https://openalex.org/W2120138780","https://openalex.org/W2120226363","https://openalex.org/W2120553816","https://openalex.org/W2120662932","https://openalex.org/W2121651624","https://openalex.org/W2121754249","https://openalex.org/W2122898723","https://openalex.org/W2123528292","https://openalex.org/W2124186695","https://openalex.org/W2125567150","https://openalex.org/W2127209361","https://openalex.org/W2129396999","https://openalex.org/W2130359787","https://openalex.org/W2130708019","https://openalex.org/W2131383531","https://openalex.org/W2132764178","https://openalex.org/W2133092640","https://openalex.org/W2134650147","https://openalex.org/W2135506151","https://openalex.org/W2135838271","https://openalex.org/W2135913015","https://openalex.org/W2137035181","https://openalex.org/W2139474277","https://openalex.org/W2139499592","https://openalex.org/W2140646145","https://openalex.org/W2141067543","https://openalex.org/W2141599538","https://openalex.org/W2141795340","https://openalex.org/W2142060283","https://openalex.org/W2142712146","https://openalex.org/W2143327951","https://openalex.org/W2143430700","https://openalex.org/W2144005841","https://openalex.org/W2144954864","https://openalex.org/W2145040425","https://openalex.org/W2146157811","https://openalex.org/W2146573379","https://openalex.org/W2146989813","https://openalex.org/W2147114673","https://openalex.org/W2147716555","https://openalex.org/W2147851642","https://openalex.org/W2149238710","https://openalex.org/W2152093499","https://openalex.org/W2152186846","https://openalex.org/W2152931086","https://openalex.org/W2153504753","https://openalex.org/W2154137397","https://openalex.org/W2154797189","https://openalex.org/W2154817329","https://openalex.org/W2155085170","https://openalex.org/W2155206039","https://openalex.org/W2157153072","https://openalex.org/W2157189324","https://openalex.org/W2157993486","https://openalex.org/W2158201714","https://openalex.org/W2159452410","https://openalex.org/W2159659449","https://openalex.org/W2159990074","https://openalex.org/W2160421139","https://openalex.org/W2160957947","https://openalex.org/W2161810908","https://openalex.org/W2162193671","https://openalex.org/W2165023381","https://openalex.org/W2165710306","https://openalex.org/W2165959813","https://openalex.org/W2166298553","https://openalex.org/W2167816721","https://openalex.org/W2167905925","https://openalex.org/W2168922292","https://openalex.org/W2169494292","https://openalex.org/W2170416930","https://openalex.org/W2171218796","https://openalex.org/W2171258458","https://openalex.org/W2171483790","https://openalex.org/W2172180689","https://openalex.org/W2181323446","https://openalex.org/W2182006177","https://openalex.org/W2182893955","https://openalex.org/W2198367915","https://openalex.org/W2263735455","https://openalex.org/W2317790835","https://openalex.org/W2324291877","https://openalex.org/W2326886626","https://openalex.org/W2327877875","https://openalex.org/W2395197791","https://openalex.org/W2411115276","https://openalex.org/W2411808662","https://openalex.org/W2415101317","https://openalex.org/W2417569984","https://openalex.org/W2418256209","https://openalex.org/W2423764619","https://openalex.org/W2441730539","https://openalex.org/W4313310130","https://openalex.org/W4313376294"],"related_works":["https://openalex.org/W2165890607","https://openalex.org/W2134650147","https://openalex.org/W2067986351","https://openalex.org/W2004939857","https://openalex.org/W2047187392","https://openalex.org/W127522524","https://openalex.org/W2012231601","https://openalex.org/W2143430700","https://openalex.org/W2055852936","https://openalex.org/W1970575840"],"abstract_inverted_index":{"SHP-1":[0,118,158,168,213,228],"is":[1,68,72,163,257,263],"a":[2,82,91,122,136,278],"protein":[3,38],"tyrosine":[4,152,177,183],"phosphatase":[5],"that":[6,182,212,223],"often":[7],"targets":[8,102],"the":[9,31,48,75,149,164,172,191,218,224,239,251],"phosphatidylinositol":[10],"3'-kinase":[11],"(PI3K)/Akt":[12],"signalling":[13,16],"pathway.":[14],"PI3K/Akt":[15],"regulates":[17,238],"cell":[18,133,261],"growth":[19,138],"and":[20,23,41,46,106,119,154,169,186,199,206,214,220,222,236],"survival,":[21],"proliferation":[22],"differentiation.":[24],"Growth":[25],"factor-stimulated":[26],"PI3K":[27,144],"phospholipid":[28],"production":[29],"at":[30],"plasma":[32],"membrane":[33],"helps":[34],"to":[35,148,277],"recruit":[36],"3'-phosphoinositide-dependent":[37],"kinase-1":[39],"(PDK1)":[40],"Akt,":[42],"where":[43],"PDK1":[44,54,71,100,120,151,170,180,194,215,234,242],"phosphorylates":[45],"activates":[47],"pro-survival":[49],"kinase":[50,105,146],"Akt.Tyrosine":[51],"phosphorylation":[52,153],"of":[53,128,143,166,176,193,227,233,241,246,274],"may":[55],"regulate":[56],"its":[57,63,155,269],"function":[58],"and,":[59],"perhaps":[60],"more":[61],"importantly,":[62],"nuclear":[64,83,92],"localization.":[65],"Yet,":[66],"it":[67,78,88,209],"unclear":[69],"how":[70],"imported":[73],"into":[74],"nucleus":[76,219],"as":[77,162,266],"does":[79,89,114],"not":[80],"contain":[81,90],"localization":[84],"signal":[85,94],"(NLS),":[86],"although":[87],"export":[93,249],"(NES).":[95],"Interestingly,":[96],"several":[97],"tyrosines":[98],"in":[99,171,179,259],"are":[101,107,159,188,202],"for":[103,111,190,271],"Src":[104],"putative":[108],"target":[109],"motifs":[110],"SHP-1,":[112],"which":[113,256],"have":[115],"an":[116],"NLS.Hypothesis:":[117],"form":[121],"tyrosine-dependent,":[123],"nucleo-cytoplasmic":[124],"shuttling":[125],"complex.":[126],"Removal":[127],"serum":[129],"from":[130,250],"C6":[131],"glioma":[132],"cultures":[134],"induces":[135],"platelet-derived":[137],"factor":[139],"receptor":[140],"(PDGFR)-sensitive":[141],"redistribution":[142],"lipid":[145],"activity":[147],"nucleus.":[150,173,252],"association":[156],"with":[157,195],"also":[160],"increased,":[161],"accumulation":[165],"both":[167],"Site-directed":[174],"mutagenesis":[175],"residues":[178],"reveals":[181],"9":[184],"(Tyr9)":[185],"Tyr376":[187,237],"important":[189],"interaction":[192],"SHP1,":[196],"whereas":[197],"Tyr333":[198],"Tyr":[200],"373":[201],"not.":[203],"Using":[204],"pharmacological":[205],"genetic":[207],"manipulations,":[208],"was":[210],"demonstrated":[211],"shuttle":[216],"between":[217],"cytoplasm,":[221],"C-terminal-expressed":[225],"NLS":[226],"facilitates":[229],"shuttling,":[230],"while":[231],"dephosphorylation":[232],"Tyr9":[235],"rate":[240],"(and":[243],"by":[244,268],"virtue":[245],"association,":[247],"SHP-1)":[248],"The":[253],"SHP-1/PDK1":[254],"complex,":[255],"constitutive":[258],"most":[260],"lines,":[262],"functionally":[264],"relevant":[265],"indicated":[267],"requirement":[270],"NGF-induced":[272],"differentiation":[273],"preneuronal":[275],"cells":[276],"neuronal":[279],"phenotype.":[280]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}