{"id":"https://openalex.org/W403552376","doi":null,"title":"Tea polyphenols as prostate cancer preventive agents","display_name":"Tea polyphenols as prostate cancer preventive agents","publication_year":2011,"publication_date":"2011-05-01","ids":{"openalex":"https://openalex.org/W403552376","mag":"403552376"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/10103126","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Tea_Polyphenols_as_Prostate_Cancer_Preventive_Agents/10103126","pdf_url":"https://figshare.com/articles/thesis/Tea_Polyphenols_as_Prostate_Cancer_Preventive_Agents/10103126","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/thesis/Tea_Polyphenols_as_Prostate_Cancer_Preventive_Agents/10103126","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. F. Thorpe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J. F. Thorpe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8410000205039978},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tea-polyphenols","display_name":"tea polyphenols","score":0.9990000128746033},{"id":"https://openalex.org/keywords/catechins","display_name":"catechins","score":0.9259999990463257},{"id":"https://openalex.org/keywords/theaflavins","display_name":"theaflavins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/black-tea","display_name":"black tea","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tramp-mouse-model","display_name":"TRAMP mouse model","score":0.8410000205039978},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.8730000257492065},{"id":"https://openalex.org/keywords/transurethral-resection-of-the-prostate","display_name":"transurethral resection of the prostate","score":0.8539999723434448},{"id":"https://openalex.org/keywords/prostate-tissue","display_name":"prostate tissue","score":0.32600000500679016}],"concepts":[{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.6473681330680847},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5455881357192993},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5105170011520386},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.47798866033554077},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4701027274131775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43191248178482056},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.245146244764328},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2372061312198639},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13360026478767395},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.11676585674285889}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:figshare.com:article/10103126","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Tea_Polyphenols_as_Prostate_Cancer_Preventive_Agents/10103126","pdf_url":"https://figshare.com/articles/thesis/Tea_Polyphenols_as_Prostate_Cancer_Preventive_Agents/10103126","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:hdl:10068/984997","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/984997","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:lra.le.ac.uk:2381/9634","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2381/9634","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:403552376","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539847","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/10103126","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Tea_Polyphenols_as_Prostate_Cancer_Preventive_Agents/10103126","pdf_url":"https://figshare.com/articles/thesis/Tea_Polyphenols_as_Prostate_Cancer_Preventive_Agents/10103126","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320314494","display_name":"Hope Foundation","ror":"https://ror.org/05wf1w785"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W403552376.pdf","grobid_xml":"https://content.openalex.org/works/W403552376.grobid-xml"},"referenced_works_count":239,"referenced_works":["https://openalex.org/W5694759","https://openalex.org/W106733404","https://openalex.org/W122817384","https://openalex.org/W142832026","https://openalex.org/W205075771","https://openalex.org/W1522923500","https://openalex.org/W1551102474","https://openalex.org/W1559303165","https://openalex.org/W1582872071","https://openalex.org/W1614488569","https://openalex.org/W1655460658","https://openalex.org/W1667158691","https://openalex.org/W1676754695","https://openalex.org/W1775942876","https://openalex.org/W1805263181","https://openalex.org/W1819691041","https://openalex.org/W1844088319","https://openalex.org/W1891879236","https://openalex.org/W1892091311","https://openalex.org/W1899863764","https://openalex.org/W1899936169","https://openalex.org/W1928958763","https://openalex.org/W1937169612","https://openalex.org/W1939806678","https://openalex.org/W1942214720","https://openalex.org/W1948931726","https://openalex.org/W1949240784","https://openalex.org/W1957318924","https://openalex.org/W1963554650","https://openalex.org/W1965421359","https://openalex.org/W1965795307","https://openalex.org/W1965928275","https://openalex.org/W1966666646","https://openalex.org/W1967304777","https://openalex.org/W1968448996","https://openalex.org/W1968512875","https://openalex.org/W1970266087","https://openalex.org/W1970530418","https://openalex.org/W1973262582","https://openalex.org/W1973303608","https://openalex.org/W1974257634","https://openalex.org/W1974623964","https://openalex.org/W1975444842","https://openalex.org/W1975707648","https://openalex.org/W1980548655","https://openalex.org/W1980796821","https://openalex.org/W1983064145","https://openalex.org/W1983546164","https://openalex.org/W1983969534","https://openalex.org/W1984017820","https://openalex.org/W1984041392","https://openalex.org/W1985730135","https://openalex.org/W1986819031","https://openalex.org/W1987562801","https://openalex.org/W1989877475","https://openalex.org/W1992512664","https://openalex.org/W1994116295","https://openalex.org/W1995141996","https://openalex.org/W1995753424","https://openalex.org/W1996624210","https://openalex.org/W2000139196","https://openalex.org/W2000385281","https://openalex.org/W2000737188","https://openalex.org/W2000825526","https://openalex.org/W2000902052","https://openalex.org/W2002907671","https://openalex.org/W2003647365","https://openalex.org/W2007712979","https://openalex.org/W2007769372","https://openalex.org/W2008744726","https://openalex.org/W2009686658","https://openalex.org/W2010057554","https://openalex.org/W2010257889","https://openalex.org/W2011666969","https://openalex.org/W2013400361","https://openalex.org/W2014310617","https://openalex.org/W2014604539","https://openalex.org/W2015135300","https://openalex.org/W2016313181","https://openalex.org/W2016998573","https://openalex.org/W2017334428","https://openalex.org/W2018341352","https://openalex.org/W2018385269","https://openalex.org/W2019017347","https://openalex.org/W2020636054","https://openalex.org/W2022486722","https://openalex.org/W2023595441","https://openalex.org/W2024038105","https://openalex.org/W2024069082","https://openalex.org/W2025444969","https://openalex.org/W2025903599","https://openalex.org/W2026541054","https://openalex.org/W2028236892","https://openalex.org/W2029809937","https://openalex.org/W2031137111","https://openalex.org/W2031147772","https://openalex.org/W2032054487","https://openalex.org/W2032649515","https://openalex.org/W2032729098","https://openalex.org/W2034269086","https://openalex.org/W2035808001","https://openalex.org/W2037735499","https://openalex.org/W2043343126","https://openalex.org/W2043557846","https://openalex.org/W2043700181","https://openalex.org/W2045644088","https://openalex.org/W2046928699","https://openalex.org/W2048330292","https://openalex.org/W2048859720","https://openalex.org/W2049153532","https://openalex.org/W2050428134","https://openalex.org/W2050451392","https://openalex.org/W2051065236","https://openalex.org/W2051592657","https://openalex.org/W2052396334","https://openalex.org/W2053571455","https://openalex.org/W2054386661","https://openalex.org/W2054429544","https://openalex.org/W2056852544","https://openalex.org/W2057184021","https://openalex.org/W2057218203","https://openalex.org/W2057477877","https://openalex.org/W2060296667","https://openalex.org/W2063151956","https://openalex.org/W2063974672","https://openalex.org/W2066396162","https://openalex.org/W2070769230","https://openalex.org/W2074279684","https://openalex.org/W2075908319","https://openalex.org/W2076436776","https://openalex.org/W2077669101","https://openalex.org/W2077956417","https://openalex.org/W2079647288","https://openalex.org/W2079907181","https://openalex.org/W2084024327","https://openalex.org/W2084085849","https://openalex.org/W2084541894","https://openalex.org/W2084995559","https://openalex.org/W2087692771","https://openalex.org/W2087705572","https://openalex.org/W2088576316","https://openalex.org/W2089091539","https://openalex.org/W2089415609","https://openalex.org/W2091685154","https://openalex.org/W2093593899","https://openalex.org/W2093604820","https://openalex.org/W2093948565","https://openalex.org/W2094354425","https://openalex.org/W2100531189","https://openalex.org/W2100915449","https://openalex.org/W2101285661","https://openalex.org/W2102305832","https://openalex.org/W2102888924","https://openalex.org/W2103119277","https://openalex.org/W2103498170","https://openalex.org/W2104448960","https://openalex.org/W2105408725","https://openalex.org/W2106188989","https://openalex.org/W2106955965","https://openalex.org/W2109893157","https://openalex.org/W2110862365","https://openalex.org/W2112392983","https://openalex.org/W2113831436","https://openalex.org/W2115559349","https://openalex.org/W2115868186","https://openalex.org/W2116189789","https://openalex.org/W2116541931","https://openalex.org/W2116597521","https://openalex.org/W2116740279","https://openalex.org/W2117847301","https://openalex.org/W2118462445","https://openalex.org/W2118495034","https://openalex.org/W2118681564","https://openalex.org/W2120292596","https://openalex.org/W2120595047","https://openalex.org/W2120730389","https://openalex.org/W2123230901","https://openalex.org/W2124958721","https://openalex.org/W2125399775","https://openalex.org/W2125565767","https://openalex.org/W2126044750","https://openalex.org/W2126078036","https://openalex.org/W2126432659","https://openalex.org/W2127718764","https://openalex.org/W2128016549","https://openalex.org/W2128569359","https://openalex.org/W2129249902","https://openalex.org/W2129268315","https://openalex.org/W2131260081","https://openalex.org/W2132795355","https://openalex.org/W2133929387","https://openalex.org/W2135393211","https://openalex.org/W2137330819","https://openalex.org/W2138050321","https://openalex.org/W2138220389","https://openalex.org/W2138302361","https://openalex.org/W2140573009","https://openalex.org/W2142038272","https://openalex.org/W2142285790","https://openalex.org/W2142565364","https://openalex.org/W2143246086","https://openalex.org/W2144099695","https://openalex.org/W2144312885","https://openalex.org/W2146291138","https://openalex.org/W2147039086","https://openalex.org/W2148236046","https://openalex.org/W2149247750","https://openalex.org/W2149461204","https://openalex.org/W2149556400","https://openalex.org/W2152835156","https://openalex.org/W2154621970","https://openalex.org/W2155009866","https://openalex.org/W2156570889","https://openalex.org/W2157996158","https://openalex.org/W2158602227","https://openalex.org/W2159036859","https://openalex.org/W2159318197","https://openalex.org/W2162181948","https://openalex.org/W2162511447","https://openalex.org/W2162923066","https://openalex.org/W2163579386","https://openalex.org/W2164942212","https://openalex.org/W2165057232","https://openalex.org/W2165332652","https://openalex.org/W2167673013","https://openalex.org/W2168740776","https://openalex.org/W2169427980","https://openalex.org/W2186652366","https://openalex.org/W2209259861","https://openalex.org/W2316095838","https://openalex.org/W2316462755","https://openalex.org/W2317926428","https://openalex.org/W2323868208","https://openalex.org/W2395949319","https://openalex.org/W2401667666","https://openalex.org/W2409444078","https://openalex.org/W2417576535","https://openalex.org/W2502134830","https://openalex.org/W3005452597"],"related_works":["https://openalex.org/W1966940678","https://openalex.org/W2170079644","https://openalex.org/W1481797752","https://openalex.org/W2138050321","https://openalex.org/W2142285790","https://openalex.org/W7099980350","https://openalex.org/W2116021196","https://openalex.org/W4223972269","https://openalex.org/W2116619120","https://openalex.org/W2100052188"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1,19,54,62,91,146,207,262],"is":[2,10,83,138],"an":[3],"ideal":[4],"candidate":[5],"for":[6,14,35,129,159,266],"chemoprevention.":[7,208],"Tea":[8,23],"drinking":[9],"a":[11,176,192,202,269],"possible":[12],"explanation":[13],"the":[15,64,70,98,112,130,139,155,160,168,180,243],"rarity":[16],"of":[17,69,90,118,144,182,194,205,223,233,248],"prostate":[18,53,61,102,122,145,189,206,246,261],"among":[20],"Chinese":[21],"men.":[22],"(Camellia":[24],"sinensis)":[25],"contains":[26],"flavonoid":[27],"polyphenols":[28,76,110,254],"called":[29],"catechins,":[30,224],"believed":[31],"to":[32,154,219,230,291],"be":[33,278,280],"responsible":[34],"this":[36,171,275,289],"anti-carcinogenesis.":[37],"In":[38,167],"black":[39,149],"tea":[40,75,109,150,165],"these":[41],"catechins":[42,257],"are":[43],"oxidised":[44],"into":[45],"theaflavins.":[46],"Catechins":[47,59],"and":[48,88,127,133,152,255],"theaflavins":[49,151,225],"both":[50],"inhibit":[51,60],"human":[52,96,210,271],"cell":[55],"proliferation":[56],"in":[57,63,79,94,111,141,179,188,238,242,268,282],"vitro.":[58],"TRAMP":[65,113],"mouse":[66],"animal":[67,86],"model":[68],"disease.":[71],"To":[72],"determine":[73],"if":[74],"warrant":[77],"investigation":[78],"large":[80],"trials,":[81],"evidence":[82,143,158],"required":[84],"from":[85,245],"models":[87],"biomarkers":[89],"prevention":[92,263],"identified":[93],"small":[95],"studies.\\nIn":[97],"work":[99],"presented":[100],"here,":[101],"carcinogenesis":[103],"was":[104,173,198,212,240],"inhibited":[105],"by":[106,148,163],"orally":[107],"administered":[108],"mouse.":[114],"Following":[115],"26":[116],"weeks":[117,222],"polyphenol":[119,228],"administration":[120],"median":[121],"masses":[123],"were":[124],"0.54g,":[125],"0.28g":[126],"1.01g":[128],"theaflavin,":[131],"catechin":[132,169],"control":[134],"group":[135],"respectively.":[136],"This":[137],"first":[140,279],"vivo":[142],"chemoprevention":[147,172],"adds":[153],"previously":[156],"published":[157],"same":[161],"effect":[162],"green":[164],"catechins.":[166],"group,":[170],"associated":[174],"with":[175],"significant":[177,236],"reduction":[178,237],"concentration":[181],"oxidative":[183,195],"DNA":[184,196,244],"adduct":[185],"malondialdehydedeoxyguanosine":[186],"(M1G)":[187],"tissue.":[190],"M1G,":[191],"marker":[193],"damage,":[197],"therefore":[199,259],"proposed":[200],"as":[201],"putative":[203],"biomarker":[204,286],"A":[209,235],"trial":[211,273],"then":[213],"performed":[214],"involving":[215],"18":[216],"men":[217,249],"randomised":[218],"receive":[220],"four":[221],"or":[226],"no":[227],"prior":[229],"transurethral":[231],"resection":[232],"prostate.":[234],"M1G":[239],"detected":[241],"tissue":[247],"who":[250],"had":[251],"received":[252],"catechins.\\nTea":[253],"particularly":[256],"may":[258],"represent":[260],"agents":[264],"suitable":[265],"study":[267,295],"larger":[270],"intervention":[272],"however,":[274],"finding":[276],"should":[277],"tested":[281],"further":[283],"better":[284],"designed":[285],"studies":[287],"using":[288],"result":[290],"inform":[292],"decisions":[293],"on":[294],"population":[296],"size.":[297]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
