{"id":"https://openalex.org/W402551080","doi":null,"title":"MODELLING NUCLEOCYTOPLASMIC TRANSPORT WITH APPLICATION TO THE INTRACELLULAR DYNAMICS OF THE TUMOR SUPPRESSOR PROTEIN P53","display_name":"MODELLING NUCLEOCYTOPLASMIC TRANSPORT WITH APPLICATION TO THE INTRACELLULAR DYNAMICS OF THE TUMOR SUPPRESSOR PROTEIN P53","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W402551080","mag":"402551080"},"language":"en","primary_location":{"id":"pmh:hdl:10068/883200","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/883200","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/883200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037322991","display_name":"Luna Dimitrio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"DIMITRIO, Luna","raw_affiliation_strings":["Nonlinear Analysis for Biology and Geophysical flows"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nonlinear Analysis for Biology and Geophysical flows","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085242140","display_name":"Jean Clairambault","orcid":"https://orcid.org/0000-0002-8336-9641","observed_orcids":["https://orcid.org/0000-0002-8336-9641"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CLAIRAMBAULT, Jean","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028629975","display_name":"Roberto Natalini","orcid":"https://orcid.org/0000-0002-5453-6383","observed_orcids":["https://orcid.org/0000-0002-5453-6383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"NATALINI, Roberto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5037322991"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.6528000235557556,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.6528000235557556,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.1665000021457672,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-transport","display_name":"nuclear transport","score":0.9950000047683716},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9380000233650208},{"id":"https://openalex.org/keywords/microtubule-based-transport","display_name":"microtubule transport","score":0.890999972820282},{"id":"https://openalex.org/keywords/motor-proteins","display_name":"motor proteins","score":0.8820000290870667},{"id":"https://openalex.org/keywords/brownian-diffusion","display_name":"Brownian diffusion","score":0.7979999780654907},{"id":"https://openalex.org/keywords/partial-differential-equations","display_name":"partial differential equations","score":0.7229999899864197},{"id":"https://openalex.org/keywords/atm","display_name":"ATM","score":0.4659999907016754},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8349999785423279},{"id":"https://openalex.org/keywords/p53-oscillations","display_name":"p53 oscillations","score":0.8550000190734863},{"id":"https://openalex.org/keywords/bifurcation-analysis","display_name":"bifurcation analysis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/spatiotemporal-dynamics","display_name":"spatiotemporal dynamics","score":0.9039999842643738},{"id":"https://openalex.org/keywords/robustness-analysis","display_name":"robustness analysis","score":0.5950000286102295},{"id":"https://openalex.org/keywords/tumor-suppressor-proteins","display_name":"tumor suppressor proteins","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.7279346585273743},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.5717068314552307},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5699999332427979},{"id":"https://openalex.org/C93126451","wikidata":"https://www.wikidata.org/wiki/Q2383767","display_name":"Motor protein","level":3,"score":0.5397025942802429},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5373254418373108},{"id":"https://openalex.org/C160408235","wikidata":"https://www.wikidata.org/wiki/Q423905","display_name":"Molecular motor","level":2,"score":0.5298064947128296},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.49669963121414185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40454283356666565},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3471771478652954},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3365601599216461},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24169278144836426},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11703327298164368}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:hdl:10068/883200","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/883200","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:HAL:tel-00769901v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00769901","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Quantitative Methods [q-bio.QM]. Universit\u00e9 Pierre et Marie Curie - Paris VI; Universit\u00e0 degli studi di Roma I, 2012. English. &#x27E8;NNT : &#x27E9;","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:iris.uniroma1.it:11573/918073","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/918073","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:padis.uniroma1.it:10805/1675","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10805/1675","pdf_url":null,"source":{"id":"https://openalex.org/S4406922397","display_name":"Pubblicazioni Aperte Digitali Interateneo Sapienza","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral Thesis"}],"best_oa_location":{"id":"pmh:hdl:10068/883200","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/883200","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W3044475","https://openalex.org/W95204905","https://openalex.org/W1544054537","https://openalex.org/W1650579874","https://openalex.org/W1856360008","https://openalex.org/W1875257387","https://openalex.org/W1926834804","https://openalex.org/W1959487747","https://openalex.org/W1963670734","https://openalex.org/W1967381786","https://openalex.org/W1972362449","https://openalex.org/W1979634817","https://openalex.org/W1980396134","https://openalex.org/W1985190908","https://openalex.org/W1991362198","https://openalex.org/W1994361639","https://openalex.org/W1995117660","https://openalex.org/W1996786959","https://openalex.org/W1997751143","https://openalex.org/W1998597603","https://openalex.org/W1998765157","https://openalex.org/W2002164453","https://openalex.org/W2004968694","https://openalex.org/W2007249806","https://openalex.org/W2007935491","https://openalex.org/W2013253155","https://openalex.org/W2013765436","https://openalex.org/W2014977510","https://openalex.org/W2015748683","https://openalex.org/W2015884353","https://openalex.org/W2018385269","https://openalex.org/W2021176126","https://openalex.org/W2027202090","https://openalex.org/W2029635647","https://openalex.org/W2030836169","https://openalex.org/W2030945597","https://openalex.org/W2033194496","https://openalex.org/W2035192595","https://openalex.org/W2036947100","https://openalex.org/W2037086486","https://openalex.org/W2042145670","https://openalex.org/W2043415140","https://openalex.org/W2044972507","https://openalex.org/W2048492672","https://openalex.org/W2049222491","https://openalex.org/W2049451587","https://openalex.org/W2049527615","https://openalex.org/W2055148721","https://openalex.org/W2056650825","https://openalex.org/W2057382102","https://openalex.org/W2058041522","https://openalex.org/W2059999514","https://openalex.org/W2063843701","https://openalex.org/W2064330613","https://openalex.org/W2068359474","https://openalex.org/W2068912983","https://openalex.org/W2068920904","https://openalex.org/W2069500900","https://openalex.org/W2070831615","https://openalex.org/W2072278366","https://openalex.org/W2078361436","https://openalex.org/W2082979850","https://openalex.org/W2083563185","https://openalex.org/W2083625284","https://openalex.org/W2084559690","https://openalex.org/W2085418817","https://openalex.org/W2085849675","https://openalex.org/W2087662066","https://openalex.org/W2089654173","https://openalex.org/W2092372914","https://openalex.org/W2093279379","https://openalex.org/W2093673674","https://openalex.org/W2097651998","https://openalex.org/W2106243159","https://openalex.org/W2107618142","https://openalex.org/W2111184079","https://openalex.org/W2111859411","https://openalex.org/W2114261502","https://openalex.org/W2116145077","https://openalex.org/W2117037202","https://openalex.org/W2117931389","https://openalex.org/W2118411078","https://openalex.org/W2123017967","https://openalex.org/W2123100388","https://openalex.org/W2123555845","https://openalex.org/W2126679757","https://openalex.org/W2127006805","https://openalex.org/W2152750766","https://openalex.org/W2152993287","https://openalex.org/W2157031202","https://openalex.org/W2159555806","https://openalex.org/W2168002602","https://openalex.org/W2170494099","https://openalex.org/W2170991710","https://openalex.org/W2405367459","https://openalex.org/W2483155018","https://openalex.org/W2612743911","https://openalex.org/W3022542029"],"related_works":["https://openalex.org/W7100062398","https://openalex.org/W7096498639","https://openalex.org/W7161814470","https://openalex.org/W956139556","https://openalex.org/W2080801531","https://openalex.org/W2405367459","https://openalex.org/W237940658","https://openalex.org/W2134983040","https://openalex.org/W1643206581","https://openalex.org/W1675493145"],"abstract_inverted_index":{"In":[0,197],"this":[1],"thesis,":[2,203],"I":[3,12,111,136,204,259,283,301,330],"discuss":[4],"two":[5,14],"main":[6],"subjects":[7],"coming":[8],"from":[9,189],"biology":[10],"and":[11,102,162,173,178,206,256,313,342,347],"propose":[13,112],"models":[15,133],"that":[16,90],"mimic":[17],"the":[18,21,29,49,70,81,93,123,138,183,198,202,213,219,224,239,267,271,274,291,294,304,307,315,322,327,333,336],"behaviours":[19],"of":[20,28,35,43,56,88,117,140,152,185,201,215,223,242,250,270,296,309,318,324,335],"biological":[22],"networks":[23],"studied.":[24],"The":[25,231],"first":[26],"part":[27,200],"thesis":[30],"deals":[31],"with":[32],"intracellular":[33,51],"transport":[34,52,119],"molecules.":[36],"Proteins,":[37],"RNA":[38],"and,":[39],"generally,":[40],"any":[41],"kind":[42],"cargo":[44,107],"molecules":[45],"move":[46,103],"freely":[47],"in":[48,131,159,218,238,246,293,326],"cytoplasm:":[50],"as":[53,62],"a":[54,63,85,106,113,141,150,208,261,285,310],"consequence":[55],"Brownian":[57],"motion":[58],"is":[59,147,171,277],"classically":[60],"modelled":[61],"diffusion":[64,195],"process.":[65],"Some":[66],"specific":[67],"proteins,":[68],"like":[69],"tumour":[71],"suppressor":[72],"p53,":[73],"use":[74],"microtubules":[75],"to":[76,99,109,127,180,182,265,289],"facilitate":[77],"their":[78,194],"way":[79],"towards":[80,92],"nucleus.":[82],"Microtubules":[83],"are":[84,157,176],"dense":[86],"network":[87],"filaments":[89,101],"point":[91],"cell":[94,251,345],"centre.":[95],"Motor":[96],"proteins":[97,187],"bind":[98],"these":[100],"along,":[104],"bearing":[105],"bound":[108],"them.":[110],"simplified":[114],"bi-dimensional":[115],"model":[116,146,211,264,305],"nucleocytoplasmic":[118],"taking":[120],"into":[121],"account":[122],"kinetic":[124],"processes":[125],"linked":[126],"microtubule":[128,190],"transport.":[129],"Unlike":[130],"other":[132],"we":[134],"know,":[135],"represented":[137],"position":[139],"single":[142],"MT":[143],"filament.":[144],"This":[145],"given":[148],"by":[149,164,228,306],"system":[151,337],"partial":[153],"differential":[154],"equations":[155],"which":[156,186],"cast":[158],"different":[160],"dimensions":[161],"connected":[163],"suitable":[165],"exchange":[166],"rules.":[167],"A":[168],"numerical":[169,286],"scheme":[170],"introduced":[172],"several":[174],"scenarios":[175],"presented":[177],"discussed":[179],"answer":[181],"question":[184],"benefit":[188],"transport,":[191],"depending":[192],"on":[193],"coefficients.":[196],"second":[199],"design":[205],"analyse":[207],"physiologically":[209],"based":[210],"representing":[212],"accumulation":[214],"protein":[216,226,233,276],"p53":[217,232,275],"nucleus":[220],"after":[221],"triggering":[222],"sentinel":[225],"ATM":[227],"DNA":[229],"damage.":[230],"plays":[234],"an":[235],"essential":[236],"role":[237],"physiological":[240],"maintenance":[241],"healthy":[243],"tissue":[244],"integrity":[245],"multicellular":[247],"organisms":[248],"(regulation":[249],"cycle":[252],"arrest,":[253],"repair":[254],"pathways":[255],"apoptosis).":[257],"Firstly,":[258],"developed":[260],"compartmental":[262],"ODE":[263],"represent":[266],"temporal":[268],"dynamics":[269,317],"protein.":[272],"Since":[273],"known":[278],"for":[279],"its":[280],"oscillatory":[281],"behaviour,":[282],"performed":[284],"bifurcation":[287],"study":[288],"verify":[290],"existence,":[292],"model,":[295],"stable":[297],"periodic":[298],"solutions.":[299],"Next,":[300],"have":[302,331],"expanded":[303],"addition":[308],"spatial":[311,328,339],"variable":[312],"analysed":[314,332],"spatio-temporal":[316],"p53.":[319],"After":[320],"checking":[321],"existence":[323],"oscillations":[325],"setting,":[329],"robustness":[334],"under":[338],"variations":[340],"(diffusion":[341],"permeability":[343],"coefficients,":[344],"shape":[346],"size).":[348]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
