{"id":"https://openalex.org/W40430408","doi":null,"title":"Biologically active peptide-containing fractions in schizophrenia and childhood autism.","display_name":"Biologically active peptide-containing fractions in schizophrenia and childhood autism.","publication_year":1981,"publication_date":"1981-01-01","ids":{"openalex":"https://openalex.org/W40430408","mag":"40430408","pmid":"https://pubmed.ncbi.nlm.nih.gov/7010949"},"language":"en","primary_location":{"id":"pmid:7010949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7010949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in biochemical psychopharmacology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111685548","display_name":"K. L. Reichelt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K L Reichelt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071437267","display_name":"Kjell Hole","orcid":"https://orcid.org/0000-0003-2960-2462","observed_orcids":["https://orcid.org/0000-0003-2960-2462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Hole","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072899776","display_name":"Anders Hamberger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Hamberger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026690673","display_name":"Gry Anette S\u00e6lid","orcid":"https://orcid.org/0000-0003-3347-0749","observed_orcids":["https://orcid.org/0000-0003-3347-0749"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Saelid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082542884","display_name":"Paul D. Edminson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P D Edminson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111893020","display_name":"C. Br\u00e6strup","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C B Braestrup","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039064935","display_name":"Ottar Lingj\u00e6rde","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Lingjaerde","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008652170","display_name":"P\u00e5l Ledaal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Ledaal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032826637","display_name":"Harald \u00d8rbeck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Orbeck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3391,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.56045605,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"28","issue":null,"first_page":"627","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.49900001287460327,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.49900001287460327,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.32760000228881836,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.049400001764297485,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.8709999918937683},{"id":"https://openalex.org/keywords/childhood-autism","display_name":"childhood autism","score":0.972000002861023},{"id":"https://openalex.org/keywords/urinary-peptides","display_name":"urinary peptides","score":0.7850000262260437},{"id":"https://openalex.org/keywords/peptidergic-neurons","display_name":"peptidergic neurons","score":0.8379999995231628},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.925000011920929},{"id":"https://openalex.org/keywords/neurotransmitter-modulation","display_name":"neurotransmitter modulation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.6299999952316284},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.5519999861717224},{"id":"https://openalex.org/keywords/neurochemistry","display_name":"neurochemistry","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.8896806240081787},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.6781700253486633},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.6201640963554382},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.5007145404815674},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4910757541656494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.483122318983078},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4279116690158844},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.378330796957016},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22348347306251526},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1860204041004181},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.18399864435195923}],"mesh":[{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7010949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7010949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in biochemical psychopharmacology","raw_type":"Journal Article"},{"id":"mag:40430408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7010949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2068440119","https://openalex.org/W2070601577","https://openalex.org/W194368495","https://openalex.org/W2355773089","https://openalex.org/W7098981679","https://openalex.org/W2014631837","https://openalex.org/W2051996824","https://openalex.org/W4391478036","https://openalex.org/W2040600491","https://openalex.org/W7214715767"],"abstract_inverted_index":{"It":[0],"is":[1,248],"well":[2,53,110],"documented":[3],"that":[4,72],"peptides":[5,42,94,117],"have":[6,56,99,196],"a":[7,149,198,214],"major":[8,159],"role":[9],"in":[10,105,165,206,220],"the":[11,96,114,140,146,156,166,174,221,231,255,258,263],"effective":[12],"functioning":[13],"of":[14,39,68,74,84,86,92,116,139,148,151,154,158,162,169,200,224,233,245,257,267],"higher":[15],"animals":[16],"at":[17,242],"all":[18],"levels":[19,83],"from":[20,121,126,130],"enzyme":[21],"stabilization":[22],"to":[23,58,80,90,102,135,145,209,252,262],"homeostatic":[24],"mechanisms":[25],"governing":[26],"essential":[27],"functions":[28],"such":[29,225],"as":[30,66,171,180],"eating,":[31],"sexual":[32],"behavior,":[33],"and":[34,48,71,107,118,129,189,239,265,269],"temperature":[35],"regulation.":[36],"The":[37],"effects":[38],"exogenously":[40],"administered":[41],"on":[43,213,254],"neurotransmitter":[44],"release,":[45],"uptake,":[46],"metabolism":[47],"behavioral":[49],"consequences":[50],"are":[51,164,176],"also":[52,177],"established.":[54],"We":[55,98,195],"attempted":[57],"extend":[59],"these":[60,163],"findings":[61],"by":[62,185],"postulating":[63],"peptidergic":[64],"neurons":[65],"transducers":[67],"multisignal":[69],"inputs,":[70],"development":[73],"pathological":[75],"states":[76],"may":[77],"be":[78],"due":[79],"genetically-determined":[81],"reduced":[82],"activity":[85],"key":[87],"peptidases,":[88],"leading":[89],"excretion":[91],"regulatory":[93],"into":[95,229],"circulation.":[97],"been":[100,183],"able":[101],"demonstrate":[103],"that,":[104],"schizophrenia":[106,268],"autism":[108],"(in":[109],"defined":[111],"clinical":[112],"cases),":[113],"patterns":[115],"associated":[119],"proteins":[120],"urinary":[122],"samples":[123],"differ":[124],"considerably":[125],"each":[127],"other":[128],"normal":[131],"controls.":[132],"In":[133],"addition":[134],"this,":[136],"further":[137],"purification":[138,181],"material":[141],"obtained":[142],"has":[143,182],"led":[144],"discovery":[147],"number":[150,199],"factors":[152],"capable":[153],"modulating":[155],"function":[157],"neurotransmitters.":[160],"Some":[161],"final":[167],"stages":[168],"characterization":[170],"peptides,":[172,179],"while":[173],"remainder":[175],"probably":[178],"followed":[184],"both":[186],"biological":[187,215,260],"testing":[188],"chemical":[190],"analysis":[191],"for":[192],"peptidic":[193],"material.":[194],"outlined":[197],"parameters":[201],"which":[202],"we":[203],"consider":[204],"relevant":[205],"any":[207],"attempt":[208],"put":[210],"psychiatric":[211],"disorders":[212,226],"foundation.":[216],"Any":[217],"new":[218],"advances":[219],"neurochemical":[222],"understanding":[223],"must":[227],"take":[228],"consideration":[230],"observations":[232],"several":[234],"different":[235],"disciplines":[236],"including":[237],"genetics":[238],"psychology.":[240],"However,":[241],"this":[243],"stage":[244],"research":[246],"it":[247],"far":[249],"too":[250],"early":[251],"speculate":[253],"relevance":[256],"various":[259],"activities":[261],"etiology":[264],"symptomatology":[266],"childhood":[270],"autism.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
