{"id":"https://openalex.org/W40412007","doi":"https://doi.org/10.1042/cs0940677","title":"Regional Differences in Protein Carboxymethylation in Post-Mortem Human Brain","display_name":"Regional Differences in Protein Carboxymethylation in Post-Mortem Human Brain","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W40412007","doi":"https://doi.org/10.1042/cs0940677","mag":"40412007","pmid":"https://pubmed.ncbi.nlm.nih.gov/9854468"},"language":"en","primary_location":{"id":"doi:10.1042/cs0940677","doi":"https://doi.org/10.1042/cs0940677","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs0940677","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090286753","display_name":"Michael Goggins","orcid":"https://orcid.org/0000-0002-4286-2296","observed_orcids":["https://orcid.org/0000-0002-4286-2296"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Michael Goggins","raw_affiliation_strings":["Department of Clinical Medicine, University of Dublin, Trinity College, Trinity Centre for Health Sciences, St. James' Hospital, James' St, Dublin 8, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, University of Dublin, Trinity College, Trinity Centre for Health Sciences, St. James' Hospital, James' St, Dublin 8, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049362478","display_name":"John M. Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"John M. Scott","raw_affiliation_strings":["Department of Clinical Medicine, University of Dublin, Trinity College, Trinity Centre for Health Sciences, St. James' Hospital, James' St, Dublin 8, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, University of Dublin, Trinity College, Trinity Centre for Health Sciences, St. James' Hospital, James' St, Dublin 8, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111677092","display_name":"Donald G. Weir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210154619","display_name":"St. James's Hospital","ror":"https://ror.org/04c6bry31","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210154619"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Donald G. Weir","raw_affiliation_strings":["Department of Clinical Medicine, University of Dublin, Trinity College, Trinity Centre for Health Sciences, St. James' Hospital, James' St, Dublin 8, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, University of Dublin, Trinity College, Trinity Centre for Health Sciences, St. James' Hospital, James' St, Dublin 8, Ireland","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210154619"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1162,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.38411431,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"94","issue":"6","first_page":"677","last_page":"685"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.48489999771118164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.48489999771118164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.0949999988079071,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.8109999895095825},{"id":"https://openalex.org/keywords/regional-brain-differences","display_name":"regional brain differences","score":0.6060000061988831},{"id":"https://openalex.org/keywords/cortical-white-matter","display_name":"cortical white matter","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vitamin-b12-deficiency","display_name":"vitamin B12 deficiency","score":0.8270000219345093},{"id":"https://openalex.org/keywords/hypomethylation","display_name":"hypomethylation","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.5069399476051331},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43852242827415466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3583771884441376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.251825213432312},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2044135332107544}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011497","descriptor_name":"Protein O-Methyltransferase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1042/cs0940677","doi":"https://doi.org/10.1042/cs0940677","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs0940677","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},{"id":"pmid:9854468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9854468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical science (London, England : 1979)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5899999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W46965905","https://openalex.org/W62398597","https://openalex.org/W1488195106","https://openalex.org/W1492953040","https://openalex.org/W1547336749","https://openalex.org/W1594700207","https://openalex.org/W1775749144","https://openalex.org/W1988732691","https://openalex.org/W1991476606","https://openalex.org/W1993833985","https://openalex.org/W2003267467","https://openalex.org/W2005186311","https://openalex.org/W2013281474","https://openalex.org/W2026663403","https://openalex.org/W2026770293","https://openalex.org/W2039451581","https://openalex.org/W2070469985","https://openalex.org/W2107959354","https://openalex.org/W2114829862","https://openalex.org/W2132510575","https://openalex.org/W2157811676","https://openalex.org/W2444365178"],"related_works":["https://openalex.org/W2040511112","https://openalex.org/W2036002830","https://openalex.org/W2042337953","https://openalex.org/W2027918409","https://openalex.org/W2017813386","https://openalex.org/W2749356602","https://openalex.org/W2903792037","https://openalex.org/W134159595","https://openalex.org/W2024474376","https://openalex.org/W2093287088"],"abstract_inverted_index":{"1.":[0],"The":[1,22,45],"aim":[2],"of":[3,11,17,24,32,35,47,107,114,184,186,196,209,215,223,253,271,302,309,327],"this":[4],"study":[5,326],"was":[6,28,53,92,124,235],"to":[7,78,131,173,202,305],"determine":[8],"the":[9,18,33,66,101,112,121,143,162,182,203,207,213,238,254,272,275,299,306,325],"pattern":[10],"protein":[12,25,48,82,102,144,216,263,290,336],"carboxymethylation":[13,49,83,185,217,291],"in":[14,50,85,100,105,142,147,218,237,245,262,338],"different":[15,201],"regions":[16,222,252,270],"human":[19,60,151,164,189,219,230,280,334],"brain.":[20],"2.":[21],"availability":[23],"methylation":[26,337],"sites":[27,288],"determined":[29,54],"by":[30,55],"measurement":[31],"incorporation":[34],"methyl-3H":[36],"groups":[37],"into":[38],"proteins":[39,187],"isolated":[40,149],"from":[41,150,161,188,228],"post-mortem":[42,51,57,86,190,224],"brain":[43,52,61,88,109,152,165,191,225,255,294,317,335],"tissue.":[44],"stability":[46],"sampling":[56],"pig":[58,87,108],"and":[59,243],"tissue":[62,123,166,318],"at":[63,111,126,168,206],"intervals":[64],"during":[65],"first":[67],"24":[68,132,174,194],"h":[69,133,154,175,195],"after":[70,134,155,176],"death.":[71,135,177,210],"This":[72,296],"method":[73],"has":[74],"previously":[75],"been":[76],"used":[77],"demonstrate":[79],"that":[80,118,159,181],"decreased":[81],"occurred":[84],"when":[89,120],"methionine":[90],"synthase":[91],"inhibited.":[93],"3.":[94],"There":[95],"were":[96,138,226,266],"no":[97,139],"significant":[98,140,260],"differences":[99,141,261],"carboxymethyltransferase":[103,145,233,264],"activity":[104,146,234,265],"samples":[106,148],"obtained":[110,119,160,192],"time":[113,208],"death":[115,156,197],"compared":[116,157,249],"with":[117,158,250,312],"same":[122,163],"maintained":[125,167],"room":[127,169],"temperature":[128,170],"for":[129,171,289,324],"up":[130,172],"Similarly,":[136],"there":[137,284],"12":[153],"These":[178],"results":[179],"suggest":[180],"level":[183,204],"within":[193],"is":[198],"not":[199],"significantly":[200],"present":[205],"To":[211],"characterize":[212],"distribution":[214],"brain,":[220],"nine":[221],"sampled":[227],"16":[229],"subjects.":[231],"Protein":[232],"lowest":[236],"cerebellum":[239],"(P":[240,256],"<":[241,257],"0.05)":[242],"highest":[244],"cortical":[246,281],"white":[247,282,303],"matter":[248,283,304],"other":[251,269,293],"0.05).":[258],"No":[259],"noted":[267],"between":[268],"cortex":[273],"or":[274,329],"subcortical":[276],"regions.":[277,295],"4.":[278],"In":[279],"are":[285],"more":[286],"available":[287],"than":[292],"may":[297],"explain":[298],"greater":[300],"sensitivity":[301],"adverse":[307],"consequences":[308],"hypomethylation":[310],"associated":[311],"vitamin":[313],"B12":[314],"deficiency.":[315],"Post-mortem":[316],"can":[319],"serve":[320],"as":[321],"a":[322],"tool":[323],"physiological":[328],"pathological":[330],"factors":[331],"which":[332],"influence":[333],"vivo.":[339]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
