{"id":"https://openalex.org/W4033585","doi":null,"title":"Normotensive sepsis is associated with increased lipid peroxidation products in skeletal muscle","display_name":"Normotensive sepsis is associated with increased lipid peroxidation products in skeletal muscle","publication_year":1990,"publication_date":"1990-02-26","ids":{"openalex":"https://openalex.org/W4033585","mag":"4033585"},"language":"en","primary_location":{"id":"mag:4033585","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/scitech/biblio/6007088","pdf_url":null,"source":{"id":"https://openalex.org/S4306510356","display_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108348571","display_name":"C. Lam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Lam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Gordon Fox","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon Fox","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112099803","display_name":"A. Neal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Neal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102000549","display_name":"Christopher D. Webb","orcid":"https://orcid.org/0000-0002-7514-432X","observed_orcids":["https://orcid.org/0000-0002-7514-432X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher D. Webb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062960141","display_name":"Frank S. Rutledge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Rutledge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111599185","display_name":"M. G. Myers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. G. Myers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072258146","display_name":"London Uwo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"London Uwo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00064573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9679999947547913},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9629999995231628},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.7020000219345093},{"id":"https://openalex.org/keywords/conjugated-dienes","display_name":"conjugated dienes","score":0.996999979019165},{"id":"https://openalex.org/keywords/hyperdynamic-sepsis","display_name":"hyperdynamic sepsis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.8539999723434448},{"id":"https://openalex.org/keywords/organ-failure","display_name":"organ failure","score":0.6740000247955322},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.7279999852180481},{"id":"https://openalex.org/keywords/sheep-model","display_name":"sheep model","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.8124189376831055},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6572800278663635},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.6571770906448364},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.6312273740768433},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5282413363456726},{"id":"https://openalex.org/C2775872116","wikidata":"https://www.wikidata.org/wiki/Q943203","display_name":"Gastrocnemius muscle","level":3,"score":0.5208035707473755},{"id":"https://openalex.org/C2778456384","wikidata":"https://www.wikidata.org/wiki/Q1508510","display_name":"Perforation","level":3,"score":0.49855828285217285},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4565751552581787},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4488624632358551},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43333572149276733},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4202512502670288},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3477369546890259},{"id":"https://openalex.org/C2778527123","wikidata":"https://www.wikidata.org/wiki/Q11750728","display_name":"Punching","level":2,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:4033585","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/scitech/biblio/6007088","pdf_url":null,"source":{"id":"https://openalex.org/S4306510356","display_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"FASEB Journal (Federation of American Societies for Experimental Biology); (United States)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2415629303","https://openalex.org/W2004052382","https://openalex.org/W2076302905","https://openalex.org/W4387392091","https://openalex.org/W7160926910","https://openalex.org/W2349640659","https://openalex.org/W2115647896","https://openalex.org/W110933961","https://openalex.org/W2404983203","https://openalex.org/W2043987331"],"abstract_inverted_index":{"Reactive":[0],"oxygen":[1],"species":[2],"(ROS)":[3],"have":[4],"been":[5],"implicated":[6],"in":[7,44,51,69,107,135,161,171,182],"the":[8,34,65,77,99,111,128,136,140,152,162,187],"development":[9],"of":[10,26,79,113,177,189],"sepsis-induced":[11],"multiple":[12],"systems":[13],"organ":[14],"failure,":[15],"possibly":[16],"through":[17],"biomembrane":[18],"lipid":[19],"perioxidation":[20],"(BLP)":[21],"which":[22,116],"produces":[23,175],"a":[24],"loss":[25],"cell":[27,42],"integrity":[28],"and":[29,62,85,96,104,123,146,156],"function.":[30],"The":[31,54,91],"authors":[32,55],"examined":[33],"hypothesis":[35],"that":[36,168],"ROS":[37,179],"activity":[38],"contributes":[39],"to":[40,139],"non-pulmonary":[41,183],"injury":[43],"hyperdynamic":[45,80],"sepsis":[46,81,170],"by":[47,60,64,82],"measuring":[48],"BLP":[49,114,181],"products":[50],"skeletal":[52],"muscle.":[53],"measured":[56],"systemic":[57],"flow":[58],"(Q)":[59],"thermodilution":[61],"Q-gastrocnemius":[63,147],"radioactive":[66],"microsphere":[67],"technique":[68],"10":[70],"awake":[71],"sheep,":[72],"48":[73,129],"hours":[74,130],"following":[75],"(i)":[76],"induction":[78],"cecal":[83],"ligation":[84],"perforation":[86],"or":[87],"(ii)":[88],"sham":[89,141],"laparotomy.":[90],"animals":[92],"were":[93,102,148,158],"then":[94],"anesthetized":[95],"biopsies":[97],"from":[98,186],"gastrocnemius":[100],"muscle":[101],"taken":[103],"flash":[105],"frozen":[106],"liquid":[108],"nitrogen":[109],"for":[110],"determination":[112],"products,":[115],"included":[117],"conjugated":[118],"dienes":[119],"(CD),":[120],"malondialdehyde":[121],"(MDA),":[122],"acid-soluble":[124],"sulfhydryls":[125],"(SH).":[126],"At":[127],"study,":[131],"Q":[132],"was":[133,166],"increased":[134,160,178],"septic":[137,163],"compared":[138],"group":[142],"while":[143],"mean":[144],"BP":[145],"not":[149],"different":[150],"between":[151],"groups.":[153],"Both":[154],"CD":[155],"SH":[157],"significantly":[159],"group.":[164],"It":[165],"concluded":[167],"normotensive":[169],"this":[172],"animal":[173],"model":[174],"evidence":[176],"mediated":[180],"organs":[184],"distant":[185],"site":[188],"inflammation.":[190]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
