{"id":"https://openalex.org/W40374102","doi":"https://doi.org/10.1016/0034-5288(88)90014-8","title":"Pharmacokinetics, metabolism and excretion of phenylbutazone in cattle following intravenous, intramuscular and oral administration","display_name":"Pharmacokinetics, metabolism and excretion of phenylbutazone in cattle following intravenous, intramuscular and oral administration","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W40374102","doi":"https://doi.org/10.1016/0034-5288(88)90014-8","mag":"40374102","pmid":"https://pubmed.ncbi.nlm.nih.gov/3375589"},"language":"en","primary_location":{"id":"doi:10.1016/0034-5288(88)90014-8","doi":"https://doi.org/10.1016/0034-5288(88)90014-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0034-5288(88)90014-8","pdf_url":null,"source":{"id":"https://openalex.org/S196403249","display_name":"Research in Veterinary Science","issn_l":"0034-5288","issn":["0034-5288","1532-2661"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in Veterinary Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007405150","display_name":"P. Lees","orcid":"https://orcid.org/0000-0002-8966-3737","observed_orcids":["https://orcid.org/0000-0002-8966-3737"]},"institutions":[{"id":"https://openalex.org/I133836048","display_name":"Royal Veterinary College","ror":"https://ror.org/01wka8n18","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I133836048"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. Lees","raw_affiliation_strings":["Department of Physiology, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK","Department of Physiology, Royal Veterinary College, North Mymms, Hatfield, Hertfordshire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK","institution_ids":["https://openalex.org/I133836048"]},{"raw_affiliation_string":"Department of Physiology, Royal Veterinary College, North Mymms, Hatfield, Hertfordshire","institution_ids":["https://openalex.org/I133836048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051633683","display_name":"T. R. AYLIFFE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133836048","display_name":"Royal Veterinary College","ror":"https://ror.org/01wka8n18","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I133836048"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. Ayliffe","raw_affiliation_strings":["Department of Surgery, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK","institution_ids":["https://openalex.org/I133836048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057190991","display_name":"Timothy Maitho","orcid":"https://orcid.org/0000-0003-2649-5788","observed_orcids":["https://orcid.org/0000-0003-2649-5788"]},"institutions":[{"id":"https://openalex.org/I133836048","display_name":"Royal Veterinary College","ror":"https://ror.org/01wka8n18","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I133836048"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T.E. Maitho","raw_affiliation_strings":["Department of Physiology, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, The Royal Veterinary College, Hawkshead Campus, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK","institution_ids":["https://openalex.org/I133836048"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004159640","display_name":"J. B. Taylor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.B.O. Taylor","raw_affiliation_strings":["MacCarthys Laboratories Ltd, Chesham House, Chesham Close, Romford, Essex RM14SX, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MacCarthys Laboratories Ltd, Chesham House, Chesham Close, Romford, Essex RM14SX, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":null,"fwci":8.1045,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.98441698,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"44","issue":"1","first_page":"57","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenylbutazone","display_name":"phenylbutazone","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9580000042915344},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.7379999756813049},{"id":"https://openalex.org/keywords/urinary-excretion","display_name":"urinary excretion","score":0.968999981880188},{"id":"https://openalex.org/keywords/cattle","display_name":"cattle","score":0.7279999852180481},{"id":"https://openalex.org/keywords/intramuscular-administration","display_name":"intramuscular administration","score":0.8859999775886536},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.9570000171661377},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.9710000157356262},{"id":"https://openalex.org/keywords/three-compartment-model","display_name":"three-compartment model","score":0.6679999828338623},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.8709999918937683},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.5879999995231628},{"id":"https://openalex.org/keywords/oxyphenbutazone","display_name":"oxyphenbutazone","score":0.8339999914169312},{"id":"https://openalex.org/keywords/enterohepatic-circulation","display_name":"enterohepatic circulation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/drug-sequestration","display_name":"drug sequestration","score":0.5080000162124634},{"id":"https://openalex.org/keywords/abomasum","display_name":"abomasum","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C2775844104","wikidata":"https://www.wikidata.org/wiki/Q421342","display_name":"Phenylbutazone","level":2,"score":0.8059630393981934},{"id":"https://openalex.org/C2777837344","wikidata":"https://www.wikidata.org/wiki/Q4116192","display_name":"Oxyphenbutazone","level":3,"score":0.7683631777763367},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6945167779922485},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6562261581420898},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5840457677841187},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.5292900204658508},{"id":"https://openalex.org/C2778620825","wikidata":"https://www.wikidata.org/wiki/Q1344633","display_name":"Enterohepatic circulation","level":3,"score":0.5177196860313416},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.51441890001297},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48543649911880493},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4793042242527008},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.46235546469688416},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35633161664009094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35097426176071167},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2590138018131256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2160530686378479},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09988859295845032},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007273","descriptor_name":"Injections, Intramuscular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010113","descriptor_name":"Oxyphenbutazone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010653","descriptor_name":"Phenylbutazone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010653","descriptor_name":"Phenylbutazone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010653","descriptor_name":"Phenylbutazone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010653","descriptor_name":"Phenylbutazone","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0034-5288(88)90014-8","doi":"https://doi.org/10.1016/0034-5288(88)90014-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0034-5288(88)90014-8","pdf_url":null,"source":{"id":"https://openalex.org/S196403249","display_name":"Research in Veterinary Science","issn_l":"0034-5288","issn":["0034-5288","1532-2661"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in Veterinary Science","raw_type":"journal-article"},{"id":"pmid:3375589","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3375589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in veterinary science","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W15640077","https://openalex.org/W130614201","https://openalex.org/W241439682","https://openalex.org/W610595393","https://openalex.org/W1977580995","https://openalex.org/W1983943581","https://openalex.org/W1986438429","https://openalex.org/W1996862350","https://openalex.org/W2024803530","https://openalex.org/W2037041939","https://openalex.org/W2037767040","https://openalex.org/W2047035301","https://openalex.org/W2053542325","https://openalex.org/W2062022307","https://openalex.org/W2076534794","https://openalex.org/W2084398333","https://openalex.org/W2099286542","https://openalex.org/W2117421251","https://openalex.org/W2125604734","https://openalex.org/W2139330669","https://openalex.org/W2157669900","https://openalex.org/W2159324929","https://openalex.org/W2167708410","https://openalex.org/W2247938431","https://openalex.org/W2290596792","https://openalex.org/W2304131176","https://openalex.org/W2394701908","https://openalex.org/W2398210033","https://openalex.org/W2400377677","https://openalex.org/W2414433069","https://openalex.org/W2428951690","https://openalex.org/W2463715215","https://openalex.org/W4300633276","https://openalex.org/W4406962746","https://openalex.org/W4407211225","https://openalex.org/W4409123455","https://openalex.org/W4409134259"],"related_works":["https://openalex.org/W2269420980","https://openalex.org/W2125604734","https://openalex.org/W73401337","https://openalex.org/W7111862450","https://openalex.org/W4407210638","https://openalex.org/W2167708410","https://openalex.org/W2009258623","https://openalex.org/W1977503337","https://openalex.org/W2107678729","https://openalex.org/W1986438429"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}