{"id":"https://openalex.org/W40423819","doi":null,"title":"Carrier-mediated transport of monocarboxylate drugs in the pigmented rabbit conjunctiva.","display_name":"Carrier-mediated transport of monocarboxylate drugs in the pigmented rabbit conjunctiva.","publication_year":1998,"publication_date":"1998-07-01","ids":{"openalex":"https://openalex.org/W40423819","mag":"40423819","pmid":"https://pubmed.ncbi.nlm.nih.gov/9660492"},"language":"en","primary_location":{"id":"pmid:9660492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9660492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"parent_works":[],"lineage":["https://openalex.org/W40423819"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046928258","display_name":"Yoshihide Horibe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Horibe","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005995886","display_name":"Ken\u2010ichi Hosoya","orcid":"https://orcid.org/0000-0001-5633-3865","observed_orcids":["https://orcid.org/0000-0001-5633-3865"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Hosoya","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034115999","display_name":"Kwang-Jin Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K J Kim","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039241599","display_name":"Vincent H.L. Lee","orcid":"https://orcid.org/0000-0001-7708-6269","observed_orcids":["https://orcid.org/0000-0001-7708-6269"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V H Lee","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":3.7498,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.92827586,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"39","issue":"8","first_page":"1436","last_page":"1443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6118000149726868,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6118000149726868,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.21950000524520874,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.053300000727176666,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conjunctiva","display_name":"conjunctiva","score":0.9359999895095825},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.7730000019073486},{"id":"https://openalex.org/keywords/fluoroquinolones","display_name":"fluoroquinolones","score":0.9929999709129333},{"id":"https://openalex.org/keywords/paracellular-pathway","display_name":"paracellular pathway","score":0.5170000195503235},{"id":"https://openalex.org/keywords/transcellular-pathway","display_name":"transcellular pathway","score":0.8600000143051147},{"id":"https://openalex.org/keywords/ouabain-sensitivity","display_name":"ouabain sensitivity","score":0.8199999928474426},{"id":"https://openalex.org/keywords/sodium-dependence","display_name":"sodium dependence","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6490330696105957},{"id":"https://openalex.org/C2779533339","wikidata":"https://www.wikidata.org/wiki/Q4036893","display_name":"DIDS","level":3,"score":0.5195068120956421},{"id":"https://openalex.org/C176285220","wikidata":"https://www.wikidata.org/wiki/Q7833830","display_name":"Transcellular","level":2,"score":0.5144634246826172},{"id":"https://openalex.org/C2775984611","wikidata":"https://www.wikidata.org/wiki/Q273554","display_name":"Conjunctiva","level":2,"score":0.504456639289856},{"id":"https://openalex.org/C2779133857","wikidata":"https://www.wikidata.org/wiki/Q285911","display_name":"Ouabain","level":3,"score":0.4861299991607666},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.4589475393295288},{"id":"https://openalex.org/C2781217356","wikidata":"https://www.wikidata.org/wiki/Q83426191","display_name":"Monocarboxylate transporter","level":4,"score":0.4355430006980896},{"id":"https://openalex.org/C60903277","wikidata":"https://www.wikidata.org/wiki/Q2051926","display_name":"Paracellular transport","level":4,"score":0.4265179932117462},{"id":"https://openalex.org/C2779932011","wikidata":"https://www.wikidata.org/wiki/Q581885","display_name":"Ussing chamber","level":3,"score":0.42507797479629517},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.42191651463508606},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4159516990184784},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35848289728164673},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3260385990142822},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3246116638183594},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32350513339042664},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.1861990988254547},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.1794283092021942},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.1502533257007599},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.147865891456604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14498645067214966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10734537243843079},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.10390275716781616},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.09341216087341309},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07374119758605957},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003228","descriptor_name":"Conjunctiva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009883","descriptor_name":"Ophthalmic Solutions","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D024841","descriptor_name":"Fluoroquinolones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9660492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9660492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:40423819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9660492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.335.4570","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.4570","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.iovs.org/content/39/8/1436.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6673898576","display_name":"Regulation of lung alveolar epithelial protein transport","funder_award_id":"R01HL038658","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7954717709","display_name":"ION TRANSPORT PROCESSES IN THE CONJUNCTIVA OF THE EYE","funder_award_id":"R01EY010421","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W65271911","https://openalex.org/W105867857","https://openalex.org/W112993562","https://openalex.org/W118596193","https://openalex.org/W167734904","https://openalex.org/W184887858","https://openalex.org/W298827286","https://openalex.org/W341728983","https://openalex.org/W1498947772","https://openalex.org/W1548826219","https://openalex.org/W1592679953","https://openalex.org/W1958525759","https://openalex.org/W1973163595","https://openalex.org/W1974899753","https://openalex.org/W1990007590","https://openalex.org/W1990669317","https://openalex.org/W2003189871","https://openalex.org/W2005234207","https://openalex.org/W2029752117","https://openalex.org/W2037725684","https://openalex.org/W2041618097","https://openalex.org/W2050627585","https://openalex.org/W2050710821","https://openalex.org/W2074167049","https://openalex.org/W2075512547","https://openalex.org/W2082301118","https://openalex.org/W2087596583","https://openalex.org/W2092225238","https://openalex.org/W2092773523","https://openalex.org/W2093256553","https://openalex.org/W2093806477","https://openalex.org/W2094780451","https://openalex.org/W2117934735","https://openalex.org/W2135300477","https://openalex.org/W2168341893","https://openalex.org/W2404246432","https://openalex.org/W2407187813","https://openalex.org/W2411225477","https://openalex.org/W2417712982","https://openalex.org/W2998066997"],"related_works":["https://openalex.org/W2001141138","https://openalex.org/W1955919277","https://openalex.org/W1961065329","https://openalex.org/W2052301002","https://openalex.org/W345827556","https://openalex.org/W154364077","https://openalex.org/W1973163595","https://openalex.org/W2149347308","https://openalex.org/W6964344709"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"determine":[2],"whether":[3],"an":[4],"Na+-dependent":[5,145,244,280],"monocarboxylate":[6,31,205,245,281],"transport":[7,113,136,188,230,246,260,282],"process":[8,146,154,247,283],"exists":[9],"on":[10,265],"the":[11,15,27,54,67,108,115,138,148,156,160,163,170,179,190,200,225,266,270,279],"mucosal":[12,68,109,201,267],"side":[13,69,268],"of":[14,29,56,79,142,203,269],"pigmented":[16,43,271],"rabbit":[17,44,272],"conjunctiva":[18,45],"and":[19,60,74,86,128,151,178,217,224,237,255],"to":[20,26,66,197,233,262,286],"evaluate":[21],"how":[22],"it":[23],"may":[24,249,284],"contribute":[25],"absorption":[28],"ophthalmic":[30],"drugs.":[32],"METHODS:":[33],"L-lactate":[34,135],"was":[35,46,100,167,173,185,193],"used":[36,251],"as":[37,80,82],"a":[38,49,91,143,152],"model":[39],"substrate.":[40],"The":[41],"excised":[42],"mounted":[47],"in":[48,90,98,114,137,189],"modified":[50],"Ussing":[51],"chamber":[52],"for":[53,259,278],"measurement":[55],"short-circuit":[57],"current":[58],"(Isc)":[59],"14C-L.-lactate":[61],"transport.":[62],"RESULTS:":[63],"When":[64],"added":[65],"at":[70,75,102,119],"37":[71],"degrees":[72,104],"C":[73,105],"pH":[76,133],"7.4,":[77],"applications":[78],"much":[81],"40":[83],"mM":[84,121],"L-":[85],"D-lactate":[87],"increased":[88],"Isc":[89,99],"saturable":[92,144,161],"manner.":[93],"By":[94],"contrast,":[95],"no":[96,240],"change":[97],"observed":[101],"4":[103],"or":[106],"under":[107],"Na+-free":[110],"condition.":[111],"14C-L-lactate":[112,187,229],"mucosal-to-serosal":[116],"(m-s)":[117],"direction":[118,140,192],"0.01":[120],"revealed":[122],"directionality,":[123],"temperature":[124],"dependency,":[125,127],"Na+":[126,181],"ouabain":[129],"sensitivity,":[130],"but":[131,207],"not":[132,208],"dependency.":[134],"m-s":[139,191],"consisted":[141],"by":[147,155,199,209,231,252],"transcellular":[149],"pathway":[150],"nonsaturable":[153],"paracellular":[157],"pathway.":[158],"For":[159],"process,":[162],"apparent":[164,180],"Michaelis-Menten":[165],"constant":[166],"1.9":[168],"mM,":[169],"maximum":[171],"flux":[172],"8.9":[174],"nanomoles/cm2":[175],"per":[176],"hour,":[177],":L-lactate":[182],"coupling":[183],"ratio":[184],"2:1.":[186],"significantly":[194],"inhibited":[195,228],"(46%":[196],"83%)":[198],"presence":[202],"various":[204],"compounds,":[206,211],"dicarboxylate":[210],"zwitterionic":[212],"compound,":[213],"D-glucose,":[214],"amino":[215],"acids,":[216],"peptidomimetic":[218],"antibiotics.":[219],"Monocarboxylate":[220],"nonsteroidal":[221],"anti-inflammatory":[222,254],"drugs":[223,258],"antibacterial":[226,257],"fluoroquinolones":[227],"40%":[232],"85%,":[234],"whereas":[235],"prostaglandins":[236],"cromolyn":[238],"had":[239],"effect.":[241],"CONCLUSIONS:":[242],"An":[243],"that":[248],"be":[250,263,285],"non-steroidal":[253],"fluoroquinolone":[256],"appears":[261],"present":[264],"conjunctiva.":[273],"A":[274],"possible":[275],"physiologic":[276],"role":[277],"salvage":[287],"tear":[288],"lactate.":[289]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}
